Article
Chemistry, Analytical
Hilary Urena-Saborio, Anu Prathap M. Udayan, Emilia Alfaro-Viquez, Sergio Madrigal-Carballo, Jess D. Reed, Sundaram Gunasekaran
Summary: Consumption of cranberries can prevent urinary tract infections by the interaction of proanthocyanidins with virulence factors on UTI-causing bacteria. Functionalized biosensors using cranberry PAC were shown to effectively detect and diagnose UTIs associated with ExPEC, exhibiting high sensitivity, selectivity, reproducibility, and stability.
Article
Infectious Diseases
Concetta Caglioti, Rossana Iannitti, Giada Ceccarelli, Laura Selan, Marco Artini, Rosanna Papa, Antonio Malvasi, Rosaria Gentile, Diletta Del Bianco, Florinda Apone, Paola Angelini, Federico Palazzetti, Bernard Fioretti
Summary: Urinary tract infections primarily affect women and are commonly treated with antibiotics. However, antibiotic resistance can limit the effectiveness of this approach. Proanthocyanidins found in cranberry extracts have shown promise as a treatment for UTIs due to their ability to inhibit bacterial adhesion, reducing virulence. This study demonstrated via microscopy and scattering measurements that a mixture of cranberry and chondroitin sulfate can form a crosslinked structure with barrier properties. The best mixture was identified through experimentation and confirmed to have barrier properties using transepithelial electrical resistance chambers. Additionally, the mixture showed variable inhibitory effects on biofilm formation by antibiotic-resistant Escherichia coli strains, suggesting potential benefits for UTIs with antibiotic resistance profiles.
Article
Biochemical Research Methods
Kuo-Wei Hsu, Wen-Bin Lee, Huey-Ling You, Mel S. Lee, Gwo-Bin Lee
Summary: Urinary tract infections are common in females, posing risks to kidney function and often requiring broad-spectrum antibiotics. The rise of drug-resistant strains has led to high recurrence rates, emphasizing the need for accurate antibiotic selection. A newly developed portable system allows for rapid and precise measurement of antibiotic sensitivity in urine samples, offering promise for future personalized medicine.
Review
Infectious Diseases
Faiza Morado, Darren W. Wong
Summary: Urinary tract infection is a common bacterial infection with challenges in diagnosis. To limit unnecessary testing and antibiotic use, various diagnostic stewardship initiatives involving multidisciplinary approaches and education of healthcare providers are effective in decreasing inappropriate testing and prescribing.
Article
Medicine, General & Internal
Xuhui Li, Hua Fan, Hao Zi, Hankun Hu, Binghui Li, Jiao Huang, Pengcheng Luo, Xiantao Zeng
Summary: This study aimed to estimate the global and regional burden of bacterial antimicrobial resistance (AMR) in urinary tract infections (UTI) in 2019. The results showed that globally, there were approximately 64.89 thousand deaths attributed to and 0.26 million deaths associated with bacterial AMR in UTI. Escherichia coli and Klebsiella pneumoniae had the highest resistance rates, including resistance to fluoroquinolones, carbapenems, and third-generation cephalosporins. Tailored strategies, such as enhanced surveillance and rational use of antibiotics, should be developed for different regions based on their specific pathogen-antibiotic situations and resources.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Infectious Diseases
Ariadna Jazmin Ortega-Lozano, Estefani Yaquelin Hernandez-Cruz, Tania Gomez-Sierra, Jose Pedraza-Chaverri
Summary: Urinary tract infections (UTIs) are common worldwide, with Escherichia coli being the main cause. Antibiotics are commonly used for treatment but face challenges such as antibiotic resistance and biofilm formation. Medicinal plants, specifically spices, offer an alternative with their antimicrobial properties. This article summarizes research on the antimicrobial activity of cinnamon, clove, cumin, oregano, pepper, and rosemary against uropathogens responsible for UTIs.
Review
Chemistry, Multidisciplinary
Andreea Crintea, Rahela Carpa, Andrei-Otto Mitre, Robert Istvan Petho, Vlad-Florin Chelaru, Sebastian-Mihail Nadasan, Lidia Neamti, Alina Gabriela Dutu
Summary: Urinary tract infections (UTIs) are preventable health issues, but the widespread use of antibiotics as treatments is concerning. Nanotechnologies may provide a solution to antibiotic resistance. This review presents promising nano-solutions for UTIs, along with clinical and epidemiological aspects, diagnostic instruments, and non-antibiotic treatments.
Article
Veterinary Sciences
Fergus Allerton, Koen B. Pouwels, Julien Bazelle, Sarah Caddy, Andria Cauvin, Luisa De Risio, James Swann, James Warland, Andrew Kent
Summary: Current research on course lengths for common canine infections is limited. This prospective study aims to determine the shortest course duration for female dogs with lower urinary tract signs, providing guidelines for antimicrobial decision-making in clinical practice.
BMC VETERINARY RESEARCH
(2021)
Article
Medicine, General & Internal
Oghenekome Gbinigie, Julie Allen, Nicola Williams, Michael Moore, Alastair D. Hay, Carl Heneghan, Anne-Marie Boylan, Christopher C. Butler
Summary: This study aimed to assess the feasibility of a randomized trial testing the effectiveness of cranberry extract in reducing antibiotic use for women with symptoms of acute, uncomplicated UTI. The study found that it was feasible to conduct such a trial in general practice, with high recruitment rates and participant compliance.
Article
Pharmacology & Pharmacy
Rama Alkhawaldeh, Rana Abu Farha, Khawla Abu Hammour, Eman Alefishat
Summary: This study evaluated the impact of urine culture and sensitivity results on the treatment of urinary tract infections (UTIs). The results revealed a high rate of inappropriate treatment for UTIs despite the availability of culture and sensitivity data, indicating a need for improvement in optimizing treatment strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Camilla Smoglica, Giulia Evangelisti, Caterina Fani, Fulvio Marsilio, Michele Trotta, Francesca Messina, Cristina Esmeralda Di Francesco
Summary: The available data on antimicrobial resistance in pets are limited compared to those collected for food-producing animals. In this study, laboratory investigations were conducted on dogs and cats with urinary tract infections in Central Italy to provide additional data on bacterial urinary pathogens and their antimicrobial resistance patterns. The study found a high prevalence of resistant bacteria and a significant proportion of isolates classified as multidrug-resistant.
Article
Infectious Diseases
Guadalupe Miranda-Novales, Karen Flores-Moreno, Yolanda Lopez-Vidal, Samuel Ponce de Leon-Rosales
Summary: This study evaluated the antimicrobial susceptibility patterns of Escherichia coli and Klebsiella pneumoniae, and found that multidrug-resistant bacteria represented 61% of all isolates.
Article
Clinical Neurology
Wouter Peelaerts, Gabriela Mercado, Sonia George, Marie Villumsen, Alysa Kasen, Miguel Aguileta, Christian Linstow, Alexandra B. Sutter, Emily Kuhn, Lucas Stetzik, Rachel Sheridan, Liza Bergkvist, Lindsay Meyerdirk, Allison Lindqvist, Martha L. Escobar Gavis, Chris van den Haute, Scott J. Hultgren, Veerle Baekelandt, J. Andrew Pospisilik, Tomasz Brudek, Susana Aznar, Jennifer A. Steiner, Michael X. Henderson, Lena Brundin, Magdalena I. Ivanova, Tom J. Hannan, Patrik Brundin
Summary: Symptoms in the urogenital organs are common in MSA, and our study suggests that infection of the genitourinary tract could trigger alphaSyn aggregation, leading to MSA diagnosis. Urinary tract infections are associated with future MSA diagnosis and impact both men and women. Bacterial infection of the urinary bladder triggers synucleinopathy in mice, indicating a potential link between bacterial infections and MSA.
ACTA NEUROPATHOLOGICA
(2023)
Review
Biochemistry & Molecular Biology
Maria Maisto, Fortuna Iannuzzo, Ettore Novellino, Elisabetta Schiano, Vincenzo Piccolo, Gian Carlo Tenore
Summary: Urinary tract infections (UTIs) are a common bacterial infection, especially in women. The main etiological agents are E. coli, Pseudomonas aeruginosa, and Proteus mirabilis. Due to the increase in antimicrobial resistance, there is a need for natural alternatives for UTI treatment. This review summarizes the potential therapeutic effects of natural polyphenol-based nutraceuticals and foods through in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Giovanni Autore, Luca Bernardi, Claudio La Scola, Filippo Ghidini, Federico Marchetti, Andrea Pasini, Luca Pierantoni, Claudia Castellini, Claudia Gatti, Cristina Malaventura, Gabriella Pelusi, Francesco Antodaro, Andrea Bergomi, Franco Mazzini, Giovanni Parente, Roberto Pillon, Francesca Cusenza, Giacomo Biasucci, Alessandro De Fanti, Lorenzo Iughetti, Serafina Perrone, Andrea Pession, Mario Lima, Susanna Esposito
Summary: Urinary tract infection (UTI) is a common infectious disease in children, leading to antibiotic consumption and hospitalizations. This study aims to evaluate the agreement on UTI management in pediatric age in Emilia-Romagna Region, Italy, and assess the need to change current recommendations. The consensus provides clear indications based on the most updated literature to guide physicians in UTI management and avoid antibiotic abuse.
Review
Nutrition & Dietetics
Antonios Dakanalis, Maria Mentzelou, Souzana K. Papadopoulou, Dimitrios Papandreou, Maria Spanoudaki, Georgios K. Vasios, Eleni Pavlidou, Maria Mantzorou, Constantinos Giaginis
Summary: Emotional eating refers to the tendency to eat in response to emotions, and it is considered a critical risk factor for recurrent weight gain. This study aims to summarize and evaluate the interconnections among emotional eating and overweight/obesity, depression, anxiety/stress, and dietary patterns.
Article
Chemistry, Multidisciplinary
Efstratios Christodoulou, Georgia-Eirini Deligiannidou, Christos Kontogiorgis, Constantinos Giaginis, Antonios E. Koutelidakis
Summary: This study explored the relationship between Natural Functional Foods (NFFs) and the Mediterranean Diet (MD) and Mediterranean Lifestyle (MEDILIFE) in Greece, as well as their association with Psychological Resilience (PsyR) and other health-related parameters. The results showed a significant association between NFFs grown and produced in the Mediterranean region and the MD and MEDILIFE. These NFFs also had a positive effect on PsyR, sleep quality, and maintaining a healthy weight.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Maria Mantzorou, Maria Mentzelou, Georgios K. Vasios, Christos Kontogiorgis, Georgios Antasouras, Konstantinos Vadikolias, Evmorfia Psara, Theofanis Vorvolakos, Efthymios Poulios, Aspasia Serdari, Sousana K. Papadopoulou, Constantinos Giaginis
Summary: This study aims to assess the impact of Mediterranean diet adherence on health-related quality of life, physical activity levels, and sleep quality in a representative Greek elderly population. The results showed that high adherence to the Mediterranean diet was associated with better quality of life, higher physical activity levels, and adequate sleep quality.
Article
Nutrition & Dietetics
Eleni Pavlidou, Sousana K. Papadopoulou, Maria Mentzelou, Antonios Dakanalis, Theofanis Vorvolakos, Georgios Antasouras, Maria Spanoudaki, Aimilia-Lynn Pandi, Aspasia Serdari, Maria Chrysafi, Sofia Dimoliani, Constantinos Giaginis
Summary: This study investigates the potential effect of Mediterranean diet (MD) adherence on COVID-19-induced complications. The results show that MD compliance is associated with female gender, better economic status, non-smoking, higher physical activity levels, better sleep quality, better quality of life, and reduced probability of anxiety and depression.
Article
Nutrition & Dietetics
Sousana K. Papadopoulou, Eleni Pavlidou, Antonios Dakanalis, Georgios Antasouras, Theofanis Vorvolakos, Maria Mentzelou, Aspasia Serdari, Aimilia-Lynn Pandi, Maria Spanoudaki, Olga Alexatou, Exakousti-Petroula Aggelakou, Constantinos Giaginis
Summary: Postpartum depression is a pressing health concern that negatively impacts both mothers' and infants' health. Nutrition has been identified as a crucial factor for managing and treating this condition. A survey was conducted to determine the possible association between postpartum depression and various factors, including socio-demographic characteristics, anthropometric parameters, perinatal outcomes, breastfeeding practices, and Mediterranean diet adherence.
Article
Nutrition & Dietetics
Konstantinos Papadimitriou, Paraskevi Detopoulou, Konstantinos Soufleris, Gavriela Voulgaridou, Despoina Tsoumana, Panagiotis Ntopromireskou, Constantinos Giaginis, Ioanna P. Chatziprodromidou, Maria Spanoudaki, Sousana K. Papadopoulou
Summary: The purpose of this study was to assess malnutrition and sarcopenia in patients with Crohn's disease. Based on the studied anthropometric, nutritional, and functional variables, sarcopenia was not diagnosed in the CD patients in this study. However, body composition patterns were related to the inflammatory burden, highlighting the interplay between inflammation and malnutrition, even in remission states. Further studies on older populations and during disease exacerbation are necessary to explore the potential link between CD, inflammation, and sarcopenia.
Article
Nutrition & Dietetics
Eleni Pavlidou, Dimitrios Papandreou, Zainab Taha, Maria Mantzorou, Stefanos Tyrovolas, Dimitrios N. Kiortsis, Evmorfia Psara, Sousana K. Papadopoulou, Marios Yfantis, Maria Spanoudaki, Georgios Antasouras, Maria Mentzelou, Constantinos Giaginis
Summary: This study found that pre-pregnancy overweight and obesity is becoming more common in reproductive-aged women in middle- and high-income populations. Maternal excess body mass index (BMI) before gestation is associated with children's anthropometric characteristics and perinatal and postnatal outcomes. Encouraging healthy lifestyle promotion and focusing on obesity population policies and nutritional interventions among women of reproductive age is necessary.
Review
Nutrition & Dietetics
Alice Caldiroli, Davide La Tegola, Francesca Manzo, Alberto Scalia, Letizia Maria Affaticati, Enrico Capuzzi, Fabrizia Colmegna, Marios Argyrides, Constantinos Giaginis, Leonardo Mendolicchio, Massimiliano Buoli, Massimo Clerici, Antonios Dakanalis
Summary: The aim of this systematic review was to examine the impact of the COVID-19 pandemic on binge eating disorder, including new onset and clinical changes. Twelve studies with 4326 participants were included, and the findings suggest an increase in BED diagnoses and worsening of symptoms during the pandemic. However, the quality of the included studies was weak to moderate, and there was high heterogeneity among the studies, indicating a need for further research to validate these findings and develop preventive strategies and personalized treatments.
Article
Green & Sustainable Science & Technology
Maria Gialeli, Andreas Y. Troumbis, Constantinos Giaginis, Sousana K. Papadopoulou, Ioannis Antoniadis, Georgios K. Vasios
Summary: The concept of sustainable diets (SDs) refers to diets that promote environmental health, ensure food and nutrition security, and support a healthy lifestyle in humans. International events have played a significant role in promoting the importance of SDs and increasing knowledge and awareness among scientists and policymakers. This study is the first to analyze the trends and turning points in SDs research using bibliometric analysis, revealing the exponential growth in literature on SDs since 2009, with a focus on climate change, food systems, and health. The Mediterranean Diet (MD) emerged as the most popular dietary pattern among local SDs, with collaborations and partnerships between countries contributing to research advancements. Overall, this study maps the expansion of knowledge on SDs over the past 36 years and highlights the impact of international events on scientific research.
Article
Medicine, General & Internal
Sousana K. Papadopoulou, Maria Mentzelou, Eleni Pavlidou, Georgios K. Vasios, Maria Spanoudaki, Georgios Antasouras, Anastasia Sampani, Evmorfia Psara, Gavriela Voulgaridou, Gerasimos Tsourouflis, Maria Mantzorou, Constantinos Giaginis
Summary: This study found that caesarean section delivery is associated with childhood overweight/obesity, low birth anthropometric indices, and postnatal complications. Caesarean section increases the risk of childhood overweight/obesity and low birth anthropometric indices, highlighting the need for health policies to inform mothers about its risks.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Maria Mantzorou, Dimitrios Papandreou, Eleni Pavlidou, Sousana K. K. Papadopoulou, Maria Tolia, Maria Mentzelou, Antigoni Poutsidi, Georgios Antasouras, Georgios K. K. Vasios, Constantinos Giaginis
Summary: This study investigated the associations between maternal gestational diabetes mellitus (GDM) and childhood weight status, anthropometric and sociodemographic factors, and perinatal outcomes. The results showed that GDM doubles the probability of childhood overweight/obesity at ages 2-5 years old, independently of multiple confounding factors.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, Research & Experimental
Chrysanthi Liliana Tzartza, Nikolaos Karapalis, Gavriela Voulgaridou, Christiana Zidrou, Anastasios Beletsiotis, Ioanna P. Chatziprodromidou, Constantinos Giaginis, Sousana K. Papadopoulou
Summary: This study aimed to compare the impact of sarcopenia and osteoarthritis on patients' rehabilitation and symptom improvement after total knee arthroplasty. The results showed no significant differences in muscle strength between the two groups, but significant differences in muscle mass and pain relief. The improvement in KOOS scores before and after surgery was not significantly different for both groups.
Article
Oncology
Maria Tolia, Emmanouil K. Symvoulakis, Emmanouil Matalliotakis, Apostolos Kamekis, Marios Adamou, Panteleimon Kountourakis, Davide Mauri, Antonios Dakanalis, Petros Alexidis, Antonios Varveris, Chrysostomos Antoniadis, Dimitris Matthaios, Maria Paraskeva, Constantinos Giaginis, Konstantinos Kamposioras
Summary: This study described the impact of radical practice and perceived changes on cancer patients' mental well-being and investigated potential outcome descriptors. The results showed that anxiety and depression were statistically associated with low mental well-being. Mild to more severe anxiety was related to mental health conditions and cancer stage. 36.2% of participants were considered to have depression, which was related to older age, previous mental health conditions, concerns about the impact of COVID-19 on cancer treatment, and perception of the pandemic affecting mental health. Most participants had a good well-being score.
Article
Medicine, General & Internal
Dimitrios Papandreou, Eleni Pavlidou, Stefanos Tyrovolas, Maria Mantzorou, Eleni Andreou, Evmorfia Psara, Georgios Antasouras, Georgios K. Vasios, Efthymios Poulios, Constantinos Giaginis
Summary: This study aimed to assess the potential impacts of maternal sociodemographic, anthropometric, and prenatal and perinatal factors on the prevalence of childhood asthma in pre-school children. The survey revealed a prevalence of 4.5% of childhood asthma in pre-school age. Maternal age, pre-pregnancy overweight and obesity, caesarean section, gestational diabetes and hypertension, and not breastfeeding were found to be associated with childhood asthma.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Georgios Antasouras, Sousana K. Papadopoulou, Olga Alexatou, Dimitrios Papandreou, Maria Mentzelou, Athanasios Migdanis, Evmorfia Psara, Ioannis Migdanis, Maria Chrysafi, Stefanos Tyrovolas, Aikaterini Louka, Constantinos Giaginis
Summary: This study assessed the potential association between adherence to the Mediterranean diet during pregnancy and various sociodemographic and anthropometric parameters, perinatal outcomes, and breastfeeding practices. The results showed that higher compliance with the Mediterranean diet was associated with older age, higher educational status, better economic status, lower incidences of pre-pregnancy overweight/obesity and gestational diabetes, higher rates of vaginal delivery, and longer duration of exclusive breastfeeding.
MEDICINA-LITHUANIA
(2023)
