Article
Biology
Emory Bibb, Noura Alajlan, Saad Alsuwailem, Benjamin Mitchell, Amy Brady, Muhammad Maqbool, Remo George
Summary: Research shows that internalized nanoceria can reduce reactive oxygen species levels at different radiation doses, improving the health of breast cancer cells and providing radiation protection.
Article
Oncology
Yvonne Wesseling-Rozendaal, Arie van Doorn, Karen Willard-Gallo, Anja van de Stolpe
Summary: Immunotherapy is a potential cure for cancer, but only a small number of breast cancer patients benefit from it. CD4+ T cells play a role in the immune response and resistance to immunotherapy. Researchers have developed a new technology to measure the activity of signal transduction pathways in these cells and found abnormal function of CD4+ T cells in breast cancer patients. The abnormal activity suggests that CD4+ T cells have transformed into regulatory T cells, which inhibit the immune response and are associated with resistance to immunotherapy. This new technology can be used to identify patients who will benefit from immunotherapy.
Article
Genetics & Heredity
Shan Wang, Pei Shang, Guangyu Yao, Changsheng Ye, Lujia Chen, Xiaolei Hu
Summary: This study delved into the molecular mechanisms of breast cancer at the genomic and transcriptomic levels in different subtypes, aiming to provide a theoretical basis for personalized treatments and precision medicine. It was found that carcinogenesis and development of triple-negative breast cancer were the most important and complex processes, and the luminal A subtype exhibited a different pathogenesis compared to the other subtypes. Additionally, 16 hub genes related to good prognosis in triple-negative breast cancer were identified, and new transcription factors and microRNAs were introduced, offering novel perspectives for breast cancer research and treatment.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Simona Serini, Roberta Cassano, Federica Curcio, Sonia Trombino, Gabriella Calviello
Summary: This article critically analyzes the results of recent studies investigating the effects of omega-3 PUFA-containing nanoformulations in breast cancer and ovarian cancer. The studies show that omega-3 PUFAs have anti-inflammatory, antiangiogenic, and antitumor effects, and can enhance drug delivery and minimize side effects. These findings provide a theoretical basis for further interventional clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Keng-Shiang Huang, Yi-Ting Wang, Omkar Byadgi, Ting-Yu Huang, Mi-Hsueh Tai, Jei-Fu Shaw, Chih-Hui Yang
Summary: The study found that chlorophyllides composites can modulate the expression of various genes in breast cancer cells, including those associated with the endocrine and nervous systems. These findings provide valuable information for further research and development of novel cancer therapies.
Article
Oncology
Amal AlKahlout, Manal Fardoun, Joelle Mesmar, Rola Abdallah, Adnan Badran, Suzanne A. Nasser, Serine Baydoun, Firas Kobeissy, Abdullah Shaito, Rabah Iratni, Khalid Muhammad, Elias Baydoun, Ali H. Eid
Summary: This study demonstrates that Origanum syriacum L. aqueous extract (OSE) can inhibit proliferation, induce autophagy and apoptosis in TNBC cells. Additionally, OSE promotes cell-cell adhesion and decreases migration, adhesion, and invasion abilities of TNBC cells. OSE also inhibits angiogenesis and reduces nitric oxide production. These findings suggest that Origanum syriacum L. could be a promising herbal source for therapeutic compounds against TNBC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: Lysophosphatidic acid receptors (LPARs) play a role in promoting tumorigenesis and therapy resistance in various cancer subtypes. Our study found that increased expression of LPAR1, LPAR4, and LPAR6 correlated with a less aggressive phenotype, while high expression of LPAR2 was associated with increased tumor grade, mutational burden, and decreased survival. Different LPARs were also expressed in different cell types, suggesting potential compensatory signaling in LPAR inhibitor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yi-Fong Chen, Yung-Ning Yang, Hung-Ru Chu, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis
Summary: The study reveals that doxycycline inhibits proliferation and downregulates PD-L1 gene expression in breast cancer cells, possibly by interacting with integrin alpha v beta 3 and inhibiting ERK1/2 activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Toxicology
Rokaya E. Maarouf, Khaled Shaaban Azab, Neama M. El Fatih, Hamed Helal, Laila Rashed
Summary: This study aimed to assess the role of Withania somnifera (Ashwagandha) in promoting apoptosis in MCF7 or MDA-MB 231 breast cancer cells. The results showed that Withania somnifera has an anti-proliferative action on these cells by enhancing apoptosis. Furthermore, it was found to increase the expression of SIRT1 and BCL2, while decreasing the expression of BAX.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Jun Xu, Sek Man Su, Xin Zhang, Un In Chan, Ragini Adhav, Xiaodong Shu, Jianlin Liu, Jianjie Li, Lihua Mo, Yuqing Wang, Tingting An, Josh Haipeng Lei, Kai Miao, Chu-Xia Deng, Xiaoling Xu
Summary: This study found that low expression of ATP11B and high expression of PTDSS2 in breast cancer cells are associated with poor prognosis and enhanced metastasis. An ATP11B(lo)PTDSS2(hi) phenotype is associated with increased levels of nonapoptotic phosphatidylserine (PS), which acts as a global immunosuppressive signal promoting breast cancer metastasis. Changing the phenotype to ATP11B(hi)PTDSS2(lo) can effectively overcome the metastatic processes associated with ATP11B(lo)PTDSS2(hi) cancer cells.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Svenja Kemmer, Mireia Berdiel-Acer, Eileen Reinz, Johanna Sonntag, Nooraldeen Tarade, Stephan Bernhardt, Mirjam Fehling-Kaschek, Max Hasmann, Ulrike Korf, Stefan Wiemann, Jens Timmer
Summary: Breast cancer subtypes differ in their treatment and prognosis due to the expression and activity of different receptors. The HER2 subtype has been successfully targeted with anti-HER2 therapies, and this study explores whether the HER2 receptor and downstream signaling network could be potential therapeutic targets beyond the HER2-positive subtype. The findings suggest that major parts of the intracellular signal transduction network are unchanged between subtypes, and alterations in this network could render anti-HER therapies relevant beyond the HER2-positive subtype.
Article
Pharmacology & Pharmacy
Ganesan Shilpa, Sreerenjini Lakshmi, Vellekkatt Jamsheena, Ravi Shankar Lankalapalli, Ved Prakash, Sadasivam Anbumani, Sulochana Priya
Summary: The study shows that two synthetic biaryl conjugates of diindolylmethane (DIM) exhibit cytotoxicity in triple negative breast cancer cells, inducing apoptosis and inhibiting cell migration and metastasis. This is achieved by blocking the EGF receptor and modulating the PI3K-Akt-mTOR signaling pathway.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Food Science & Technology
Gozde Ozge Onder, Ozge Goktepe, Munevver Baran, Nazmiye Bitgen, Funda Aydin, Arzu Yaya
Summary: Hesperidin, a flavonoid found in citrus fruits, induces apoptosis in breast cancer cells by inhibiting Bcl-2 and enhancing Bax protein expression in MCF-7 cells, while using a different mechanism to induce apoptosis in MDA-MB-231 cells. These findings suggest that hesperidin has therapeutic potential for preventing breast cancer progression.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Raghuveer Kavarthapu, Maria L. L. Dufau
Summary: PRLR plays a crucial role in breast epithelium growth, differentiation, lactation, and breast cancer development. Its expression in humans is controlled by multiple promoters, leading to alternative splice products such as short forms that can inhibit the long form activity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Vanessa M. Ruscetta, Taj J. J. Seaton, Aleen Shakeel, Stanley N. S. Vasconcelos, Russell D. D. Viirre, Marc J. J. Adler, Michael F. F. Olson
Summary: Cytoskeleton organization and dynamics are regulated by post-translational modifications of key target proteins, including the phosphorylation of myosin light chain proteins by MRCK kinases. Compared to ROCK kinases, the contributions of MRCK kinases are less characterized due to the late discovery of selective inhibitors. The recent development of selective MRCK inhibitors has expanded the tools to study MRCK function and shown therapeutic benefits in cancer studies.