Article
Biochemistry & Molecular Biology
Guang Huan Shen, Joon Hee Hong
Summary: This review discusses the synthesis of five series of 4'-truncated nucleotide phosphonic acid analogues and briefly discusses their biological activity results.
CARBOHYDRATE RESEARCH
(2022)
Article
Chemistry, Medicinal
Franck Amblard, Julia C. LeCher, Ramyani De, Shu Ling Goh, Chengwei Li, Mahesh Kasthuri, Nicolas Biteau, Longhu Zhou, Zahira Tber, Jessica Downs-Bowen, Keivan Zandi, Raymond F. Schinazi
Summary: This study reports the synthesis and evaluation of a series of novel NHC analogs for the treatment of early SARS-CoV-2 infections, among which Molnupiravir is approved for emergency use.
Article
Biochemistry & Molecular Biology
Ryuichi Majima, Tiffany C. C. Edwards, Christine D. D. Dreis, Robert J. J. Geraghty, Laurent F. F. Bonnac
Summary: We present a short synthesis method for novel C-nucleoside Remdesivir analogues and evaluate their cytotoxicity and in vitro efficacy against SARS-CoV-2 (CoV2). These compounds are nucleoside analogues with a nitrogen heterocycle as purine analogues. The designed hybrid structures aim to enhance the anti-CoV2 activity of Remdesivir. We discuss the impact of sugar and base modifications on the biological activities of these compounds, their lack of cytotoxicity, and their antiviral efficacy.
Article
Biochemistry & Molecular Biology
Simon Gonzalez, Gabriela Brzuska, Abdelhakim Ouarti, Florian Gallier, Carmen Solarte, Angelique Ferry, Jacques Uziel, Ewelina Krol, Nadege Lubin-Germain
Summary: The compound 2 carrying an N-hydroxy carboxamide function exhibited the most inhibitory activities against both Zika virus (ZIKV) and hepatitis C virus (HCV), suggesting it could be a potential candidate for the development of new anti-HCV and anti-ZIKV drugs.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Suliman Khan, Farnoosh Attar, Samir Haj Bloukh, Majid Sharifi, Faisal Nabi, Qian Bai, Rizwan Hasan Khan, Mojtaba Falahati
Summary: The study aimed to present an overview of NAs-based drug repurposing for targeting SARS-CoV-2 RdRp through computational analysis. Additionally, the clinical development of some NAs including Favipiravir, Sofosbuvir, Ribavirin, Tenofovir, and Remdesivir as potential inhibitors of RdRp was surveyed. Overall, exploring broad-spectrum NAs as promising inhibitors of RdRp may provide useful information about potential antiviral repurposed drugs against SARS-CoV-2.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Chenglong Zhao, Xiao Jia, Dominique Schols, Jan Balzarini, Chris Meier
Summary: This study presents the design of new nucleoside analogue derivatives with the aim of developing more effective anti-HIV drugs. These compounds were shown to be active against HIV in cell culture experiments, and the hydrolysis of the prodrug masks was investigated.
Review
Biochemistry & Molecular Biology
Guang Huan Shen, Joon Hee Hong
Summary: This review focuses on the synthesis of cyclic 5'-deoxynucleoside phosphonate analogs, discussing various methods for the formation of different alkyl moieties and the coupling of nucleobases with cyclic moieties. The biological activity of these analogs is summarized.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiao Jia, Dominique Schols, Chris Meier
Summary: This article describes the synthesis of two types of nucleotide prodrugs containing different nucleoside analogs and their effective inhibition against HIV-2 replication. The prodrugs exhibited high stability and antiviral activity in cell extracts.
Article
Chemistry, Organic
Jessica de Vries, Maik Assmann, Jasmin Janneschuetz, Judith Krauss, Mirja Gudzuhn, Stephanie Stanelle-Bertram, Guelsah Gabriel, Wolfgang R. Streit, Nina Schuetzenmeister
Summary: A series of chlorinated natural products, rubrolides, and their analogues were synthesized efficiently in only five steps using a divergent synthetic strategy. These compounds showed promising antiviral and antibiofilm activities against influenza A virus strains.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Dinesh J. Paymode, N. Vasudevan, Saeed Ahmad, Appasaheb L. Kadam, Flavio S. P. Cardoso, Justina M. Burns, Daniel W. Cook, Rodger W. Stringham, David R. Snead
Summary: This study presents a two-step synthesis of molnupiravir with high overall yield of 60%, emphasizing practical reaction and purification conditions. By limiting the total concentration of solvent and using environmentally friendly solvents, excellent throughput and sustainability were achieved in the operations.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Catarina Maria, Amelia P. Rauter
Summary: Nucleosides have attracted attention since the discovery of DNA structure. Nucleoside analogues can be synthesized through multiple pathways, with N-glycosylation of a nucleobase being the most common method. This review focuses on the synthesis and therapeutic applications of FDA approved nucleoside analogues as antiviral and anticancer agents, as well as their potential as antibacterial and anti-Alzheimer's disease agents.
CARBOHYDRATE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Sarkar M. A. Kawsar, Mohammed A. Hosen, Sajjad Ahmad, Youness El Bakri, Hamid Laaroussi, Taibi Ben Hadda, Faisal A. Almalki, Yasuhiro Ozeki, Souraya Goumri-Said
Summary: The study focuses on the modification and analysis of the RNA-dependent RNA polymerase of SARS-CoV-2, revealing promising antiviral properties of the modified derivatives and suggesting them as potential inhibitors against SARS-CoV-2.
Article
Microbiology
Julia C. LeCher, Keivan Zandi, Vivian Vasconcelos Costa, Franck Amblard, Sijia Tao, Dharmeshkumar Patel, Sujin Lee, Felipe Rocha da Silva Santos, Matheus Rodrigues Goncalves, Celso Martins Queroz-Junior, Fernanda Martins Marim, Katie Musall, Shu Ling Goh, Tamara McBrayer, Jessica Downs-Bowen, Ramyani De, Niloufar Azadi, James Kohler, Mauro Martins Teixeira, Raymond F. Schinazi
Summary: This study reports potential antiviral drugs against yellow fever virus, showing low toxicity, high intracellular metabolism, and strong anti-YFV activity in different models. The findings provide a new therapeutic option for treating yellow fever virus infections.
Article
Chemistry, Medicinal
Martina Salerno, Carmine Varricchio, Federica Bevilacqua, Dirk Jochmans, Johan Neyts, Andrea Brancale, Salvatore Ferla, Marcella Bassetto
Summary: Different viruses, such as enterovirus 71, rely on the host enzyme METTL3 to complete their cytoplasmic life cycle stages. By modulating the activity of this enzyme, it is possible to interfere with a broad range of viral infections. In this study, a series of nucleoside analogues were designed as inhibitors of human METTL3 to target multiple viral infections. Through molecular docking studies and synthesis, several novel and potent inhibitors of enterovirus 71 were identified.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Wendy Tran, Ali S. Kusay, Paige M. E. Hawkins, Chen-Yi Cheung, Gayathri Nagalingam, Venugopal Pujari, Daniel J. Ford, Alexander Stoye, Jessica L. Ochoa, Rebecca E. Audette, Elinor Hortle, Stefan H. Oehlers, Susan A. Charman, Roger G. Linington, Eric J. Rubin, Christopher G. Dowson, David Roper, Dean C. Crick, Thomas Balle, Gregory M. Cook, Warwick J. Britton, Richard J. Payne
Summary: The study reports the design and synthesis of inhibitors targeting Mtb MurX enzyme, showing potent antimicrobial activity against Mycobacterium tuberculosis. These inhibitors have the potential to be developed into new drugs for tuberculosis treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sushila Maharjan, Dinesh Koju, Hei Chan Lee, Jin Cheol Yoo, Jae Kyung Sohng
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Jaya Ram Simkhada, Hah-Young Yoo, Yun Hee Choi, Seung Wook Kim, Jin Cheol Yoo
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2012)
Article
Chemistry, Medicinal
Poonam Mander, Yun Hee Choi, Jeong Heon Seong, Baek Hee Na, Seung Sik Cho, Hyo Jeong Lee, Jin Cheol Yoo
ARCHIVES OF PHARMACAL RESEARCH
(2013)
Article
Biotechnology & Applied Microbiology
Seung Sik Cho, Da Jeong Park, Jaya Ram Simkhada, Joon Hee Hong, Jae Kyung Sohng, Oh Hyung Lee, Jin Cheol Yoo
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2012)
Article
Biotechnology & Applied Microbiology
Jaya Ram Simkhada, Hah Young Yoo, Seung Sik Cho, Yun Hee Choi, Seung Wook Kim, Don Hee Park, Jin Cheol Yoo
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2012)
Article
Biotechnology & Applied Microbiology
Seung Sik Cho, Yun Hee Choi, Jaya Ram Simkhada, Poonam Mander, Da Jeong Park, Jin Cheol Yoo
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2012)
Article
Biotechnology & Applied Microbiology
Jaya Ram Simkhada, Hah Young Yoo, Don Hee Park, Yun Hee Choi, Hyo Jeong Lee, Seung Wook Kim, Jin Cheol Yoo
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2013)
Article
Biotechnology & Applied Microbiology
Poonam Mander, Seung Sik Cho, Jaya Ram Simkhada, Yun Hee Choi, Da Jeong Park, Jung Wan Ha, Jin Cheol Yoo
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2012)
Article
Chemistry, Multidisciplinary
Hua Li, Jin Cheol Yoo, Joon Hee Hong
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2011)
Article
Chemistry, Multidisciplinary
Lien Kang, Eunae Kim, Eun Joo Choi, Jin Cheol Yoo, Wonjae Lee, Joon Hee Hong
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2012)
Article
Infectious Diseases
Yun Hee Choi, Seung Sik Cho, Jaya Ram Simkhada, Jin Cheol Yoo
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2012)
Correction
Biochemistry & Molecular Biology
Gwang Mo Namgoong, Prem Khanal, Hae-Guk Cho, Sung-Chul Lim, Yoon Kyeong Oh, Bong Seok Kang, Jung-Hyun Shim, Jin-Cheol Yoo, Hong Seok Choi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biotechnology & Applied Microbiology
Dinesh Koju, Sushila Maharjan, Dipesh Dhakal, Jin Cheol Yoo, Jae Kyung Sohng
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Poonam Mander, Seung Sik Cho, Jaya Ram Simkhada, Yun Hee Choi, Da Jeong Park, Jin Cheol Yoo
PROCESS BIOCHEMISTRY
(2012)
Article
Hematology
Jaya Ram Simkhada, Seung Sik Cho, Poonam Mander, Yun Hee Choi, Jin Cheol Yoo
THROMBOSIS RESEARCH
(2012)
