Article
Endocrinology & Metabolism
Monika Drozdz, Anna Moczulska, Andrzej Rudzinski, Dorota Drozdz
Summary: This study aimed to identify the most significant risk factors of left ventricular hypertrophy (LVH) in children with chronic kidney disease (CKD). The results showed that metabolic syndrome, hypertension, and CKD stage were the most important risk factors for LVH.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Amelia K. Fotheringham, Linda A. Gallo, Danielle J. Borg, Josephine M. Forbes
Summary: Since the 1980s, the incidence of chronic kidney disease (CKD) has increased by almost 25%. This is partly due to changes in lifestyle and the global consumption of a western diet, which is high in energy, low in fruits and vegetables, and rich in animal protein and processed foods. These dietary trends have led to an increase in the consumption of advanced glycation end products (AGEs) and metabolic disorders, obesity, and diabetes, which contribute to the production of endogenous AGEs in the body. Excessive accumulation of AGEs can be pathologic through receptor-mediated and non-receptor-mediated pathways. AGEs are cleared by the kidneys, making them particularly susceptible to AGE-mediated damage, and high levels of circulating AGEs are associated with an increased risk of CKD and all-cause mortality. Individuals with significant loss of renal function have increased AGE burden, particularly in those with uremia, and there is evidence that lowering AGEs through diet or pharmacological inhibition may be beneficial for CKD. This review explores the pathways of AGE formation and regulation in the body, the impact of diet on endogenous AGE production and dietary AGE consumption, the contribution of AGEs to kidney disease, and the potential of AGE-targeted therapies for kidney disease.
Review
Biochemistry & Molecular Biology
Elena Dozio, Simone Vettoretti, Giuseppe Lungarella, Piergiorgio Messa, Massimiliano M. Corsi Romanelli
Summary: Sarcopenia in chronic kidney disease is independently associated with morbidity and mortality, with advanced glycation end products (AGE) playing a key role in its pathogenesis. The imbalance of oxidant/antioxidant capacities in CKD patients leads to AGE accumulation, which can promote CKD progression and related complications by inducing inflammation and fibrosis. Understanding the link between AGE and oxidative stress in the onset of sarcopenia may help identify new markers for disease progression and therapeutic targets.
Article
Nutrition & Dietetics
Lianqin Sun, Qing Li, Zhiying Sun, Suyan Duan, Guangyan Nie, Jiaxin Dong, Chengning Zhang, Ming Zeng, Bin Sun, Yanggang Yuan, Ningning Wang, Huijuan Mao, Changying Xing, Bo Zhang
Summary: This study found that a higher level of overhydration was associated with a higher occurrence of left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD) who were not on dialysis, especially in patients with CKD stages 1-2.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Dimitra Bacharaki, Ioannis Petrakis, Periklis Kyriazis, Anastasia Markaki, Christos Pleros, Georgios Tsirpanlis, Marios Theodoridis, Olga Balafa, Anastasia Georgoulidou, Eleni Drosataki, Kostas Stylianou
Summary: Adherence to a Mediterranean-style diet has a positive impact on the cardiovascular health of chronic kidney disease patients on dialysis, reducing the occurrence of left ventricular hypertrophy and abnormal cardiac geometry. This is of significant importance in managing the risk of cardiovascular disease in dialysis patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Takahiro Imaizumi, Naohiko Fujii, Takayuki Hamano, Wei Yang, Masataka Taguri, Mayank Kansal, Rupal Mehta, Tariq Shafi, Jonathan Taliercio, Alan Go, Panduranga Rao, L. Lee Hamm, Rajat Deo, Shoichi Maruyama, Masafumi Fukagawa, Harold I. Feldman
Summary: It has been found that patients receiving dialysis therapy in the United States are more prone to cardiovascular disease (CVD) compared to those in Japan. Left ventricular mass index (LVMI) and ejection fraction (EF) showed significant differences between the two cohorts, and low EF and high LVMI were significantly associated with subsequent CVD in both groups. The higher LV mass and lower EF, even within the normal range, were found to be predictive of CVD in chronic kidney disease (CKD) patients.
KIDNEY INTERNATIONAL
(2023)
Review
Pediatrics
Andrea Grund, Manish D. Sinha, Dieter Haffner, Maren Leifheit-Nestler
Summary: FGF23 is a key factor in the development of cardiovascular risk factors in pediatric CKD patients, with limited data on its prevalence and determinants in this population. Current research mainly focuses on the impact of FGF23 in adult CKD, and further investigation is needed for pediatric CKD patients.
FRONTIERS IN PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Elena Dozio, Lara Caldiroli, Paolo Molinari, Giuseppe Castellano, Nicholas Walter Delfrate, Massimiliano Marco Corsi Romanelli, Simone Vettoretti
Summary: Advanced glycation end products (AGEs) are aging products that accumulate in chronic kidney disease (CKD) due to increased production, reduced excretion, and imbalance between oxidant/antioxidant capacities. This review aims to summarize the knowledge of AGEs in CKD onset and progression, focusing on related disorders and mortality. The role of AGEs as etiopathogenetic molecules and potential markers or therapeutic targets will be discussed.
Article
Medicine, General & Internal
Xiaohua Liu, Lixin Chen, Xiaofang Zhong, Guijuan Peng, Yuanyuan Sheng, Jian Li, Qian Liu, Bobo Shi, Yuxiang Huang, Jinfeng Xu, Yingying Liu
Summary: This study evaluated myocardial injury in patients with chronic kidney disease by analyzing global myocardial work through left ventricular pressure-strain loop analysis. The results showed that GWW increased and GWE decreased in CKD patients with left ventricular hypertrophy, and GWW increased and GWE decreased in CKD patients with elevated systolic blood pressure. The study suggested that noninvasive left ventricular PSL analysis could be used to assess global myocardial work in CKD patients.
Article
Biochemistry & Molecular Biology
Paolo Molinari, Lara Caldiroli, Elena Dozio, Roberta Rigolini, Paola Giubbilini, Massimiliano M. Corsi Romanelli, Giuseppe Castellano, Simone Vettoretti
Summary: This study found that advanced glycation end-products (AGEs) are associated with the presence of sarcopenia in patients with chronic kidney disease (CKD), while soluble receptor for AGE (sRAGE) is not. AGEs may contribute to the complex pathophysiology leading to the development of sarcopenia in CKD patients.
Review
Peripheral Vascular Disease
Ioannis Goulas, Kleo Evripidou, Ioannis Doundoulakis, Konstantinos Kollios, Thomai Nika, Athanasia Chainoglou, Vasilios Kotsis, Stella Stabouli
Summary: Limited studies have been conducted on the assessment of blood pressure status in young patients with CKD on dialysis or after kidney transplantation using ABPM. This meta-analysis found a high prevalence of masked hypertension and left ventricular hypertrophy in children and young adults with CKD on dialysis or after kidney transplantation. Therefore, ABPM and echocardiography play a crucial role in assessing BP status and cardiovascular risk in this population.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Paolo Verdecchia, Fabio Angeli, Gianpaolo Reboldi
Summary: This study found that chronic kidney disease and left ventricular hypertrophy are important modifiers of the prognostic value of the circadian blood pressure changes. The night-to-day systolic blood pressure ratio was independently associated with outcomes, but lost its association when chronic kidney disease and left ventricular hypertrophy were considered. The night-to-day systolic blood pressure ratio provided less information and did not improve the information provided by chronic kidney disease and left ventricular hypertrophy.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Urology & Nephrology
Davide Bolignano, Salvatore De Rosa, Marta Greco, Pierangela Presta, Gemma Patella, Giuseppina Crugliano, Jolanda Sabatino, Antonio Strangio, Letizia Rosa Romano, Alessandro Comi, Paola Cianfrone, Michele Andreucci, Francesco Dragone, Ciro Indolfi, Daniela Patrizia Foti, Giuseppe Coppolino
Summary: The study found that MBG levels were higher in ESKD patients compared to healthy controls, and were associated with LV geometry and cardiac dysfunction. MBG may serve as a novel biomarker to improve cardiac assessment in this high-risk population.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Jingfu Bao, Yinghui Lu, Qinying She, Weijuan Dou, Rong Tang, Xiaodong Xu, Mingchao Zhang, Ling Zhu, Qing Zhou, Hui Li, Guohua Zhou, Zhongzhou Yang, Shaolin Shi, Zhihong Liu, Chunxia Zheng
Summary: In CKD rats, restoration of cardiomyocyte-specific miRNA-30 helps to alleviate LVH, while blockade of miRNA-30 leads to cardiomyocyte hypertrophy. CKD-related factors suppress cardiac miRNA-30 expression, while supplementation of miRNA-30 mitigates cardiomyocyte hypertrophy induced by these factors.
Review
Medicine, General & Internal
Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah B. Yildiz, Metehan Berkkan, Kathherine R. Tuttle, Carmine Zoccali
Summary: Metabolically healthy overweight and obese individuals have a higher risk of chronic kidney disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Urology & Nephrology
Mehmet Kanbay, Sidar Copur, Duygu Ucku, Carmine Zoccali
Summary: The effect of donor obesity on kidney transplantation success has been overlooked for a long time. Excessive body fat has been found to have deleterious effects on renal function and graft survival. However, there is a lack of clinical trials addressing weight loss in kidney donors and transplant patients.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Carmine Zoccali, Francesca Mallamaci, Marcin Adamczak, Rodrigo Bueno de Oliveira, Ziad A. Massy, Pantelis Sarafidis, Rajiv Agarwal, Patrick B. Mark, Peter Kotanko, Charles J. Ferro, Christoph Wanner, Michel Burnier, Raymond Vanholder, Andrzej Wiecek
Summary: Chronic kidney disease (CKD) is a progressive condition that increases the risk of cardiovascular diseases. Traditional and non-traditional risk factors contribute to the progression of cardiovascular complications in CKD patients. Arterial disease in CKD patients is characterized by calcification and vascular stiffness. Recent clinical trials have shown promising potential treatments for CKD patients, including hypoxia-inducible factor prolyl hydroxylase inhibitors, intravenous iron for treating anemia, and sodium/glucose cotransporter-2 inhibitors. However, more research is needed in this area.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Carmine Zoccali, Francesca Mallamaci
Summary: With a global burden of 844 million, chronic kidney disease (CKD) is now considered a public health priority. Low-grade systemic inflammation plays a crucial role in adverse cardiovascular outcomes in CKD patients. Various factors, including cellular senescence, gut microbiota-dependent immune activation, lipoprotein modifications, and neuroimmune interactions, contribute to the unique severity of inflammation in CKD.
CIRCULATION RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carmine Zoccali, Francesca Mallamaci
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Mehmet Kanbay, Cem Tanriover, Sidar Copur, Ibrahim B. B. Peltek, Ali Mutlu, Francesca Mallamaci, Carmine Zoccali
Summary: Social isolation and loneliness are often overlooked conditions that have a negative impact on quality of life, overall health, and mortality. This review discusses the health consequences of these conditions, including potential causes, pathophysiological processes, associations with non-communicable diseases, and effects on health-related behaviors. It also explores current and novel management strategies. Healthcare professionals should be knowledgeable about social isolation and loneliness, thoroughly assess patients, and provide education and treatment options through shared decision-making. Further research is needed to better understand the underlying mechanisms and improve treatment strategies for these conditions.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Editorial Material
Urology & Nephrology
Carmine Zoccali
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci, Michel Halimi, Patrick Rossignol, Pantelis Serafidis, Raffaele De Caterina, Robert Giugliano, Faiez Zannad
Summary: This review discusses the problems with the current classification of cardio renal syndrome, proposing the term chronic cardiovascular-kidney disorder (CCKD) instead. It highlights the shared risk factors and pathophysiological mechanisms between cardiovascular and chronic kidney disease (CKD), as well as the potential for treatments targeting both conditions to improve outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Mehmet Kanbay, Sidar Copur, Abdullah B. Yildiz, Cem Tanriover, Francesca Mallamaci, Carmine Zoccali
Summary: Physical exercise plays a crucial role in improving multiple pathophysiological mechanisms and the quality of life for patients with chronic kidney disease (CKD). However, its direct impact on kidney function remains uncertain and further research is needed.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Editorial Material
Urology & Nephrology
Carmine Zoccali, Vianda Stel, Friedo Dekker, Kitty J. Jager
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Pasquale Fabio Provenzano, Grazia Caridi, Giovanna Parlongo, Daniela Leonardis, Elvira Puntorieri, Giovanni Tripepi, Carmine Zoccali, Francesca Mallamaci
Summary: This study investigated the sex differences in cardiovascular risk and outcomes in CKD patients not on dialysis, and found that male patients had a higher risk of cardiovascular events compared to female patients.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Graziella D'Arrigo, Mercedes Gori, Daniela Leonardis, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
Summary: This study found that higher bicarbonate trajectories were associated with a lower risk of adverse renal outcomes in CKD patients, suggesting that maintaining higher bicarbonate levels may benefit patients with CKD. However, further high-quality randomized trials are needed to confirm these findings and recommend bicarbonate supplementation as a strategy to delay CKD progression.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Carmine Zoccali
Summary: The debate on kidney biopsy in diabetic kidney disease (DKD) is multifaceted. One side argues for its broader application, citing precise diagnostic data and personalized treatment plans, while the other side opposes it, pointing out insufficient evidence, resource constraints, and potential risks. Both sides agree on the need for individualized patient care and open discussions between healthcare providers and patients.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci, Luca De Nicola, Roberto Minutolo
Summary: Resistant hypertension is a condition associated with an increased risk of cardiovascular and renal complications. Current treatment options include non-pharmacological interventions and specific antihypertensive drug combinations. New compounds targeting different pathways have shown varied effectiveness in clinical trials. Further research is needed to improve our understanding and treatment of this condition.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci, Giovanni Tripepi, Edouard L. Fu, Vianda S. Stel, Friedo W. Dekker, Kitty J. Jager
Summary: The 'legacy effect' describes the long-term benefits of intensive therapy in reducing complications and mortality in chronic diseases. It is evident in studies related to chronic kidney disease (CKD) and highlights the importance of intensive treatment. However, the legacy effect is more pronounced in early-stage diabetes and less evident in long-term, established diabetes patients.
CLINICAL KIDNEY JOURNAL
(2023)
