Article
Pharmacology & Pharmacy
Jocelyn C. Ayala-Fuentes, Melissa Zulahi Gallegos-Granados, Luis Jesus Villarreal-Gomez, Marilena Antunes-Ricardo, Daniel Grande, Rocio Alejandra Chavez-Santoscoy
Summary: Quercetin, a bioactive component with therapeutic potential, faces challenges in stability and bioavailability in the gastrointestinal tract. The use of inulin-coated nanoparticles can overcome these limitations, ensuring the stability and release of quercetin in target cells.
Article
Cell Biology
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Joana Maria dos Santos Alves, Paula Goes, Karuza Maria Alves Pereira, Ana Paula Negreiros Nunes Alves, Mariana Lima Vale, Delane Viana Gondim
Summary: The study found that QT and/or MX therapy could alleviate inflammatory symptoms in a rat model of arthritis, and the hepatotoxicity induced by MX could be improved through combination therapy with QT. However, MX had a downregulation effect on IL-10. QT has the potential to support MX therapy and exhibit anti-inflammatory and hepatoprotective effects in this model.
Article
Chemistry, Multidisciplinary
Yunxiu Sun, Baoli Wang, Xiaoli He, Yitong Wang, Lin Chen, Yuxin Zhu, Guangjiu Li, Wei Sun
Summary: The study demonstrated that modifying the glassy carbon electrode (GCE) with two-dimensional MXene Ti3C2Tx can enhance the electrochemical detection performance of quercetin, showing good sensitivity and stability.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Cell Biology
Kohei Yamaura, Anna Laura Nelson, Haruki Nishimura, Joan C. Rutledge, Sudheer K. Ravuri, Chelsea Bahney, Marc J. Philippon, Johnny Huard
Summary: This study summarized and analyzed the current literature on the effects of quercetin on osteoarthritis (OA) cartilage in in vivo preclinical studies. The results showed that quercetin had a protective effect on OA cartilage and significantly improved cartilage histological scores. Further clinical trials are needed to verify its efficacy in OA treatment.
AGEING RESEARCH REVIEWS
(2023)
Review
Nutrition & Dietetics
Serpil Oezsoy Gokbilen, Eda Becer, Hafize Seda Vatansever
Summary: Cellular senescence is crucial in aging and cancer initiation. Quercetin, a natural compound, shows potential as a senolytic agent and has anti-tumor effects.
NUTRITION RESEARCH
(2022)
Review
Nutrition & Dietetics
Getinet M. Adinew, Equar Taka, Patricia Mendonca, Samia S. Messeha, Karam F. A. Soliman
Summary: Flavonoids, as new promising molecules, show various biological activities and can modulate miRNAs to affect the progression of TNBC, emphasizing their potential role in the prevention and treatment of TNBC.
Article
Plant Sciences
Qingqing Liu, Dasheng Zhang, Fengluan Liu, Zhuoxing Liu, Xiaohan Wang, Yong Yang, Shanshan Li, Hanchun Li, Daike Tian, Liangsheng Wang
Summary: American lotus petals contain mainly flavonols, with quercetin 3-O-glucuronide as the dominant pigment. Three genes, NlFLS1, NlFLS2, and NlFLS3, were identified and found to be involved in pigment accumulation and composition. Their expression patterns correlated with the variation in flavonol content during flower development. The substrate preferences and competition between flavonol synthases and other enzymes contribute to the specific flavonol composition in American lotus petals.
HORTICULTURAL PLANT JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hernan Speisky, Maria Fernanda Arias-Sante, Jocelyn Fuentes
Summary: Recent research challenges the belief that the oxidation of flavonoids would result in a loss of their antioxidant properties. It has been found that the oxidation of quercetin and its analogue kaempferol leads to the formation of metabolites with significantly higher antioxidant potency than the precursors. The amplification of antioxidant properties is even greater for kaempferol, with a 100-fold increase compared to quercetin.
Review
Oncology
Lili Cao, Jiawei Wang, Yujuan Zhang, Feng Tian, Chunfang Wang
Summary: Traditional herbal flavonoids can be used as alternative drugs to prevent and treat osteoporosis. Compounds like quercetin and icariin promote bone formation and have been widely studied over the past five years.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Luisa Muratori, Federica Fregnan, Monica Maurina, Kirsten Haastert-Talini, Giulia Ronchi
Summary: Peripheral nerve injuries can lead to loss of motor and sensory function, and current methods for nerve regeneration have limited success. A potential approach for enhancing peripheral nerve regeneration is through improving diet and lifestyle, and consuming polyphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Fernanda Miyuki Kashiwagi, Brenno Wendler Miranda, Fabio de Oliveira Pedrosa, Emanuel Maltempi de Souza, Marcelo Muller-Santos
Summary: Controlling gene expression is crucial for biotechnological applications, using transcriptional regulators activated by specific signals that work independently and signal should be orthogonal. Transcriptional regulators activated by plant metabolites such as flavonoids are candidates to control gene expression in bacteria.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Microbiology
Sudeep Ghimire, Supapit Wongkuna, Ranjini Sankaranarayanan, Elizabeth P. Ryan, G. Jayarama Bhat, Joy Scaria
Summary: This study found that rice bran had a greater impact on gut microbiome composition and enriched more bacterial species compared to quercetin. The combination of quercetin and rice bran also led to enrichment of various species and promoted beneficial bacteria while reducing potential pathogens.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ivan Kreft, Mateja Germ, Aleksandra Golob, Blanka Vombergar, Francesco Bonafaccia, Zlata Luthar
Summary: Tartary buckwheat is a crop grown in Asia and Europe, known for its high content of rutin and other phenolic compounds. These compounds have an impact on digestion and can contribute to the functional and health-promoting properties of buckwheat products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Chunnuan Zhang, Dongxue Jiang, Junhui Wang, Qian Qi
Summary: The study found that dietary quercetin improves growth performance, reduces oxidative stress, lowers apoptosis, and decreases inflammation in zebrafish exposed to triphenyltin.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Meng Cui, Zhiyan Liang, Yuxin Liu, Qifang Sun, Dong Wu, Liping Luo, Yingbin Hao
Summary: Global warming poses a serious threat to plant growth and yield. This study aimed to investigate the flavonoid responses of Anoectochilus roxburghii under heat stress and the effect of exogenous quercetin application on heat stress tolerance. Metabolome and transcriptome analyses revealed the upregulation of quercetin, tricetin, isorhamnetin, scutellarein, and 4',7-Isoflavandiol in A. roxburghii under heat stress. Exogenous quercetin application improved the antioxidant capacity and physiological parameters of A. roxburghii under heat stress. These findings provide insights into enhancing the biological value of A. roxburghii.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Oncology
Hardeep S. Tuli, Vaishali Aggarwal, Gaurav Parashar, Diwakar Aggarwal, Nidarshana C. Parashar, Muobarak J. Tuorkey, Mehmet Varol, Katrin Sak, Manoj Kumar, Harpal S. Buttar
Summary: The overwhelming global burden of cancer has presented challenges and opportunities for developing anti-cancer therapies. Phytochemicals have emerged as promising compounds with potential anti-cancer effects, especially in synergy with conventional drugs. Xanthohumol, a prenylated phytoflavonoid, has demonstrated key anti-cancer activities at cellular and molecular levels, making it a potential candidate for inhibiting tumor progression.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Hardeep Singh Tuli, Hiral Mistry, Ginpreet Kaur, Diwakar Aggarwal, Vivek Kumar Garg, Sonam Mittal, Mukerrem Betul Yerer, Katrin Sak, Md Asaduzzaman Khan
Summary: Phytochemicals, including gallic acid, have been used for thousands of years to prevent cancer and have recently gained interest due to their anti-cancer properties. Gallic acid exerts its anti-cancer effects through various cellular pathways and synergizes with existing chemotherapeutic drugs. Nanotechnology approaches are also discussed to enhance the bioavailability and therapeutic efficacy of gallic acid.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Hardeep Singh Tuli, Katrin Sak, Shubham Adhikary, Ginpreet Kaur, Diwakar Aggarwal, Jagjit Kaur, Manoj Kumar, Nidarshana Chaturvedi Parashar, Gaurav Parashar, Uttam Sharma, Aklank Jain
Summary: This article presents the multifaceted anti-cancer action of propolis-derived flavonoid, galangin, discussing its effects in various cancer cells, including antioxidant, anti-inflammatory, antiproliferative, pro-apoptotic, anti-angiogenic, and anti-metastatic. It also explores the co-effects with standard chemotherapeutic drugs and other natural compounds, as well as modern nanotechnological advancements for overcoming the low bioavailability issue of galangin. Further studies are needed to confirm the anti-cancer potential of galangin in vivo malignant systems, but exploring this natural compound may open new perspectives in molecular oncology.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Katrin Sak
Summary: The approval and development of boronic acid-based drugs have sparked great interest in medicinal chemistry. However, potential interactions between these drugs and common dietary flavonoids containing catechol groups remain unclear, which could impact drug efficacy and clinical outcomes.
CURRENT CANCER DRUG TARGETS
(2022)
Review
Pharmacology & Pharmacy
Hardeep Singh Tuli, Vivek Kumar Garg, Ajay Kumar, Diwakar Aggarwal, Uttpal Anand, Nidarshana Chaturvedi Parashar, Adesh K. Saini, Ranjan K. Mohapatra, Kuldeep Dhama, Manoj Kumar, Tejveer Singh, Jagjit Kaur, Katrin Sak
Summary: This review article provides a comprehensive description of the potential applications of Oroxylin A (OA), a constituent of Scutellariae plants, in the treatment of malignant tumors. It discusses the various mechanisms of action, including antiproliferative, anti-inflammatory, and proapoptotic effects, and explores the synergistic effects with conventional anticancer agents as well as the advantages of nanotechnological methods in OA application.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Toxicology
Hardeep Singh Tuli, Jagjit Kaur, Kanupriya Vashishth, Katrin Sak, Ujjawal Sharma, Renuka Choudhary, Tapan Behl, Tejveer Singh, Sheetu Sharma, Adesh K. Saini, Kuldeep Dhama, Mehmet Varol, Gautam Sethi
Summary: ROS plays important roles in living organisms, with moderate levels affecting disease development and excessive levels leading to cell death. Current research is focused on using chemotherapy drugs and herbal agents to induce cancer cell death, while maintaining ROS homeostasis is crucial for cell development and survival.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Vivek K. Garg, Renuka Choudhary, Ashif Iqubal, Katrin Sak, Adesh K. Saini, Reena V. Saini, Kanupriya Vashishth, Kuldeep Dhama, Ranjan K. Mohapatra, Dhruv Sanjay Gupta, Ginpreet Kaur
Summary: Lung cancer is a highly lethal form of cancer with rapidly increasing incidence. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cases, with adenocarcinoma, squamous cell carcinoma and large cell carcinoma as the main subtypes. Immune checkpoint inhibitors have led to significant advances in the treatment of solid tumors, improving cancer patient survival rates.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Hardeep Singh Tuli, Vivek Kumar Garg, Sakshi Bhushan, Vivek Uttam, Uttam Sharma, Aklank Jain, Katrin Sak, Vikas Yadav, Jose M. Lorenzo, Kuldeep Dhama, Tapan Behl, Gautam Sethi
Summary: Cancer prevalence and incidence rates have been increasing over the past few decades. To combat this disease, it is necessary to explore safer and more effective molecules. Flavonoids, a class of polyphenols, have shown potential against cancer without significant toxicity to normal cells. They modulate microRNAs to enhance drug sensitivity and suppress cancer cell proliferation, metastasis, and angiogenesis. This review comprehensively discusses the structure, chemistry, and effects of flavonoids like quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin on various cancer types. Targeting miRNAs by flavonoids in cancer cells could be a promising approach for future clinical investigations and affirmation.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Manoj Kumar, Kuldeep Dhama, E. Hui Clarissa Lee, Kenneth Chun-Yong Yap, Sharah Mae Capinpin, Alan Prem Kumar
Summary: Cucurbitacins, a group of highly oxidized tetracyclic triterpenoids found in cucumbers, have potential medical uses. They interact with various cellular targets to inhibit cancer cell growth through induction of apoptosis, cell-cycle arrest, anti-metastasis, and anti-angiogenesis. They may also be used in combination with other drugs to overcome treatment resistance in cancer cells. This study focuses on finding molecular targets for cucurbitacins in suppressing malignant processes.
Editorial Material
Nutrition & Dietetics
Katrin Sak
Summary: Over the past few decades, the anticancer effects of various plant-derived flavonoids have been extensively studied. Flavonoids, which are synthesized in response to environmental stresses in plants, have diverse biological activities in the human body. They possess antioxidant, anti-inflammatory, antiproliferative, proapoptotic, anti-migratory, anti-invasive, anti-metastatic, and anti-angiogenic properties, which can help prevent and slow the development of different types of cancer. However, global warming may lead to a decrease in the content and composition of flavonoids in plant-based diets, potentially contributing to the increasing worldwide incidence of cancer cases.
CURRENT NUTRITION & FOOD SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Hardeep Singh Tuli, Hemant Joshi, Kanupriya Vashishth, Seema Ramniwas, Mehmet Varol, Manoj Kumar, Isha Rani, Vibha Rani, Katrin Sak
Summary: This review article discusses the anticancer properties of a natural biflavone compound called amentoflavone, derived from various plants such as ginkgo, hinoki, and St. John`s wort. It has been found to suppress malignant growth, induce apoptosis in tumor cells, and inhibit angiogenesis and metastasis. Amentoflavone shows promise as a potential lead compound for the development of novel anticancer drugs, and further in vivo studies and clinical trials are warranted.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, Hardeep Singh Tuli
Summary: Due to the rising incidence rates of liver cancer and concerns regarding toxicity of current chemotherapy drugs, there is an increasing need for alternative treatment methods. Quercetin, a flavonoid found in fruits, vegetables, and herbs, has shown promising results in inducing apoptotic cell death in cancer cells. It targets apoptosis-related proteins and has the potential for chemoprevention. This review discusses the mechanisms of action, nanodelivery strategies, and other potential cellular effects of quercetin in liver cancer.
Review
Chemistry, Medicinal
Hardeep Singh Tuli, Sakshi Bhushan, Ajay Kumar, Poonam Aggarwal, Katrin Sak, Seema Ramniwas, Kanupriya Vashishth, Tapan Behl, Rashmi Rana, Shafiul Haque, Miguel A. Prieto
Summary: This review article focuses on the role of Scutellaria flavones in regulating the autophagic machinery in diverse cancer models, highlighting their potential as lead compounds for the fight against malignant neoplasms. Flavonoids exhibit a dual-edged sword property of acting as both anti- and proautophagic agents.
Review
Pharmacology & Pharmacy
Hemant Joshi, Dhruv Sanjay Gupta, Ginpreet Kaur, Tejveer Singh, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Raunak Singh Chhabra, Madhu Gupta, Adesh K. Saini, Hardeep Singh Tuli
Summary: Quercetin, a natural antioxidant, has shown numerous pharmacological properties in preclinical and clinical research, including anti-inflammatory and anti-cancer effects. Recent studies suggest that using nanoformulations can help overcome the hydrophobicity of quercetin while enhancing its stability and cellular bioavailability.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Hardeep Singh Tuli, Ruchira Joshi, Ginpreet Kaur, Vivek Kumar Garg, Katrin Sak, Mehmet Varol, Jagjit Kaur, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Diwakar Aggarwal, Kuldeep Dhama, Vivek Sheel Jaswal, Sonam Mittal, Gautam Sethi
Summary: Nanotechnology has led to the development of new materials (metal nanoparticles) that have specific applications in healthcare, particularly in the diagnosis and treatment of cancer. Metal nanoparticles can modulate molecular expression in the tumor microenvironment and have anti-cancer effects by inducing apoptosis and cell cycle arrest. They can also inhibit tumor angiogenesis, metastasis, and inflammation, thus preventing cancer proliferation.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)