Article
Clinical Neurology
Mackenzie Cervenka, Juan M. Pascual, Jong M. Rho, Elizabeth Thiele, Gary Yellen, Vicky Whittemore, Adam L. Hartman
Summary: Despite past efforts to evaluate metabolism-based therapies for epilepsy, there is still uncertainty on how alterations in metabolism relate to epilepsy. A comprehensive, creative, and inclusive problem-directed research agenda is needed, with renewed adherence to rigor and transparency across all investigation levels, to benefit people with epilepsy.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Oncology
Thomas N. Seyfried, Gabriel Arismendi-Morillo, Giulio Zuccoli, Derek C. Lee, Tomas Duraj, Ahmed M. Elsakka, Joseph C. Maroon, Purna Mukherjee, Linh Ta, Laura Shelton, Dominic D'Agostino, Michael Kiebish, Christos Chinopoutos
Summary: Glioblastoma relies on fermentation metabolism for energy and biomass synthesis, contributing to an acidified microenvironment and drug resistance. Treatment methods for GBM can further acidify the microenvironment, but restricting glucose and glutamine while increasing non-fermentable ketone bodies may provide a non-toxic therapeutic strategy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Daniela D. Weber, Sepideh Aminzadeh-Gohari, Maheshwor Thapa, Anna-Sophia Redtenbacher, Luca Catalano, Tania Capeloa, Thibaut Vazeille, Michael Emberger, Thomas K. Felder, Rene G. Feichtinger, Peter Koelblinger, Guido Dallmann, Pierre Sonveaux, Roland Lang, Barbara Kofler
Summary: The study demonstrates that ketogenic diets have significant inhibitory effects on tumor growth and metastasis, regardless of the tumor's genetic background, metabolic characteristics, and host immune status. Ketogenic diets create an unfavorable environment for melanoma cell proliferation by affecting multiple metabolic pathways.
CANCER & METABOLISM
(2022)
Article
Otorhinolaryngology
Erin M. Lopez, April Michelle Tanner, Eugenie Du, Samip N. Patel, Jared Weiss, Mark C. Weissler, Trevor Hackman, Gaorav P. Gupta, Jose Zevallos, Sandra Elmore, Renee Betancourt, Leigh Thorne, Siddharth Sheth, Margaret L. Gulley
Summary: Background DNA sequencing panels can quantify human and viral tumor markers in blood simultaneously. The study found that levels of cancer-specific markers decreased after surgical resection, providing a potential method to evaluate efficacy of interventions by tracking viral and human markers over time.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lucas Marti-Flich, Matthias Schlund, Stephanie Dapke, Constantinus Politis, Sebastien Aubert, Thomas Wojcik, Florent Barry, Francois Mouawad, Claire Majoufre, Bernard Leyman, Sylvie Testelin, Romain Nicot
Summary: The aim of this retrospective study was to better characterize and evaluate the surgical treatment of head and neck solitary fibrous tumors (SFTs). A total of 34 patients with SFTs were included, predominantly located in the oral cavity and neck region. Complete resection was the treatment of choice, with recurrence being highly correlated with positive surgical margins. Long-term follow-up is recommended.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Review
Biology
Paschalis Devranis, Emilia Vassilopoulou, Vasileios Tsironis, Panagiotis Marios Sotiriadis, Michail Chourdakis, Michalis Aivaliotis, Magdalini Tsolaki
Summary: This study systematically reviewed the evidence of three dietary patterns, the Mediterranean diet, the ketogenic diet, and the MIND diet, for the prevention of cognitive decline. The analysis showed that all three dietary interventions could slow the rate of cognitive decline.
Review
Medicine, Research & Experimental
Taiana Campos Leite, Rebecca Jean Watters, Kurt Richard Weiss, Giuseppe Intini
Summary: Osteosarcoma is the most common primary bone cancer in children and adolescents, with a poor survival rate for metastatic cases. Tumor metabolism plays a crucial role in tumor growth and metastasis, offering a potential target for novel therapies. Dietary interventions targeting cancer cell metabolism may be an effective approach.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Eleni M. Rettig, Daniel L. Faden, Shaiba Sandhu, Kristine Wong, William C. Faquin, Chloe Warinner, Phil Stephens, Sunil Kumar, Charlotte Kuperwasser, Jeremy D. Richmon, Ravindra Uppaluri, Mark Varvares, Rosh Sethi, Glenn J. Hanna, Herve Sroussi
Summary: This study found that circulating tumor HPV DNA can be detected at least several years before the diagnosis of HPV-positive head and neck squamous cell carcinoma (HNSCC) in some patients, which may serve as a biomarker for early diagnosis of HPV16-positive HNSCC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Rossella Tozzi, Federica Campolo, Enke Baldini, Mary Anna Venneri, Carla Lubrano, Salvatore Ulisse, Lucio Gnessi, Stefania Mariani
Summary: The effect of a ketogenic diet on SIRT1 levels in different tissues was examined in mice. The results showed increased SIRT1 expression in adipose tissue and serum, but not in brown adipose tissue and the liver. The findings suggest that the potential metabolic health benefits of a ketogenic diet may involve a synergistic interaction with SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Joanna Berger, Henrike Barbara Zech, Konstantin Hoffer, Clara Marie von Bargen, Lena Nordquist, Lara Bussmann, Fruzsina Gatzemeier, Chia-Jung Busch, Niko Moeckelmann, Adrian Muenscher, Christian Stefan Betz, Cordula Petersen, Kai Rothkamm, Thorsten Rieckmann, Sabrina Koecher, Malte Kriegs
Summary: Analysis of protein tyrosine kinase (PTK) activity in head and neck cancer patient samples, both snap-frozen and ex vivo-cultured, showed a quantitative decline in overall kinase activity after 24-48 hours, but conservation of signaling characteristics in approximately two thirds of ex vivo-cultured samples, highlighting the potential of this method in cancer research.
Article
Multidisciplinary Sciences
Martin Leu, J. Kitz, Y. Pilavakis, S. Hakroush, H. A. Wolff, M. Canis, S. Rieken, M. A. Schirmer
Summary: The study evaluated the potential of MCT1 and MCT4 as biomarkers in HNSCC patients, finding that positive staining for MCT1 was strongly associated with worsened PFS and OS, indicating it could be a promising biomarker in HNSCC treated by primary RCT.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Erin C. Tracy, Mary-Jo Bowman, Ravindra K. Pandey, Heinz Baumann
Summary: This study identified tumor cell-specific photosensitizer retention patterns in head and neck cancer cells and tumor tissues and developed a diagnostic evaluation method to predict the effectiveness of photodynamic therapy in individual cancer cases. These findings assist in designing conditions for optimized photosensitizer application and photodynamic therapy of head and neck cancer lesions for each patient's case.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Review
Nutrition & Dietetics
Simone Dal Bello, Francesca Valdemarin, Deborah Martinuzzi, Francesca Filippi, Gian Luigi Gigli, Mariarosaria Valente
Summary: In recent years, there has been increasing scientific interest in the use of the ketogenic diet (KD) as a complementary approach to standard cancer therapy, particularly for central nervous system (CNS) tumors. The metabolic differences between healthy and neoplastic cells suggest that KD may have an impact on cancer treatment. However, further research is needed to definitively validate its role.
Review
Health Care Sciences & Services
Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva, Timur Fatkhudinov
Summary: Head-and-neck cancers, particularly squamous cell carcinomas, are aggressive tumors with low survival rates. The immune system plays a crucial role in the development and progression of these cancers. The interactions between different cell types in the tumor microenvironment shape the structure and function of the tumor, facilitating angiogenesis, proliferation, and metastasis. Understanding these interactions is important for the development of advanced therapies for head-and-neck cancers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Nutrition & Dietetics
Jing Li, Haiyan Zhang, Zhu Dai
Summary: The systematic review and meta-analysis indicated that ketogenic diet supplementation significantly prolonged survival time, reduced tumor weight and volume, and showed remarkable effects in animals with limited tumor types.
FRONTIERS IN NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Georg Fuernau, Johannes Beck, Steffen Desch, Ingo Eitel, Christian Jung, Sandra Erbs, Norman Mangner, Philipp Lurz, Karl Fengler, Alexander Jobs, Reinhard Vonthein, Suzanne de Waha-Thiele, Marcus Sandri, Gerhard Schuler, Holger Thiele
Article
Medicine, Research & Experimental
Anna C. Lohman, Ingrid Van Rijn, Christina L. Lindhardt, Reinhard Vonthein, Dirk Rades, Niels Henrik Hollander
Article
Endocrinology & Metabolism
Esther Mueller-Godeffroy, Reinhard Vonthein, Carmen Ludwig-Seibold, Bettina Heidtmann, Claudia Boettcher, Miriam Kramer, Nicole Hessler, Doerte Hilgard, Eggert Lilienthal, Andreas Ziegler, Verena M. Wagner
PEDIATRIC DIABETES
(2018)
Article
Surgery
Jens Cordes, Michael Zimbelmann, Axel S. Merseburger, Mario Kramer, Reinhard Vonthein, Hartwig Buettner, Andreas Recke, Birgit K. Kahle
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2019)
Article
Cardiac & Cardiovascular Systems
Alexander Jobs, Amr Abdin, Suzanne de Waha-Thiele, Ingo Eitel, Holger Thiele, Cor de Wit, Reinhard Vonthein
CLINICAL RESEARCH IN CARDIOLOGY
(2019)
Review
Public, Environmental & Occupational Health
Reinhard Vonthein
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ
(2019)
Article
Physiology
Friedhelm Sayk, Christoph Twesten, Isabel Adametz, Klaas Franzen, Reinhard Vonthein, Christoph Dodt, Moritz Meusel
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Review
Endocrinology & Metabolism
Stephanie M. J. Fliedner, Philipp E. R. Winkelmann, Robert Wesley, Reinhard Vonthein, Hendrik Lehnert
Summary: This study analyzed individual patient data of 364 cases of ganglioneuromas, showing that a majority were diagnosed in adults, more commonly in females. The most common location for ganglioneuromas was abdomen/pelvis, with decreasing complication rates in older patients. Age-related differences in tumor location and hormone production suggest tailored management strategies may be needed.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Physiology
M. Meusel, M. Herrmann, F. Machleidt, K. Franzen, R. Vonthein, F. Sayk
Summary: Oxytocin is involved in the neuroendocrine regulation of sympathetic blood pressure homeostasis, with intranasal administration inducing vasoconstrictory sympathoactivation and an increase in diastolic blood pressure in healthy males. This suggests a potential oxytocin-mediated impact on the vascular baroreflex set point in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Editorial Material
Ophthalmology
Rebekka Heitmar, Reinhard Vonthein
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Neurosciences
M. Meusel, J. Voss, A. Krapalis, F. Machleidt, R. Vonthein, M. Hallschmid, F. Sayk
Summary: This study investigated the effects of intranasal administration of orexin A on vascular sympathetic baroreflex function in healthy humans. The results showed that intranasal orexin A increased sympathetic activity without affecting blood pressure, heart rate, or sympathovagal balance.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Kay Neumann, Antonia Masuch, Reinhard Vonthein, Marion Depenbusch, Askan Schultze-Mosgau, Tanja K. Eggersmann, Georg Griesinger
Summary: This study investigated the plasma concentrations of dydrogesterone (DYD) and its metabolite, 20 alpha-dihydrodydrogesterone (DHD), in frozen embryo transfer cycles. The study found that DYD and DHD plasma levels reached steady state on Day 3 of intake and were strongly correlated. Women with lower DYD or DHD levels on the day of embryo transfer had a reduced chance of ongoing pregnancy.
HUMAN REPRODUCTION
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan Borov, Benito Baldauf, Jana Henke, Herribert Pavaci, Arben Perani, Bernhard Zrenner, Josef Dietl, Julinda Mehilli, Ernest W. Lau, Reinhard Vonthein, Hendrik Bonnemeier
Summary: In a prospective observational study, Tauropace was found to be safer and more effective than hydrogen peroxide (H2O2) in reducing cardiac implantable electronic device (CIED) infection.
Article
Biochemical Research Methods
Reinhard Vonthein, Benito Baldauf, Stefan Borov, Ernest W. Lau, Marzia Giaccardi, Roberto Cemin, Ojan Assadian, Philippe Chevalier, Kerstin Bode, Hendrik Bonnemeier
Summary: This study aims to explore the adjunctive use of taurolidine in reducing CIED infections. The ETPR registry will prospectively evaluate CIED placement procedures with TauroPace (TM) use and follow up participants for several years to assess the outcomes. This study is expected to provide important case data for future randomized controlled trials.
METHODS AND PROTOCOLS
(2023)
Article
Surgery
Birgit Wulff, Stefan Stahlhoff, Reinhard Vonthein, Andreas Schmidt, Matthias Sigler, Giovanni B. Torsello, Monika Herten
ANNALS OF VASCULAR SURGERY
(2017)