期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 29, 期 4-6, 页码 314-320出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257771003738634
关键词
Urat1; knockout mice; urate; allantoin
资金
- Grants-in-Aid for Scientific Research [21590355] Funding Source: KAKEN
In order to elucidate the mechanisms of post-exercise acute renal failure, one of the complications of hereditary renal hypouricemia, we have targeted the mouse Slc22a12 gene by the exchange of exons 1-4 with pMC1neo-polyA. The knockout mice revealed no gross anomalies. The concentration ratio of urinary urate/creatinine of the knockout mice was significantly higher than that of wildtype mice, indicating an attenuated renal reabsorption of urate. The plasma levels of urate were around 11 M and were similar among the genotypes. Although the fractional excretion of urate of knockout mice was tend to higher than that of wildtype mice, the urate reabsorption ability remained in the kidney of knockout mice, indicating a urate reabsorptive transporter other than Urat1.
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