Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Violetta Rosiek, Beata Kos-Kudla
Summary: This study investigated the potential relationship between leptin, adiponectin, and the leptin-adiponectin ratio with the grade, stage, and metastases of PanNENs. It was found that adiponectin concentration was significantly higher in the control group compared to the study group, and both leptin and adiponectin levels were higher in females than males. An increased leptin-adiponectin ratio was observed in well-differentiated PanNENs and PanNENs with low Ki-67. Additionally, lower leptin levels and a decreased leptin-adiponectin ratio were found in PanNENs with distal disease. These findings suggest that leptin, adiponectin, and their ratio may serve as potential biomarkers for the diagnosis, prognosis, and prediction of PanNENs.
Article
Multidisciplinary Sciences
Joyce Ikedife, Jianlin He, Yufeng Wei
Summary: Phosphorylation of PEA-15 mediates conformational changes and alters specific binding, regulating mitogen-activated protein kinase and apoptosis pathways.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Ahmed Abdel-Razik, Nasser Mousa, Walaa Shabana, Ahmed H. Yassen, Mostafa Abdelsalam, Mohamed M. Wahba, Eman Mohamed Helmy, Ahmed M. Tawfik, Khaled Zalata, Ahmad S. Hasan, Rania Elhelaly, Rasha Elzehery, Aya Ahmed Fathy, Niveen El-Wakeel, Waleed Eldars
Summary: This study found that increased central obesity and leptin/adiponectin ratio (LAR) were independently associated with the development of PVT in non-cirrhotic NAFLD patients, suggesting that they may be considered as risk factors in the multifactorial pathogenesis of PVT.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Shuai Zheng, Min Shen, Yu Qian, Shushu Li, Yang Chen, Hemin Jiang, Hui Lv, Doudou Chen, Ruiling Zhao, Xuqin Zheng, Min Sun, Tao Yang, Yun Shi, Qi Fu
Summary: This study aimed to evaluate the roles of GDF-15, adiponectin, and GDF-15/adiponectin ratio as biomarkers for detecting metabolic syndrome. The results suggest that the G/A ratio and adiponectin are potential biomarkers for detecting metabolic syndrome in women and men, respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Andreea Roxana Florian, Gheorghe Cruciat, Raluca Maria Pop, Adelina Staicu, Muresan Daniel, Stamatian Florin
Summary: This study revealed that elevated levels of leptin (L) in the early stages of pregnancy are strongly associated with the development of gestational diabetes mellitus (GDM). Meanwhile, adiponectin (AN) and CMPF levels showed no significant correlation with GDM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemical Research Methods
Stephen A. Wise, Johanna E. Camara, Carolyn Q. Burdette, Grace Hahm, Federica Nalin, Adam J. Kuszak, Joyce Merkel, Ramon A. Durazo-Arvizu, Emma L. Williams, Christian Popp, Christian Beckert, Jan Schultess, Glen Van Slooten, Carole Tourneur, Camille Pease, Ravi Kaul, Alfredo Villarreal, Marcelo Cidade Batista, Heather Pham, Alex Bennett, Eugene Jansen, Dilshad Ahmed Khan, Mark Kilbane, Patrick J. Twomey, James Freeman, Neil Parker, Sohail Mushtaq, Christine Simpson, Pierre Lukas, Etienne Cavalier, Christopher T. Sempos
Summary: The study conducted by VDSP evaluated the performance of ligand binding assays for measuring serum total 25-hydroxyvitamin D, finding that only half of the assays met the established criteria. Multiple regression analysis showed that most assays underestimated certain vitamin D metabolites, with some assays potentially having cross-reactivity issues.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Christopher T. Sempos, Ernst Lindhout, Nicolas Heureux, Michel Hars, Damon A. Parkington, Emily Dennison, Ramon Durazo-Arvizu, Kerry S. Jones, Stephen A. Wise
Summary: The majority of circulating 25-hydroxyvitamin D (25(OH)D) is protein bound. The measurement of free 25(OH)D in human serum is proposed as a better indicator of vitamin D health status. A new enzyme-linked immunosorbent assay (ELISA) provides a method for direct measurement of non-protein bound 25(OH)D. The ELISA was used to measure free 25(OH)D in three existing Standard Reference Materials (SRMs).
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Lorena Desdentado, Jaime Navarrete, Maria Folgado-Alufre, Ana de Blas, Jessica Navarro-Siurana, Francisco Ponce, Guadalupe Molinari, Andrea Jimeno-Martinez, Azahara I. Ruperez, Gloria Bueno-Lozano, Aida Cuenca-Royo, Emili Corbella, Zaida Aguera, Rosa M. Banos, Julio Alvarez-Pitti
Summary: This study found that higher levels of ghrelin concentration were associated with lower scores in restrained eating. No other relationships were found between obesity-related biomarkers and eating behaviors.
Article
Food Science & Technology
Hatim Boughanem, Andrea G. Izquierdo, Pablo Hernandez-Alonso, Isabel Arranz-Salas, Felipe F. Casanueva, Francisco J. Tinahones, Ana B. Crujeiras, Manuel Macias-Gonzalez
Summary: This study identifies a novel association between vitamin D and DNA methylation in CRC tumors, revealing new epigenetic loci and pathways related to cell adhesion, extracellular matrix, and signaling transduction. Further research is needed to validate and expand upon these findings.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Surgery
Anna M. Ernst, Marianne Steiner, Verena Kainz, Herbert Tempfer, Gabriel Spitzer, Tanja Plank, Hans-Christian Bauer, Nikolaus Bresgen, Andreas Habenbacher, Hannelore Bauer, Anna-Theresa Lipp
Summary: In this study, the adipogenic potential of lipedema and nonlipedema adipose tissue-derived stromal/stem cells were compared. The expression of adipogenic genes was found to be upregulated in adipocytes from nonobese lipedema donors. Furthermore, a reduced adiponectin/leptin ratio and increased occurrence of myofibroblast-like cells were observed in adipocytes from obese lipedema donors.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Endocrinology & Metabolism
Zhuohui Chen, Menghui Liu, Xingfeng Xu, Lixiang He, Peng Wang, Xiaojie Cai, Rihua Huang, Shaozhao Zhang, Xinghao Xu, Yuhui Lai, Yiquan Huang, Miaohong Li, Yifen Lin, Peihan Xie, Xinxue Liao, Xiaodong Zhuang, Yue Guo
Summary: This study investigated the joint association of serum 25-hydroxyvitamin D [25(OH)D] and klotho with mortality risk in American community-dwelling adults. The results showed that vitamin D-associated mortality risk is observed only with concurrently decreasing klotho, indicating that vitamin D metabolism dysfunction increases the risk of mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Mohammed Faraz Rafey, Razk Abdalgwad, Paula Mary O'Shea, Siobhan Foy, Brid Claffey, Colin Davenport, Derek Timothy O'Keeffe, Francis Martin Finucane
Summary: This study found that completion of a low energy liquid diet led to a reduction in insulin resistance and cardiovascular risk in patients with severe obesity, proportional to weight loss.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Jordan D. Reis, Roy Heyne, Charles R. Rosenfeld, Maria Caraig, L. Steven Brown, P. J. Burchfield, Cheryl S. Lair, Elen Petrosyan, Theresa Jabob, David B. Nelson, Luc P. Brion
Summary: This study compared the effects of two modes of human milk fortification on very low-birthweight infants. Infants in the experimental arm showed similar body mass index, blood pressure, and estimated glomerular filtration rate compared to controls, but had higher rates of central obesity and serum leptin:adiponectin ratio.
JOURNAL OF PERINATOLOGY
(2023)
Review
Food Science & Technology
Luigi Barrea, Matteo Megna, Sara Cacciapuoti, Evelyn Frias-Toral, Gabriella Fabbrocini, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Psoriasis is a chronic immune-mediated skin disease influenced by genetic and lifestyle factors. Nutrition and obesity are significant contributors to its pathogenesis and severity. Certain diets with anti-inflammatory properties, such as the very-low-calorie ketogenic diet (VLCKD), may improve clinical severity by reducing weight and systemic inflammation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Dario Tuccinardi, Eleonora Moriconi, Laura Di Renzo, Giovanna Muscogiuri, Annamaria Colao, Silvia Savastano
Summary: Cancer cells predominantly utilize aerobic glycolysis for metabolism. This characteristic has led to the hypothesis that dietary manipulation, such as a ketogenic diet, can influence tumor treatment and prognosis. The effectiveness of the ketogenic diet in cancer management may be attributed to various mechanisms, beyond the originally proposed glucose/insulin signaling inhibition. A qualified nutritionist is essential in managing the potential complications of this dietary therapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Giovanna Muscogiuri, Luigi Barrea, Massimiliano Caprio, Florencia Ceriani, Alberto O. Chavez, Marwan El Ghoch, Evelyn Frias-Toral, Rucha J. Mehta, Verna Mendez, Stavroula A. Paschou, Agnieszka Pazderska, Silvia Savastano, Annamaria Colao
Summary: Obesity and its related comorbidities, such as type 2 diabetes, are significant global public health issues. Insulin resistance in muscle and liver is the underlying pathophysiologic defect leading to obesity and predicting the onset of type 2 diabetes. Despite the well-recognized role of insulin resistance in metabolic diseases, there are currently no specific nutritional recommendations for managing this condition. An international panel of experts reviewed the literature on this topic and aimed to provide nutritional advice for managing insulin resistance, hyperinsulinemia, and reactive hypoglycemia to prevent the progression or worsening of insulin resistance and, ultimately, type 2 diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Luigi Barrea, Gabriella Pugliese, Evelyn Frias-Toral, Marwan El Ghoche, Bianca Castellucci, Sebastian Pablo Chapela, Maria de los Angeles Carignano, Daniela Laudisio, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This review provides an update on the benefits of coffee consumption on health outcomes, highlighting its potential for preventing inflammatory and oxidative stress-related diseases, reducing the incidence of certain cancers, and lowering the risk of all-cause mortality. However, more randomized controlled studies are needed to establish a causal link between coffee intake and health outcomes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Luigi Barrea, Claudia Vetrani, Massimiliano Caprio, Marwan El Ghoch, Evelyn Frias-Toral, Rucha J. Mehta, Verna Mendez, Eleonora Moriconi, Stavroula A. Paschou, Agnieszka Pazderska, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This article reviews the evidence and uncertainties surrounding nutritional therapy for patients with type 2 diabetes and obesity, providing guidance for clinical practice.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cell Biology
Mario Detomas, Claudia Pivonello, Bianca Pellegrini, Laura-Sophie Landwehr, Silviu Sbiera, Rosario Pivonello, Cristina L. Ronchi, Annamaria Colao, Barbara Altieri, Maria Cristina De Martino
Summary: Non-coding RNAs play a crucial role in regulating gene expression and have potential applications in the diagnosis, treatment, and management of various human diseases. Dysregulation of non-coding RNAs may be involved in the development and progression of adrenocortical carcinoma.
Article
Endocrinology & Metabolism
Marianna Minnetti, Valeria Hasenmajer, Emilia Sbardella, Francesco Angelini, Chiara Simeoli, Nicola Di Paola, Alessia Cozzolino, Claudia Pivonello, Dario De Alcubierre, Sabrina Chiloiro, Roberto Baldelli, Laura De Marinis, Rosario Pivonello, Riccardo Pofi, Andrea M. Isidori
Summary: This study developed the ICARO questionnaire to investigate the prevalence of infections in patients with glucocorticoid disorders. The results showed a high prevalence of self-reported infections in these patients. The ICARO questionnaire could serve as a valuable tool for monitoring infections in various clinical settings.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ludovica Verde, Maria Dalamaga, Xavier Capo, Giuseppe Annunziata, Maria Hassapidou, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea
Summary: High adherence to the Mediterranean diet (MD) leads to better results in the very low-calorie ketogenic diet (VLCKD), possibly due to the antioxidant and anti-inflammatory properties of the MD, which create a metabolic state favorable for more effective ketosis.
Review
Biochemistry & Molecular Biology
Luigi Barrea, Claudia Vetrani, Ludovica Verde, Evelyn Frias-Toral, Florencia Ceriani, Simona Cernea, Annamaria Docimo, Chiara Graziadio, Devjit Tripathy, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Diet is crucial in the pathogenesis of T2DM. Individualized medical nutritional therapy has been shown to improve outcomes, and various eating patterns have proven benefits for T2DM patients. Personalized meal plans should be considered, with reduced carbohydrate intake and replacement of high GI foods. The quality of fats is important, and supplementation with antioxidants or micronutrients is not recommended.
Review
Toxicology
Cristina de Angelis, Giacomo Galdiero, Davide Menafra, Francesco Garifalos, Nunzia Verde, Mariangela Piscopo, Mariarosaria Negri, Renata Simona Auriemma, Chiara Simeoli, Claudia Pivonello, Annamaria Colao, Rosario Pivonello
Summary: Cadmium is a known human carcinogen that affects male reproductive function. Epidemiological studies on the link between cadmium and testis cancer in humans are limited, but experimental studies in laboratory animals have shown that cadmium induces testis tumors. These tumors can be benign or malignant, and recent studies suggest that cadmium may contribute to tumor development through endocrine-independent mechanisms. However, there is a lack of direct investigation on testis tumor samples from cadmium-treated animals. This review focuses on the available human and animal studies on cadmium and testis cancer, and discusses the translational potential of experimental findings.
CRITICAL REVIEWS IN TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano, Filomena Morisco, Silvia Savastano
Summary: Visceral obesity is associated with the progression of NASH. CK18 epitopes M30 and M65 are accurate markers for detecting NASH. This study found that CK18M30 and CK18M65 levels were significantly correlated with anthropometric and metabolic characteristics, liver stiffness, and indices of steatosis and fibrosis in subjects with visceral obesity. These levels could serve as good biomarkers for early identification of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Nutrition & Dietetics
Mikiko Watanabe, Silvia Savastano, Carla Lubrano, Giovanni Spera
Article
Endocrinology & Metabolism
Barbara Altieri, Luigi Barrea, Roberta Modica, Filomena Bottiglieri, Federica de Cicco, Giovanna Muscogiuri, Luisa Circelli, Giovanni Savarese, Carolina Di Somma, Silvia Savastano, Annamaria Colao, Antongiulio Faggiano
Summary: Vitamin D deficiency is common among GEP-NET patients and may be associated with high tumor grade and disease progression. Monitoring of 25(OH)D levels is essential in these patients, and vitamin D supplementation should be considered in the management of GEP-NET patients with vitamin D deficiency or insufficiency.