期刊
NUTRITION JOURNAL
卷 12, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1475-2891-12-137
关键词
Geriatrics; Cholecalciferol; Osteoporosis; Vitamin D deficiency; Bread fortification
Background: We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials. gov registration NCT00789503). Methods: At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH) D), parathyroid hormone (PTH) and bone mineral density were measured in 23 of the original study subjects, aged 60-82 years who had consumed bread buns (100 g) fortified with 320 mg elemental calcium and 125 mu g (5,000 IU) vitamin D3 daily for one year. Results: At the end of the 1-year supplementation phase (receiving vitamin D3 fortified bread daily), mean (SD) serum 25(OH) D was 127.3 +/- 37.8 nmol/L (baseline for this follow-up). At 1-year follow-up, the serum 25(OH) D was 64.9 +/- 24.8 nmol/L (p = 0.001, vs. baseline); and at 3-year follow-up it was 28.0 +/- 15.0 nmol/L (p = 0.001 vs. baseline). Serum PTH was 18.8 +/- 15.6 pg/ml at baseline while at Year 3 it was 48.4 +/- 18.4 pg/ml (p = 0.001 vs. baseline). Lumbar spine BMD did not change from baseline to Year 3. However, by Year 3, hip BMD had decreased (0.927 +/- 0.130 g/cm(2) vs. 0.907 +/- 0.121 g/cm(2), p= 0.024). Conclusion: Vitamin D nutritional status exhibits a long half-life in the body, and a true steady-state plateau may not even be reached 1 year after a discontinuation in dose. Furthermore, once the need for vitamin D has been established, based on a low baseline serum 25(OH) D concentrations, the appropriate action is to maintain corrective vitamin D supplementation over the long term.
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