Review
Pharmacology & Pharmacy
Mattia Ferraiolo, Emmanuel Hermans
Summary: L-DOPA and dopamine agonists are key therapeutic options for managing the motor symptoms of Parkinson's disease. Despite similarities in their mechanism of action, pramipexole, ropinirole, and rotigotine have distinct clinical profiles possibly due to differences in their pharmacological properties. This review aims to explore the properties of these dopamine agonists from both clinical and molecular perspectives, providing a unified framework for interpretation.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Chemistry, Analytical
Fatma Agin
Summary: This review focuses on voltammetric methods used for determination of dopamine agonists, with cabergoline, pramipexole, and ropinirole being the most studied drugs in the literature. Differential pulse voltammetry and square wave voltammetry methods are commonly applied for the determination of these drugs, while other voltammetric methods are less commonly used. Modified electrodes play a significant role in the analysis of dopamine agonists, providing good stability, repeatability, reproducibility, and high recovery for the analyte analysis.
CURRENT ANALYTICAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Laura I. Kuerbitz, Peer Briken
Summary: CSBD has a higher prevalence in men, while neuroticism and stress vulnerability appear to play a more important role in the symptomatology of CSBD in women.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
E. L. SASSOVER, A. V. WEINSTEIN
Summary: There is currently insufficient evidence to support the classification of compulsive sexual behavior disorder as a behavioral addiction. Most of the existing literature relies on anecdotal evidence and lacks a consensus on defining criteria. The available empirical evidence mainly focuses on individual symptoms rather than the disorder as a whole construct.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2022)
Article
Psychiatry
Lukas Blinka, Anna Sevcikova, Michael Dreier, Katerina Skarupova, Klaus Woelfling
Summary: This study found that problematic sexual internet use in a clinical population is characterized by patterns such as pornography use, cybersex, and excessive masturbation. Most participants met the criteria for behavioral addiction and experienced erectile dysfunction and negative consequences.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Daniel Turner, Peer Briken, Joshua Grubbs, Leo Malandain, Gemma Mestre-Bach, Marc N. Potenza, Florence Thibaut
Summary: The study aims to evaluate the role of pharmacological agents in the treatment of patients with CSBD. The results indicate that psychoeducation and psychotherapy are the first-choice treatments, while selective serotonin reuptake inhibitors and naltrexone are the most relevant pharmacological treatments. Hormonal agents may be indicated for CSBD with comorbid paraphilic disorders.
DIALOGUES IN CLINICAL NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Wenhua Ren, Yumeng Qi, Yan Liu, Yayun Yan, Xiaoqi Zheng, Shuxian Jin, Ying Chang
Summary: This study determined the prevalence of impulse control disorder (ICD) in Parkinson's disease (PD) patients in northern China and analyzed the associated risk factors. The results showed that ICD was associated with disease duration, motor symptoms, dyskinesia, depression, REM sleep behavior disorder (RBD), and cognitive decline. Multiple ICDs were related to coffee history, motor symptoms, dyskinesia, depression, apathy, and RBD. The prediction model demonstrated good performance.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Psychiatry
Jun-Fang Zhang, Xi-Xi Wang, Ya Feng, Robert Fekete, Joseph Jankovic, Yun-Cheng Wu
Summary: ICDs in PD refer to aberrant behaviors such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically result from dopaminergic therapy. Research has focused on the broad spectrum of ICDs-related behaviors and their significant impact on patients and their families, with recent advances improving our understanding of this issue.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Eli Coleman, Todd Jennings, Neil Gleason, Samuel Danielson, Katja H. Nielsen, Michael H. Miner, Ryan L. Rahm-Knigge
Summary: This study examines the relationships between religious orientations, moral disapproval, and compulsive sexual behavior (CSB), and finds that moral disapproval mediates the relationships between different religious orientations and CSB.
JOURNAL OF SEX & MARITAL THERAPY
(2023)
Article
Substance Abuse
Steffen Moritz, Lara Buecker, Charlotte Wittekind, Lukasz Gaweda, Josefine Gehlenborg
Summary: The study examined the factorial structure of the PG-YBOCS in individuals with gambling problems, revealing a two-dimensional structure with the first dimension representing gambling severity and the second dimension reflecting resistance to thoughts/urges and behavior. Unlike in OCD, no independent factors tapping thoughts versus behaviors were obtained, indicating functional differences between the two disorders.
INTERNATIONAL GAMBLING STUDIES
(2021)
Article
Psychiatry
Zsolt Demetrovics, Wim van den Brink, Borbala Paksi, Zsolt Horvath, Aniko Maraz
Summary: Impulsivity and compulsivity play different roles in symptom severity of various behavioral addictions. Compulsivity dominates over impulsivity in most problematic groups, except for gambling. The correlation between impulsivity and compulsivity is stronger in more severe cases. Relief-driven behavior appears to be more prominent than reward-driven behavior in severe cases of behavioral addiction.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Substance Abuse
Andreas Chatzittofis, Adrian Desai E. Bostrom, Josephine Savard, Katarina Gorts Oberg, Stefan Arver, Jussi Jokinen
Summary: Evidence suggests that the neuroendocrine and hormonal systems are involved in the pathophysiology of compulsive sexual behavior disorder. The hypothalamus-pituitary adrenal axis, the hypothalamus-pituitary-gonadal axis, and the oxytocinergic system have been implicated.
CURRENT ADDICTION REPORTS
(2022)
Article
Medicine, General & Internal
Mateusz Tos, Anna Grazynska, Sofija Antoniuk, Joanna Siuda
Summary: Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor and non-motor symptoms. Impulse Control Disorders (ICDs) are a group of disorders in which patients have a strong desire for specific activities. This study aimed to develop a profile of Polish PD patients with ICDs and assess the frequency and risk factors associated with these disorders.
MEDICINA-LITHUANIA
(2023)
Article
Psychiatry
Dennis Jepsen, Petra J. J. Brzank
Summary: This study aims to describe the characterization of hypersexual behavior (HB), identify personality correlates, and associations between HB and a lack of sexual education and reflection during school time. The study found that male sex, problematic pornography consumption, and impulsive tendencies were predictors of HB. There were strong correlates between HB and promiscuity, as well as impairments in important areas of life. However, no association was found between HB and a lacking sexual education during school time.
Article
Health Policy & Services
Aymeric Brody
Summary: This article examines the process by which individuals with gambling addiction problems identify as "compulsive gamblers" and accept their claimed "illness". Through field surveys and in-depth interviews with members of a Gamblers Anonymous group, the author explores their recovery process and how they construct their stories of becoming compulsive gamblers. The findings reveal that the group functions as a narrative framework for the individuals to understand their gambling trajectories and seek recovery.
SCIENCES SOCIALES ET SANTE
(2022)
Article
Neurosciences
E. A. Kelly, T. M. Love, J. L. Fudge
Summary: Dopamine is involved in stress-related illnesses, and corticotropin-releasing factor plays a role in stress responses. This study examined the synaptic terminals between dopamine and non-dopamine cells and found that dopamine regulation may occur indirectly through contacts with non-dopamine neurons.