Article
Agriculture, Dairy & Animal Science
Nicolas Busse, Madison L. Gonzalez, Mackenzie L. Krason, Sally E. Johnson
Summary: Consumption of HMB increased the percentage of type IIA and IIA/X muscle fibers in the GM, but did not improve athletic performance in horses. Additionally, HMB supplementation did not have measurable effects on the biomechanical properties of the muscles in horses.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Rehabilitation
Rafael Fortuna, Andrew Sawatsky, John C. Fuller, Walter Herzog
Summary: The study found that while HMB did not completely prevent muscle mass and strength loss induced by BoNT-A injection, it did reduce the loss of contractile material in the injected muscles and prevented strength loss in the contralateral non-injected muscles.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Fisheries
Hua Mu, Chenbin Yang, Yu Zhang, Shengdi Chen, Panpan Wang, Binlun Yan, Qingqi Zhang, Chaoqing Wei, Huan Gao
Summary: An 8-week feeding trial was conducted to investigate the effects of dietary HMB supplementation on growth performance and muscle quality of kuruma shrimp. The results showed that HMB supplementation improved weight gain, growth rate, and feed conversion ratio. It also increased trypsin activity, activated TOR pathway, and enhanced muscle collagen content and changed myofiber morphology.
AQUACULTURE NUTRITION
(2023)
Review
Endocrinology & Metabolism
Danielle E. Bear, Alfonso J. Cruz-Jentoft, Jeffrey R. Stout
Summary: Interest in using HMB to prevent and treat sarcopenia has grown in recent years, but there is limited research on its effects in hospitalized and community-dwelling older adults, with existing studies having suboptimal methodological quality. More high-quality studies are needed to investigate the effectiveness of HMB on outcomes related to sarcopenia.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2021)
Article
Nutrition & Dietetics
Alejandro Barranco, Llenalia Garcia, Agnes Gruart, Jose Maria Delgado-Garcia, Ricardo Rueda, Maria Ramirez
Summary: HMB, a metabolite of leucine, has been shown to preserve muscle mass and strength during aging. This study evaluated the effects of different doses of HMB on synaptic potentiation in the hippocampus and working memory in animals. The results suggest that medium or high doses of HMB can enhance neuronal plasticity and improve cognitive performance.
Article
Biochemistry & Molecular Biology
Martina Baraldo, Leonardo Nogara, Georgia Ana Dumitras, Achille Homere Tchampda Dondjang, Alessia Geremia, Marco Scalabrin, Clara Turk, Frederik Telkamp, Lorena Zentilin, Mauro Giacca, Marcus Kruger, Bert Blaauw
Summary: Loss of Raptor diminishes muscle hypertrophy and force increase after Akt activation, indicating mTORC1 as the key mediator of Akt-dependent muscle growth regulating the mitochondrial proteome critical for enhancing muscle force.
Article
Geriatrics & Gerontology
L. -N. Peng, Y. -C. Cheng, P. -C. Yu, W. -J. Lee, M. -H. Lin, Liang-Kung Chen
Summary: The supplementation of high protein oral nutrition shakes containing 3g of HMB per day significantly increased muscle mass, improved nutritional status and physical performance, and reduced intramuscular adiposity in pre-frail older persons. Further research is needed to explore the long-term benefits of HP-HMB supplementation for older adults' muscle and metabolic health.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Nutrition & Dietetics
Kei Higuchi, Sathish Sivaprakasam, Souad R. Sennoune, Jiro Ogura, Yangzom D. Bhutia, Ricardo Rueda, Suzette L. Pereira, Vadivel Ganapathy
Summary: HMB can enter human BBB endothelial cells through H+-coupled monocarboxylate transporters, leading to intracellular acidification and mTOR activation causing changes in transporter expression, especially positively affecting LAT1.
Article
Oncology
Michael F. Coleman, Kristyn A. Liu, Alexander J. Pfeil, Suhas K. Etigunta, Xiaohu Tang, Salvador Fabela, Laura M. Lashinger, Zhengrong Cui, Stephen D. Hursting
Summary: Pancreatic cancer is a deadly disease exacerbated by obesity, with limited responses to immune and chemotherapy treatments. Dietary supplementation with beta-hydroxy-beta-methylbutyrate has been shown to enhance immunosurveillance in PDAC tumors and protect muscle. This supplement may potentially serve as an important adjuvant in PDAC therapy, particularly in enhancing responses to immunotherapy.
Article
Sport Sciences
Yosuke Osuka, Narumi Kojima, Ken Nishihara, Hiroyuki Sasai, Kyohsuke Wakaba, Kiyoji Tanaka, Hunkyung Kim
Summary: This study aimed to investigate whether HMB supplementation enhances the effects of resistance training on muscle quality in older women with low muscle mass. The results showed that HMB supplementation did not enhance the treatment effects of resistance training on muscle quality parameters, but resistance training reduced the decline in functional muscle quality.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Biochemistry & Molecular Biology
Ewa Tomaszewska, Janine Donaldson, Jakub Kosinski, Piotr Dobrowolski, Agnieszka Tomczyk-Warunek, Monika Hulas-Stasiak, Krzysztof Lamorski, Dorota Laskowska-Wozniak, Siemowit Muszynski, Rudolf Blicharski, Tomasz Blicharski
Summary: HMB supplementation during pregnancy increases bone density and strength, prevents bone loss, and alters cartilage and bone composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
William D. Fairfield, Dennis M. Minton, Christian J. Elliehausen, Alexander D. Nichol, Taylor L. Cook, John A. Rathmacher, Lisa M. Pitchford, Scott A. Paluska, Adam J. Kuchnia, Jacob M. Allen, Adam R. Konopka
Summary: HMB + D supplementation can increase skeletal muscle volume, decrease intermuscular adipose tissue, and prevent muscle loss in middle-aged women.
Review
Nutrition & Dietetics
Ziru Lin, Anqi Zhao, Jiguo He
Summary: This meta-analysis demonstrates that supplementation of HMB and preparations containing HMB ingredients can increase muscle strength in elderly individuals, which is crucial for their overall health.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Silvia Espina, Alejandro Sanz-Paris, Yolanda Gonzalez-Irazabal, Patricia Perez-Matute, Fernando Andrade, Beatriz Garcia-Rodriguez, Christian Carpene, Alexia Zakaroff, Vanesa Bernal-Monterde, Javier Fuentes-Olmo, Jose M. Arbones-Mainar
Summary: Oral HMB supplementation improves liver function and increases fat mass index, but has no effect on fat-free mass. In patients with cirrhosis and malnutrition, the HMB group showed an upward trend in handgrip strength and a downward trend in minimal hepatic encephalopathy.
Review
Geriatrics & Gerontology
Carla M. Prado, Camila E. Orsso, Suzette L. Pereira, Philip J. Atherton, Nicolaas E. P. Deutz
Summary: Low muscle mass is common among cancer patients, and HMB supplementation shows beneficial effects on muscle mass, function, and survival. However, its impact on quality of life and body weight is limited. Further well-designed trials are needed to explore the clinical benefits of HMB supplementation in this patient population.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Sandra Maria Chemin Seabra da Silva, Aline de Piano Ganen, Deborah Cristina Landi Masquio, Marcus V. L. Dos Santos Quaresma, Debora Estadella, Lila Missae Oyama, Lian Tock, Marco Tulio de Mello, Ana Raimunda Damaso, Claudia Maria da Penha Oller do Nascimento, Danielle Arisa Caranti
Summary: This study aimed to verify the relationships between serum-free fatty acids (FA), inflammatory processes, and depressive symptoms in obese adolescents. The results showed positive correlations between depressive symptoms and saturated fatty acids (SFA) content, body fat, and inflammatory adipokines. On the other hand, n-3 polyunsaturated fatty acids (PUFA) content was negatively correlated with depressive symptoms. However, further longitudinal studies are needed to confirm the causality between dietary SFA and depression in obese individuals.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Physiology
Adriano A. L. Carmo, Karine N. O. Goulart, Christian E. T. Cabido, Ygor A. T. Martins, Gabriela C. F. Santos, Felipe L. T. Shang, Luciano S. Prado, Danusa D. Soares, Marco T. de Mello, Thiago T. Mendes, Emerson Silami-Garcia, Samuel P. Wanner
Summary: This study investigated the effects of an active warm-up and time-of-day variation on repeated-sprint performance and post-exercise recovery. The results showed that a warm-up improved sprint performance, and sprints performed in the late afternoon were better. Additionally, warm-up also led to faster post-exercise recovery.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
V. R. Munoz, R. C. Gaspar, M. C. S. Mancini, R. D. de Lima, R. F. L. Vieira, B. M. Crisol, G. C. Antunes, J. C. S. Trombeta, I. L. P. Bonfante, F. M. Simabuco, A. S. R. da Silva, C. R. Cavaglieri, E. R. Ropelle, D. E. Cintra, J. R. Pauli
Summary: The study found that short-term aerobic exercise can improve overall glucose and insulin sensitivity as well as hepatic metabolism in aged rodents. These effects contribute to late-life metabolic health and help prevent the development of age-related T2D.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Rehabilitation
Isadora Grade, Henrique Andrade, Renato Guerreiro, Eduardo Stieler, Flavia R. da Silva, Hesojy G. V. da Silva, Roberto Vital, Renan A. Resende, Dawit A. P. Goncalves, Andre G. Andrade, Marco T. de Mello, Andressa Silva
Summary: A systematic review found that Paralympic athletes have poor sleep quality and quantity, with high rates of daytime sleepiness. Subjective questionnaires are commonly used to assess their sleep.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Medicine, Research & Experimental
Ana P. Pinto, Vitor R. Munoz, Maria Eduarda A. Tavares, Jonathas R. dos Santos, Macario A. Rebelo, Luciane C. Alberici, Fernando M. Simabuco, Giovana R. Teixeira, Jose R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Ellen C. Freitas, Donato A. Rivas, Adelino S. R. da Silva
Summary: Aging can alter the structure and function of the liver, while exercise training may have positive effects on autophagy processes, mitochondrial function, and cellular senescence in the liver. This study investigates the effects of aging and exercise on hepatic circadian markers, autophagy, and mitochondria activity using both mouse models and human datasets. The findings suggest that exercise can improve liver function and maintain mitochondrial and autophagy markers associated with liver diseases.
Article
Physiology
Marlene Salvina Fernandes da Costa, Vinicius de Oliveira Damasceno, Marco Tulio de Melo, Marcos Andre Moura dos Santos, Wlaldemir Roberto dos Santos, Fernanda Veruska Narciso, Walmir Romario dos Santos, Saulo Fernandes Melo de Oliveira, Pedro Pinheiro Paes
Summary: This study aims to investigate the direct influence of training load on sleep behavior during the tapering phase of training for young swimmers. The results show that there is no significant influence of training load on sleep variables. However, a strong association between total sleep time (TST) and external load (EL) was observed in the irregular sleep group.
REVISTA BRASILEIRA DE MEDICINA DO ESPORTE
(2023)
Article
Nutrition & Dietetics
Rayssa Sousa-Silva, Jason M. Cholewa, Kassiana de Araujo Pessoa, Zhi Xia, Jakob D. Lauver, Fabricio E. Rossi, Nelo Eidy Zanchi
Summary: This study compared the effects of an 8-week creatine (CR) or placebo (PL) supplementation on muscle strength, thickness, endurance, and body composition with blood flow restriction (BFR) vs. traditional resistance training (TRAD). The results showed that creatine supplementation increased muscle thickness in both TRAD and BFR groups compared to the placebo, without a significant difference between treatments. Additionally, TRAD training improved maximum strength compared with BFR, and repetitions to failure were higher in the BFR-CR group at 30% 1RM. Overall, the study suggests that creatine supplementation can enhance muscle adaptation following BFR training.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Jose R. Pauli, Vitor R. Munoz, Renan Fudoli Lins Vieira, Susana C. B. R. Nakandakari, Ana Paula Azevedo Macedo, Robson Damasceno de Lima, Gabriel Calheiros Antunes, Fernando M. Simabuco, Adelino Sanchez Ramos da Silva, Leandro P. de Moura, Eduardo R. Ropelle, Dennys E. Cintra, Rania A. Mekary, Iman Zaghloul
Summary: This study aimed to investigate the effects of gliadin on liver metabolism and inflammation and whether aerobic exercise could mitigate these effects in rodents. The results showed that gliadin administration impaired weight gain, increased gluconeogenesis and lipogenesis, and induced hepatic inflammation compared to the control group. However, exercise in combination with gliadin administration resulted in weight recovery, improved insulin sensitivity, and a reduction in gluconeogenesis, lipogenesis, and hepatic inflammation compared to the gliadin group.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Rodrigo Xavier das Neves, Alex S. Yamashita, Daniela M. R. Riccardi, Julia Kohn-Gaone, Rodolfo G. Camargo, Nelson I. Neto, Daniela Caetano, Silvio P. Gomes, Felipe H. Santos, Joanna D. C. C. Lima, Miguel L. Batista Jr, Jose Cesar Rosa-Neto, Paulo Sergio Martins De Alcantara, Linda F. Maximiano, Jose P. Otoch, Giorgio Trinchieri, Janina E. E. Tirnitz-Parker, Marilia Seelaender
Summary: Liver inflammation and metabolic disruption are observed in both animal models and colon cancer patients with cachexia. The increase in myeloid cells and activation of the hepatic inflammasome pathway contribute to systemic inflammation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Food Science & Technology
Andressa Roehrig Volpe-Fix, Elias de Franca, Jean Carlos Silvestre, Ronaldo Vagner Thomatieli-Santos
Summary: Food bioactive compounds (FBC) are substances found in fruits, vegetables, and other sources that have physiological effects on individuals who consume them. Some FBCs, such as polyphenols, have antioxidant and anti-inflammatory properties. This review explores the effects of supplementing with various polyphenols on oxidative stress and post-exercise inflammation markers. The findings suggest that cocoa, green tea extract, and curcumin can help alleviate cell damage and inflammation caused by exercise, but conflicting results are found for anthocyanins, quercetins, and resveratrol. The impact of simultaneously supplementing multiple FBCs is also discussed.
Review
Rehabilitation
Eduardo Stieler, Marco T. de Mello, Ingrid L. B. Lobo, Dawit A. Goncalves, Renan Resende, Andre G. Andrade, Thiago F. Lourenco, Anselmo A. C. Silva, Henrique A. Andrade, Renato Guerreiro, Andressa Silva
Summary: This review examines the methods used to assess external load in Paralympic sports, aiming to provide scientific evidence for multidisciplinary teams to prescribe and monitor athlete's development, enhance performance, and reduce injury/illness risks. The study identified 8 methods to quantify external load in 8 different Paralympic sports and highlights the need for further research to validate the effectiveness and reliability of these methods.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Nutrition & Dietetics
Ronaldo Angelo Dias da Silva, Leszek Antoni Szmuchrowski, Joao Paulo Pereira Rosa, Marcos Antonio Pereira dos Santos, Marco Tulio de Mello, Lucas Savoi, Yves Ferreira Porto, Francisco de Assis Dias Martins, Marcos Daniel Motta Drummond
Summary: Intermittent fasting (IF) is commonly used by combat sports athletes for weight loss but may decrease performance. This study examined the effects of IF on body weight and Taekwondo performance. The results showed that IF led to a decrease in body weight in the first two weeks but stabilized afterwards. Performance in vertical jumping had different patterns in fed and fasted states. Despite the decrease in body weight, IF did not significantly impact performance.
Article
Immunology
Bruna Spolador de Alencar Silva, Telmo Pereira, Luciele Guerra Minuzzi, Camila Souza Padilha, Caique Figueiredo, Tiago Olean-Oliveira, Ivete Vera Medeiros dos Santos, Ana Elisa von Ah Morano, Osmar Marchioto, Jose Procopio Jabur Ribeiro, Vanessa Ribeiro Dos Santos, Marilia Seelaender, Alexandre Abilio Teixeira, Ronaldo Vagner T. Dos Santos, Valdir de Aquino Lemos, Ana Paula Coelho Figueira Freire, Gilson Pires Dorneles, Bruna Marmett, Andre Olean-Oliveira, Marcos F. S. Teixeira, Patricia M. Seraphim, Armando Caseiro, Ricardo Aurino Pinho, Hashim Islam, Jonathan Peter Little, Karsten Krueger, Jose Cesar Rosa-Neto, Manuel-Joao Coelho-E-Silva, Fabio Santos Lira
Summary: This study aimed to evaluate the association between physical activity and immunometabolic responses in young adults after mild-to-moderate COVID-19 infection. The results showed that COVID-19 patients had lower physical activity levels and exhibited impacts on lung function, immune cell phenotype, and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matheus Santos de Sousa Fernandes, Tiago Ramos Lacerda, Debora Eduarda da Silva Fidelis, Gabriela Carvalho Jurema Santos, Tayrine Ordonio Filgueira, Raphael Fabricio de Souza, Claudia Jacques Lagranha, Fabio S. Lira, Angela Castoldi, Fabricio Oliveira Souto
Summary: This systematic review evaluates the impact of environmental enrichment (EE) on oncological factors in experimental studies on various cancer models. The findings demonstrate that different EE protocols effectively reduce tumor growth and development in terms of angiogenesis, volume, weight, and the number of mice with tumors. Additionally, EE enhances the rate of tumor inhibition. These findings emphasize the importance of EE as a valuable tool in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
