期刊
NUTRITION RESEARCH
卷 29, 期 4, 页码 221-228出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nutres.2009.03.012
关键词
Vitamin K; ucOC; Fracture; Geometry; Postmenopausal women
Although systematic review and meta-analysis of randomized controlled trials (RCTs) have concluded that vitamin K is effective in preventing fractures, the effect of vitamin K on the skeleton remains a matter of controversy. The objective of the present review of the literature was to evaluate the effect of vitamin K supplementation on the skeleton of postmenopausal women. PubMed was used to search the reliable literature for RCTs by using the search terms vitamin K-1 or vitamin K-2, bone, and postmenopausal women and the following inclusion criteria: approximately 50 or more Subjects per group and study period of 2 years or longer. Seven RCTs met the inclusion criteria. The results of these RCTs showed that vitamin K-1 and vitamin K-2 supplementation reduced serum undercarboxylated osteocalcin levels regardless of dose but that it had inconsistent effects on serum total osteocalcin levels and no effect on bone resorption. Despite the lack of a significant change or the occurrence of only a modest increase in bone mineral density, high-dose vitamin K-1 and vitamin K-2 supplementation improved indices of bone strength in the femoral neck and reduced the incidence of clinical fractures. The review of the reliable literature confirmed the effect of vitamin K-1 and vitamin K-2 supplementation on the skeleton of postmenopausal women mediated by mechanisms other than bone mineral density and bone turnover. (C) 2009 Elsevier Inc. All rights reserved.
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