Review
Medicine, General & Internal
Sara Deleu, Kathleen Machiels, Jeroen Raes, Kristin Verbeke, Severine Vermeire
Summary: Short-chain fatty acids play important roles in the gut microbiome and intestinal immune system, exerting various effects on host metabolism and immune system. Further research is needed on the cross-feeding mechanisms in the gut microbiome and the therapeutic potential of SCFAs in different disease models.
Article
Cell Biology
Kishor Pant, Seth Richard, Sergio A. Gradilone
Summary: This study found that butyrate can inhibit cell proliferation and migration in cholangiocarcinoma cells, and enhance the anti-cancer effects of HDAC6 inhibitors by increasing cilia formation and reducing the expression of related proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Linxing Yao, Emily A. Davidson, Maliha W. Shaikh, Christopher B. Forsyth, Jessica E. Prenni, Corey D. Broeckling
Summary: Short-chain fatty acids (SCFAs) are volatile fatty acids produced by gut microbial fermentation of dietary nondigestible carbohydrates. This study presents a sensitive method for quantifying SCFAs through extraction with methyl tert-butyl ether after plasma/serum acidification. The method simplifies sample preparation, reduces contamination risk, and offers potential for automated sample preparation.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Sara Gomes, Fatima Baltazar, Elisabete Silva, Ana Preto
Summary: The composition of colon microbiota affects the development of colorectal cancer and has an impact on cellular phenotypes. Short-chain fatty acids (SCFAs) exhibit selective and anticancer effects on colon cancer cells and could be a potential therapy for CRC by modulating the composition of colon microbiota.
Review
Medicine, Research & Experimental
Faezeh Golpour, Mehrsa Abbasi-Alaei, Fatemeh Babaei, Mohammadreza Mirzababaei, Siavash Parvardeh, Ghazaleh Mohammadi, Marjan Nassiri-Asl
Summary: The metabolites of gut microbiota, particularly short-chain fatty acids (SCFAs), play a crucial role in interacting with the immune system. SCFAs, including acetate, propionate, and butyrate, regulate the development and function of various immune cells in the gut. They provide protection to colonic health, reduce inflammation, and may slow down the development of autoimmune disorders. This study aims to summarize the immunomodulatory effects of SCFAs and their potential therapeutic role in autoimmune diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mingjing Hu, Bilal Alashkar Alhamwe, Brigitte Santner-Nanan, Sarah Miethe, Hani Harb, Harald Renz, Daniel P. Potaczek, Ralph K. Nanan
Summary: This study aimed to generate fully functional human iTregs in vitro using SCFAs and to identify potential phenotypic markers best characterizing human iTregs. The results showed that the addition of butyrate or propionate can potentiate the differentiation of human naive CD4(+) non-Tregs towards iTregs and enhance their suppressive capacity. GITR, ICOS, CD39, PD-1, and PD-L1 were proven to be potential markers of human iTregs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Virginie Mansuy-Aubert, Yann Ravussin
Summary: Short-chain fatty acids (SCFAs), produced by the gut's metabolism of dietary fibers, have wide-ranging effects throughout the body, modulating the enteric and central nervous systems, benefiting anti-inflammatory pathways, and serving as energy sources. Recent research has revealed them as crucial communicators between the gut and brain, forming the gut-brain axis. This perspective highlights key findings and discusses the signaling mechanisms connecting SCFAs to the brain, aiming to inspire innovative research in this rapidly developing field.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xin Li, Suzhen Lei, Lu Liu, Yi Zhang, Baodong Zheng, Hongliang Zeng
Summary: The combination of lotus seed resistant starch (LRS) and short-chain fatty acids (SCFAs) can promote the growth of fecal microbiota, increase the production of SCFAs, and influence the intestinal flora, which is beneficial for health and disease management.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nutrition & Dietetics
Franziska Dengler, Anika Kraetzig, Gotthold Gaebel
Summary: The large intestinal epithelium has a strong adaptive capacity to hypoxia, and the protective effect of butyrate on colon epithelium under hypoxia may not only be based on its nutritive function, but rather on the intracellular signaling effects of SCFA.
Article
Physiology
Xuan Jiang, Ying Zhang, Huaxing Zhang, Xiaoguang Zhang, Xiaopeng Yin, Fang Yuan, Sheng Wang, Yanming Tian
Summary: This study investigated the effects and mechanisms of acetate, a short-chain fatty acid, on myocardial contraction. It was found that acetate transiently inhibits contraction via the short-chain fatty acid receptor GPR43 in rat cardiomyocytes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Microbiology
Zhen Chen, Qingqing Xu, Yang Liu, Yihan Wei, Shancai He, Wei Lin, Yingge Wang, Li Li, Yuanteng Xu
Summary: This study found that gut microbiota dysbiosis increased susceptibility and severity of allergic rhinitis, which is significantly related to reduced SCFA-producing bacteria, fecal SCFAs, and specific bacterial taxa. Treatment with sodium butyrate significantly reduced levels of total IgE, OVA-sIgE, IL-4, and IL-5 in serum, and improved inflammation infiltration in nasal and colon mucosa.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Ziyang Zhan, Hao Tang, Ying Zhang, Xinxiang Huang, Min Xu
Summary: Short-chain fatty acids (SCFAs) are important metabolites located in the gut that play a crucial role in regulating gut function and resisting pathogens. Different SCFAs influence bacterial processes by promoting the acylation of key bacterial proteins, and they also prevent pathogenic bacteria invasion by regulating host gut barrier function and immune status.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Peripheral Vascular Disease
Natalie C. Ward, Revathy Carnagarin, Janis M. Nolde, Leslie Marisol Lugo-Gavidia, Justine Chan, Ancy Jose, Sandi Robinson, Anu Joyson, Markus P. Schlaich
Summary: This study found that serum acetate levels were significantly lower in patients with resistant hypertension, while propionate levels were lower and butyrate levels were higher in patients with essential hypertension. The number and class of antihypertensive drugs may influence the levels of short-chain fatty acids. This study identified a potential therapeutic target for patients with resistant hypertension for the first time.
JOURNAL OF HYPERTENSION
(2022)
Review
Nutrition & Dietetics
Karolline S. May, Laura J. den Hartigh
Summary: Obesity is a major risk factor for various pathological conditions, and an altered gut microbiota can contribute to the development of obesity and its associated metabolic complications. The interaction between gut microbiota and peripheral organs, such as adipose tissue, is still not fully understood. This review highlights the influence of circulating gut-derived short chain fatty acids (SCFAs) on adipose tissue metabolism and discusses their role as a prominent host energy source. Exploring the mechanisms by which SCFAs impact adipose tissue metabolism appears to be a promising approach to improve metabolic conditions related to obesity.
Article
Multidisciplinary Sciences
Tianqun Lang, Runqi Zhu, Xiao Zhu, Wenlu Yan, Yu Li, Yihui Zhai, Ting Wu, Xin Huang, Qi Yin, Yaping Li
Summary: Gut microbiota plays a significant role in colorectal cancer (CRC) therapy. Researchers have developed nanoparticles loaded with the chemotherapy drug capecitabine, which are made from prebiotic micelles. These nanoparticles enhance the probiotic response, increase anti-tumour immunity, and improve survival in CRC preclinical murine models when administered orally. This prebiotics-based nanoparticle shows promise as a combination therapy for CRC by modulating gut microbiota and providing chemotherapy.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Glen S. Patten, Luz Sanguansri, Mary Ann Augustin, Mahinda Y. Abeywardena, Anthony R. Bird, Craig S. Patch, Damien P. Belobrajdic
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2017)
Article
Chemistry, Applied
Franziska Bottger, Didier Dupont, Dorota Marcinkowska, Balazs Bajka, Alan Mackie, Adam Macierzanka
FOOD HYDROCOLLOIDS
(2019)
Article
Multidisciplinary Sciences
Guy A. Channell, Gary G. Adams, YuDong Lu, Richard B. Gillis, Vlad Dinu, Myriam M. -L. Grundy, Balazs Bajka, Peter J. Butterworth, Peter R. Ellis, Alan Mackie, Simon Ballance, Stephen E. Harding
SCIENTIFIC REPORTS
(2018)
Review
Physiology
Domenico Sergi, Nenad Naumovski, Leonie Kaye Heilbronn, Mahinda Abeywardena, Nathan O'Callaghan, Lilla Lionetti, Natalie Luscombe-Marsh
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Nutrition & Dietetics
Welma Stonehouse, Bianca Benassi-Evans, Genevieve James-Martin, Mahinda Abeywardena
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Food Science & Technology
Cathrina H. Edwards, Peter Ryden, Ana M. Pinto, Alice van der Schoot, Costanza Stocchi, Natalia Perez-Moral, Peter J. Butterworth, Balazs Bajka, Sarah E. Berry, Sandra E. Hill, Peter R. Ellis
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Food Science & Technology
Myriam M. L. Grundy, Dorah K. Momanyi, Claire Holland, Fanuel Kawaka, Serene Tan, Malinda Salim, Ben J. Boyd, Balazs Bajka, Ana-Isabel Mulet-Cabero, Jacob Bishop, Willis O. Owino
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Multidisciplinary Sciences
Lukasz Krupa, Balazs Bajka, Robert Staron, Didier Dupont, Harjinder Singh, Krzysztof Gutkowski, Adam Macierzanka
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Applied
Balazs H. Bajka, Ana M. Pinto, Jennifer Ahn-Jarvis, Peter Ryden, Natalia Perez-Moral, Alice van der Schoot, Costanza Stocchi, Catherine Bland, Sarah E. Berry, Peter R. Ellis, Cathrina H. Edwards
Summary: Research has shown that replacing wheat flour with legume cell powder can significantly reduce the glycemic impact of white bread, without affecting the texture, appearance, or palatability of the bread. This alternative processing method that preserves cell integrity may provide a new, promising way to offer healthier low glycemic staple foods, improving dietary options for diabetes care.
FOOD HYDROCOLLOIDS
(2021)
Article
Food Science & Technology
Peter H. Butterworth, Balazs H. Bajka, Cathrina H. Edwards, Frederick J. Warren, Peter R. Ellis
Summary: Starch is a major source of carbohydrates and energy in the diet, and the glycemic responses to foods containing starch can vary greatly. Low GI/GL foods are beneficial for managing cardiometabolic disorders. The rate and extent of digestion of starch-containing foods can significantly impact blood sugar levels.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Applied
Natalia Perez-Moral, Shikha Saha, Ana M. Pinto, Balazs H. Bajka, Cathrina H. Edwards
Summary: The encapsulated protein from cellular chickpea powders becomes bioaccessible during digestion, leading to higher serum amino acid responses in healthy humans. CCP-enriched bread improves the amount and diversity of bioavailable essential amino acids.
Article
Medicine, Research & Experimental
Julie Clarke, Alex Boussioutas, Brooke Flanders, Trevor Lockett, Karen Harrap, Ian Saunders, Patrick Lynch, Mark Appleyard, Allan Spigelman, Don Cameron, Finlay Macrae
Summary: The objective of this clinical trial is to evaluate the potential chemoprotective effects of high amylose maize starch (HAMSB) on polyp burden in individuals with Familial Adenomatous Polyposis (FAP). The study is a multi-site, double blind, randomised, placebo-controlled crossover trial undertaken in Australia. The primary outcome measure is the global large bowel polyp number.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Alan Mackie, Simon Gourcy, Neil Rigby, Jonathan Moffat, Isabel Capron, Balazs Bajka
Correction
Immunology
Eliana Marino, James L. Richards, Keiran H. McLeod, Dragana Stanley, Yu Anne Yap, Jacinta Knight, Craig McKenzie, Jan Kranich, Ana Carolina Oliveira, Fernando J. Rossello, Balasubramanian Krishnamurthy, Christian M. Nefzger, Laurence Macia, Alison Thorburn, Alan G. Baxter, Grant Morahan, Lee H. Wong, Jose M. Polo, Robert J. Moore, Trevor J. Lockett, Julie M. Clarke, David L. Topping, Leonard C. Harrison, Charles R. Mackay
Article
Gastroenterology & Hepatology
Alan R. Mackie, Balazs H. Bajka, Neil M. Rigby, Peter J. Wilde, Fatima Alves-Pereira, Ellen F. Mosleth, Anne Rieder, Bente Kirkhus, Louise J. Salt
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2017)