Review
Nutrition & Dietetics
Leontien Depoorter, Yvan Vandenplas
Summary: The administration of probiotics in children has been studied extensively worldwide, showing significant benefits. However, due to study heterogeneity and risk of bias, there is currently no broad consensus on specific probiotic strains, doses, and treatment regimens for certain pediatric indications.
Review
Gastroenterology & Hepatology
Monika Kvakova, Anna Kamlarova, Jana Stofilova, Veronika Benetinova, Izabela Bertkova
Summary: Colorectal cancer is a major cause of death worldwide. Conventional anticancer therapy is not always effective, leading to growing interest in drug-free cancer treatments or interventions that improve the efficacy of established therapy. Supplementing patient treatment with probiotics, next-generation probiotics, or postbiotics can restore gut microbiota composition and/or signaling to the host, providing an effective and accessible complementary anticancer strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Allergy
Gerdien Tramper-Stranders, Dominika Ambrozej, Alessandra Arcolaci, Marina Atanaskovic-Markovic, Cristina Boccabella, Matteo Bonini, Aspasia Karavelia, Ervin Mingomataj, Liam O' Mahony, Milena Sokolowska, Eva Untersmayr, Wojciech Feleszko
Summary: The composition and activities of microbiota play a crucial role in the education and development of a healthy immune system, with microbial dysbiosis being associated with allergic diseases. Improper use of antibiotics increases the risk of allergic diseases. Research shows potential for microbial therapies such as probiotics in the prevention and treatment of allergic diseases.
Article
Infectious Diseases
Mohamed F. Ghaly, Zahraa M. Nasr, Amira I. Abousaty, Hanan G. Seadawy, Mohamed A. A. Shaheen, Sarah Albogami, Mohammad M. Al-Sanea, Mahmoud M. Bendary
Summary: The study found a high prevalence rate of Salmonella in meat products, with most isolates being multidrug-resistant but susceptible to cefotaxime. Out of 13 plant extracts, cinnamon oil and paprika water extract showed antimicrobial activity and synergistic effect with cefotaxime. Therefore, cinnamon oil is recommended as a food additive to combat resistant foodborne pathogens.
Review
Biochemistry & Molecular Biology
Jelena Popov, Valentina Caputi, Nandini Nandeesha, David Avelar Rodriguez, Nikhil Pai
Summary: Ulcerative colitis (UC) is a chronic autoimmune disorder that affects the colonic mucosa. Its etiology remains unclear, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in UC pathogenesis, and the potential for modulating intestinal inflammation through microbial-targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Tao Zhang, Guangqi Gao, Lai-Yu Kwok, Zhihong Sun
Summary: The advent of high-throughput 'omics' technologies has improved our understanding of the connection between gut microbiome and Alzheimer's disease (AD). Modulating the gut microbiota has emerged as a novel approach for clinical management of AD. This review provides an overview of the association between gut dysbiosis and AD, the mechanisms of gut microbiota in driving AD progression, and the success and challenges of gut microbiome-targeted therapies in AD studies.
Review
Oncology
Thien Nguyen, Sabine Mueller, Fatema Malbari
Summary: Surgery, chemotherapy and radiation have been the main treatments for pediatric brain tumors, but recently new modalities have emerged. These new therapies aim to improve survival and reduce complications, but their side effects are not well understood yet. Treatment complications can be caused by drug toxicity or vascular, infectious, or autoimmune mechanisms. More research is needed to improve neurocognitive outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Guillem Pascual-Pasto, Brendan McIntyre, Rawan Shraim, Samantha N. Buongervino, Amy K. Erbe, Doncho Zhelev, Shakhnozakhon Sadirova, Anna M. Giudice, Daniel Martinez, Laura Garcia-Gerique, Dimiter S. Dimitrov, Paul M. Sondel, Kristopher R. Bosse
Summary: This study characterizes the immunomodulatory properties of a GPC2-targeted ADC and demonstrates the efficacy of combination immunotherapies in diverse neuroblastoma preclinical models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Nutrition & Dietetics
Simon Alesi, Carolyn Ee, Lisa J. Moran, Vibhuti Rao, Aya Mousa
Summary: This review provides an up-to-date, comprehensive synthesis of the highest level of evidence regarding the effects of nutritional supplements and complementary therapies in the treatment and management of polycystic ovary syndrome (PCOS). The evidence suggests that specific vitamins, vitamin-like nutrients, minerals, and some complementary approaches may be beneficial in PCOS. However, there are still uncertainties and limitations that need to be addressed.
ADVANCES IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Kyung Jae Lee, Eell Ryoo, Yoo Min Lee, Jung Min Yoon, Hyo-Jeong Jang, So Yoon Choi, You Jin Choi, Hyun Jin Kim, Ju Young Chung, Jung Ok Shim
Summary: This study investigated the effectiveness of Saccharomyces boulardii and lactulose for treating childhood functional constipation. The results showed that Saccharomyces boulardii monotherapy was not superior to lactulose monotherapy or combination therapy, and had a lower drug maintenance rate.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Gastroenterology & Hepatology
Mijra Koning, Hilde Herrema, Max Nieuwdorp, Abraham S. Meijnikman
Summary: Humans have a diverse gut microbiome, consisting of bacteria, fungi, viruses, and archaea. Patients with NAFLD have an altered gut microbiome and compromised gut barrier function. Preclinical studies suggest that adjusting the gut microbiome could be a promising therapeutic strategy for NAFLD. This overview summarizes the current information on both untargeted techniques (such as probiotics and fecal microbiota transplantation) and targeted microbiome-focused therapies (including engineered bacteria, prebiotics, postbiotics, and phages) for the treatment of NAFLD.
Review
Pediatrics
Jitendra Meena, Christy C. Thomas, Jogender Kumar, Sumantra Raut, Pankaj Hari
Summary: Cranberry and probiotics are two effective non-antibiotic interventions for reducing the risk of urinary tract infection recurrence in children, showing better efficacy compared to placebo and lower risk of antibiotic resistance than antibiotics.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Lukasz Dembinski, Aleksandra Banaszkiewicz, Katarzyna Deren, Aleksandra Pituch-Zdanowska, Teresa Jackowska, Jaroslaw Walkowiak, Artur Mazur
Summary: Complementary feeding is crucial for the health of infants and toddlers, but parents often struggle with the timing and sequence of introducing complementary foods. Additionally, this study revealed that a significant number of pediatricians face challenges in providing nutritional counseling, highlighting the importance of increasing their nutritional awareness for better support to parents.
Review
Biology
Minna Rodrigo, Xinzhong Dong, Daphne Chien, Wikrom Karnsakul
Summary: Pediatric patients with liver disease commonly experience itching, which can significantly affect their quality of life. The cause of itching in liver disease is not fully known and may be caused by many factors. Treating this symptom can be difficult and may require surgical interventions in certain cases. Understanding the cause of itching may help identify better treatment options.
Article
Biochemistry & Molecular Biology
Maritza P. Garrido, Allison N. Fredes, Lorena Lobos-Gonzalez, Manuel Valenzuela-Valderrama, Daniela B. Vera, Carmen Romero
Summary: Epithelial ovarian cancer is one of the deadliest gynaecological malignancies. Late diagnosis is frequent due to the absence of specific symptoms and the molecular complexity of the disease. Recently, anti-angiogenic therapy and PARP inhibitors have been introduced, which have shown to increase the survival of ovarian cancer patients. However, the identification of patients who benefit the most is still under investigation.
Article
Gastroenterology & Hepatology
Tamar Ringel-Kulka, Johnson McRorie, Yehuda Ringel
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Gastroenterology & Hepatology
Nitsan Maharshak, Yehuda Ringel, David Katibian, Ashley Lundqvist, R. Balfour Sartor, Ian M. Carroll, Tamar Ringel-Kulka
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Nursing
Abigail L. Liberty, Kathryn Wouk, Ellen Chetwynd, Tamar Ringel-Kulka
JOURNAL OF HUMAN LACTATION
(2019)
Article
Gastroenterology & Hepatology
Eyal Zifman, Hagar Banai, Raanan Shamir, Tamar Ringel-Kulka, Noam Zevit
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Review
Medicine, Research & Experimental
Tomasz Dworzanski, Rafal Fornal, Lukasz Kozba, Krzysztof Celinski, Ewa Dworzanska
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2018)
Article
Gastroenterology & Hepatology
Keren Hod, Yehuda Ringel, Miranda A. L. van Tilburg, Tamar Ringel-Kulka
DIGESTIVE DISEASES AND SCIENCES
(2019)
Article
Multidisciplinary Sciences
Pavlo Khodakivskyi, Christian L. Lauber, Aleksey Yevtodiyenko, Arkadiy A. Bazhin, Stephen Bruce, Tamar Ringel-Kulka, Yehuda Ringel, Bertrand Betrisey, Joana Torres, Jianzhong Hu, Chieh Jason Chou, Elena A. Goun
Summary: The study developed a novel optical tool for quantifying BSH activity across various biological contexts in a quick and cost-effective manner, with potential clinical applications, particularly in predicting the clinical status of IBD patients.
Article
Environmental Sciences
Hilde Kristin Vindenes, Cecilie Svanes, Stein Hakon Lastad Lygre, Francisco Gomez Real, Tamar Ringel-Kulka, Randi Jacobsen Bertelsen
Summary: The study investigated the associations between the use of personal care products and urine biomarker levels of phenols and parabens, as well as the potential impact on inflammatory diseases like allergies and overweight. The results showed correlations between several chemicals and conditions such as eczema, rhinitis, asthma, specific IgE, and body mass index.
ENVIRONMENTAL HEALTH
(2021)
Article
Genetics & Heredity
Chris Eijsbouts, Tenghao Zhen, Nicholas A. Kennedy, Ferdinando Bonfiglio, Carl A. Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, Alexandru-loan Voda, Gianrico Farrugia, Andre Franke, Matthias Huebenthal, Goncalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tonu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J. Whorwell, Robin Spiller, Gil McVean, Mauro D'Amato, Luke Jostins, Miles Parkes
Summary: An analysis of the genome-wide association of irritable bowel syndrome has identified and confirmed six genetic susceptibility loci, with implicated genes linked to mood and anxiety disorders. There is a strong correlation between the risk of IBS and anxiety, neuroticism, and depression, suggesting shared pathways with mood and anxiety disorders rather than anxiety directly causing abdominal symptoms.
Article
Art
Tomas Kulka
Summary: Contrary to popular belief, this paper argues that the aesthetic value of artworks has been overrated and that artistic value is equally important. The author suggests that the monetary value of artworks, although not directly related to their aesthetic or artistic value, can provide insights into the overall value and relative importance of these two components.
BRITISH JOURNAL OF AESTHETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Randi Jacobsen Bertelsen, Antonio Manuel Perez Barrionuevo, Rajesh Shigdel, Stein Atle Lie, Huang Lin, Francisco Gomez Real, Tamar Ringel-Kulka, Anne Nordrehaug Astrom, Cecilie Svanes
Summary: Research findings have shown that increasing self-reported gingival bleeding frequency is associated with increased gingival bacterial diversity. Frequent gingival bleeding is associated with increased abundance of certain bacteria (such as Porphyromonas endodontalis, Treponema denticola, and Fretibacterium spp.), but decreased abundance of bacteria within the gram-positive phyla Firmicutes and Actinobacteria. Additionally, using dental floss and mouthwash twice daily is associated with increased total abundance of bacteria in the Proteobacteria phylum, but decreased bacterial diversity.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Microbiology
Hilde Kristin Vindenes, Huang Lin, Rajesh Shigdel, Tamar Ringel-Kulka, Francisco Gomez Real, Cecilie Svanes, Shyamal D. Peddada, Randi J. Bertelsen
Summary: This study explores the impact of antimicrobial and environmental chemicals on the composition of oral bacteria. The results show that high levels of certain chemicals are associated with changes in the abundance of oral bacteria, highlighting the need for a better understanding of how antimicrobial chemical exposure influences the human microbiome.
FRONTIERS IN MICROBIOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Yehuda Ringel, Chieh J. Chou, Stephen J. Bruce, Hugues Henry, Christian Lauber, Bertrand Betrisey, Elena Goun, Tamar Ringel-Kulka
Article
Materials Science, Multidisciplinary
M. Rossi, M. Retegan, C. Giacobbe, R. Fumagalli, A. Efimenko, T. Kulka, K. Wohlfeld, A. I. Gubanov, M. Moretti Sala
Meeting Abstract
Critical Care Medicine
R. J. Bertelsen, T. Ringel-Kulka, S. Peddada, A. Kaul, F. G. Real, C. Svanes
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
