One-Pot, Facile, Highly Efficient, and Green Synthesis of Acridinedione Derivatives Using Vitamin B1

An efficient methodology for the synthesis of acridinedione derivatives 4a-o has been achieved by one-pot, multicomponent condensation of dimedone 1, various amines 2a-d, and substitute aromatic aldehydes 3a-k, in the presence of the easily available, inexpensive, and nontoxic catalyst vitamin B-1 (VB1) as a versatile biodegradable. Synthesis of acridine-type compounds was performed in good yields in water as green solvent. Its high-yield efficiency; clean, ecofriendly, simple workup procedure; and easy purification are regarded as the main advantages of this method besides its green solvent. The synthesized compounds are characterized using spectroscopic analyses (FTIR, H-1 NMR, C-13 NMR, and high-resolution mass spectrometry) techniques.