Article
Biochemistry & Molecular Biology
Ran Wei, Zhucheng Su, Gerardo G. Mackenzie
Summary: This study evaluated the gut protecting effect of CGA and EGCG, major constituents of coffee and green tea, on d-galactose-induced aging mice. CGA plus EGCG improved cognition deficits and protected gut barrier function more effectively compared to the agents alone. Additionally, CGA and EGCG modulated the gut microbiome and reduced gut inflammation.
Article
Biochemistry & Molecular Biology
Shih-Chung Huang, Yung-Hsi Kao, Shao-Fu Shih, Min-Chien Tsai, Chin-Sheng Lin, Liv Weichien Chen, Yi-Ping Chuang, Pi-Fen Tsui, Ling-Jun Ho, Jenn-Haung Lai, Sy-Jou Chen
Summary: EGCG can suppress cytokine secretion in activated human primary T cells, likely mediated by AP-1 inactivation through the ERK and JNK pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Anatomy & Morphology
Amir Raoofi, Melody Omraninava, Roghayeh Javan, Davood Maghsodi, Auob Rustamzadeh, Davood Nasiry, Alireza Ghaemi
Summary: Chronic scrotal hyperthermia (SHT) can lead to serious male reproductive system disorders, mainly due to oxidative stress. Epigallocatechin gallate (EGCG) as a potent antioxidant can alleviate cellular and tissue damage caused by SHT. EGCG improves sperm parameters, testosterone levels, and reduces cellular apoptosis and oxidative stress.
Article
Dentistry, Oral Surgery & Medicine
Katy Vaillancourt, Amel Ben Lagha, Daniel Grenier
Summary: Green tea extract and EGCG can reduce the cytotoxicity of the chemotherapeutic agent irinotecan towards oral epithelial cells, decrease intracellular ROS production, inhibit cell proliferation and migration, and suppress the secretion of cytokines and MMPs.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Sejin Kim, Hyunjae Lee, Hanbyeol Moon, Ran Kim, Minsuk Kim, Seongtae Jeong, Hojin Kim, Sang Hyeon Kim, Soo Seok Hwang, Min Young Lee, Jongmin Kim, Byeong-Wook Song, Woochul Chang
Summary: Cardiac tissue damage following ischemia leads to cardiomyocyte apoptosis and myocardial fibrosis. The active polyphenol flavonoid or catechin epigallocatechin-3-gallate (EGCG) protects ischemic myocardium and is involved in the regulation of endothelial-to-mesenchymal transition (EndMT). In this study, EGCG treatment was shown to regenerate ischemic tissue and induce cardioprotection by regulating proteins associated with the EndMT process, as well as positively regulating cardiomyocyte apoptosis and fibrosis.
Article
Food Science & Technology
Qianqian Zhang, Xiaofeng Yu, Linghan Tian, Yanjun Cong, Linfeng Li
Summary: This study investigated the mechanism of two tea-derived polyphenols, EGC and EGCG, on anti-alpha s1-casein allergy. The results showed that both EGC and EGCG significantly reduced levels of mast cell protease, histamine, specific IgE antibodies, and Th2 cytokines in allergic mice, and reduced tissue damage.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Sana Iram, Safikur Rahman, Shahid Ali, Jihoe Kim
Summary: Epigallocatechin gallate inhibits the activation of plasminogen by binding to tetranectin, showing anticancer effects on CT-26 colon cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu
Summary: The combination of EGCG with Vc and glycerol could effectively increase its stability and uric acid-lowering activity, which sheds light on the development and application of EGCG in the fields of food and medicine.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Gyanendra Singh, Riddhi Thaker, Anupama Sharma, Dharati Parmar
Summary: Arsenic is a common toxicant in the environment, and flavonoids such as biochanin A, phloretin, and epigallocatechin-3-gallate have been found to significantly mitigate arsenic toxicity in Swiss albino mice. The flavonoids were able to restore sperm motility, reduce arsenic concentrations in kidney and liver tissues, and modulate antioxidant markers and signaling pathways to enhance the intracellular antioxidant response system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Dermatology
C. Braegelmann, D. Niebel, S. Ferring-Schmitt, T. Fetter, J. Landsberg, M. Hoelzel, M. Effern, N. Glodde, S. Steinbuch, T. Bieber, J. Wenzel
Summary: This study investigated the effects of EGCG on interface dermatitis (ID) by analyzing its impact on the expression of interferon-associated mediators CXCL10 and MxA in both lesional skin of lichen planus patients and epidermal equivalents. The results showed that EGCG can reduce the intensity of CXCL10 and MxA staining in epidermal equivalents and secretion of CXCL10 by keratinocytes, suggesting its potential as a topical therapeutic in autoimmune skin diseases associated with ID.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Microbiology
Xiaoge Jiang, An Lin, Shijia Li, Yangyang Shi, Fangjie Zhou, Grace Gomez Felix Gomez, Richard L. Gregory, Chaoliang Zhang, Song Chen, Ruijie Huang
Summary: The study found that the combination of artificial honey and epigallocatechin-3-gallate has a stronger inhibitory effect on Streptococcus pyogenes, suppressing its growth, biofilm formation, and expression of certain virulence genes better than when they are used alone.
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Biotechnology & Applied Microbiology
Yiming Wang, Wenqi Luo, Feng Lin, Wanguo Liu, Rui Gu
Summary: EGCG-Se NP shows superior neuroprotective effect in spinal cord injury (SCI) through scavenging reactive oxygen species (ROS) and attenuating inflammation, making it a promising and effective treatment option.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)