Article
Multidisciplinary Sciences
Venera Russo, Alberto Continella, Carmelo Drago, Alessandra Gentile, Stefano La Malfa, Claudia Giovanna Leotta, Luana Pulvirenti, Giuseppe Ruberto, Giovanni Mario Pitari, Laura Siracusa
Summary: Immature fruits from pomegranate, a neglected byproduct of production, have high potential for anticancer activity due to their rich content of beneficial compounds. These fruits demonstrated robust anticancer properties, inducing tumor cytotoxicity and cell death mechanisms, suggesting unexplored value for virtuous circular economy.
Article
Food Science & Technology
Manuel Reynaldo Cruz-Valenzuela, Rosa E. Ayala-Soto, Jesus Fernando Ayala-Zavala, Brenda A. Espinoza-Silva, Gustavo A. Gonzalez-Aguilar, Olga Martin-Belloso, Robert Soliva-Fortuny, Filomena Nazzaro, Florinda Fratianni, Melvin R. Tapia-Rodriguez, Ariadna Thalia Bernal-Mercado
Summary: Aqueous pomegranate peel extract (PPE) shows higher total phenolic and flavonoid content, better antioxidant capacity, and exhibits antimicrobial and anti-quorum sensing activity. The main phenolic compounds identified are chlorogenic and gallic acids. Treatment of alfalfa sprouts with aqueous PPE reduces bacterial counts and enhances antioxidant capacity.
Article
Biochemistry & Molecular Biology
Jose M. Lorente-Mento, Fabian Guillen, Salvador Castillo, Domingo Martinez-Romero, Juan M. Valverde, Daniel Valero, Maria Serrano
Summary: The study demonstrated that melatonin treatment could enhance the content of bioactive compounds and antioxidant activity in pomegranate fruit, leading to an extension of the fruit shelf-life. Fruit quality traits were improved in melatonin-treated fruits compared to controls, with higher levels of bioactive compounds and antioxidant activity.
Article
Biochemistry & Molecular Biology
Vuyisa Sigwela, Maryna De Wit, Alba du Toit, Gernot Osthoff, Arno Hugo
Summary: This study analyzed aqueous betalain extracts obtained from different colored plants, finding that amaranth had significantly higher antioxidant contents than other plants, while beetroot extracts with added ascorbic acid showed higher content.
Article
Plant Sciences
Ghulam Mustafa, Ishtiaq A. Rajwana, Hafiz Nazar Faried, Tanveer Ul Haq, Muhammad Azhar Bashir
Summary: The excessive fruit load on fruit trees hinders sustainable production. Fruit thinning can improve fruit quality attributes by reducing crop load. A study on pomegranate showed that leaving only one fruit per cluster significantly improved the physical and biochemical qualities of the fruit.
PAKISTAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Kaja Kupnik, Mateja Primozic, Katja Vasic, Zeljko Knez, Maja Leitgeb
Summary: The pomegranate fruit, known for its health-promoting properties, is increasingly utilized for food purposes, resulting in the generation of biological waste products such as peels. A circular bioeconomy strategy for biowaste holds promise for sustainable development. Extracts from pomegranate peels were found to be rich in secondary metabolites with high antioxidant potential, and showed significant antibacterial efficacy against various strains of bacteria. These findings highlight the great potential of pomegranate in various industries for its antibacterial activity and other health benefits.
Article
Food Science & Technology
Qianting Liu, Xiaohong Guo, Jiaming Du, Yidan Guo, Xiaocheng Guo, Liping Kou
Summary: The deterioration of pomegranate husk, aroma components, and antioxidant contents of pomegranate juice play a crucial role in postharvest storage quality and vary among different cultivars. The study focused on three cultivars ('Tunisia soft seed', 'Jingpitian', and 'Lishanhong') from Shaanxi, China, and observed their storability differences during 90 days of cold storage. The findings revealed variations in microstructure, moisture, aroma compounds, and fruit quality characteristics among the cultivars, providing valuable information for selecting suitable varieties for fresh sales or storage.
Article
Plant Sciences
Aveen N. Adham, Alaadin M. Naqishbandi, Thomas Efferth
Summary: This study examined the cytotoxic activity of Fumaria officinalis extracts on leukemia and multiple myeloma cell lines, and found that chloroform and ethyl acetate fractions exhibited significant cytotoxic effects on certain cell lines. The fractions induced apoptosis, autophagic cell death, and iron-dependent cell death, and were found to contain isoquinoline alkaloids and flavonoids as active components.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Nihal M. El Newehy, Mohammad M. Abd-Alhaseeb, Gamal A. Omran, Fathallah M. Harraz, Eman Shawky
Summary: This study utilized metabolomics analysis to investigate different parts of pomegranate fruit, revealing their potential as sources of bioactive compounds. The findings highlight the importance of utilizing the full resources of pomegranate fruit and its waste.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Tandokazi Pamela Magangana, Nokwanda P. Makunga, Chris la Grange, Maria A. Stander, Olaniyi Amos Fawole, Umezuruike Linus Opara
Summary: Pomegranate peel is rich in phytochemicals and can be effectively used for the development of value-added products through blanching pre-treatment, which enhances the yield, polyphenol content, antioxidant properties, and antibacterial activity of the extracts. This study supports the commercial utilization of pomegranate peel as a valuable source for various industries.
Article
Biochemistry & Molecular Biology
Esra Eroglu Ozkan, Mehmet Fatih Seyhan, Ozlem Kurt Sirin, Tugba Yilmaz- Ozden, Ezgi Ersoy, Seda Damla Hatipoglu Cakmar, Ahmet Ceyhan Goren, Hulya Yilmaz Aydogan, Oguz Ozturk
Summary: This study evaluated the antioxidant and cytotoxic effects of eight commercially valuable pomegranate cultivars from Turkey on breast cancer cells. The extract from cultivar P7 demonstrated the strongest cytotoxic activity against MCF-7 breast cancer cell lines. These cultivars have potential to be used as natural antioxidant and anticancer agents.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Gokhan Zengin, Stefano Dall' Acqua, Kouadio Ibrahime Sinan, Abdullahi Ibrahim Uba, Stefania Sut, Gregorio Peron, Ouattara Katinan Etienne, Manoj Kumar, Carlos L. Cespedes-Acuna, Julio Alarcon-Enos, Adriano Mollica, Mohamad Fawzi Mahomoodally
Summary: Extracts from F. virosa contain abundant triterpenes with antioxidant and enzyme inhibitory effects, with antioxidant capacity correlated with total phenolic contents. These compounds show potential as a new ingredient for the development of novel functional products.
Article
Biochemistry & Molecular Biology
Chrysanthi Mitsagga, Konstantinos Petrotos, Ioannis Giavasis
Summary: Novel antimicrobials were produced from agricultural byproducts containing olive, pomegranate, and orange fruit pulp extracts, and their antimicrobial activity was evaluated in vitro and in food samples; the results showed that these encapsulated extracts could serve as natural antimicrobials with wide spectrum, and the 100% olive extract was most inhibitory against E. coli, S. typhimurium, and L. monocytogenes in fresh burger and cheese spread samples.
Article
Pharmacology & Pharmacy
Rokayya Sami, Ebtihal Khojah, Ahmed M. A. Mansour, Amina A. M. Al-Mushhin, Abeer Elhakem, Dina M. El-Sherif, Mohammed Saeed Alkaltham, Ahmad Mohammad Salamatullah
Summary: This study analyzed the nutritional values, microbial population, bioactive components, and antioxidant activities of pomegranate peel extracts from four different varieties. Results showed differences in various parameters among the varieties, but overall similar antioxidant activities were observed across the pomegranate peel extracts.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2021)
Article
Horticulture
Fatemeh Nazoori, Samaneh Mollai, Fereshteh Sobhani, Seyed Hossein Mirdehghan, Seyyed Rasoul Sahhafi
Summary: The research aimed to evaluate the effects of applying carnauba wax and carboxymethyl cellulose coating on pomegranate fruits during storage. The study found that carnauba wax treatment was more effective in preserving anthocyanin, flavonoid, and fruit firmness, while carboxymethyl cellulose treatment was better at maintaining fruit weight, pH, vitamin C content, and phenolic compounds. Carboxymethyl cellulose (1%) showed the best results after 100 days of storage, while carnauba wax (1%) worked best after 50 days of storage. Rating: 7/10.
SCIENTIA HORTICULTURAE
(2023)
Article
Chemistry, Analytical
Lucy E. Flint, Gregory Hamm, Joseph D. Ready, Stephanie Ling, Catherine J. Duckett, Neil A. Cross, Laura M. Cole, David P. Smith, Richard J. A. Goodwin, Malcolm R. Clench
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Bryn Flinders, Josie Morrell, Peter S. Marshall, Lisa E. Ranshaw, Ron M. A. Heeren, Malcolm R. Clench
Summary: A straightforward method to generate 3D MALDI-MS images of selected molecules in lung tissue was presented, providing a deeper understanding of the distribution of molecules related to different anatomical features throughout the entire organ.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Review
Biochemistry & Molecular Biology
Laura Baumgartner, Karin Wuertz-Kozak, Christine L. Le Maitre, Francis Wignall, Stephen M. Richardson, Judith Hoyland, Carlos Ruiz Wills, Miguel A. Gonzalez Ballester, Michael Neidlin, Leonidas G. Alexopoulos, Jerome Noailly
Summary: Degenerative changes in the intervertebral disc are a major risk factor for low back pain, with accelerated progression in some individuals as they age. Understanding the disease requires identifying key regulatory processes at various levels, from cells to organs. Experimental research and computational modeling have contributed significantly to our understanding of cell signaling pathways and complex interactions within the intervertebral disc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
T. Nichol, J. Callaghan, R. Townsend, I Stockley, P. Hatton, C. Le Maitre, T. J. Smith, R. Akid
Summary: This study aimed to develop a controlled antibiotic release single-layer hybrid organic-inorganic sol-gel coating for cementless hydroxyapatite-coated titanium orthopaedic prostheses. Both laboratory and in vivo tests showed promising results in terms of antibiotic release kinetics, antibacterial activity, biocompatibility, physical bonding, and osseointegration. The sol-gel coating demonstrated rapid and effective antibiotic release, as well as successful eradication of bacterial biofilms and promotion of osteoblast differentiation in vitro and in vivo, suggesting its potential in preventing implant-related deep infection.
BONE & JOINT JOURNAL
(2021)
Article
Orthopedics
Chitra L. Dahia, Julie B. Engiles, Sarah E. Gullbrand, James C. Iatridis, Alon Lai, Christine L. Le Maitre, Jeffrey C. Lotz, Koichi Masuda, Cheryle A. Seguin, Marianna A. Tryfonidou
Summary: This perspective summarizes the genesis, development, and potential future directions of the multispecies JOR Spine histopathology series.
Article
Orthopedics
Christine L. Le Maitre, Chitra L. Dahia, Morgan Giers, Svenja Illien-Junger, Claudia Cicione, Dino Samartzis, Gianluca Vadala, Aaron Fields, Jeffrey Lotz
Summary: The study aimed to develop a standardized histopathology scoring scheme for human IVD degeneration, showing high intra-rater reliability but emphasizing the need for improved training. Future evaluation in real-world settings is necessary to further refine criteria and understand the relationship between IVD degeneration and back pain.
Article
Chemistry, Analytical
Oana M. Voloaca, Malcolm R. Clench, Gunda Koellensperger, Laura M. Cole, Sarah L. Haywood-Small, Sarah Theiner
Summary: This study reports the use of laser ablation-inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOFMS) to analyze human malignant pleural mesothelioma (MPM) samples at the cellular level for the first time. The technique allows for simultaneous detection of asbestos fibers, metallome monitoring, and biomarker identification with high spatial resolution. The results provide insights into the pathology and potential toxic elements associated with MPM.
ANALYTICAL CHEMISTRY
(2022)
Review
Orthopedics
Rebecca J. Williams, Marianna A. Tryfonidou, Joseph Wiliam Snuggs, Christine Lyn Le Maitre
Summary: This article discusses cell therapy specifically targeting the restoration of the nucleus pulposus in the intervertebral disc, which is believed to be a key initiation site of disc degeneration. Various cell sources have been extensively analyzed for their regenerative potential, with induced pluripotent stem cells showing the most promising outcomes.
Article
Orthopedics
Philip Poillot, Joseph W. Snuggs, Christine L. Le Maitre, Jacques M. Huyghe
Summary: This study identifies the presence of multiple voltage-gated ion channels (VGICs) in the intervertebral disc (IVD), with evidence supporting the role of L-type voltage-gated calcium channels (VGCCs) in mechanotransduction. These findings highlight the importance of further research in this area to fully elucidate the mechanotransduction pathways in the IVD and improve treatment strategies for IVD degeneration.
Article
Orthopedics
Lisanne T. Laagland, Frances C. Bach, Laura B. Creemers, Christine L. Le Maitre, Deepani W. Poramba-Liyanage, Marianna A. Tryfonidou
Summary: Increasing medium osmolarity during expansion improves the phenotype of NPCs, enhancing their potential as cell-based therapies for intervertebral disc regeneration.
Review
Orthopedics
Shirley N. Tang, Andres F. Bonilla, Nadeen O. Chahine, Aimee C. Colbath, Jeremiah T. Easley, Sibylle Grad, Lisbet Haglund, Christine L. Le Maitre, Victor Leung, Annette M. McCoy, Devina Purmessur, Simon Y. Tang, Stephan Zeiter, Lachlan J. Smith
Summary: Intervertebral disc degeneration is a common cause of low back pain, and appropriate preclinical models are crucial for research and treatment development. This article presents contrasting arguments for in vivo animal models and ex vivo organ culture models for disc studies, aiming to reach a consensus on model selection and implementation. The authors conclude that combining multiple model types and leveraging their unique advantages can lead to high-impact research in most cases.
Article
Materials Science, Biomaterials
Joseph W. Snuggs, Kaj S. Emanuel, Christine Rustenburg, Ronak Janani, Simon Partridge, Christopher Sammon, Theo H. Smit, Christine L. Le Maitre
Summary: Back pain, mainly caused by intervertebral disc degeneration, is a leading cause of disability. However, there are currently no therapies targeting this cause. This study investigated the efficacy of an injectable hydrogel system, NPgel, in halting or reversing the degenerative processes of intervertebral disc degeneration. The results showed that NPgel administration significantly decreased the histological grade of degeneration and promoted new matrix production, highlighting its potential as a future therapy for intervertebral disc degeneration.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sonia Guarnerio, Robert Tempest, Rawan Maani, Stuart Hunt, Laura M. Cole, Christine L. Le Maitre, Keith Chapple, Nicholas Peake
Summary: This study explores the cellular responses to cancer extracellular vesicles as potential complementary biomarkers for stage separation in colorectal cancer patients. It demonstrates the potential of using a combination of plasma extracellular vesicle markers and cellular responses to separate patients according to disease stage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
C. M. E. Rustenburg, J. W. Snuggs, K. S. Emanuel, A. Thorpe, C. Sammon, C. L. Le Maitre, T. H. Smit
EUROPEAN CELLS & MATERIALS
(2020)
Article
Orthopedics
Abbie Binch, Joseph Snuggs, Christine L. Le Maitre
