期刊
NUCLEIC ACIDS RESEARCH
卷 38, 期 2, 页码 353-359出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkp1037
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资金
- National Institute of Health [R01 GM079523]
- Science Foundation Ireland
- Biotechnology and Biological Sciences Research Council, UK [BB/E024467/1]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079523] Funding Source: NIH RePORTER
- BBSRC [BB/E024467/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E024467/1] Funding Source: researchfish
In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.
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