期刊
NUCLEIC ACIDS RESEARCH
卷 41, 期 2, 页码 1363-1371出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gks1127
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- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) [021.002.024, 700.55.425]
Repairing damaged DNA is essential for an organism's survival. UV damage endonuclease (UVDE) is a DNA-repair enzyme that can recognize and incise different types of damaged DNA. We present the structure of Sulfolobus acidocaldarius UVDE on its own and in a pre-catalytic complex with UV-damaged DNA containing a 6-4 photoproduct showing a novel 'dual dinucleotide flip' mechanism for recognition of damaged dipyrimidines: the two purines opposite to the damaged pyrimidine bases are flipped into a dipurine-specific pocket, while the damaged bases are also flipped into another cleft.
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