Article
Cell Biology
Feng-Min Zhang, Hao-Fan Wu, Han-Ping Shi, Zhen Yu, Cheng-Le Zhuang
Summary: Sarcopenia is a systemic skeletal muscle disorder that often affects the elderly population and is more common in cancer patients. It not only changes body composition but also leads to increased complications, reduced treatment efficacy, and shortened survival.
AGEING RESEARCH REVIEWS
(2023)
Article
Endocrinology & Metabolism
Muhammad Arif Aslam, Eun Bi Ma, Joo Young Huh
Summary: Sarcopenia, a geriatric disorder characterized by a decline in muscle mass and function, is associated with adverse health outcomes. This review consolidates knowledge on the genetic factors influencing sarcopenia and emphasizes their interaction with environmental factors. It aims to inform the development of therapeutic interventions for sarcopenia.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Cell Biology
Marita A. Wallace, Nicholas W. Aguirre, George R. Marcotte, Andrea G. Marshall, Leslie M. Baehr, David C. Hughes, Karyn L. Hamilton, Megan N. Roberts, Jose Alberto Lopez-Dominguez, Benjamin F. Miller, Jon J. Ramsey, Keith Baar
Summary: This study demonstrates that a long-term ketogenic diet (KD) can effectively mitigate sarcopenia by preserving oxidative muscle fibers and enhancing mitochondrial and antioxidant capacity. These adaptations lead to a healthier cellular environment, reducing oxidative and ER stress which results in decreased protein turnover, thereby assisting mice in maintaining muscle mass and function with age.
Article
Biochemistry & Molecular Biology
Athanasios Moustogiannis, Anastassios Philippou, Orjona Taso, Evangelos Zevolis, Maria Pappa, Antonios Chatzigeorgiou, Michael Koutsilieris
Summary: This study investigated the impact of senescence/aging on skeletal myogenesis through in vitro experiments. Aged myoblasts showed cell cycle arrest, DNA damage, increased SA-beta-gal activity, and altered expression of various factors compared to control cells during differentiation. The findings suggest that aging disrupts myogenic lineage and leads to a reduction in differentiation capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jong Hyeon Yoon, Seung-Min Lee, Younglang Lee, Min Ju Kim, Jae Won Yang, Jeong Yi Choi, Ju Yeon Kwak, Kwang-Pyo Lee, Yong Ryoul Yang, Ki -Sun Kwon
Summary: Alverine citrate (AC) has been identified as a potential therapeutic candidate for improving muscle weakness and sarcopenia by inhibiting atrophy signals and enhancing myoblast fusion. Its treatment showed positive effects on muscle mass and physical performance in aged and hindlimb-disused mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Taichi Fukunaga, Shuuichi Mori, Takuya Omura, Yoshihiro Noda, Yasunori Fujita, Ikuroh Ohsawa, Kazuhiro Shigemoto
Summary: Mitochondrial dysfunction is considered a major cause of sarcopenia, and its effects differ based on fiber type. Oxidative stress is associated with age-related muscle fiber atrophy, while specific mitochondrial changes may correlate with muscle quality rather than muscle mass.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Nutrition & Dietetics
Jeong-Hoon Hahm, Farida S. Nirmala, Tae Youl Ha, Jiyun Ahn
Summary: A decline in function and loss of mass, known as sarcopenia, is observed in skeletal muscles during aging. Sarcopenia negatively impacts the quality of life for the elderly, increasing the risk of mobility issues, falls, and type 2 diabetes. Mitochondrial dysfunction plays a significant role in muscle aging, highlighting the need for strategies to improve mitochondrial function in sarcopenia treatment. Although specific drugs are not yet approved, studies suggest that nutritional intake and dietary control can be alternative approaches to mitigate muscle aging.
Article
Chemistry, Multidisciplinary
Xi Yu, Yun Wang, Liyu Ran, Yang Jiang, Ming Chen, Hao Du, Yao Zhang, Diwei Wu, Xiaona Xiang, Jiawei Zhang, Ning Jiang, Hongchen He, Yueming Song, Zhou Xiang, Chengqi He, Zongke Zhou, Jiancheng Zeng, Yong Xiang, Shi-shu Huang, Yunfeng Lin
Summary: Sarcopenia, a type of age-related muscle atrophy, affects over a quarter of elderly population worldwide, characterized by progressive decline in muscle mass, strength, and performance. Current clinical treatments are limited to rehabilitative interventions and dietary supplements. Tetrahedral framework nucleic acids (tFNAs), a novel DNA-based nanomaterial, show superior anti-apoptosis capacity in cells, tissues, organs, and systems. In this study, the therapeutic effect of tFNAs treatment on sarcopenia was evaluated in vivo and in vitro, showing improvement in muscle function, endurance, and morphological changes in muscle fibers. In vitro experiments also demonstrated the amelioration of DEX-induced sarcopenic myotube atrophy through inhibition of mitochondria-mediated cell apoptosis. Overall, tFNAs treatment may serve as an alternative option for sarcopenia in the future.
Article
Geriatrics & Gerontology
Sarah K. Burke, Andrew Fenton, Yana Konokhova, Russell T. Hepple
Summary: Muscle atrophy in aging is most pronounced in fast twitch muscle like the gastrocnemius, with similar effects in the extensor digitorum longus and slow-twitch soleus, while the slow-twitch adductor longus increases in mass. Only the soleus shows significant alterations in fiber type with aging. Muscles that atrophy show an increased fraction of severely atrophic myofibers, while the adductor longus does not exhibit this phenomenon.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Medicine, General & Internal
Abdurrahman Aslan, Lauren Harlow, Xin-Hua Liu, Rita De Gasperi, William A. Bauman, Marco Brotto, Christopher P. Cardozo
Summary: Skeletal muscle undergoes rapid and extensive atrophy following nerve transection, but the mechanisms behind this process are not fully understood. This study investigated the role of Notch signaling and Numb expression in denervation atrophy. The results showed that nandrolone treatment increased Numb expression and reduced Notch signaling in denervated muscle. However, neither nandrolone nor nandrolone plus testosterone changed the rate of denervation atrophy. Furthermore, conditional knockout of Numb in myofibers had no effect on denervation atrophy. These findings suggest that Numb does not alter the course of denervation atrophy and that upregulation of Numb and inhibition of Notch signaling do not change the progression of denervation atrophy.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Yi Su, Amany Elshorbagy, Cheryl Turner, Helga Refsum, Timothy Kwok
Summary: This study found that the dietary inflammatory index (DII) is associated with the serum amino acid profile and affects muscle health. Higher levels of serum branched chain amino acids (BCAAs), aromatic amino acids, and total glutathione (tGSH) are correlated with better muscle status. On the other hand, a more pro-inflammatory diet is associated with higher levels of total homocysteine and cystathionine and is indirectly linked to a decline in hand grip strength.
Article
Cell Biology
Kamil Karolczak, Agnieszka Guligowska, Joanna Kostanek, Bartlomiej Soltysik, Tomasz Kostka, Cezary Watala
Summary: Aging increases the risk of thrombotic diseases, but dietary amino acid content can modulate platelet reactivity. This study found that older adults who consume higher amounts of essential amino acids in their daily diet have lower platelet responsiveness to certain stimuli, depending on their sex. Therefore, dietary amino acid content may attenuate platelet reactivity in a sex-specific and agonist-specific manner.
Review
Food Science & Technology
Gavriela Voulgaridou, Sophia D. Papadopoulou, Maria Spanoudaki, Fovi S. Kondyli, Ioanna Alexandropoulou, Stella Michailidou, Paul Zarogoulidis, Dimitris Matthaios, Dimitrios Giannakidis, Maria Romanidou, Sousana K. Papadopoulou
Summary: This study aimed to review the current evidence on the independent and combined effects of diet and exercise and their impact on skeletal muscle mass in the elderly population. The combination of exercise and diet is known to be a potent anabolic stimulus through stimulation of muscle protein synthesis from amino acids. Aging is strongly associated with a generalized deterioration of physiological function, including a progressive reduction in skeletal muscle mass. Sarcopenia, an age-related syndrome, is primarily used to describe the gradual and generalized loss of skeletal muscle mass and function. Multimodal training and adequate protein intake have been recognized as effective interventions to promote skeletal muscle growth in the elderly.
Review
Cell Biology
Luisa Gorza, Matteo Sorge, Laura Secli, Mara Brancaccio
Summary: Muscle atrophy development can be partially antagonized by targeting the Atrogene pathway, but may have limited effects in different contexts. Costameres, as macromolecular complexes, play a crucial role in sensing mechanical load and transducing it into biochemical signals to regulate muscle mass.
Article
Medicine, General & Internal
Amelia Brunani, Raffaella Cancello, Michele Gobbi, Elisa Lucchetti, Giulia Di Guglielmo, Sabrina Maestrini, Stefania Cattaldo, Paolo Pitera, Chiara Ruocco, Alessandra Milesi, Alessandra Valerio, Paolo Capodaglio, Enzo Nisoli
Summary: This study aimed to assess the impact of protein or amino acid supplements on muscle mass loss in middle-aged men. The results showed that the PD-E07 supplement group had a notable increase in muscle mass compared to the control group, while the protein and BCAA supplement groups did not exhibit a significant difference. Therefore, amino acid-based supplements may effectively mitigate the loss of muscle mass during weight reduction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ecology
Brandilyn A. Peters, Stella S. Yi, Jeannette M. Beasley, Emilia N. Cobbs, Hee Sun Choi, Dia B. Beggs, Richard B. Hayes, Jiyoung Ahn
Review
Public, Environmental & Occupational Health
Jeannette M. Beasley, Janelle M. Wagnild, Tessa M. Pollard, Timothy R. Roberts, Nasima Ahkter
Article
Nutrition & Dietetics
Jeannette M. Beasley, Eileen Rillamas-Sun, Lesley F. Tinker, Judith Wylie-Rosett, Yasmin Mossavar-Rahmani, Mridul Datta, Bette J. Caan, Andrea Z. LaCroix
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2020)
Article
Nutrition & Dietetics
Jeannette M. Beasley, Melanie J. Firestone, Collin J. Popp, Rienna Russo, Stella S. Yi
FRONTIERS IN NUTRITION
(2020)
Article
Medicine, General & Internal
Sandra Wittleder, Shea Smith, Binhuan Wang, Jeannette M. Beasley, Stephanie L. Orstad, Victoria Sweat, Allison Squires, Laura Wong, Yixin Fang, Paula Doebrich, Damara Gutnick, Craig Tenner, Scott E. Sherman, Melanie Jay
Summary: This study aims to test the efficacy of the Peer-Assisted Lifestyle (PAL) intervention compared with enhanced usual care (EUC) to improve body mass loss, clinical and behavioral outcomes among US veterans. The study also aims to identify predictors of body mass loss and increase primary care provider counseling.
Letter
Nutrition & Dietetics
Jeannette M. Beasley, Eileen Rillamas-Sun, Lesley F. Tinker, Judith Wylie-Rosett, Yasmin Mossavar-Rahmani, Mridul Datta, Bette J. Caan, Andrea Z. LaCroix
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2021)
Editorial Material
Public, Environmental & Occupational Health
Jeannette M. Beasley, Megha Shah, Laura C. Wyatt, Jennifer Zanowiak, Chau Trinh-Shevrin, Nadia S. Islam
Summary: Evidence-based strategies addressing comorbid hypertension and diabetes are necessary among minority communities. In a study analyzing the outcome of blood pressure control in New York City, interventions conducted by community health workers showed significant reductions in blood pressure among participants with comorbid hypertension and diabetes.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Jeannette M. Beasley, Stella Yi, Matthew Lee, Agnes Park, Lorna E. Thorpe, Simona C. Kwon, Pasquale Rummo
Summary: This study aims to provide a dietary screener questionnaire for English-speaking Asian Americans to understand and intervene on their dietary behaviors. The questionnaire was culturally adapted by adding culturally specific examples of foods to reflect the dietary patterns of Asian Americans.
HEALTH PROMOTION PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Valerie K. Sullivan, Emily A. Johnston, Melanie J. Firestone, Stella S. Yi, Jeannette M. Beasley
Summary: This study found that self-rated diet quality is closely associated with the Healthy Eating Index-2015 and cardiometabolic risk factors. While there were variations in the assessment of diet quality among different racial/ethnic groups, individuals with higher self-ratings were consistently associated with better diet quality scores.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jeannette M. Beasley, Joyce C. Ho, Sarah Conderino, Lorna E. Thorpe, Megha Shah, Unjali P. Gujral, Jennifer Zanowiak, Nadia Islam
Summary: This study compared the burden of diabetes and hypertension among South Asian patients in two US cities and found differences in disease prevalence between New York City and Atlanta. It also highlighted the need for better ethnic subgroup characterization in electronic health records and intervention studies to reduce the risk of type 2 diabetes and hypertension in South Asians.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Education, Scientific Disciplines
Emily A. Johnston, Jeannette M. Beasley, Melanie Jay
Summary: A presentation on nutrition was conducted with medical students, with a majority of students indicating that it met the objectives and they would discuss nutrition with patients in the future. Many students acknowledged the importance of nutrition for disease prevention and management.
ADVANCES IN MEDICAL EDUCATION AND PRACTICE
(2021)
Article
Endocrinology & Metabolism
Jie Li, Andrea J. Glenn, Qingling Yang, Ding Ding, Lingling Zheng, Wei Bao, Jeannette Beasley, Erin LeBlanc, Kenneth Lo, JoAnn E. Manson, Lawrence Philips, Lesley Tinker, Simin Liu
Summary: This study found that substituting plant protein for animal protein may decrease the risk of type 2 diabetes (T2D) by reducing obesity-related inflammation, based on findings from two large prospective cohorts.
Article
Nutrition & Dietetics
Lindsey Kirshner, Stella S. Yi, Judith Wylie-Rosett, Nirupa R. Matthan, Jeannette M. Beasley
CURRENT DEVELOPMENTS IN NUTRITION
(2020)
Article
Obstetrics & Gynecology
James M. Shikany, JoAnn E. Manson, Aladdin H. Shadyab, Lorena Garcia, Cora E. Lewis, Marian L. Neuhouser, Lesley F. Tinker, Jeannette M. Beasley, Shirley A. A. Beresford, Oleg Zaslavsky, Mara Z. Vitolins, Shawnita Sealy-Jefferson, Sejong Bae
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)
Article
Geriatrics & Gerontology
M. El Shatanofy, J. Chodosh, M. A. Sevick, J. Wylie-Rose, L. Deluca, J. M. Beasley
JOURNAL OF FRAILTY & AGING
(2020)