期刊
SYNTHESIS-STUTTGART
卷 47, 期 12, 页码 1709-1715出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1378719
关键词
iron; nitrogen; bromine; alkenes; diastereoselectivity
资金
- National Institutes of Health [GM110382]
- Georgia State University
A new iron-catalyzed diastereoselective aminobromination method is reported for both internal and terminal olefins (yield up to 90% and dr up to >20:1). In this transformation, a functionalized hydroxylamine and bromide ion were used as the nitrogen and bromine source, respectively. This method is compatible with a broad range of olefins and provides a convenient approach to synthetically valuable vicinal bromo primary amines. Our studies suggest that both the diastereoselectivity and enantioselectivity for the olefin aminobromination can be controlled by iron catalysts.
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