期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 11, 页码 4577-4586出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq1230
关键词
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资金
- Spanish Ministerio de Educacion y Ciencia [SAF2008-1578]
- Association Pour La Recherche sur le Cancer [4980]
- La Ligue contre le Cancer
- CNRS
- Agence National de la Recherche
- Institut National du Cancer
- Association for International Cancer Research
- Ligue Contre le Cancer
- Medical Research Council
- SPARKs
- Wellbeing for Women
- Wellcome Trust
- Ramon y Cajal research fellowship
- FPU
Imprinted retrotransposed genes share a common genomic organization including a promoter-associated differentially methylated region (DMR) and a position within the intron of a multi-exonic 'host' gene. In the mouse, at least one transcript of the host gene is also subject to genomic imprinting. Human retrogene orthologues are imprinted and we reveal that human host genes are not imprinted. This coincides with genomic rearrangements that occurred during primate evolution, which increase the separation between the retrogene DMRs and the host genes. To address the mechanisms governing imprinted retrogene expression, histone modifications were assayed at the DMRs. For the mouse retrogenes, the active mark H3K4me2 was associated with the unmethylated paternal allele, while the methylated maternal allele was enriched in repressive marks including H3K9me3 and H4K20me3. Two human retrogenes showed monoallelic enrichment of active, but not of repressive marks suggesting a partial uncoupling of the relationship between DNA methylation and repressive histone methylation, possibly due to the smaller size and lower CpG density of these DMRs. Finally, we show that the genes immediately flanking the host genes in mouse and human are biallelically expressed in a range of tissues, suggesting that these loci are distinct from large imprinted clusters.
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