Review
Biochemistry & Molecular Biology
Giovanni Tossetta, Sonia Fantone, Gaia Goteri, Stefano Raffaele Giannubilo, Andrea Ciavattini, Daniela Marzioni
Summary: Ovarian cancer is a dangerous gynecologic malignancy with high fatality rate. Oxidative stress and NQO1 play important roles in the occurrence and progression of ovarian cancer. This review summarizes the evidence from literature regarding the effect of NQO1 on ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ya-ping Dong, Shu-zhen Chen, Hui-si He, Zhuo-ran Sun, Li-xuan Jiang, Yan-qiu Gu, Ying Zhang, Fei Feng, Chun Chen, Zhe-cai Fan, Xiao-fei Chen, Wen Wen, Hong-yang Wang
Summary: In this study, four compounds were screened from Scutellaria baicalensis as potential NQO1 inhibitors. Among them, skullcapflavone II (SFII) showed the most promising inhibitory activity against NQO1. SFII was found to alleviate AAI-induced DNA damage and apoptosis in human liver and renal cells, as well as ameliorate AAI-induced renal fibrosis and dysfunction in adult mice. Furthermore, SFII suppressed AAI-induced hepatocellular carcinoma initiation in infant mice.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Devoshree Mukherjee, Riaz Ahmad, Shahid Nayeem
Summary: Protein modulation is a process of changing protein structure, which can be used to understand disease mechanisms or develop novel therapeutics. This study found that COX-2, iNOS, and GST may be the dynamic molecular targets of Quercetin action to restore tissue biochemistry and anatomy during experimental liver injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Analytical
Bo Peng, Gang Chen, Yahui Li, Hao Zhang, Jianliang Shen, Ji-Ting Hou, Zhipeng Li
Summary: In this study, a new pancreatic cancer-specific probe was developed, which can trigger near-infrared emission and selectively induce cell death. The probe showed good imaging results in both experimental and clinical samples, suggesting its potential clinical application for the treatment and diagnosis of pancreatic cancer.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Youfu Lin, Qi Xiao, Qianwen Hao, Zijin Qian, Xuexia Li, Peng Li, Hong Li, Lian Chen
Summary: This study investigated the role of Glutathione S-transferases (GSTs) in cold acclimation and cold stress-response mechanisms in the invasive snail P. canaliculata. A total of 30 PcGSTs were classified into seven classes and their expression patterns in different tissues were examined. RNA-seq analysis and qRT-PCR experiments revealed significant changes in expression levels of certain PcGST genes during cold acclimation, providing insights into the mechanisms underlying cold stress responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Peter Tsvetkov, Julia Adler, Romano Strobelt, Yaarit Adamovich, Gad Asher, Nina Reuven, Yosef Shaul
Summary: This passage demonstrates the interaction between SIRT1 and NQO1, indicating that SIRT1 can regulate the expression of NQO1 and exert a protective role under mitochondrial stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Wang-Soo Lee, Woojin Ham, Jaetaek Kim
Summary: NQO1 is an antioxidant flavoprotein that exerts antioxidant activities, anti-inflammatory effects, and interacts with tumor suppressors. Recent studies have highlighted the promising roles of NQO1 in protecting against cardiovascular damage and related diseases.
Article
Engineering, Environmental
Madhu Tiwari, Maria Kidwai, Prasanna Dutta, Shiv Narayan, Neelam Gautam, Khushboo Chawda, Pramod Arvind Shirke, Arun Kumar Mishra, Debasis Chakrabarty
Summary: Arsenic is a hazardous metalloid that hampers physiological activities in rice. In this study, the role of OsGSTU5 in arsenic tolerance was investigated. OsGSTU5 was found to enhance arsenic tolerance by regulating antioxidant activities and participating in arsenic chelation and transport processes.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Plant Sciences
Maria Font Farre, Daniel Brown, Maurice Konig, Brian J. Killinger, Farnusch Kaschani, Markus Kaiser, Aaron T. Wright, Jonathan Burton, Renier A. L. van der Hoorn
Summary: This study presents an easy and quick assay for photoaffinity labeling of GSTs in different plant species. The results demonstrate that GSTs can be induced by various types of stress and this method is useful for studying GST induction in different plant species.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nobuaki Okumura, Takashi Ito, Tomomi Degawa, Mariko Moriyama, Hiroyuki Moriyama
Summary: The study found that 10H2DA in royal jelly protected the skin from oxidative stress by upregulating NQO1 expression, demonstrating its antioxidative and detoxifying role in skin protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Yu-Wen Zhao, Chu-Kun Wang, Xiao-Yu Huang, Da-Gang Hu
Summary: Anthocyanins play vital biological roles in plant growth and development, with GSTs being essential for their transportation. The study identified 38 GST genes in the apple genome and found 32 orthologous gene pairs between apple and Arabidopsis. MdGSTU12 was significantly correlated with anthocyanin variation in apple, indicating its importance in anthocyanin accumulation.
Article
Environmental Sciences
Y. Yang, J. Li, H. Li, Y. Ding, W. Wu, R. Qin, J. Ni, R. Xu, P. Wei, J. Yang
Summary: Two newly identified GST genes, OsGSTU5 and OsGSTU37, play a role in the regulatory mechanism of cadmium tolerance in rice by enhancing the activity of antioxidant enzymes and glutathione reductase.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Tanmaya Nayak, Paritosh Patel, Aishee Ghosh, Faizan Zarreen Simnani, Khushbu Kumari, Sourav Das, Aditya Nandi, Arpan Ghosh, Pritam Kumar Panda, Nagendra Kumar Kaushik, Vishakha Raina, Suresh K.Verma
Summary: The combined process of solar Photo-Fenton treatment and bacterial degradation using Ochrobactrum sp. CPD-03 has been found effective in degrading Chlorpyrifos (CP) in wastewater. In vivo biotoxicity analysis showed that the use of this combined process reduces the toxic effects of CP on embryonic zebrafish. The study suggests the use of this technique for efficient degradation of CP and reduction of in vivo biotoxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Mingxue Ran, Qingbin Li, Yufeng Xin, Shaohua Ma, Rui Zhao, Min Wang, Luying Xun, Yongzhen Xia
Summary: Heterotrophic bacteria and human mitochondria use sulfide: quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) to oxidize sulfide to sulfite and thiosulfate. RHOD domains play multiple roles in sulfide oxidation by promoting thiosulfate formation and facilitating the reaction between inorganic polysulfide and glutathione. The fused and dissociated forms of the DUF442 domain modulate the activity of SQRCp and PDOCp, respectively, affecting the accumulation of cellular sulfane sulfur and the production of thiosulfate.
Article
Food Science & Technology
Sujin Park, YoonA Kim, Jaewang Lee, Hyunsoo Seo, Sang-Jip Nam, Dong-Gyu Jo, Dong-Hoon Hyun
Summary: This study investigates the neuroprotective effects of 4-hydroxycinnamic acid (HCA) by analyzing cell survival, abnormal protein levels, and mitochondrial functions. The results show that HCA protects neuronal cells by increasing the expression of plasma membrane redox enzymes and improving the NAD+/NADH ratio. HCA also enhances mitochondrial activities, ATP production, and promotes mitochondrial fusion while decreasing mitochondrial fission. These findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Food Science & Technology
Riccardo Secci, Alexander Hartmann, Michael Walter, Hans Joergen Grabe, Sandra van der Auwera-Palitschka, Axel Kowald, Daniel Palmer, Gerald Rimbach, Georg Fuellen, Israel Barrantes
Summary: This review focuses on the role of diet in protecting against aging, discussing biomarkers based on omics and clinical data, as well as the effects of berry-based interventions. It also emphasizes the importance of individuals' dietary history in geroprotection.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Medicine, General & Internal
Svenja Fedde, Gerald Rimbach, Karin Schwarz, Anja Bosy-Westphal
Summary: Ultra-processed food constitutes a significant portion of daily energy intake in Germany and is associated with non-communicable diseases such as obesity, diabetes, cancer, cardiovascular disease, and depression. This association could be attributed to factors like high energy density, imbalanced nutritional composition, high glycemic index, and adverse additives found in ultra-processed food.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Article
Nutrition & Dietetics
Daan Kremer, Adrian Post, Ulrike Seidel, Patricia Huebbe, Yvonne van der Veen, Dion Groothof, Antonio W. Gomes-Neto, Tim J. Knobbe, Kai Lueersen, Michele F. Eisenga, Gerjan J. Navis, Gerald Rimbach, Stephan J. L. Bakker
Summary: Through investigating the impact of boron intake on the long-term outcomes of kidney transplant recipients, the study found a strong association between high boron excretion and a lower risk of mortality, suggesting the potential for improving long-term survival through pathways other than previously suggested mechanisms.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Nutrition & Dietetics
Maryam S. Hafiz, Matthew D. Campbell, Lauren L. O'Mahoney, Melvin Holmes, Caroline Orfila, Christine Boesch
Summary: The study showed that pulse intake can significantly reduce postprandial glucose concentration in both diabetic and nondiabetic individuals, and has a positive impact on long-term glycemic control parameters.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Katharina S. Weber, Ilka Ratjen, Janna Enderle, Ulrike Seidel, Gerald Rimbach, Wolfgang Lieb
Summary: The study found that higher plasma boron concentrations were associated with a healthier diet, lower BMI, a more favorable cardio-metabolic risk profile, and seasonal variations.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Virginia Eickelberg, Kai Lueersen, Stefanie Staats, Gerald Rimbach
Summary: This article introduces the application of Drosophila melanogaster as a model organism in nutrition research, and provides a detailed description of the methods for phenotyping Drosophila. The practical application of fly phenotyping is demonstrated through a discussion of obese phenotypes in response to high-sugar diet and high-fat diet feeding. It is also found that the diets have impacts on the transcriptome and metabolome of Drosophila, which is important for understanding the underlying molecular mechanisms.
Article
Chemistry, Applied
Ganwarige Sumali N. Fernando, Natalia N. Sergeeva, Maria J. Frutos, Lisa J. Marshall, Christine Boesch
Summary: The present study focused on the development of a new purification protocol using flash chromatography suitable for betanin and other major betalains. The purification method achieved high purity and pigment yield. In terms of antioxidant and radical scavenging properties, betanin exhibited the highest potential.
Review
Agronomy
Raul Huertas, Barbara Karpinska, Sophia Ngala, Bertha Mkandawire, Joyce Maling'a, Elizabeth Wajenkeche, Paul M. Kimani, Christine Boesch, Derek Stewart, Robert D. Hancock, Christine H. Foyer
Summary: Micronutrient deficiencies, particularly in iron and zinc, are a serious public health challenge affecting more than three billion people globally. Various strategies, including dietary diversification, food fortification, agronomic approaches, and biotechnology, are being used to address the problem. This review focuses on the genes and processes associated with iron and zinc accumulation in common beans and discusses the different approaches, such as conventional breeding, transgenics, and gene editing, being used to improve their nutritional content.
FOOD AND ENERGY SECURITY
(2023)
Article
Food Science & Technology
Ruixian Han, Alan J. Hernandez Alvarez, Joanne Maycock, Brent S. Murray, Christine Boesch
Summary: This study investigated the anti-inflammatory activities of hydrolyzed oilseed proteins and compared them with dairy proteins. The results showed that rapeseed hydrolysates exhibited the strongest anti-inflammatory effects, reducing the expression of inflammatory cytokines and upregulating anti-inflammatory cytokines. Furthermore, rapeseed, sesame, and soybean hydrolysates suppressed the NF-kappa B pathway and reduced the recognition of LPS, thereby weakening the inflammatory response.
Article
Biochemistry & Molecular Biology
Yunqing Wang, Ganwarige Sumali N. Fernando, Natalia N. Sergeeva, Nikolaos Vagkidis, Victor Chechik, Thuy Do, Lisa J. Marshall, Christine Boesch
Summary: The present study compared the absorption and transport patterns of three main betalains, betanin, vulgaxanthin I, and indicaxanthin, in intestinal epithelial cells. The results showed that these compounds have different molecular effects on inflammatory and redox-related cell signaling. Betanin demonstrated a potent dose-dependent radical scavenging activity.
Article
Nutrition & Dietetics
Sebastian Schaffer, Gerald Rimbach, David Pieper, Niklas Hommen, Alexandra Fischer, Marc Birringer, Ulrike Seidel
Summary: This study investigated the contribution of minerals and trace elements in beverages to the daily intake of German consumers. The results showed that phosphorous, calcium, and magnesium were the main minerals found in beverages, while manganese was the most significant trace element. The study provides a foundation for the establishment of a mineral and trace element database for beverages in the future.
Article
Cell Biology
Virginia Eickelberg, Gerald Rimbach, Yvonne Seidler, Mario Hasler, Stefanie Staats, Kai Lueersen
Summary: This study found that both the quantity and quality of dietary fat can affect various traits in fruit flies, such as lifespan and fertility.
Article
Nutrition & Dietetics
Kai Lueersen, Alexandra Fischer, Ilka Bauer, Patricia Huebbe, Yukiko Uekaji, Keita Chikamoto, Daisuke Nakata, Naoto Hiramatsu, Keiji Terao, Gerald Rimbach
Summary: In the context of the growing prevalence of type 2 diabetes (T2DM), control of postprandial hyperglycemia is crucial for its prevention. Isoflavones in soy extract, enriched with hydroxylated metabolites through fermentation, exhibit anti-diabetic properties by inhibiting key enzymes, reducing glucose transport, and decreasing inflammatory markers. These properties are confirmed in an in vivo model using Drosophila melanogaster.
Article
Biochemistry & Molecular Biology
Manuela Yepes-Calderon, Daan Kremer, Adrian Post, Camilo G. G. Sotomayor, Ulrike Seidel, Patricia Huebbe, Tim J. J. Knobbe, Kai Lueersen, Michele F. F. Eisenga, Eva Corpeleijn, Martin H. H. De Borst, Gerjan J. J. Navis, Gerald Rimbach, Stephan J. L. Bakker
Summary: A study found that kidney transplant recipients have an increased risk of cardiovascular mortality. It also revealed an association between post-transplantation copper status and the risk of cardiovascular mortality, with a potential effect modification by sex. Among male recipients, higher plasma copper concentration was independently associated with a higher risk of cardiovascular mortality, while this association was absent among female recipients.
Correction
Biochemistry & Molecular Biology
S. Staats, A. E. Wagner, K. Luersen, A. Kunstner, T. Meyer, A. K. Kahns, S. Derer, S. Graspeuntner, J. Rupp, H. Busch, C. Sina, I. R. Ipharraguerre, G. Rimbach
