Review
Nutrition & Dietetics
Patrizia Gnagnarella, Valeria Muzio, Saverio Caini, Sara Raimondi, Chiara Martinoli, Susanna Chiocca, Claudia Miccolo, Paolo Bossi, Diego Cortinovis, Ferdinando Chiaradonna, Roberta Palorini, Federica Facciotti, Federica Bellerba, Stefania Canova, Sara Gandini
Summary: The studies on the effects of vitamin D supplementation on cancer patient survival show conflicting results, with potential benefits for cancer patients but not significant effects in the general population. Further research is needed to fully evaluate the association and determine the potential use of vitamin D supplementation as a treatment for improving survival in cancer patients.
Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Hanseul Kim, Chen Yuan, Long H. Nguyen, Kimmie Ng, Edward L. Giovannucci
Summary: The study found that lower 25(OH)D levels were associated with higher mortality among patients with colorectal cancer (CRC). The researchers also investigated the relationship between vitamin D binding protein isoforms and 25(OH)D levels and CRC mortality. The results showed that deficient 25(OH)D concentrations were linked to higher overall mortality, but not CRC-specific mortality, and this association did not differ according to Gc isoforms.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. R. Delanghe, Marijn M. M. Speeckaert
Summary: Vitamin D is an immune modulator that affects infection susceptibility. The relationship between vitamin D deficiency and mortality in sepsis patients remains unclear. Adequate vitamin D concentration may reduce mortality in sepsis patients with severe deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Hyeri Seok, Jooyun Kim, Won Suk Choi, Dae Won Park
Summary: A prospective cohort study found that severe vitamin D deficiency significantly increased mortality in sepsis patients. Evaluating vitamin D levels in sepsis patients may become necessary in an aging society.
Article
Nutrition & Dietetics
Linnea Huss, Salma Tuna Butt, Signe Borgquist, Karin Elebro, Malte Sandsveden, Jonas Manjer, Ann Rosendahl
Summary: This study found no association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality.
Review
Endocrinology & Metabolism
Fiammetta Romano, Domenico Serpico, Mariateresa Cantelli, Antonella Di Sarno, Carmine Dalia, Rossana Arianna, Mariarosaria Lavorgna, Annamaria Colao, Carolina Di Somma
Summary: Osteoporosis (OP) and Dermatoporosis (DP) are age-related conditions affecting the bones and skin. Both conditions are associated with increased morbidity in elderly individuals, and vitamin D deficiency plays a role in their development. Vitamin D is involved in various mechanisms related to these diseases, including immunomodulation. Deficiency of vitamin D inhibits calcium absorption and optimal bone health, leading to OP. Proper vitamin D is also important in preventing age-related skin issues like DP, as it affects collagen production, epidermal barrier function, inflammation regulation, wound healing, and sun protection.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Georgeta Bocheva, Radomir M. Slominski, Andrzej T. Slominski
Summary: The active metabolites of vitamin D-3 and lumisterol have antiaging and photoprotective effects on the skin through immunomodulation, antioxidative responses, and DNA repair mechanisms. They interact with multiple nuclear receptors and have potential for preventing, attenuating, or treating premature skin aging. Further clinical evaluation of topically applied derivatives is needed for future trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Francois Parant, Justin Bouloy, Julie Haesebaert, Lamia Bendim'red, Karine Goldet, Philippe Vanhems, Laetitia Henaff, Thomas Gilbert, Charlotte Cuerq, Emilie Blond, Muriel Bost, Marc Bonnefoy
Summary: This study aimed to assess the relationships between vitamin D status and supplementation and the severity of COVID-19 in older adults. The study found that vitamin D supplementation taken during the 3 months preceding the infection onset may have a protective effect on the development of severe forms of COVID-19. Age, gender, and BMI were also found to be associated with the severity of COVID-19.
Article
Nutrition & Dietetics
Adriana J. van Ballegooijen, Joline W. J. Beulens, Lyanne M. Kieneker, Martin H. de Borst, Ron T. Gansevoort, Ido P. Kema, Leon J. Schurgers, Marc G. Vervloet, Stephan J. L. Bakker
Summary: Combined low vitamin D and K status are associated with increased all-cause mortality risk and possibly with cardiovascular mortality and cardiovascular events compared with adequate vitamin D and K status.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Qi Lu, Zhenzhen Wan, Jingyu Guo, Liegang Liu, An Pan, Gang Liu
Summary: In adults with prediabetes, higher serum 25-hydroxyvitamin D levels were associated with lower all-cause and cardiovascular disease mortality rates, suggesting a potential protective effect of vitamin D on health outcomes in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Murat Erdogan, Huseyin Avni Findikli
Summary: This study found that VDR levels were closely related to the 28-day mortality in patients with sepsis, and negatively correlated with the health status and disease severity of the patients. VDR levels can be used as a predictor for poor outcomes in sepsis patients.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Mehmet Emin Arayici, Yasemin Basbinar, Hulya Ellidokuz
Summary: This study used a meta-meta-analysis method to examine the effects of Vitamin D intake and serum 25-hydroxyvitamin-D levels on cancer incidence and mortality. The findings showed that higher Vitamin D intake and serum levels were associated with lower cancer risk and mortality. However, careful evaluation according to cancer types is important and recommended.
Article
Nutrition & Dietetics
Beatrice Arosio, Paolo Dionigi Rossi, Evelyn Ferri, Matteo Cesari, Giovanni Vitale
Summary: Vitamin D levels are significantly associated with cognitive decline, with the lowest levels seen in dementia patients and higher levels in mild cognitive impairment patients.
Article
Biochemistry & Molecular Biology
Jiaxin Li, Yang Cao, Jie Xu, Jing Li, Chunmei Lv, Qiang Gao, Chi Zhang, Chongfei Jin, Ran Wang, Runsheng Jiao, Hui Zhu
Summary: Vitamin D plays a positive role in learning and memory in aging mice, and it alleviates ferroptosis in aging hippocampal neurons by regulating ferroptosis-related proteins and activating the Nrf2/HO-1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
J. Gong, K. K. Nishimura, L. Fernandez-Rhodes, J. Haessler, S. Bien, M. Graff, U. Lim, Y. Lu, M. Gross, M. Fornage, S. Yoneyama, C. R. Isasi, P. Buzkova, M. Daviglus, D-Y Lin, R. Tao, R. Goodloe, W. S. Bush, E. Farber-Eger, J. Boston, H. H. Dilks, G. Ehret, C. C. Gu, C. E. Lewis, K-D H. Nguyen, R. Cooper, M. Leppert, M. R. Irvin, E. P. Bottinger, L. R. Wilkens, C. A. Haiman, L. Park, K. R. Monroe, I. Cheng, D. O. Stram, C. S. Carlson, R. Jackson, L. Kuller, D. Houston, C. Kooperberg, S. Buyske, L. A. Hindorff, D. C. Crawford, R. J. F. Loos, L. Le Marchand, T. C. Matise, K. E. North, U. Peters
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Geriatrics & Gerontology
Denise K. Houston, Rebecca H. Neiberg, Michael E. Miller, James O. Hill, John M. Jakicic, Karen C. Johnson, Edward W. Gregg, Van S. Hubbard, Xavier Pi-Sunyer, W. Jack Rejeski, Rena R. Wing, John P. Bantle, Elizabeth Beale, Robert I. Berkowitz, Maria Cassidy-Begay, Jeanne M. Clark, Mace Coday, Linda M. Delahanty, Gareth Dutton, Caitlin Egan, John P. Foreyt, Frank L. Greenway, Helen P. Hazuda, Andrea Hergenroeder, Edward S. Horton, Robert W. Jeffery, Steven E. Kahn, Anne Kure, William C. Knowler, Cora E. Lewis, Corby K. Martin, Sara Michaels, Maria G. Montez, David M. Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A. Wadden, Karen White, Susan Z. Yanovski, Ping Zhang, Stephen B. Kritchevsky
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2018)
Article
Food Science & Technology
Caren E. Smith, Jack L. Follis, Hassan S. Dashti, Toshiko Tanaka, Mariaelisa Graff, Amanda M. Fretts, Tuomas O. Kilpelainen, Mary K. Wojczynski, Kris Richardson, Mike A. Nalls, Christina-Alexandra Schulz, Yongmei Liu, Alexis C. Frazier-Wood, Esther van Eekelen, Carol Wang, Paul S. de Vries, Vera Mikkila, Rebecca Rohde, Bruce M. Psaty, Torben Hansen, Mary F. Feitosa, Chao-Qiang Lai, Denise K. Houston, Luigi Ferruci, Ulrika Ericson, Zhe Wang, Renee de Mutsert, Wendy H. Oddy, Ester A. L. de Jonge, Ilkka Seppala, Anne E. Justice, Rozenn N. Lemaitre, Thorkild I. A. Sorensen, Michael A. Province, Laurence D. Parnell, Melissa E. Garcia, Stefania Bandinelli, Marju Orho-Melander, Stephen S. Rich, Frits R. Rosendaal, Craig E. Pennell, Jessica C. Kiefte-de Jong, Mika Kahonen, Kristin L. Young, Oluf Pedersen, Stella Aslibekyan, Jerome I. Rotter, Dennis O. Mook-Kanamori, M. Carola Zillikens, Olli T. Raitakari, Kari E. North, Kim Overvad, Donna K. Arnett, Albert Hofman, Terho Lehtimaeki, Anne Tjonneland, Andre G. Uitterlinden, Fernando Rivadeneira, Oscar H. Franco, J. Bruce German, David S. Siscovick, L. Adrienne Cupples, Jose M. Ordovas
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Endocrinology & Metabolism
Jaeyoung Hong, Kathryn E. Hatchell, Jonathan P. Bradfield, Andrew Bjonnes, Alessandra Chesi, Chao-Qiang Lai, Carl D. Langefeld, Lingyi Lu, Yingchang Lu, Pamela L. Lutsey, Solomon K. Musani, Mike A. Nalls, Cassianne Robinson-Cohen, Jeffery D. Roizen, Richa Saxena, Katherine L. Tucker, Julie T. Ziegler, Dan E. Arking, Joshua C. Bis, Eric Boerwinkle, Erwin P. Bottinger, Donald W. Bowden, Vicente Gilsanz, Denise K. Houston, Heidi J. Kalkwarf, Andrea Kelly, Joan M. Lappe, Yongmei Liu, Erin D. Michos, Sharon E. Oberfield, Nicholette D. Palmer, Jerome I. Rotter, Bishwa Sapkota, John A. Shepherd, James G. Wilson, Saonli Basu, Ian H. de Boer, Jasmin Divers, Barry I. Freedman, Struan F. A. Grant, Hakon Hakanarson, Tamara B. Harris, Bryan R. Kestenbaum, Stephen B. Kritchevsky, Ruth J. F. Loos, Jill M. Norris, Arnita F. Norwood, Jose M. Ordovas, James S. Pankow, Bruce M. Psaty, Dharambir K. Sanghera, Lynne E. Wagenknecht, Babette S. Zemel, James Meigs, Josee Dupuis, Jose C. Florez, Thomas Wang, Ching-Ti Liu, Corinne D. Engelman, Liana K. Billings
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Geriatrics & Gerontology
D. Clark Files, Rebecca Neiberg, Julia Rushing, Peter E. Morris, Michael P. Young, Hilsa Ayonayon, Tamara Harris, Anne Newman, Susan Rubin, Eric Shiroma, Denise Houston, Michael E. Miller, Stephen B. Kritchevsky
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2018)
Article
Biochemistry & Molecular Biology
Jordi Merino, Hassan S. Dashti, Sherly X. Li, Chloe Sarnowski, Anne E. Justice, Misa Graff, Constantina Papoutsakis, Caren E. Smith, George V. Dedoussis, Rozenn N. Lemaitre, Mary K. Wojczynski, Satu Mannisto, Julius S. Ngwa, Minjung Kho, Tarunveer S. Ahluwalia, Natalia Pervjakova, Denise K. Houston, Claude Bouchard, Tao Huang, Marju Orho-Melander, Alexis C. Frazier-Wood, Dennis O. Mook-Kanamori, Louis Perusse, Craig E. Pennell, Paul S. de Vries, Trudy Voortman, Olivia Li, Stavroula Kanoni, Lynda M. Rose, Terho Lehtimaki, Jing Hua Zhao, Mary F. Feitosa, Jian'an Luan, Nicola M. McKeown, Jennifer A. Smith, Torben Hansen, Niina Eklund, Mike A. Nalls, Tuomo Rankinen, Jinyan Huang, Dena G. Hernandez, Christina-Alexandra Schulz, Ani Manichaikul, Ruifang Li-Gao, Marie-Claude Vohl, Carol A. Wang, Frank J. A. van Rooij, Jean Shin, Ioanna P. Kalafati, Felix Day, Paul M. Ridker, Mika Kahonen, David S. Siscovick, Claudia Langenberg, Wei Zhao, Arne Astrup, Paul Knekt, Melissa Garcia, D. C. Rao, Qibin Qi, Luigi Ferrucci, Ulrika Ericson, John Blangero, Albert Hofman, Zdenka Pausova, Vera Mikkila, Nick J. Wareham, Sharon L. R. Kardia, Oluf Pedersen, Antti Jula, Joanne E. Curran, M. Carola Zillikens, Jorma S. Viikari, Nita G. Forouhi, Jose M. Ordovas, John C. Lieske, Harri Rissanen, Andre G. Uitterlinden, Olli T. Raitakari, Jessica C. Kiefte-de Jong, Josee Dupuis, Jerome I. Rotter, Kari E. North, Robert A. Scott, Michael A. Province, Markus Perola, L. Adrienne Cupples, Stephen T. Turner, Thorkild I. A. Sorensen, Veikko Salomaa, Yongmei Liu, Yun J. Sung, Lu Qi, Stefania Bandinelli, Stephen S. Rich, Renee de Mutsert, Angelo Tremblay, Wendy H. Oddy, Oscar H. Franco, Tomas Paus, Jose C. Florez, Panos Deloukas, Leo-Pekka Lyytikainen, Daniel I. Chasman, Audrey Y. Chu, Toshiko Tanaka
MOLECULAR PSYCHIATRY
(2019)
Letter
Obstetrics & Gynecology
Candace Y. Parker-Autry, Denise Houston, Stephen Kritchevsky, Holly E. Richter
OBSTETRICS AND GYNECOLOGY
(2018)
Article
Nutrition & Dietetics
Ashley A. Weaver, Denise K. Houston, Sue A. Shapses, Mary F. Lyles, Rebecca M. Henderson, Daniel P. Beavers, Arlynn C. Baker, Kristen M. Beavers
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Nutrition & Dietetics
Jiayi Xu, Traci M. Bartz, Geetha Chittoor, Gudny Eiriksdottir, Ani W. Manichaikul, Fangui Sun, Natalie Terzikhan, Xia Zhou, Sarah L. Booth, Guy G. Brusselle, Ian H. de Boer, Myriam Fornage, Alexis C. Frazier-Wood, Mariaelisa Graff, Vilmundur Gudnason, Tamara B. Harris, Albert Hofman, Ruixue Hou, Denise K. Houston, David R. Jacobs, Stephen B. Kritchevsky, Jeanne Latourelle, Rozenn N. Lemaitre, Pamela L. Lutsey, George O'Connor, Elizabeth C. Oelsner, James S. Pankow, Bruce M. Psaty, Rebecca R. Rohde, Stephen S. Rich, Jerome I. Rotter, Lewis J. Smith, Bruno H. Stricker, V. Saroja Voruganti, Thomas J. Wang, M. Carola Zillikens, R. Graham Barr, Josee Dupuis, Sina A. Gharib, Lies Lahousse, Stephanie J. London, Kari E. North, Albert V. Smith, Lyn M. Steffen, Dana B. Hancock, Patricia A. Cassano
BRITISH JOURNAL OF NUTRITION
(2018)
Article
Geriatrics & Gerontology
Barbara J. Nicklas, Tina E. Brinkley, Denise K. Houston, Mary F. Lyles, Christina E. Hugenschmidt, Kristen M. Beavers, Xiaoyan Leng
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Nutrition & Dietetics
Amely M. Verreijen, Marielle F. Engberink, Denise K. Houston, Ingeborg A. Brouwer, Peggy M. Cawthon, Ann B. Newman, Frances A. Tylavsky, Tamara B. Harris, Peter J. M. Weijs, Marjolein Visser
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Cardiac & Cardiovascular Systems
Tina E. Brinkley, Iris Leng, Margie J. Bailey, Denise K. Houston, Christina E. Hugenschmidt, Barbara J. Nicklas, W. Gregory Hundley
Summary: Combining aerobic exercise with moderate caloric restriction leads to greater improvements in proximal aortic stiffness in older adults with obesity than exercise alone.
Article
Cardiac & Cardiovascular Systems
Theresa Anderson, Thomas M. Cascino, Todd M. Koelling, Daniel Perry, Gillian Grafton, Denise K. Houston, Bharathi Upadhya, Dalane W. Kitzman, Scott L. Hummel
Summary: In patients with HFpEF, commonly used predictive equations systematically overestimate measured RMR. Direct measurement of RMR may be needed to effectively tailor dietary guidance for this population.
CIRCULATION-HEART FAILURE
(2021)
Article
Nutrition & Dietetics
Denise K. Houston, Anthony P. Marsh, Rebecca H. Neiberg, Jamehl L. Demons, Claudia L. Campos, Stephen B. Kritchevsky, Osvaldo Delbono, Janet A. Tooze
Summary: This study investigated the effect of daily vitamin D supplementation on leg power and physical performance in older adults with low 25(OH)D concentrations. The results showed that 2000 IU/d vitamin D3 did not improve leg power, physical performance, or muscle fiber composition.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, Research & Experimental
Mariana Murea, Randolph L. Geary, Matthew S. Edwards, Shahriar Moossavi, Ross P. Davis, Matthew P. Goldman, Justin Hurie, Timothy K. Williams, Gabriela Velazquez-Ramirez, Todd W. Robinson, Benjamin Bagwell, Audrey B. Tuttle, Kathryn E. Callahan, Michael V. Rocco, Denise K. Houston, Nicholas M. Pajewski, Jasmin Divers, Barry I. Freedman, Jeff D. Williamson
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2019)