Article
Genetics & Heredity
Derek H. Janssens, Michael P. Meers, Steven J. Wu, Ekaterina Babaeva, Soheil Meshinchi, Jay F. Sarthy, Kami Ahmad, Steven Henikoff
Summary: This study maps fusion-specific targets of KMT2A oncofusion proteins across the genome, revealing aberrant chromatin regulation induced by these fusion proteins and cell-to-cell heterogeneity at these sites, which can predict sensitivity to therapeutic agents. Automated and single-cell CUT&Tag profiling characterizes the effects of KMT2A fusion proteins on chromatin in human primary leukemia samples, identifying oncogenic networks and fusion-specific therapeutic vulnerabilities.
Review
Pharmacology & Pharmacy
Sandeep Kumar, Sunil Kumar Singh, Basabi Rana, Ajay Rana
Summary: Protein kinases are highly sought-after drug targets, with MAPK family members playing significant roles in various cancers; however, there is no effective monotherapy available.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Mathematics, Interdisciplinary Applications
Asifa Tassaddiq, Muhammad Tanveer, Muhammad Azhar, Muhammad Arshad, Farha Lakhani
Summary: In this article, an escape criteria using DK-iteration, complex sine function, and complex exponential function is established to analyze the dynamical behavior of specific fractals such as Julia set and Mandelbrot set. By generalizing existing algorithms, beautiful fractals for m=2, 3, and 4 are visualized. The image generation time using different input parameter values is also computed.
FRACTAL AND FRACTIONAL
(2023)
Article
Immunology
Yayi Gao, Monica Zamisch, Melanie Vacchio, Laura Chopp, Thomas Ciucci, Elliott L. Paine, Gaelyn C. Lyons, Jia Nie, Qi Xiao, Ekaterina Zvezdova, Paul E. Love, Charles R. Vinson, Lisa M. Jenkins, Remy Bosselut
Summary: The NuRD complex is identified as a critical cofactor for Thpok, a BTB-ZF transcription factor that controls T cell development. NuRD is involved in the repression of CD8(+) lineage genes by Thpok, but is dispensable for Cd4 expression. This study reveals the importance of cofactor binding in the functional specificity of BTB-ZF factors.
SCIENCE IMMUNOLOGY
(2022)
Article
Cell Biology
Ruiheng Wang, Shufeng Xie, Shouhai Zhu, Yong Sun, Bowen Shi, Dan Li, Ting Kang, Yuanli Wang, Zhenshu Xu, Han Liu
Summary: Oncogene-induced tumorigenesis leads to epigenetic modifications and increased cellular stress in cancer cells. In the case of MLL-rearranged acute myeloid leukemia (AML), hydroxyurea (HU) can induce cell death through necroptosis by targeting matrix metallopeptidase 2 (MMP2) deficiency. Iron chelation of HU is also crucial for inducing cell stress, and MMP2 plays a role in preventing protein response activation under innocuous endoplasmic reticulum stress. These findings suggest a potential application of HU in MLL-r AML treatment.
CELL DEATH DISCOVERY
(2022)
Review
Oncology
Xin Li, Yongcheng Song
Summary: MLL1 is a critical transcription factor essential for gene regulation during embryonic development and hematopoiesis, with dysregulation leading to leukemia. Targeted therapies against oncogenic fusion MLL1 are needed, with studies focused on protein-protein interactions for potential therapeutic interventions.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Biology
Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G. Kharas, Robert K. Bradley, Christopher R. Vakoc, Richard P. Koche, Alex Kentsis
Summary: The dysregulated gene expression in human cancers is often attributed to aberrant assembly of transcriptional co-activator complexes, as demonstrated in the case of acute myeloid leukemia (AML) subtypes. Targeted interference with MYB:CBP/P300 complexes can induce myeloid differentiation and apoptosis, providing a unified mechanism for oncogenic gene expression in AML. This study establishes a promising strategy for pharmacologic reprogramming and therapeutic targeting in diverse leukemias and potentially other human cancers.
Article
Mathematics, Applied
Yue Ma, Xinmin Hou, Jun Gao, Boyuan Liu, Zhi Yin
Summary: This article investigates rainbow independent sets in graphs and provides properties of the minimal number k under certain conditions. It also proves the validity of one conjecture assuming another conjecture is true.
DISCRETE APPLIED MATHEMATICS
(2022)
Article
Biochemistry & Molecular Biology
Corrado Caslini, Amparo Serna
Summary: MLL fusion proteins can regulate telomere transcription, leading to increased levels of telomeric repeat-containing RNA in patients with leukemia. The high levels of repeat-containing RNA are correlated with telomere length and chromatin structure, and are associated with the genomic stability caused by MLL fusion proteins in pediatric leukemia.
Review
Mathematics, Applied
Hui Xu, Tonghua Zhang, Huidong Cheng
Summary: This paper proposes and discusses a predation model with nonlinear state feedback control. The properties of the Poincare map defined on the phase set and the dynamic properties of the impulsive dynamic system are investigated. The precise pulse set and phase set of the Poincare map are discussed in various situations, and the analytical properties of the Poincare map are studied. The necessary and sufficient conditions for the global stability of the order-1 periodic solution of the impulsive semi-dynamic system are also examined.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Microbiology
Edgar E. Llontop, William Cenens, Denize C. Favaro, German G. Sgro, Roberto K. Salinas, Cristiane R. Guzzo, Chuck S. Farah
Summary: The study reveals that in Xanthomonas citri, the ATPase PilB can form a complex with two regulatory proteins, PilZ and c-di-GMP receptor FimX, and these proteins colocalize at the leading poles of the bacterial cells during surface motility. The X-ray structures of PilZ in complex with PilB's N-terminal domain and FimX's C-terminal domain allow for a proposed model of the three-way interaction between these proteins.
Article
Oncology
Timothy Kirtek, Weina Chen, Dorottya Laczko, Adam Bagg, Prasad Koduru, Kathryn Foucar, Elise Venable, Meredith Nichols, Heesun J. Rogers, Wayne Tam, Attilio Orazi, Eric D. Hsi, Robert P. Hasserjian, Sa A. Wang, Daniel A. Arber, Olga K. Weinberg
Summary: Mixed phenotype acute leukemia (MPAL) is a heterogenous group of acute leukemias characterized by leukemic blasts that express markers of multiple lineages. The genetic features of MPAL with complex karyotype (CK) remain poorly characterized due to its rarity. However, our study found that MPAL with CK showed similarly poor outcomes regardless of lineage differentiation and that TP53 mutations conferred a poor prognosis in all lineages. These results support the exclusion of MPAL with CK from MPAL and confirm the approach proposed in the revised 4th edition WHO to include them as AML with myelodysplasia-related changes and similar myelodysplasia-related AML categories of newer classifications.
Article
Oncology
Maolin Ge, Qiongyu Xu, Ting Kang, Dan Li, Ruiheng Wang, Zhihong Chen, Shufeng Xie, Wenbin Wang, Han Liu
Summary: Drug resistance is a major challenge in cancer treatment, and regulating cyclin A1 to alter reversible cell cycle dynamics can promote the development of PI tolerance. Combination therapy with PI and DUB inhibitors can overcome this drug resistance.
Article
Multidisciplinary Sciences
Jin Huang, Jing Zhou, Min Xiao, Xia Mao, Li Zhu, Songya Liu, Qinlu Li, Jin Wang, Jianfeng Zhou, Haodong Cai, Gaoxiang Wang
Summary: Acute leukemia with ambiguous lineage (ALAL) is a rare and highly aggressive malignancy that has limited molecular characterization and therapeutic recommendations. Mutation burden may play important roles in predicting the clinical outcomes of ALAL, and further large-scale prospective clinical studies are needed to evaluate the association of genetic complexity of blast cells with clinical outcomes and rationality of the diagnostic criteria of WHO system.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Charu Mehta, Isabela Fraga de Andrade, Daniel R. Matson, Colin N. Dewey, Emery H. Bresnick
Summary: The catalytic subunits Dis3 and Exosc10 of the EC play important roles in erythropoiesis, their depletion reduces erythroid progenitors and their progeny while sparing myeloid cells. Dis3 loss severely compromises erythroid progenitor and erythroblast survival, increases sensitivity to apoptosis-inducing stimuli, and induces DNA double-stranded breaks. Dis3 establishes a disease mutation-sensitive, cell type-specific survival mechanism for differentiation.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Biology
Aamir Ali, Shweta Tyagi
JOURNAL OF BIOSCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Zaffer Ullah Zargar, Mallikharjuna Rao Kimidi, Shweta Tyagi
NUCLEIC ACIDS RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Shweta Tyagi, Winship Herr
Article
Cell Biology
Amit Mahendra Karole, Swathi Chodisetty, Aamir Ali, Nidhi Kumari, Shweta Tyagi
Review
Biochemistry & Molecular Biology
Jeyapal Sugeedha, Jyoti Gautam, Shweta Tyagi
Summary: The SET1 family of enzymes are well known for their involvement in histone 3 lysine 4 methylation, with distinct biological functions and implications if impaired. Recent studies have shown novel non-canonical functions of these enzymes beyond H3K4 methylation, highlighting their importance in cellular functions.
Article
Cell Biology
Akash Chinchole, Kaisar Ahmad Lone, Shweta Tyagi
Summary: This study highlights the importance of MLL protein in regulating cell shape and migration. It was found that MLL affects the actin cytoskeleton and cell migration by regulating the stability of Rho GTPases, rather than directly transcriptionally regulating them. Additionally, MLL was found to regulate the transcript levels of the chaperone protein RhoGDI1.
JOURNAL OF CELL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Avishek Kataria, Shweta Tyagi
Summary: Tri-methylation of H3K4 is an important epigenetic modification, and KDM5A is a known demethylase that plays multiple roles in cellular processes. Its association with various diseases makes it a significant target for drug development. However, understanding its recruitment mechanism and regulation on chromatin remains a challenge.
Article
Cell Biology
Aamir Ali, Sailaja Naga Veeranki, Akash Chinchole, Shweta Tyagi
DEVELOPMENTAL CELL
(2017)
Article
Biochemistry & Molecular Biology
Shweta Tyagi, Anna Lena Chabes, Joanna Wysocka, Winship Herr
Article
Biochemistry & Molecular Biology
Zaffer Ullah Zargar, Shweta Tyagi
TRANSCRIPTION-AUSTIN
(2012)