期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 17, 页码 7848-7857出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr489
关键词
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资金
- Italian M.U.R.S.T.
- Fonds de la Recherche Scientifique-FNRS [CC.1.5.286.09.F]
- University of Liege [FRSD-08/10]
- Walloon Region (Project FEDER FTICR)
Among non-canonical DNA secondary structures, G-quadruplexes are currently widely studied because of their probable involvement in many pivotal biological roles, and for their potential use in nanotechnology. The overall quadruplex scaffold can exhibit several morphologies through intramolecular or intermolecular organization of G-rich oligodeoxyribonucleic acid strands. In particular, several G-rich strands can form higher order assemblies by multimerization between several G-quadruplex units. Here, we report on the identification of a novel dimerization pathway. Our Nuclear magnetic resonance, circular dichroism, UV, gel electrophoresis and mass spectrometry studies on the DNA sequence dCGGTGGT demonstrate that this sequence forms an octamer when annealed in presence of K(+) or NH(4)(+) ions, through the 5'-5' stacking of two tetramolecular G-quadruplex subunits via unusual G(:C):G(:C):G(:C):G(:C) octads.
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