期刊
NUCLEIC ACIDS RESEARCH
卷 46, 期 17, 页码 8966-8977出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gky705
关键词
-
资金
- Russian Foundation for Basic Research [17-04-00948 A]
- Russian Science Foundation [16-14-10047]
- Lomonosov Moscow State University Development Program [PNR 5.13]
- Russian Science Foundation [16-14-10047] Funding Source: Russian Science Foundation
Several studies have described functional peptides encoded in RNA that are considered to be noncoding. Telomerase RNA together with telomerase reverse transcriptase and regulatory proteins make up the telomerase complex, the major component of the telomere length-maintaining machinery. In contrast to protein subunits, telomerase RNA is expressed constitutively in most somatic cells where telomerase reverse transcriptase is absent. We show here that the transcript of human telomerase RNA codes a 121 amino acid protein (hTERP). The existence of hTERP was shown by immunoblotting, immunofluorescence microscopy and mass spectroscopy. Gain-of-function and loss-of-function experiments showed that hTERP protects cells from drug-induced apoptosis and participates in the processing of autophagosome. We suggest that hTERP regulates crosstalk between autophagy and apoptosis and is involved in cellular adaptation under stress conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据