期刊
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
卷 64, 期 8, 页码 1279-1287出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/01635581.2012.722247
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资金
- Dairy Farmers of Canada
- Sainte Justine Hospital Foundation
- Canada Research Chair
Carnitine is known for its essential role in intermediary metabolism. In vitro studies suggest that its antioxidant and anti-inflammatory properties are potentially beneficial toward cancer prevention. This study tested effects of carnitine on the development of colon cancer in vivo using 2 murine models: azoxymethane (AOM) treatment as a model of carcinogen-induced colon cancer and a genetically induced model using Apc(Min/+) mice. AOM and Apc(Min/+) mice divided into dietary groups varying in lipid content, with or without carnitine supplementation (0.08%). AOM-exposed mice on a high butterfat diet had significantly increased aberrant crypts (ACF) (9.3 +/- 0.88 vs. 6.3 +/- 0.65), and macroscopic tumors (3.8 +/- 0.95 vs. 2.0 +/- 0.25) compared to mice on a control diet. In AOM mice fed the high butterfat diet, carnitine supplementation inhibited ACF (4.9 +/- 0.7 vs. 9.3 +/- 0.88, P < 0.001), crypt multi-ciplicity (1.6 +/- 0.08 vs. 1.92 +/- 0.1, P < 0.01) and tumors (1.5 +/- 0.38 vs. 3.8 +/- 0.95, P < 0.001). Carnitine supplementation resulted in significantly increased tissue carnitine and acylcarnitine levels. Carnitine inhibited the development of precancerous lesions and macroscopic colonic tumors in AOM-treated mice. However, carnitine did not exert protective effects on intestinal tumors in Apc(Min/+) mice.
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