Article
Biochemistry & Molecular Biology
Hendrik Melior, Siqi Li, Maximilian Stoetzel, Sandra Maass, Rubina Schuetz, Saina Azarderakhsh, Aleksei Shevkoplias, Susanne Barth-Weber, Kathrin Baumgardt, John Ziebuhr, Konrad U. Foerstner, Zoe Chervontseva, Doerte Becher, Elena Evguenieva-Hackenberg
Summary: Trans-acting regulatory RNAs, such as rnTrpL in Sinorhizobium meliloti, have the ability to pair with multiple mRNAs and may adjust their target specificity based on metabolic or environmental conditions. Tetracycline exposure can alter the target specificity of rnTrpL towards ribosomal protein-encoding mRNA, indicating the potential for sRNA target prioritization to shift in response to changing environmental cues.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Benjamin R. Warner, Ralf Bundschuh, Kurt Fredrick
Summary: Ribosome biogenesis occurs co-transcriptionally and involves rRNA folding, ribosomal protein binding, rRNA processing, and rRNA modification. The leader-trailer helix and the antitermination complex play important roles in 30S subunit formation in Escherichia coli. Disruption of the leader-trailer helix completely abolishes translation activity, while mutations of the antitermination complex and the leader helices show smaller decreases in activity. The absence of these leader features also leads to defects in translational fidelity, suggesting their involvement in quality control during ribosome biogenesis.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maciej Dylewski, Monika Cwiklinska, Katarzyna Potrykus
ACTA BIOCHIMICA POLONICA
(2018)
Article
Microbiology
Michal Sobala, Bozena Bruhn-Olszewska, Michael Cashel, Katarzyna Potrykus
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Maciej Dylewski, Llorenc Fernandez-Coll, Bozena Bruhn-Olszewska, Carlos Balsalobre, Katarzyna Potrykus
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Sabina Kedzierska-Mieszkowska, Katarzyna Potrykus, Zbigniew Arent, Joanna Krajewska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Stefan Tukaj, Jagoda Mantej, Michal Sobala, Katarzyna Potrykus, Krzysztof Sitko
CELL STRESS & CHAPERONES
(2020)
Article
Multidisciplinary Sciences
Llorenc Fernandez-Coll, Katarzyna Potrykus, Michael Cashel, Carlos Balsalobre
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Katarzyna Potrykus, Nathan E. Thomas, Bozena Bruhn-Olszewska, Michal Sobala, Maciej Dylewski, Tamara James, Michael Cashel
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Barbara Kedzierska, Katarzyna Potrykus, Agnieszka Szalewska-Palasz, Beata Wodzikowska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Immunology
Stefan Tukaj, Jagoda Mantej, Michal Sobala, Katarzyna Potrykus, Zbigniew Tukaj, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
Summary: The study found that Hsp70 immunization and anti-Hsp70 antibody treatment can decrease disease severity in a psoriasis-like skin inflammation mouse model by affecting T cell populations. This suggests that Hsp70 may be a promising therapeutic target for psoriasis and other autoimmune dermatoses.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Microbiology
Katarzyna Potrykus, Michael Cashel, Gert Bange
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Grzegorz M. Cech, Agnieszka Szalewska-Palasz, Katarzyna Potrykus, Anna Kloska
Summary: The development of P1vir is enhanced in the dksA mutant due to improvements in replication, virion assembly, and less efficient lysis, as shown by RNA sequencing analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Grzegorz M. Cech, Anna Kloska, Klaudyna Krause, Katarzyna Potrykus, Michael Cashel, Agnieszka Szalewska-Palasz
Summary: The deficiency in the host cell DksA protein improves the lytic development of Bacteriophage P1 by enhancing adsorption, DNA replication, and downregulating key gene expressions. Nucleotide substitutions in the phage immunity region may also contribute to the virulence of the phage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Barbara Kedzierska, Katarzyna Potrykus
Summary: The study identified the presence of a mini-gene within the Axe-txe system that influences translation of the Txe toxin, representing the first example of such a regulatory mechanism in TA modules. Translation of the two-codon mini-ORF was found to positively affect Txe expression, possibly through increasing mRNA stability. The regulatory mechanism may also be applicable to other TA systems, suggesting a potential broader impact beyond the Axe-txe cassette.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Kloska, Grzegorz M. Cech, Dariusz Nowicki, Monika Maciag-Dorszynska, Aleksandra E. Bogucka, Stephanie Markert, Doerte Becher, Katarzyna Potrykus, Paulina Czaplewska, Agnieszka Szalewska-Palasz
Summary: This study investigates the molecular adaptation mechanisms of marine bacteria to osmotic stress, focusing on adjustment at the proteome level. The results show that bacteria adjust at all levels of their biological processes in response to salinity challenges. The accumulation of DNA-binding proteins and increased polyamine uptake are suggested to play a role in protecting the nucleoid against changes in DNA topology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Monika Karczewska, Patryk Strzelecki, Krystyna Bogucka, Katarzyna Potrykus, Agnieszka Szalewska-Palasz, Dariusz Nowicki
Summary: Urinary tract infections are common bacterial diseases worldwide, with UPECs being the most prominent group among the pathogens responsible. In this study, we examined 118 UPEC isolates to determine their genetic background, antibiotic resistance, and their ability to form biofilms and induce stress responses. Our findings showed that these UPEC strains expressed unique attributes and had a significant ability to form biofilms and accumulate multi-resistance traits, which were crucial for the development of severe infections in a Galleria mellonella model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)