Article
Nutrition & Dietetics
Laura Tarancon-Diez, Miguel Genebat, Manuela Roman-Enry, Elena Vazquez-Alejo, Maria de la Sierra Espinar-Buitrago, Manuel Leal, Ma Angeles Munoz-Fernandez
Summary: This study aimed to determine a clinically relevant ferritin threshold to define absolute iron deficiency. The findings suggest that serum ferritin levels below 50 ng/mL are indicative of early iron deficiency.
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
Summary: By disrupting the expression of the Tf receptor gene in oligodendrocyte progenitor cells, researchers found that the Tf cycle is uniquely important for the development and function of oligodendrocytes. Deleting the Tfr gene resulted in impaired iron absorption and hypomyelination in mice. The Tf cycle plays a crucial role in iron homeostasis and energy production in oligodendrocyte progenitor cells.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Laura Tarancon-Diez, Marianela Iriarte-Gahete, Pilar Sanchez-Mingo, Guillermo Perez-Cabeza, Fernando Romero-Candau, Yolanda M. Pacheco, Manuel Leal, Maria Angeles Munoz-Fernandez
Summary: The study evaluated the safety and effectiveness of a generic intravenous iron treatment in Spanish patients with absolute iron deficiency. The results showed improvements in iron-related biomarkers, anemia, and ferritin levels. The recurrence of iron deficiency was associated with baseline iron stores depletion and sTfR/hepcidin ratio.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Sixtus Aguree, Arthur Owora, Misty Hawkins, Manju B. Reddy
Summary: Obesity is associated with health and nutritional problems, including impaired iron metabolism leading to anemia. We conducted a study to determine the prevalence of anemia, iron deficiency (ID), and iron deficiency anemia (IDA) in women aged 20-49 years based on body mass index (BMI). Analysis of data from the National Health and Nutrition Examination Survey (NHANES) showed higher levels of certain iron measures and lower levels of others in obese women compared to those with normal weight. The prevalence rates of ID and anemia (and IDA) were generally higher in obese women, but the choice of iron indices impacted the estimates.
Article
Nutrition & Dietetics
Kiwamu Noshiro, Takeshi Umazume, Rifumi Hattori, Soromon Kataoka, Takashi Yamada, Hidemichi Watari
Summary: This study found that hemoglobin levels during the first trimester of pregnancy are efficient predictors of anemia occurring during the third trimester. In a longitudinal assessment of 231 healthy Japanese women, it was observed that women with lower red blood cell count, hemoglobin, hematocrit, and ferritin levels during the first trimester were more likely to develop anemia in the third trimester.
Article
Endocrinology & Metabolism
Xinhui Wang, Xuexian Fang, Wanru Zheng, Jiahui Zhou, Zijun Song, Mingqing Xu, Junxia Min, Fudi Wang
Summary: Using Mendelian Randomization analysis, a causal link was found between increased systemic iron status and an increased risk of type 2 diabetes. Further research and careful interpretation of these findings are crucial for reducing the risk of type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Milton Fabian Suarez-Ortegon, Alejandra Arbelaez, Jose Maria Moreno-Navarrete, Jose Guillermo Ortega-Avila, Mildrey Mosquera, Jose Manuel Fernandez-Real
Summary: Excessive body iron levels are associated with insulin resistance and cardiometabolic risk, and oxidative stress may play a role in this relationship. This study investigated the association between soluble transferrin receptor (sTfR) levels, antioxidant status, and cardiometabolic risk markers. The results showed that sTfR levels were positively correlated with total antioxidant capacity (TAC) in both men and women. In men, sTfR levels were inversely associated with waist circumference and fasting glucose, and positively associated with LDL cholesterol. The findings suggest that sTfR levels are associated with antioxidant status and specific cardiometabolic risk variables, independent of other factors such as serum ferritin and hepcidin.
Review
Nutrition & Dietetics
Kaili Yang, Yaxian Yang, Binjing Pan, Songbo Fu, Jianguo Cheng, Jingfang Liu
Summary: This meta-analysis investigated the relationship between serum iron metabolism indexes and gestational diabetes mellitus (GDM). The results showed that GDM patients had higher levels of serum iron, ferritin, transferrin saturation, hepcidin, and hemoglobin, and lower total iron binding ability compared to non-GDM patients. High serum ferritin and hemoglobin levels were associated with an increased risk of GDM.
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Seok-Hui Kang, Bo-Yeon Kim, Eun-Jung Son, Gui-Ok Kim, Jun-Young Do
Summary: The aim of this study was to evaluate the survival rates of patients on maintenance hemodialysis (HD) according to their iron status. The study analyzed data from the National HD Quality Assessment Program and claims data (n = 42,390). The patients were divided into four groups based on their transferrin saturation rate and serum ferritin levels. The results showed that patients with normal iron status had the highest survival rates, while there were minimal differences in survival rates among the groups with abnormal iron status. Subgroup analyses based on age, hemoglobin, or serum albumin levels showed different trends.
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Qiuchen Wan, Giancarlo Denaroso, Rensheng Wan, Shaina L. Rosenblum, Pablo M. Paez
Summary: The storage of iron by astrocytes, particularly the Fth protein, is crucial for the early development of oligodendrocytes and the remyelination of the central nervous system. Knocking out Fth in astrocytes led to delays in oligodendrocyte development and myelin synthesis, as well as a decrease in the number of myelinating oligodendrocytes and the percentage of myelinated axons. These findings suggest that astrocytic iron storage plays a vital role in the myelination process and repair of myelin damage.
Article
Biochemistry & Molecular Biology
Ewa Skarzynska, Monika Wrobel, Hanna Zborowska, Mateusz Franciszek Kolek, Grzegorz Manka, Mariusz Kiecka, Michal Lipa, Damian Warzecha, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Miroslaw Wielgos, Barbara Lisowska-Myjak, Piotr Laudanski
Summary: The aim of this study was to investigate the relationship between lactoferrin and iron and its binding proteins in women with endometriosis. The results showed differences in lactoferrin, transferrin, ferritin, and iron levels between plasma and peritoneal fluid. Lactoferrin levels in plasma were associated with iron and transferrin in endometriosis, while lactoferrin in peritoneal fluid correlated with lactoferrin, iron, and transferrin in patients without endometriosis. The study suggests that assessing iron metabolism may be useful in diagnosing and monitoring endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Haoran Wang, Qianjin Qi, Shuaihua Song, Di Zhang, Li Feng
Summary: The study revealed a significant association between soluble transferrin receptor (sTfR) and hypertension, particularly systolic hypertension. Furthermore, a non-linear relationship between sTfR and systolic blood pressure was observed among U.S. adults.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Doris Gonzalez-Fernandez, Elizabeta Nemeth, Emerita Del Carmen Pons, Odalis Teresa Sinisterra, Delfina Rueda, Lisa Starr, Veena Sangkhae, Enrique Murillo, Marilyn E. Scott, Kristine G. Koski
Summary: The coexistence of maternal infections, nutrient deficiencies, and inflammation in lactating indigenous women in Panama may have an impact on maternal iron status and infant growth. Prevalent anemia was associated with indicators of malnutrition, while inflammation was related to lower serum iron levels. Maternal platelet levels were associated with lower infant growth, and higher length-for-age was associated with maternal serum vitamin D.
Article
Nutrition & Dietetics
Caroline de Godoi Rezende Costa Molino, Laurence Woll, Maud Wieczorek, Lauren A. Abderhalden, Patricia Lanz, Dominik J. Schaer, Donat R. Spahn, E. John Orav, Andreas Egli, Heike A. Bischoff-Ferrari
Summary: This study found that iron deficiency is associated with an increased number of hospitalizations in older adults, but not with the length of hospital stay. Iron deficiency is a factor in the health of older adults and efforts should be made to reduce iron deficiency to improve overall health outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Article
Biochemistry & Molecular Biology
Adekunle D. Adekile, Asma F. Azab, Sondus I. Al-Sharida, Bahia A. Al-Nafisi, Nagihan Akbulut, Rajaa A. Marouf, Nada Y. Mustafa
Letter
Medicine, General & Internal
Omer Uz, Ugur Kucuk, Zafer Isilak, Mehmet Dogan
MEDICAL PRINCIPLES AND PRACTICE
(2016)
Article
Cardiac & Cardiovascular Systems
Anwar Al-Awadhi, Adekunle Adekile, Rajaa Marouf
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2017)
Article
Hematology
Nada Y. Mustafa, Rajaa Marouf, Salah Al-Humood, Suad M. Al-Fadhli, Olusegun Mojiminiyi
ACTA HAEMATOLOGICA
(2010)
Article
Hematology
Renu Gupta, Rajaa Marouf, Adekunle Adekile
ACTA HAEMATOLOGICA
(2010)
Article
Medical Laboratory Technology
Salah Al-Humood, Rajaa Zueriq, Lama Al-Faris, Rajaa Marouf, Fahd Al-Mulla
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Rajaa Marouf
Article
Cell Biology
Salah A. Al-Humood, Aisha S. Al-Qallaf, Salem H. AlShemmari, Issam M. Francis, Thamradeen A. Junaid, Rajaa A. Marouf, Fahd Al-Mulla
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2011)
Article
Rheumatology
A. Gupta, R. Al Fulaij, R. K. Gupta, G. Gupta, R. Marouf
Article
Medicine, General & Internal
Rajaa Marouf, Nasser Behbehani, Mohammed Zubaid, Hanan Al Wazzan, Hadeel El Muzaini, Rasha Abdulla, Olusegun A. Mojiminiyi, Adekunle D. Adekile
MEDICAL PRINCIPLES AND PRACTICE
(2014)
Article
Surgery
Mousa Khoursheed, Ibtisam Al-Bader, Fahad Al-Asfar, Ali Sayed, Abdulaziz Al-Mozaini, Rajaa Marouf, Abe Fingerhut
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2013)
Article
Hematology
Anwar Al-Awadhi, Adekunle Adekile, Rajaa Marouf
Summary: The study revealed that in adult SCD patients, TSP-1 has an inhibitory effect on ADAMTS-13 activity, while in children, there is a significant negative correlation between TSP-1 and ADAMTS-13/vWF antigen ratio.
ACTA HAEMATOLOGICA
(2021)
Article
Hematology
Rajaa Marouf, Adekunle D. Adekile, Hadeel El-Muzaini, Rasha Abdulla, Olusegun A. Mojiminiyi
Summary: Sickle cell nephropathy (SCN) can be detected using NGAL as a biomarker, particularly during vaso-occlusive crises (VOC). Urine NGAL may serve as a screening biomarker, and aggressive management should be considered for VOC patients with urine NGAL levels > 12.0 ng/mL to prevent further renal damage.
ANNALS OF HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adekunle D. Adekile, Sondus Al-Sherida, Rajaa Marouf, Nada Mustafa, Diana Thomas
Article
Medicine, General & Internal
Adekunle Adekile, Asmaa Farag Azab, Rajaa Marouf, Sundus Al-Sharida, Hanan Al-Abboh
KUWAIT MEDICAL JOURNAL
(2013)