Editorial Material
Endocrinology & Metabolism
Monara Kaelle Servulo Cruz Angelim, Pedro M. Moraes-Vieira
Summary: The rate of glycolysis increases significantly during phagocytosis of apoptotic cells and macrophage activation by inflammatory signals. However, the reasons for glucose utilization differ in these two conditions.
Article
Cell Biology
Sofia Cardenas, Cecilia Colombero, Mariana Cruz, Eduardo Mormandi, Adeniyi Michael Adebesin, John R. Falck, Susana Nowicki
Summary: The membrane receptor GPR75 plays a role in regulating the expression and transcriptional activity of androgen receptor (AR) in prostate cancer (PCa) cells mediated by 20-hydroxyeicosatetraenoic acid (20-HETE). This suggests that targeting 20-HETE/GPR75 could be a potential strategy to limit the expression of AR-driven phenotype in PCa cells.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Oncology
Miki Naito, Kenichiro Ikeda, Shunya Aoyama, Mayu Kanamoto, Yasuyuki Akasaka, Yuri Kido, Mikako Nakanishi, Machi Kanna, Takeshi Yamamotoya, Akio Matsubara, Nobuyuki Hinata, Tomoichiro Asano, Yusuke Nakatsu
Summary: Par14, an isoform of Pin1 homologous to prolyl isomerases, is shown to be overexpressed in prostate cancer (PCa) and plays a critical role in PCa progression. It enhances the growth of androgen-sensitive LNCap cells and regulates the expression of androgen response genes through its association with AR and modulation of p53 localization. These findings suggest Par14 as a potential therapeutic target for PCa.
Article
Biochemistry & Molecular Biology
A. B. M. Kaiser Manjur, Joanna K. Lempiainen, Marjo Malinen, Markku Varjosalo, Jorma J. Palvimo, Einari A. Niskanen
Summary: BCOR has been identified as an essential interaction partner of GR, involved in the GC signaling pathway and affecting the expression of genes related to TNF signaling, GR signaling, and cell migration pathways. Depletion of BCOR, along with NCOR1, enhances cell migration and influences GR target gene expression in a combinatorial and gene-specific manner.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Environmental Sciences
Yuseok Moon, Tamas Korcsmaros, Arulkumar Nagappan, Navin Ray
Summary: Stress-responsive microRNAs play a role in regulating cellular homeostasis and pathological processes, such as carcinogenesis, in response to environmental or dietary xenobiotics. The targets of carcinogenic mycotoxin-responsive miRNAs are associated with metabolism- or hormone-related diseases, including sex hormone-linked cancers. This study provides novel insights into the progression and intervention against adverse outcomes of human exposure to environmental oncogenic insults.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Mark N. Adams, Laura V. Croft, Aaron Urquhart, Mohamed Ashick Mohamed Saleem, Anja Rockstroh, Pascal H. G. Duijf, Patrick B. Thomas, Genevieve P. Ferguson, Idris Mohd Najib, Esha T. T. Shah, Emma Bolderson, Shivashankar Nagaraj, Elizabeth D. Williams, Colleen C. Nelson, Kenneth J. O'Byrne, Derek J. Richard
Summary: This study evaluated the role of hSSB1/NABP2 in modulating the cellular response to androgens and ionizing radiation in prostate cancer. The expression of hSSB1 in prostate cancer is correlated with genomic instability and it regulates pathways involved in cell cycle progression and transcription. Additionally, hSSB1 is involved in modulating androgen response through transcriptional regulation. Exploiting hSSB1 in prostate cancer treatment might improve patient outcomes in ADT and/or radiotherapy.
Article
Biochemistry & Molecular Biology
Jacobus C. Buurstede, Susana N. Paul, Karolien De Bosscher, Onno C. Meijer, Jan Kroon
Summary: Glucocorticoids exert their effects by activating the glucocorticoid receptor (GR) throughout the body. This study investigated the interaction between glucocorticoids and androgen signaling in the liver transcriptome. The results showed that a substantial proportion of the hepatic transcriptome is androgen-dependent after chronic exposure, while the effects of glucocorticoids are largely androgen-independent after acute exposure. The study suggests that prolonged glucocorticoid exposure may upregulate androgen receptor expression, leading to androgen dependence not driven by direct interactions between the androgen receptor and glucocorticoid receptor.
Article
Multidisciplinary Sciences
Haitham A. Elmarakeby, Justin Hwang, Rand Arafeh, Jett Crowdis, Sydney Gang, David Liu, Saud H. AlDubayan, Keyan Salari, Steven Kregel, Camden Richter, Taylor E. Arnoff, Jihye Park, William C. Hahn, Eliezer M. Van Allen
Summary: The development of a biologically informed deep learning model P-NET enables stratification of prostate cancer patients by treatment-resistance state and evaluation of molecular drivers of treatment resistance for therapeutic targeting with complete model interpretability. This approach shows superior performance in cancer state prediction using molecular data compared to other modeling approaches.
Article
Immunology
Hongwei Wang, Xu Wang, Yubin Shen, Yanmin Wang, Tianyun Yang, Jinyuan Sun, Song Liu
Summary: Chronic intermittent hypoxia (CIH) is a characteristic pathological change of obstructive sleep apnea syndrome (OSAS). Inflammation of microglia induced by CIH plays a crucial role in OSAS-associated cognitive dysfunction. SUMO-specific proteases 1 (SENP1) has been implicated in tumor inflammatory microenvironment and cell migration, but its role in CIH-induced neuroinflammation is still unknown.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Martin L. Watzenboeck, Barbara Drobits, Sophie Zahalka, Anna-Dorothea Gorki, Asma Farhat, Federica Quattrone, Anastasiya Hladik, Karin Lakovits, Gabriel M. Richard, Therese Lederer, Birgit Strobl, Gijs A. Versteeg, Louis Boon, Philipp Starkl, Sylvia Knapp
Summary: The study demonstrates the protective role of LCN2 in influenza infection by modulating immune responses and antigen processing via CD103(+) DCs. LCN2 deficiency leads to dysregulated immune response and increased disease severity, while its effects are mediated through microbiome modulation.
Article
Oncology
Salah Boudjadi, Puspa Raj Pandey, Bishwanath Chatterjee, Thanh Hung Nguyen, Wenyue Sun, Frederic G. Barr
Summary: In a model of cancer initiated by a fusion transcription factor, constitutive activation of a downstream transcriptional target leads to fusion oncoprotein-independent recurrences, thereby highlighting a novel progression mechanism and therapeutic target.
Article
Multidisciplinary Sciences
Wooi F. Lim, Mitra Forouhan, Thomas C. Roberts, Jesse Dabney, Ruth Ellerington, Alfina A. Speciale, Raquel Manzano, Maria Lieto, Gavinda Sangha, Subhashis Banerjee, Mariana Conceicao, Lara Cravo, Annabelle Biscans, Loic Roux, Naemeh Pourshafie, Christopher Grunseich, Stephanie Duguez, Anastasia Khvorova, Maria Pennuto, Constanza J. Cortes, Albert R. La Spada, Kenneth H. Fischbeck, Matthew J. A. Wood, Carlo Rinaldi
Summary: SBMA is a neuromuscular disease caused by a polyQ expansion in AR protein, with recent studies highlighting the importance of mutant AR-altered transcriptional activity. Targeting AR isoform 2 can ameliorate the disease phenotype in SBMA mice by restoring dysregulated transcriptional activity of polyQ AR protein.
Article
Biochemistry & Molecular Biology
Paulina Kobylka, Malgorzata Kucinska, Jacek Kujawski, Dawid Lazewski, Marcin Wierzchowski, Marek Murias
Summary: Resveratrol, a plant-derived phytoalexin, has pleiotropic biological activities, particularly anticancer and chemopreventive properties. It interacts with estrogen receptors and functions as a mixed agonist/antagonist. The hydroxyl groups are crucial for its cytotoxic and antioxidative activities. Through experiments and computational simulations, specific analogues of resveratrol were found to act as selective estrogen receptor modulators.
Article
Oncology
Shalakha Sharma, Witty Tyagi, Rohini Tamang, Sanjeev Das
Summary: This study reveals that HDAC5 interacts with and deacetylates SATB1, with the acetylation of SATB1 at lysine 411 regulated by TIP60 acetyltransferase. HDAC5-mediated deacetylation is critical for the downregulation of key tumor suppressor genes by SATB1 and the repression of SDHA-induced epigenetic remodeling and anti-proliferative transcriptional program. These findings shed light on the molecular mechanisms underlying SATB1-promoted tumor growth and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Yanfang Li, Sha Li, Yizhou Zhang, Shuhong Shi, Shan Qin, Chang Wang, Juan Du, Jingle Ma, Huan Chen, Huixian Cui
Summary: This study found that the expression of androgen receptor (AR) in ovarian cancer tissues was significantly elevated, particularly in low-grade EOC, with high AR expression suggesting a worse prognosis. In vitro studies showed that testosterone promoted proliferation in AR-positive SKOV3 cells, which was blocked by flutamide, indicating the role of AR in ovarian cancer cell growth. Mechanism studies revealed that AR-dependent testosterone-induced proliferation activated the PI3K/AKT signaling pathway, suggesting that AR may be a screening indicator for anti-androgen therapy sensitive cases of EOC.
Article
Biochemistry & Molecular Biology
Prashant Rawat, Marc Boehning, Barbara Hummel, Fernando Aprile-Garcia, Anwit S. Pandit, Nathalie Eisenhardt, Ashkan Khavaran, Einari Niskanen, Seychelle M. Vos, Jorma J. Palvimo, Andrea Pichler, Patrick Cramer, Ritwick Sawarkar
Summary: Under stress conditions, NELF rapidly forms nuclear condensates, facilitating enhanced recruitment to gene promoters and driving transcriptional downregulation, which is essential for cellular viability under stress. These stress-induced condensates may play a critical role in the coordinated downregulation of transcription and translation as part of the stress survival strategy.
Article
Biochemistry & Molecular Biology
Ville Paakinaho, Joanna K. Lempiainen, Gianluca Sigismondo, Einari A. Niskanen, Marjo Malinen, Tiina Jaaskelainen, Markku Varjosalo, Jeroen Krijgsveld, Jorma J. Palvimo
Summary: SUMOylation regulates the specificity of GR by modulating its chromatin protein network and accessibility at GR-bound enhancers, affecting chromatin binding and target gene expression.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Heming Wang, Raymond Noordam, Brian E. Cade, Karen Schwander, Thomas W. Winkler, Jiwon Lee, Yun Ju Sung, Amy R. Bentley, Alisa K. Manning, Hugues Aschard, Tuomas O. Kilpelainen, Marjan Ilkov, Michael R. Brown, Andrea R. Horimoto, Melissa Richard, Traci M. Bartz, Dina Vojinovic, Elise Lim, Jovia L. Nierenberg, Yongmei Liu, Kumaraswamynaidu Chitrala, Tuomo Rankinen, Solomon K. Musani, Nora Franceschini, Rainer Rauramaa, Maris Alver, Phyllis C. Zee, Sarah E. Harris, Peter J. van Der Most, Ilja M. Nolte, Patricia B. Munroe, Nicholette D. Palmer, Brigitte Kuhnel, Stefan Weiss, Wanqing Wen, Kelly A. Hall, Leo-Pekka Lyytikainen, Jeff O. Connell, Gudny Eiriksdottir, Lenore J. Launer, Paul S. de Vries, Dan E. Arking, Han Chen, Eric Boerwinkle, Jose E. Krieger, Pamela J. Schreiner, Stephen Sidney, James M. Shikany, Kenneth Rice, Yii-Der Ida Chen, Sina A. Gharib, Joshua C. Bis, Annemarie Luik, M. Arfan Ikram, Andre G. Uitterlinden, Najaf Amin, Hanfei Xu, Daniel Levy, Jiang He, Kurt K. Lohman, Alan B. Zonderman, Treva K. Rice, Mario Sims, Gregory Wilson, Tamar Sofer, Stephen S. Rich, Walter Palmas, Jie Yao, Xiuqing Guo, Jerome Rotter, Nienke R. Biermasz, Dennis O. Mook-Kanamori, Lisa W. Martin, Ana Barac, Robert B. Wallace, Daniel J. Gottlieb, Pirjo Komulainen, Sami Heikkinen, Reedik Magi, Lili Milani, Andres Metspalu, John M. Starr, Yuri Milaneschi, R. J. Waken, Chuan Gao, Melanie Waldenberger, Annette Peters, Konstantin Strauch, Thomas Meitinger, Till Roenneberg, Uwe Volker, Marcus Dorr, Xiao-Ou Shu, Sutapa Mukherjee, David R. Hillman, Mika Kahonen, Lynne E. Wagenknecht, Christian Gieger, Hans J. Grabe, Wei Zheng, Lyle J. Palmer, Terho Lehtimaki, Vilmundur Gudnason, Alanna C. Morrison, Alexandre C. Pereira, Myriam Fornage, Bruce M. Psaty, Cornelia M. van Duijn, Ching-Ti Liu, Tanika N. Kelly, Michele K. Evans, Claude Bouchard, Ervin R. Fox, Charles Kooperberg, Xiaofeng Zhu, Timo A. Lakka, Tonu Esko, Kari E. North, Ian J. Deary, Harold Snieder, Brenda W. J. H. Penninx, W. James Gauderman, Dabeeru C. Rao, Susan Redline, Diana van Heemst
Summary: Long and short sleep durations are associated with elevated blood pressure, and genetic factors may play a role in this relationship. Interactions between specific genes and sleep duration were identified, with some genes increasing blood pressure in long sleepers and others increasing blood pressure in short sleepers. This study suggests that the mechanisms regulating blood pressure may be influenced by sleep, providing novel insights into the regulation of sleep-related blood pressure.
MOLECULAR PSYCHIATRY
(2021)
Article
Oncology
Emmi Karkkainen, Sami Heikkinen, Maria Tengstrom, Veli-Matti Kosma, Arto Mannermaa, Jaana M. Hartikainen
Summary: The study identified three small RNAs possibly acting as candidate biomarkers for breast cancer (BC), with DQ571955 showing potential as a predictive marker for radiotherapy response in estrogen receptor positive BC, DQ596932 having prognostic value in BC, and DQ570994 identified as a candidate predictive marker for tamoxifen and chemotherapy response. These findings suggest that the prevalence of piRNAs in cancer may not be as extensive as previously thought.
Article
Cell Biology
Jolien Vandewalle, Steven Timmermans, Ville Paakinaho, Lies Vancraeynest, Liza Dewyse, Tineke Vanderhaeghen, Charlotte Wallaeys, Lise Van Wyngene, Kelly Van Looveren, Louise Nuyttens, Melanie Eggermont, Sylviane Dewaele, Tiago R. Velho, Luis F. Moita, Sebastian Weis, Christoph Sponholz, Leo A. van Grunsven, Mieke Dewerchin, Peter Carmeliet, Karolien De Bosscher, Johan Van de Voorde, Jorma J. Palvimo, Claude Libert
Summary: Defects in the glucocorticoid receptor signaling pathway exacerbate sepsis pathophysiology by reducing lactate clearance and sensitizing mice to lactate-induced toxicity, ultimately leading to lethal vascular collapse.
Review
Oncology
Ville Paakinaho, Jorma J. Palvimo
Summary: Recent studies indicate that interactions between steroid receptors in breast and prostate cancers can lead to the rewiring of gene programs, altering biological processes and impacting disease progression.
ENDOCRINE-RELATED CANCER
(2021)
Article
Biochemistry & Molecular Biology
Sarah El Kharraz, Vanessa Dubois, Martin E. van Royen, Adriaan B. Houtsmuller, Ekatarina Pavlova, Nina Atanassova, Tien Nguyen, Arnout Voet, Roy Eerlings, Florian Handle, Stefan Prekovic, Elien Smeets, Lisa Moris, Wout Devlies, Claes Ohlsson, Matti Poutanen, Kevin J. Verstrepen, Geert Carmeliet, Kaisa-Mari Launonen, Laura Helminen, Jorma J. Palvimo, Claude Libert, Dirk Vanderschueren, Christine Helsen, Frank Claessens
Summary: Dimerization of the ligand-binding domain of the androgen receptor (AR) is crucial for transcriptional regulation and proper functioning of AR. Mutations disrupting LBD dimerization can lead to significant effects, as demonstrated in a mouse model in this study.
Article
Biochemistry & Molecular Biology
Tineke Vanderhaeghen, Steven Timmermans, Deepika Watts, Ville Paakinaho, Melanie Eggermont, Jolien Vandewalle, Charlotte Wallaeys, Lise Van Wyngene, Kelly Van Looveren, Louise Nuyttens, Sylviane Dewaele, Joke Vanden Berghe, Kelly Lemeire, Joey De Backer, Laura Dirkx, Wim Vanden Berghe, Guy Caljon, Bart Ghesquiere, Karolien De Bosscher, Ben Wielockx, Jorma J. Palvimo, Rudi Beyaert, Claude Libert
Summary: The study found that hypoxia impacts the hepatic response of glucocorticoid receptors to dexamethasone in mice, leading to three types of reprogramming of GR: weaker induction of classical GR-responsive genes, induction of specific genes in hypoxia, and activation of a group of genes by the HPA axis under hypoxia. Additionally, hypoxia-induced activation of the HPA axis is associated with GR-dependent lipolysis and ketogenesis.
Article
Environmental Sciences
Maria-Elisa Nordberg, Martin Taubel, Sami Heikkinen, Kaisa Jalkanen, Arto Kolio, Marianne Stranger, Hanna Leppanen, Anne Hyvarinen, Kati Huttunen
Summary: This study focused on characterizing gene expression in human airway epithelium after exposure to indoor air particulate matter from houses with and without moisture damage. The results showed that exposure to particulate matter from moisture-damaged houses activated toxicology-related genes in airway constructs, with differential expression not consistent among all matched pairs. Key potential targets in moisture damage-associated cellular responses were highlighted, including CYP1A1 and NFKB1.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Immunology
Henna-Riikka Malmberg, Andrea Hanel, Mari Taipale, Sami Heikkinen, Carsten Carlberg
Summary: This study found that 1,25(OH)(2)D-3 significantly modulates the functional consequences of immune challenges, but the effects largely depend on treatment sequence. The results suggest that a sufficient vitamin D status before an infection may be more important than vitamin D supplementation afterwards.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Kirsi Kainulainen, Piia Takabe, Sami Heikkinen, Niina Aaltonen, Carol de la Motte, Leena Rauhala, Franziska C. Durst, Sanna Oikari, Taija Hukkanen, Eija Rahunen, Ella Ikonen, Jaana M. Hartikainen, Kirsi Ketola, Sanna Pasonen-Seppanen
Summary: This study investigated the effects of proinflammatory and immunosuppressive macrophages on hyaluronan matrix formation and inflammatory response in melanoma cells. The results showed that proinflammatory macrophages stimulated the formation of a thick hyaluronan matrix and induced inflammation and invasion in melanoma cells, while immunosuppressive macrophages had no effect on these processes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Ricardo J. Samms, Christine C. Cheng, Marcel Fourcaudot, Sami Heikkinen, Ahmed Khattab, John Adams, Eugenio Cersosimo, Curtis Triplitt, Curtis Puckett, Kostas Tsintzas, Andrew. C. Adams, Muhammad A. Abdul-Ghani, Ralph A. DeFronzo, Luke Norton
Summary: In patients with type 2 diabetes treated with metformin/pioglitazone/exenatide triple therapy, total and bioactive plasma FGF21 levels were reduced, and the proportion of circulating bioactive FGF21 increased, compared to patients treated with metformin and sequential addition of glipizide and basal insulin glargine (conventional therapy). These findings suggest that FGF21 may contribute to the glycemic benefits observed following combination therapy in patients with type 2 diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Sarah El Kharraz, Vanessa Dubois, Kaisa-Mari Launonen, Laura Helminen, Jorma J. Palvimo, Claude Libert, Elien Smeets, Lisa Moris, Roy Eerlings, Dirk Vanderschueren, Christine Helsen, Frank Claessens
Summary: Research suggests that the N/C interactions in the androgen receptor (AR) are not essential for the development of male phenotype under normal physiological conditions.
Article
Multidisciplinary Sciences
Emmi Karkkainen, Sami Heikkinen, Maria Tengstrom, Veli-Matti Kosma, Arto Mannermaa, Jaana M. Hartikainen
Summary: This study demonstrates the clinical relevance of small non-coding RNAs (sncRNAs) in invasive breast cancer. SncRNAs can be used as prognostic and predictive biomarkers, providing new insights into breast cancer treatment.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Daokun Sun, Melissa A. Richard, Solomon K. Musani, Yun Ju Sung, Thomas W. Winkler, Karen Schwander, Jin Fang Chai, Xiuqing Guo, Tuomas O. Kilpelainen, Dina Vojinovic, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Michael R. Brown, Kumaraswamy Chitrala, Fernando P. Hartwig, Andrea R. V. R. Horimoto, Yongmei Liu, Alisa K. Manning, Raymond Noordam, Albert Smith, Sarah E. Harris, Brigitte Kuehnel, Leo-Pekka Lyytikainen, Ilja M. Nolte, Rainer Rauramaa, Peter J. van der Most, Rujia Wang, Erin B. Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Dan E. Arking, Donna K. Arnett, Ana Barac, Eric Boerwinkle, Ulrich Broeckel, Aravinda Chakravarti, Yii-Der Ida Chen, L. Adrienne Cupples, Martha L. Davigulus, Lisa de las Fuentes, Renee de Mutsert, Paul S. de Vries, Joseph A. C. Delaney, Ana V. Diez Roux, Marcus Dorr, Jessica D. Faul, Amanda M. Fretts, Linda C. Gallo, Hans Jorgen Grabe, C. Charles Gu, Tamara B. Harris, Catharina C. A. Hartman, Sami Heikkinen, M. Arfan Ikram, Carmen Isasi, W. Craig Johnson, Jost Bruno Jonas, Robert C. Kaplan, Pirjo Komulainen, Jose E. Krieger, Daniel Levy, Jianjun Liu, Kurt Lohman, Annemarie Luik, Lisa W. Martin, Thomas Meitinger, Yuri Milaneschi, Jeff R. O'Connell, Walter R. Palmas, Annette Peters, Patricia A. Peyser, Laura Pulkki-Raback, Leslie J. Raffel, Alex P. Reiner, Kenneth Rice, Jennifer G. Robinson, Frits R. Rosendaal, Carsten Oliver Schmidt, Pamela J. Schreiner, Lars Schwettmann, James M. Shikany, Xiao-ou Shu, Stephen Sidney, Mario Sims, Jennifer A. Smith, Nona Sotoodehnia, Konstantin Strauch, E. Shyong Tai, Kent D. Taylor, Andre G. Uitterlinden, Cornelia M. van Duijn, Melanie Waldenberger, Hwee-Lin Wee, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Donglin Zeng, Wei Zhao, Xiaofeng Zhu, Alan B. Zonderman, Diane M. Becker, Ian J. Deary, Christian Gieger, Timo A. Lakka, Terho Lehtimaki, Kari E. North, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Harold Snieder, Ya-Xing Wang, David R. Weir, Wei Zheng, Michele K. Evans, W. James Gauderman, Vilmundur Gudnason, Bernardo L. Horta, Ching-Ti Liu, Dennis O. Mook-Kanamori, Alanna C. Morrison, Alexandre C. Pereira, Bruce M. Psaty, Najaf Amin, Ervin R. Fox, Charles Kooperberg, Xueling Sim, Laura Bierut, Jerome Rotter, Sharon L. R. Kardia, Nora Franceschini, Dabeeru C. Rao, Myriam Fornage
Summary: Psychological and social factors play important roles in gene discovery for blood pressure, especially in non-European populations. The novel associations revealed that these factors are mostly related to pulse pressure, with fewer associations observed with mean arterial pressure. In African ancestry, most of the newly identified loci showed patterns of interaction with at least one psychosocial factor.
HUMAN GENETICS AND GENOMICS ADVANCES
(2021)