Article
Endocrinology & Metabolism
Nina Saatmann, Oana-Patricia Zaharia, Klaus Strassburger, Dominik Hans Pesta, Volker Burkart, Julia Szendroedi, Norbert Gerdes, Malte Kelm, Michael Roden
Summary: While endothelial function was similar across all groups, SIRD exhibited the lowest physical fitness. Interestingly, SAID showed the lowest cardiovascular risk within the first year after diabetes diagnosis compared to other diabetes subgroups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Armando Pena, Micah L. Olson, Stephanie L. Ayers, Dorothy D. Sears, Sonia Vega-Lopez, Abigail T. Colburn, Gabriel Q. Shaibi
Summary: Obesity is linked to chronic inflammation and may increase the risk of type 2 diabetes in youth. This study investigated the relationship between inflammatory biomarkers and insulin sensitivity, beta-cell function, and response to lifestyle intervention in Latino youth with obesity. The findings showed that obesity-related inflammatory mediators were associated with T2D risk factors but were not affected by lifestyle intervention in Latino youth.
Article
Oncology
Christina Schindera, Simeon Joel Zurcher, Ruedi Jung, Sarah Boehringer, Jan Willem Balder, Corina Silvia Rueegg, Susi Kriemler, Nicolas Xavier von der Weid
Summary: This study investigated the relationship between physical fitness of adult childhood cancer survivors and their risk factors for cardiovascular disease. Survivors with better physical fitness had a lower chance of having cardiovascular risk factors, suggesting that they could benefit from physical activity to decrease their risk of cardiovascular disease.
Article
Endocrinology & Metabolism
Christian Brinkmann, Hannah Hof, Detlef-Bernd Gysan, Christian Albus, Stefanie Millentrup, Birna Bjarnason-Wehrens, Joachim Latsch, Gerd Herold, Karl Wegscheider, Christian Heming, Melchior Seyfarth, Hans-Georg Predel
Summary: This study aimed to evaluate the effects of a multimodal intervention on the health and long-term cardiovascular disease mortality risk of individuals with pre-diabetes or diabetes mellitus at high CVD risk. The results showed improvements in various health markers and a significant decrease in cardiovascular disease risk score through the intervention. The study demonstrates the feasibility and potential effectiveness of a multimodal lifestyle program in improving the health of individuals with pre-diabetes or diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Drazenka Macak, Boris Popovic, Natasa Babic, Cristina Cadenas-Sanchez, Dejan M. Madic, Nebojsa Trajkovic
Summary: The study found that after 6 months of daily physical activity, preschool children showed significant improvements in muscular strength, such as grip strength and sit-ups. However, there were no significant differences between the experimental group and the control group in other fitness components.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Multidisciplinary Sciences
Patrizia Calella, Daniela Vitucci, Angela Zanfardino, Francesca Cozzolino, Alessia Terracciano, Francesco Zanfardino, Assunta Serena Rollato, Alessia Piscopo, Francesca Galle, Annamaria Mancini, Valeria Di Onofrio, Dario Iafusco, Giuliana Valerio, Pasqualina Buono, Giorgio Liguori
Summary: This study compared the clinical and biochemical characteristics, adherence to the Mediterranean Diet, lifestyle habits and physical fitness of different weight categories of Type 1 Diabetes Mellitus adolescents. The study found that despite differences in weight categories, adolescents showed similar clinical-biochemical parameters, diet adherence, and physical activity. However, normal weight adolescents performed better in agility and balance. This study highlights the importance of promoting a healthy lifestyle for Type 1 Diabetes Mellitus adolescents.
Article
Cardiac & Cardiovascular Systems
Christoph Hochsmann, James L. Dorling, Corby K. Martin, Robert L. Newton, John W. Apolzan, Candice A. Myers, Kara D. Denstel, Emily F. Mire, William D. Johnson, Dachuan Zhang, Connie L. Arnold, Terry C. Davis, Vivian Fonseca, Carl J. Lavie, Eboni G. Price-Haywood, Peter T. Katzmarzyk
Summary: A pragmatic ILI delivered in primary care setting produced clinically relevant improvements in cardiometabolic health in underserved population over 24 months, including significant weight loss and improvements in blood glucose, cholesterol levels.
Article
Endocrinology & Metabolism
Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Takanari Kitazono
Summary: This study found sex differences in Japanese patients with type 2 diabetes, with women being less likely to achieve recommended cardiovascular risk factor levels, and more likely to have unhealthy lifestyle and psychological factors.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Multidisciplinary Sciences
Elisabeth Buur Stougaard, Signe Abitz Winther, Hanan Amadid, Marie Frimodt-Moller, Frederik Persson, Tine Willum Hansen, Peter Rossing
Summary: The study aimed to assess the associations between PBR, PBR-hf, and MVHS with cardio-renal risk factors in individuals with type 1 diabetes, as well as compare these dimensions with controls. Results showed that the endothelial glycocalyx dimension was impaired in individuals with T1D compared to controls, but there was no association with albuminuria levels or cardio-renal risk factors. The use of the GlycoCheck device may not contribute significantly to cardio-renal risk stratification in T1D.
Article
Endocrinology & Metabolism
Sebastian Hoerber, Rainer Lehmann, Louise Fritsche, Juergen Machann, Andreas L. Birkenfeld, Hans-Ulrich Haering, Norbert Stefan, Martin Heni, Andreas Fritsche, Andreas Peter
Summary: Lifestyle intervention over one year significantly reduces coagulation factor activities, improves coagulation status, and lowers the risk of thrombosis. In addition to body weight, reducing liver fat, improving insulin sensitivity, and decreasing low-grade inflammation also contribute to improvements in hemostasis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jiho Park, Ji Hyun Yoon, Hyun Kyun Ki, Kyungdo Han, Hyungjin Kim
Summary: This study found that lifestyle changes, including smoking, alcohol intake, and exercise, were associated with the development of tuberculosis in patients with type 2 diabetes mellitus, highlighting the potential importance of lifestyle management in controlling tuberculosis in Korea.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Bin Wang, Ningjian Wang, Ying Sun, Xiao Tan, Jihui Zhang, Yingli Lu
Summary: This study aimed to investigate whether a healthy lifestyle can reduce the risk of dementia among individuals with diabetes. Using data from the UK Biobank cohort, the study found that adherence to a healthy lifestyle factors was associated with a significantly lower risk of dementia among participants with diabetes.
Article
Endocrinology & Metabolism
Sophia M. T. Dinges, Janosch Krotz, Felix Gass, Julian Treitschke, Isabel Fegers-Wustrow, Marisa Geisberger, Katrin Esefeld, Pia von Korn, Andre Duvinage, Frank Edelmann, Oliver Wolfram, Julia Brandts, Ephraim B. Winzer, Bernd Wolfarth, Felix Freigang, Sarah Neubauer, Thomas Nebling, Bjorn Hackenberg, Volker Amelung, Stephan Mueller, Martin Halle
Summary: This study identifies important indicators of disease severity, risk factor burden, and quality of life in patients with chronic ischaemic heart disease and type 2 diabetes mellitus. Peak VO2, BMI, and health literacy are crucial for lifestyle interventions.
DIABETES & VASCULAR DISEASE RESEARCH
(2022)
Article
Endocrinology & Metabolism
Stefano Balducci, Jonida Haxhi, Martina Vitale, Lorenza Mattia, Massimo Sacchetti, Giorgio Orlando, Patrizia Cardelli, Carla Iacobini, Lucilla Bollanti, Francesco Conti, Silvano Zanuso, Antonio Nicolucci, Giuseppe Pugliese
Summary: The study aims to investigate the relationship between changes in physical fitness and cardiovascular risk factors and scores in patients with type 2 diabetes. The findings suggest that improvement in physical fitness can independently predict a decrease in cardiovascular disease risk.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Hiwot Zewdie, Amy Y. Zhao, Hersila H. Patel, Eric Hansen, Sarah E. Messiah, Sarah C. Armstrong, Asheley C. Skinner, Cody D. Neshteruk, J. Aaron Hipp, Emily M. D'Agostino
Summary: The study found an association between neighborhood quality and the health status of minority youth, with walkability negatively related to physiological indicators such as body mass index and blood pressure, and greenspace positively related to these indicators. Disparities in youth cardiovascular disease risk may be modifiable through community interventions and built environment initiatives targeting select neighborhood factors.
ANNALS OF EPIDEMIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carla Iacobini, Martina Vitale, Carlo Pesce, Giuseppe Pugliese, Stefano Menini
Summary: The proposal of a single unifying mechanism for diabetic complications by Brownlee and colleagues marked a turning point in research, highlighting the role of ROS in diabetes-associated vascular disease pathways. Over a twenty-year journey, studies have focused on ROS generation in diabetes, cell dysfunction, and the pathogenesis of complications, while also exploring alternative mechanisms and the role of oxidative stress as an initial event in hyperglycemia-induced biochemical abnormalities.
Article
Infectious Diseases
Bianca Di Murro, Marta Moretti, Enrico De Smaele, Claudio Letizia, Carla Lubrano, Pier Carmine Passarelli, Antonio D'Addona, Giorgio Pompa, Piero Papi
Summary: This case-control study aimed to evaluate the influence of metabolic syndrome (Mets) on peri-implantitis by analyzing oral pathogens' concentrations in the peri-implant sulcus of patients. The study found significantly higher bacterial counts for certain species in Mets patients compared to healthy subjects, but no statistically significant differences were found when considering peri-implant status and dividing patients by Mets diagnosis.
Article
Medicine, General & Internal
Virginia Zamponi, Pina Lardo, Roberta Maggio, Chiara Simonini, Rossella Mazzilli, Antongiulio Faggiano, Giuseppe Pugliese, Antonio Stigliano
Summary: Women with primary adrenal insufficiency (PAI) have a higher prevalence of female sexual dysfunction (FSD) compared to healthy women, with desire being the most impaired aspect, and it is related to sexual distress and cortisol levels in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Cavallaro, Mariarita Tarallo, Ambra Chiappini, Daniele Crocetti, Andrea Polistena, Luigi Petramala, Simone Sibio, Giorgio De Toma, Enrico Fiori, Claudio Letizia
Summary: Surgery is the preferred treatment for ACC, with open adrenalectomy (OA) considered the gold standard and laparoscopic adrenalectomy (LA) gaining popularity. No significant differences were reported between LA and OA in overall recurrence rate, time to recurrence, and cancer-specific mortality, particularly for Stage I-II. Robotic adrenalectomy (RA) has advantages over LA, but there is limited documentation on its use in ACC.
Article
Health Care Sciences & Services
Antonio Del Casale, Leda Marina Pomes, Luca Bonanni, Federica Fiasche, Clarissa Zocchi, Alessio Padovano, Ottavia De Luca, Gloria Angeletti, Roberto Brugnoli, Paolo Girardi, Robert Preissner, Marina Borro, Giovanna Gentile, Maurizio Pompili, Maurizio Simmaco
Summary: Pharmacogenomics-guided treatment may be effective in the cure of treatment-resistant depression. This study evaluated the clinical changes after PGT in patients with TRD and found that the PGT group showed significant improvements in efficacy index and clinical global impression compared to the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Peripheral Vascular Disease
Luigi Petramala, Antonio Concistre, Francesco Circosta, Antonietta Gigante, Francesca Sarlo, Mauro Schina, Maurizio Soldini, Gino Iannucci, Rosario Cianci, Claudio Letizia
Summary: Aldosterone plays an important role in cardiovascular, metabolic, and renal damage in hypertensive patients. This study aimed to evaluate parameters obtained through eco-color Doppler study in asymptomatic patients with Essential Hypertension (EH) and Primary Aldosteronism (PA). The results showed that PA patients had higher renal filtration rate and albumin excretion compared to EH patients, as well as differences in various indices measured by eco-color Doppler.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2022)
Article
Health Care Sciences & Services
Antonio del Casale, Marco Paolini, Giovanna Gentile, Marina Borro, Clarissa Zocchi, Federica Fiasche, Alessio Padovano, Teodolinda Zoppi, Martina Nicole Modesti, Ottavia De Luca, Leda Marina Pomes, Roberto Brugnoli, Stefano Ferracuti, Paolo Girardi, Maurizio Pompili, Maurizio Simmaco
Summary: Patients with mental disorders have a higher smoking rate, which is influenced by various factors. This study found significant correlations between the DRD2 rs1800497 and DRD3 rs6280 polymorphisms and smoking habits and nicotine dependence in patients with psychiatric disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Luca Marino, Antonio Concistre, Marianna Suppa, Gioacchino Galardo, Antonello Rosa, Giuliano Bertazzoni, Francesco Pugliese, Claudio Letizia, Luigi Petramala
Summary: The importance of cardiovascular biomarkers in clinical practice has significantly increased, with applications ranging from diagnosis to prognostic purposes and response to treatment. This review aims to establish the role of sST2, the soluble form of the interleukin-1 receptor superfamily (ST2), in the clinical setting of acute heart failure, ischemic heart disease, and SARS-CoV-2 infection. The molecular mechanisms associated with the IL33/ST2 signaling pathways are discussed in relation to the clinical usefulness of biomarkers in early diagnosis, treatment evaluation, and prediction of adverse outcomes in cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ottavia De Luca, Gerardo Salerno, Donatella De Bernardini, Maria Simona Torre, Maurizio Simmaco, Luana Lionetto, Giovanna Gentile, Marina Borro
Summary: NGS exon sequencing can explain approximately 42.5% of DPD deficiencies, significantly improving the prediction of DPD deficiencies, but more genotype-phenotype association data is needed for clinical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Carla Iacobini, Martina Vitale, Jonida Haxhi, Carlo Pesce, Giuseppe Pugliese, Stefano Menini
Summary: Oxidative stress and hypoxia-inducible factors (HIFs) play crucial roles in the pathogenesis of diabetic cardiovascular and renal diseases, with reactive oxygen species (ROS) mediating cell signaling and contributing to the development of vascular complications.
Article
Biochemistry & Molecular Biology
Giovanna Gentile, Ottavia De Luca, Antonio Del Casale, Gerardo Salerno, Maurizio Simmaco, Marina Borro
Summary: Improper drug prescription is a major problem leading to drug-related harms and healthcare resource wastage. Through genomic profiling, we found that only 14.8% of Italian subjects had a fully normal cytochrome profile, while 26.5% had combined cytochrome dysfunction. The discussion focuses on the potential benefits of comprehensive pharmacogenomic testing in polytreated patients to improve drug selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Silvia Mezi, Andrea Botticelli, Simone Scagnoli, Giulia Pomati, Giulia Fiscon, Federica De Galitiis, Francesca Romana Di Pietro, Sofia Verkhovskaia, Sasan Amirhassankhani, Simona Pisegna, Giovanna Gentile, Maurizio Simmaco, Bjoern Gohlke, Robert Preissner, Paolo Marchetti
Summary: Drug-drug interactions (DDIs) are significantly associated with treatment-related cardiovascular toxicity. Our findings support the utility of DDI assessment in melanoma patients treated with BRAF/MEK inhibitors.
Article
Biochemistry & Molecular Biology
Antonio Del Casale, Maurizio Simmaco, Martina Nicole Modesti, Clarissa Zocchi, Jan Francesco Arena, Irene Bilotta, Alessandro Alcibiade, Giuseppe Sarli, Lorenzo Cutillo, Giulia Antonelli, Enrico La Spina, Ottavia De Luca, Robert Preissner, Marina Borro, Giovanna Gentile, Paolo Girardi, Maurizio Pompili
Summary: This study investigates the correlation between DRD2, DRD3, and HTR2A genes and resistance to antipsychotic medication, and finds that a diagnosis of schizophrenia and specific genotypes are significantly associated with high treatment resistance.
Article
Peripheral Vascular Disease
L. Petramala, A. Concistre, M. Mezzadri, F. Sarlo, F. Circosta, M. Schina, M. Soldini, G. Iannucci, C. Letizia
Summary: Arterial subclinical damage can be evaluated through arterial stiffness parameters in patients with Essential Hypertension and Primary Aldosteronism. UAE excretion can be used as an important marker to assess subclinical vascular remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2022)
Article
Nutrition & Dietetics
Carla Iacobini, Martina Vitale, Jonida Haxhi, Carlo Pesce, Giuseppe Pugliese, Stefano Menini
Summary: Carbonyl stress refers to the increase in reactive carbonyl species and the formation of irreversible covalent adducts with biological molecules. It is associated with inflammation and damage, and plays a role in diabetic cardiovascular complications, cancer risk, and the impact of modern diet on cardiometabolic and cancer risk.
