Article
Biochemistry & Molecular Biology
Laurene Sonzogni, Melanie L. Ferlazzo, Adeline Granzotto, Beatrice Fervers, Laurent Charlet, Nicolas Foray
Summary: The mechanistic model RIANS from radiobiology is crucial for understanding the recognition, repair and genotoxic stress response of DNA double-strand breaks induced by radiation. This model also applies to exposure to metal ions. Our study found that the induction of DSB by pesticides depends on their concentration and the RIANS status of cells. Impaired DSB recognition and repair, leading to toxicity, can occur when the nucleo-shuttling of ATM is delayed. Additionally, the combination of certain metal ions and pesticides can have additive or supra-additive effects on DSB recognition and/or repair.
Article
Biochemistry & Molecular Biology
Muriel Viau, Laurene Sonzogni, Melanie L. Ferlazzo, Elise Berthel, Sandrine Pereira, Larry Bodgi, Adeline Granzotto, Clement Devic, Beatrice Fervers, Laurent Charlet, Nicolas Foray
Summary: Studies suggest that metals may induce DSB through the nucleo-shuttling of ATM, affecting toxicity and carcinogenicity. The properties, concentration, and tissue type of different metals can all have an impact on this process.
Article
Oncology
Kai Zhang, Qingnan Wu, Wenzhong Liu, Yan Wang, Lianmei Zhao, Jie Chen, Haoyu Liu, Siqi Liu, Jinting Li, Weimin Zhang, Qimin Zhan
Summary: This study identified a novel DDR regulator, FAM135B, which plays a crucial role in maintaining genomic integrity and promoting DNA repair. The results demonstrated that FAM135B can enhance homologous recombination and non-homologous end-joining repairs, as well as improve DNA damage response by physically binding to TIP60 and enhancing its activity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Huidong Liu, Ye-Guang Chen
Summary: TGF-beta signaling plays a critical role in metabolism and is closely related to the progression of various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joelle Al-Choboq, Melanie L. Ferlazzo, Laurene Sonzogni, Adeline Granzotto, Laura El-Nachef, Mira Maalouf, Elise Berthel, Nicolas Foray
Summary: Usher syndrome is a rare genetic disease characterized by hearing loss, visual impairment, and vestibular dysfunctions. This study provides the first radiobiological characterization of cells from USH1 patients at both molecular and cellular levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eymeric Le Reun, Larry Bodgi, Adeline Granzotto, Laurene Sonzogni, Melanie L. Ferlazzo, Joelle Al-Choboq, Laura El-Nachef, Juliette Restier-Verlet, Elise Berthel, Clement Devic, Audrey Bouchet, Michel Bourguignon, Nicolas Foray
Summary: Tissue overreactions are a medical issue during or after anti-cancer radiotherapy, and predicting and preventing them is a major task for radiobiologists. While there is no consensus on the best predictor for tissue overreactions, radiation oncologists have proposed a scale to quantify the severity of these reactions. However, few studies have used this scale to evaluate the statistical robustness of predictive assays for radiosensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Christophe Guignabert, Laurent Savale, Athenais Boucly, Raphael Thuillet, Ly Tu, Mina Ottaviani, Christopher J. Rhodes, Pascal De Groote, Gregoire Prevot, Emmanuel Bergot, Arnaud Bourdin, Luke S. Howard, Elie Fadel, Antoine Beurnier, Anne Roche, Mitja Jevnikar, Xavier Jais, David Montani, Martin R. Wilkins, Olivier Sitbon, Marc Humbert
Summary: Activin A and FSTL3 serum levels are associated with transplant-free survival in PAH. They can serve as prognostic biomarkers for PAH, and their diagnostic values have been confirmed in an independent validation cohort. The activin signaling system in PAH involves phosphorylated Smad2/3 nuclear accumulation and differential immunoreactivities of various proteins in vascular endothelial and smooth muscle layers.
Article
Biochemistry & Molecular Biology
Aaron Mendez-Bermudez, Liudmyla Lototska, Melanie Pousse, Florent Tessier, Oliver Croce, Chrysa M. Latrick, Veronica Cherdyntseva, Joe Nassour, Jiang Xiaohua, Yiming Lu, Corinne Abbadie, Sarantis Gagos, Jing Ye, Eric Gilson
Summary: Cellular senescence triggers various types of heterochromatin remodeling, including decondensation, DNA damage, and illegitimate recombination. In this study, it was discovered that at the onset of senescence, pericentromeric heterochromatin is specifically dismantled due to telomere shortening or genotoxic stress. This process is initiated by the TP53-TRF2 axis and involves the downregulation of TRF2, resulting in heterochromatin decondensation and DNA breaks.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ammad Ahmad Farooqi, Ru Wen, Rukset Attar, Simona Taverna, Ghazala Butt, Baojun Xu
Summary: This article reviews the modulation mechanism of natural product berbamine in different cancers and oncogenic cell-signaling pathways. It also analyzes the activation of the TGF/SMAD pathway by berbamine and nanotechnological strategies for efficient delivery. Furthermore, berbamine demonstrates potent anti-cancer and anti-metastatic effects in tumor-bearing mice. However, the regulatory role of berbamine in non-coding RNAs remains insufficiently studied, and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yulia Mitiagin, Ari Barzilai
Summary: The review summarizes accumulating evidence that ataxia-telangiectasia mutated kinase is crucial for maintaining cellular homeostasis and has both nuclear and cytoplasmic functions. However, the specific functions of ataxia-telangiectasia mutated that lead to cerebellar degeneration when lost are still unknown. The review discusses the role of ataxia-telangiectasia mutated in cerebellar pathology, including its nuclear functions in DNA damage response circuits and its cytoplasmic and mitochondrial functions related to cellular homeostasis.
NEURAL REGENERATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ethan S. Lavi, Z. Ping Lin, Elena S. Ratner
Summary: This study investigated the effects of non-homologous end-joining (NHEJ) genes on clinical outcomes of ovarian cancer patients, and identified several most important genes for predicting the prognosis of ovarian cancer patients.
Article
Oncology
Hsin-Yi Chen, Shu-Jou Chan, Xinxin Liu, An-Chi Wei, Ru-In Jian, Kuan-Wei Huang, Yaw-Dong Lang, Jou-Ho Shih, Chun-Chieh Liao, Chiu-Lin Luan, Yu-Tung Kao, Shang-Yin Chiang, Pei-Wen Hsiao, Yuh-Shan Jou, Yunching Chen, Ruey-Hwa Chen
Summary: This study identifies the lncRNA Smyca as an oncogene that promotes poor prognosis in multiple cancer types. Smyca enhances tumor metabolic reprogramming, migration, invasion, cancer stemness, metastasis, and chemoresistance by potentiating TGF-beta/Smad signaling and c-Myc-mediated transcription. Targeting Smyca prevents metastasis and overcomes chemoresistance.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Weiwei Zheng, Cheng Qian, Fangming Xu, Peng Cheng, Chunmei Yang, Xiaoman Li, Yin Lu, Aiyun Wang
Summary: The study revealed that Fuxin Granules have therapeutic effects on diabetic nephropathy by improving kidney structure and function through regulating the TGF-β1/Smad and VEGF/VEGFR2 signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ihsan Dereli, Marcello Stanzione, Fabrizio Olmeda, Frantzeskos Papanikos, Marek Baumann, Sevgican Demir, Fabrizia Carofiglio, Julian Lange, Bernard de Massy, Willy M. Baarends, James Turner, Steffen Rulands, Attila Toth
Summary: This study elucidates that DSB restricts the DSB machinery through at least four distinct pathways, ensuring that DSBs are well-distributed and restricted to specific genomic locations and prophase stages to promote genome integrity.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alia dos Santos, Alexander W. Cook, Rosemarie E. Gough, Martin Schilling, Nora A. Olszok, Ian Brown, Lin Wang, Jesse Aaron, Marisa L. Martin-Fernandez, Florian Rehfeldt, Christopher P. Toseland
Summary: DNA double-strand breaks lead to genomic instability, affecting the mechanical properties of the nucleus and potentially contributing to drug resistance. Investigation using Atomic Force Microscopy showed that reducing nuclear stiffness and tension can improve DNA repair efficiency and protect against further DNA damage accumulation.
NUCLEIC ACIDS RESEARCH
(2021)