Article
Microbiology
Iris Azami-Conesa, Jose Sansano-Maestre, Rafael Alberto Martinez-Diaz, Maria Teresa Gomez-Munoz
Summary: The study found that the American mink may be an incidental host of the disease for other mammals and should be further investigated for carrying zoonotic diseases. 90.1% of the analyzed animals tested positive.
Article
Immunology
Liting Zhou, Yuanyuan Li, Song Gao, Haibo Yuan, Lingli Zuo, Chaoyi Wu, Rui Huang, Shuyan Wu
Summary: The Salmonella spvC gene inhibits autophagy, influences pyroptosis through its phosphothreonine lyase activity, and reduces the protein levels of NLRP3 and NLRC4, effects that can be altered by the autophagy inhibitor Bafilomycin A1.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yan Shao, Chang Zhao, Jianying Pan, Chun Zeng, Hongbo Zhang, Liangliang Liu, Kai Fan, Xin Liu, Bingsheng Luo, Hang Fang, Xiaochun Bai, Haiyan Zhang, Daozhang Cai
Summary: The expression of BMP5 in chondrocytes is associated with osteoarthritis, and knocking down BMP5 can inhibit chondrocyte apoptosis and senescence, slow cartilage destruction, and reduce the progression of osteoarthritis.
Article
Plant Sciences
Danying Lu, Bin Liu, Mingjie Ren, Chao Wu, Jingjing Ma, Yamei Shen
Summary: The study revealed that light deficiency significantly affects the photosynthesis system and gene expression in Magnolia sinostellata, potentially accelerating leaf abscission and repressing the expression of stress response and disease resistance-related genes.
Article
Microbiology
Claudio Fenizia, Silvia Galbiati, Claudia Vanetti, Riccardo Vago, Mario Clerici, Carlo Tacchetti, Tiziana Daniele
Summary: CsA reduces viral replication, decreases cytokine release, and provides a potential therapeutic option for severe COVID-19 patients.
MICROBIOLOGY SPECTRUM
(2022)
Article
Environmental Sciences
Yaxian Hu, Hui Zhang, Lanlan Du, Xianwen Li, Xiaorong Wei
Summary: This study investigates the impact of different layering patterns on CO2 production and transfer. The results show that thin and thick layers released significantly less CO2 compared to the well-mixed layer. The contribution of C-13-CO2 was also lower in the interlaid layers. The findings indicate that while the interlaid layers did not completely inhibit glucose decomposition, the low diffusivity of the fine layers significantly impeded CO2 transfer.
Article
Behavioral Sciences
Barbara Kosmowska, Krystyna Ossowska, Jadwiga Wardas
Summary: The study suggests the importance of the striato-subthalamo-nigro-thalamic circuit in neuroleptic-induced Tremulous Jaw Movements (TJMs). The tremorolytic effect of A2A receptor blockade seems to involve this circuit bypassing the subthalamic nucleus (STN).
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Oncology
Lu Liu, Bin Qian, Yan Li, Xinglin Zhou
Summary: This study found that Dezocine can inhibit the proliferation and migration of endometrial cancer cells, thereby suppressing the metastatic potential of EC in vitro.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2023)
Article
Fisheries
Qin-Qin Gu, Shu-Wen He, Li-Hui Liu, Guang-Hua Wang, Dong-Fang Hao, Hong-Mei Liu, Chang-Biao Wang, Chao Li, Min Zhang, Ning-Qiu Li
Summary: BO18, a N-terminal peptide derived from rock bream BPI, shows broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria by enhancing outer membrane permeability. In interactions with Vibrio alginolyticus, BO18 exerts antibacterial effects by disrupting cell membrane integrity, penetrating into the cytoplasm, and binding to genomic DNA and total RNA. Additionally, BO18 enhances immune response and reduces pathogen dissemination in aquatic organisms, while also showing cytotoxic effects on human colon cancer cells.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Plant Sciences
Alby Tom, Joice Tom Job, Rajakrishnan Rajagopal, Ahmed Alfarhan, Hak-Jae Kim, Young Ock Kim, Sae Won Na, Arunaksharan Narayanankutty
Summary: The methanol extract of Thottea siliquosa shows potential as an anti-inflammatory and anti-genotoxic agent, which can be used to prevent degenerative diseases and issues caused by different genotoxic agents.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2022)
Article
Immunology
Yun Qian, Bo Tang, Hao Zhang, Hui Yang
Summary: In this study, circ_0129657 was found to inhibit proliferation and promote apoptosis and inflammatory factor secretion in oxygen-glucose deprivation-induced human brain microvascular endothelial cells via the miR-194-5p/GMFB axis, suggesting that circ_0129657 has the potential as a useful biological molecular marker in the diagnosis of stroke.
Article
Biochemistry & Molecular Biology
Ayed A. Shati, Amro Maarouf, Amal F. Dawood, Nervana M. Bayoumy, Youssef A. Alqahtani, Refaat A. Eid, Saeed M. Alqahtani, Mohamed Abd Ellatif, Bahjat Al-Ani, Alia Albawardi
Summary: Lower extremity arterial disease (LEAD) is a major risk factor for amputation in diabetic patients. The study investigated the effect of metformin on femoral artery injury mediated by the AGEs/ET-1/NOS axis in a rat model of type 2 diabetes mellitus (T2DM)-induced LEAD. The results showed that metformin treatment improved femoral artery ultrastructure, inhibited upregulation of AGEs, ET-1, iNOS, glycated haemoglobin, TNF-alpha and dyslipidemia, and augmented arterial eNOS expression.
Article
Cell Biology
Mateusz Maciejczyk, Ewa Zebrowska, Milosz Nesterowicz, Malgorzata Zendzian-Piotrowska, Anna Zalewska
Summary: The role of alpha-lipoic acid (ALA) in reducing brain manifestations of insulin resistance was determined in this study. ALA was found to scavenge oxygen free radicals and stimulate the production of reduced glutathione (GSH), the most critical brain antioxidant. The study showed that ALA improves the function of antioxidant systems in the brain, predominantly in the hypothalamus of insulin-resistant rats. ALA reduces oxidative stress, inflammation, and apoptosis in the brain, and further research is needed to understand its molecular mechanism.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Rashmi Srivastava, Lova Prasadareddy Kajuluri, Neelam Pathak, Chhitar M. Gupta, Amogh A. Sahasrabuddhe
Review
Parasitology
C. M. Gupta, S. Thiyagarajan, A. A. Sahasrabuddhe
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Ashok Ranjan Nayak, Sharanbasappa Shrimant Karade, Vijay Kumar Srivastava, Ajay Kumar Rana, C. M. Gupta, Amogh A. Sahasrabuddhe, J. Venkatesh Pratap
JOURNAL OF STRUCTURAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Gaurav Kumar, Lova P. Kajuluri, Chhitar M. Gupta, Amogh A. Sahasrabuddhe
MOLECULAR MICROBIOLOGY
(2016)
Article
Biochemical Research Methods
Vijay Kumar Srivastava, Ajay Kumar Rana, Amogh A. Sahasrabuddhe, C. M. Gupta, J. V. Pratap
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2013)
Article
Microbiology
Gaurav Kumar, Rashmi Srivastava, Kalyan Mitra, Amogh A. Sahasrabuddhe, Chhitar M. Gupta
Article
Cell Biology
Amogh A. Sahasrabuddhe, Ramesh C. Nayak, Chhitar M. Gupta
JOURNAL OF CELL SCIENCE
(2009)
Article
Cell Biology
T. V. Satish Tammana, Amogh A. Sahasrabuddhe, Virendra K. Bajpai, Chhitar M. Gupta
JOURNAL OF CELL SCIENCE
(2010)
Article
Cell Biology
Santharam S. Katta, Trinadh V. Satish Tammana, Amogh A. Sahasrabuddhe, Virendra K. Bajpai, Chhitar M. Gupta
JOURNAL OF CELL SCIENCE
(2010)
Article
Biochemistry & Molecular Biology
Prem Prakash Pathak, S. V. S. R. Krishna Pulavarti, Anupam Jain, Amogh Anant Sahasrabuddhe, Chhitar Mal Gupta, Ashish Arora
JOURNAL OF STRUCTURAL BIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Ramesh Kumar, Suman Gupta, Rashmi Srivastava, Amogh A. Sahasrabuddhe, Chhitar M. Gupta
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Kuldeep Singh, Niranjan K. Veluru, Vishal Trivedi, Chhitar M. Gupta, Amogh A. Sahasrabuddhe
MOLECULAR MICROBIOLOGY
(2014)
Article
Multidisciplinary Sciences
Rani Bajaj, Bindu Ambaru, Chhitar M. Gupta
Article
Multidisciplinary Sciences
Bindu Ambaru, Ganesh Muthu Gangadharan, Hosahalli S. Subramanya, Chhitar M. Gupta
Summary: Profilin in Leishmania is a multi-ligand binding protein involved in cell growth, intracellular trafficking, and cell cycle regulation. It interacts with various proteins, including those involved in mRNA processing and protein translation initiation. Depletion of LdPfn leads to decreased expression of genes involved in cell cycle regulation, mRNA translation initiation, and nucleoside and amino acid transport. It also affects the cellular levels of eIF4A1 protein and alters the progression of G1-to-S phase and mitotic spindle orientation.