Review
Cell Biology
Sonia Levi, Maddalena Ripamonti, Marko Dardi, Anna Cozzi, Paolo Santambrogio
Summary: A new type of human ferritin called mitochondrial ferritin was identified in 2001, but understanding of its physiological role remains incomplete. Limited research on mitochondrial ferritin is attributed to its high similarity with cytosolic ferritin, making it challenging to obtain specific antibodies. While there is no evidence that mutations in the mitochondrial ferritin gene cause disorders, its association with certain disorders has been discussed.
Review
Nutrition & Dietetics
Marcin Delijewski, Aleksandra Barton, Beata Maksym, Natalia Pawlas
Summary: Iron is a crucial transition metal in physiological processes, but it can also be toxic due to its involvement in free radical formation. Impaired iron metabolism leads to iron deficiency, anemia, and iron overload, with different prevalences in transplant patients. Limited knowledge exists on iron metabolism in lung graft recipients and donors, complicated further by the potential impact of drugs. This overview highlights the importance of understanding iron turnover in transplant patients and assessing drug effects on iron metabolism for perioperative treatment in transplantology.
Article
Medicine, General & Internal
Jun Yeop Lee, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung
Summary: This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups. The results showed that H. pylori infection was associated with lower levels of hemoglobin and ferritin, and iron deficiency was more common in infected patients. However, there was no significant difference in anemia or IDA among H. pylori-infected patients. Logistic regression analysis indicated that female sex and H. pylori infection were factors associated with iron deficiency.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Letter
Medicine, General & Internal
Andrew J. Read, Akbar K. Waljee, Charity S. Chen, Robert Holleman, Kyle E. Kumbier, Sameer D. Saini
Summary: This cohort study examines the prevalence of appropriate testing for incident anemia in a large cohort from a national integrated health care system.
Article
Food Science & Technology
Jordi Mayneris-Perxachs, Wellington Amaral, Gabriele R. Lubach, Mark Lyte, Gregory J. Phillips, Joram M. Posma, Christopher L. Coe, Jonathan R. Swann
Summary: Infants worldwide are seriously affected by iron deficiency, but the lingering metabolic and microbial effects after natural recovery have been found in juvenile monkeys, while early treatment with iron dextran and B vitamins can prevent these long-term biochemical derangements.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jolanta Artym, Michal Zimecki, Marian L. Kruzel
Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.
Article
Nutrition & Dietetics
Andrea J. Sharma, Nicole D. Ford, Joanna E. Bulkley, Lindsay M. Jenkins, Kimberly K. Vesco, Anne M. Williams
Summary: This study assessed the feasibility of anemia, iron deficiency, and iron-deficiency anemia surveillance among first-trimester pregnancies using electronic health records. It found that approximately 2.7% of pregnancies had anemia, with about half of those cases having both low hemoglobin and low hematocrit. Iron deficiency was present in approximately 26.8% of pregnancies with anemia and 23.5% of pregnancies without anemia.
JOURNAL OF NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Heinz Zoller, Myles Wolf, Irina Blumenstein, Christian Primas, Stefan Lindgren, Lars L. Thomsen, Walter Reinisch, Tariq Iqbal
Summary: Despite comparable treatment efficacy for iron deficiency anaemia, FCM was associated with a higher incidence of hypophosphataemia compared to FDI. Further studies are needed to investigate the long-term clinical consequences of hypophosphataemia and the mechanisms underlying the differential effects of FCM and FDI on patient-reported fatigue.
Article
Nutrition & Dietetics
Andrea J. Sharma, Nicole D. Ford, Joanna E. Bulkley, Lindsay M. Jenkins, Kimberly K. Vesco, Anne M. Williams
Summary: The feasibility of monitoring anemia, iron deficiency, and iron-deficiency anemia among pregnant women using electronic health records has been assessed. This method can be used to monitor the prevalence and trends of anemia in pregnant women, but obtaining representative estimates of iron deficiency or iron-deficiency anemia may be challenging if iron assessment is not routine.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Suhua Xu, Hao Zheng, Zhaoxie Tang, Zhuohe Gu, Min Wang, Cuilan Tang, Yanqi Xie, Minli Kong, Jiajia Jing, Yanbin Su, Yanna Zhu
Summary: This study evaluated the effect of iron-rich foods (IRFs) on iron status and biomarkers of iron metabolism in late pregnancy. The results showed that IRFs can reduce the risk of iron deficiency and iron-deficiency anemia in late pregnancy. However, the current results are inadequate to confirm the ideal dosage.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Vito Leonardo Miniello, Maria Carmen Verga, Andrea Miniello, Cristina Di Mauro, Lucia Diaferio, Ruggiero Francavilla
Summary: The complementary feeding period between 6 and 24 months is crucial for infant nutrition and development, especially in addressing iron deficiency and anemia. Healthcare providers should follow guidelines to ensure adequate iron intake and address iron deficiency in infants during this critical period.
Article
Obstetrics & Gynecology
Michael Auerbach
Summary: Iron deficiency (ID) is a common disorder with low serum ferritin level. Transferrin saturation (TSAT) is the best indicator of iron status in early pregnancy or chronic inflammation. The guidelines do not recommend routine screening for ID, but urgent review is needed. Oral iron is associated with adverse effects, while intravenous iron is safer and more effective, especially for pregnant women with hemoglobin levels below 10.5 g/dL.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Food Science & Technology
Abhishek Kulkarni, Monika Khade, Sharadha Arun, Pranesh Badami, G. Raja Krishna Kumar, Tomal Dattaroy, Badrish Soni, Santanu Dasgupta
Summary: Iron deficiency anemia is a global concern that is often overlooked, with various commercial iron supplements potentially ineffective in addressing the issue. It is important to handle this situation with caution as it can have severe consequences if left untreated.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Chemistry, Medicinal
Natalia Scaramellini, Dania Fischer, Anand R. Agarvas, Irene Motta, Martina U. Muckenthaler, Christina Mertens
Summary: Mammalian cells rely on iron for various important functions and maintaining iron homeostasis is crucial. Imbalances in iron homeostasis can lead to iron deficiencies or iron overload diseases, which require clinical attention. Treating these conditions is important to prevent cellular damage and improve patient outcomes. Recent advancements in understanding iron homeostasis mechanisms have already impacted clinical practice and are expected to further enhance patient management in the future.
Article
Nutrition & Dietetics
Rishma Dhillon Pai, Yap Seng Chong, Lyra Ruth Clemente-Chua, Rima Irwinda, Trang Nguyen Khanh Huynh, Noroyono Wibowo, Maria Corazon Zaida Gamilla, Zaleha Abdullah Mahdy
Summary: The lack of standardized clinical practice is a global concern in the optimal management of iron deficiency and iron deficiency anemia in women, particularly in the Asia-Pacific region. This study aimed to determine best practices through a Delphi consensus process.