The monomeric GIY-YIG homing endonuclease I-BmoI uses a molecular anchor and a flexible tether to sequentially nick DNA

Differential scanning calorimetry as a tool for protein folding and stability

(2012) Christopher M. Johnson   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo

(2012) Andreas Brachner et al.   JOURNAL OF CELL SCIENCE

Structural, functional and evolutionary relationships between homing endonucleases and proteins from their host organisms

(2012) G. K. Taylor et al.   NUCLEIC ACIDS RESEARCH

Monomeric site-specific nucleases for genome editing

(2012) B. P. Kleinstiver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type II restriction endonuclease R.Hpy188I belongs to the GIY-YIG nuclease superfamily, but exhibits an unusual active site

(2012) Katarzyna H Kaminska et al.   BMC STRUCTURAL BIOLOGY

Target site cleavage by the monomeric restriction enzyme BcnI requires translocation to a random DNA sequence and a switch in enzyme orientation

(2011) Giedrius Sasnauskas et al.   NUCLEIC ACIDS RESEARCH

Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases

(2011) Ines Fonfara et al.   NUCLEIC ACIDS RESEARCH

Divalent Metal Ion Differentially Regulates the Sequential Nicking Reactions of the GIY-YIG Homing Endonuclease I-BmoI

(2011) Benjamin P. Kleinstiver et al.   PLoS One

Structure of Bacteriophage T4 Endonuclease II Mutant E118A, a Tetrameric GIY-YIG Enzyme

(2010) C. Evalena Andersson et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site

(2010) Giedrius Sasnauskas et al.   NUCLEIC ACIDS RESEARCH

A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI

(2010) Benjamin P. Kleinstiver et al.   NUCLEIC ACIDS RESEARCH

Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element

(2010) Mikael Crona et al.   NUCLEIC ACIDS RESEARCH

Hpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysis

(2010) M. Sokolowska et al.   NUCLEIC ACIDS RESEARCH

Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificity

(2010) S.-H. Chan et al.   NUCLEIC ACIDS RESEARCH

Nucleases: diversity of structure, function and mechanism

(2010) Wei Yang   QUARTERLY REVIEWS OF BIOPHYSICS

Folding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI

(2010) Amanda Nga-Sze Mak et al.   STRUCTURE

Selfish DNA: Homing Endonucleases Find a Home

(2009) David R. Edgell   CURRENT BIOLOGY

Oligomeric Structure Diversity within the GIY-YIG Nuclease Family

(2009) Elena M. Ibryashkina et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacteriophage T4 endonuclease II, a promiscuous GIY-YIG nuclease, binds as a tetramer to two DNA substrates

(2009) Pernilla Lagerbäck et al.   NUCLEIC ACIDS RESEARCH

Domain Organization and Functional Analysis of Type IIS Restriction EndonucleaseEco31I†

(2008) Arturas Jakubauskas et al.   BIOCHEMISTRY

Role of the Interdomain Linker in Distance Determination for Remote Cleavage by Homing Endonuclease I-TevI

(2008) Qingqing Liu et al.   JOURNAL OF MOLECULAR BIOLOGY