期刊
NUTRITION & METABOLISM
卷 8, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1743-7075-8-88
关键词
dyslipidemia; liver steatosis; vegetables; diet-induced obesity; zebrafish; DNA microarray
资金
- New Energy and Industrial Technology Development Organization
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Grants-in-Aid for Scientific Research [23659136] Funding Source: KAKEN
Background: High dietary intake of vegetable products is beneficial against obesity and its related diseases such as dyslipidemia, nonalcoholic fatty liver disease, and cancer. We previously developed a diet-induced obesity model of zebrafish (DIO-zebrafish) that develops visceral adiposity, dyslipidemia, and liver steatosis. Zebrafish is a polyphagous animal; thus we hypothesized that DIO-zebrafish could be used for transcriptome analysis of anti-obesity effects of vegetables. Results: Each vegetable exhibited different effects against obesity. We focused on Campari tomato, which suppressed increase of body weight, plasma TG, and lipid droplets in livers of DIO-zebrafish. Campari tomato decreased srebf1 mRNA by increase of foxo1 gene expression, which may depend on high contents of beta-carotene in this strain. Conclusions: Campari tomato ameliorates diet-induced obesity, especially dyslipidemia and liver steatosis via downregulation of gene expression related to lipogenesis. DIO-zebrafish can discriminate the anti-obesity effects of different strains of vegetables, and will become a powerful tool to assess outcomes and find novel mechanisms of anti-obesity effects of natural products.
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