Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Multidisciplinary Sciences
Feng Xiong, Hong Yang, Yi-Ge Song, Hai-Bin Qin, Qing-Yang Zhang, Xian Huang, Wei Jing, Manfei Deng, Yang Liu, Zhixiang Liu, Yin Shen, Yunyun Han, Youming Lu, Xiangmin Xu, Todd C. Holmes, Minmin Luo, Fei Zhao, Min-Hua Luo, Wen-Bo Zeng
Summary: The H129(Amp) tracer system is a powerful tool for tracing neuronal connectomes. It allows for fast and bright monosynaptic tracing with low toxicity through the use of an HSV amplicon-based system.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Fanghui Ren, Ryo Narita, Ahmad S. Rashidi, Stefanie Fruhwurth, Zongliang Gao, Rasmus O. Bak, Martin K. Thomsen, Georges M. G. M. Verjans, Line S. Reinert, Soren R. Paludan
Summary: Neurotropic viruses such as herpes simplex virus (HSV) can infect neurons and cause severe diseases. HSV-induced neuronal cell death is mediated by gasdermin E (GSDME) and involves endoplasmic reticulum stress, caspase activation, and mitochondria-dependent apoptosis. The necrotic neurons release alarmins, triggering inflammatory responses in microglia.
Article
Biochemistry & Molecular Biology
Raina M. Borum, Avery E. Lin, Xiangyi Dong, Mingxuan Kai, Yi Chen
Summary: DNA origami can selectively modulate virus infectivity when combined with virus capsids, and folic acid-coated origami shows higher infectivity to cells compared to naked virus capsids.
Article
Biotechnology & Applied Microbiology
Jonas Becker, Megan Lynn Stanifer, Sarah Rebecca Leist, Bettina Stolp, Olena Maiakovska, Ande West, Ellen Wiedtke, Kathleen Boerner, Ali Ghanem, Ina Ambiel, Longping Victor Tse, Oliver Till Fackler, Ralph Steven Baric, Steeve Boulant, Dirk Grimm
Summary: Multiple experiments have shown that AAV vectors co-expressing three short hairpin RNAs targeting the SARS-CoV-2 genes can effectively suppress virus infection and prevent viral escape mutations, holding great potential as a preventive or therapeutic antiviral measure for controlling the COVID-19 pandemic.
Article
Engineering, Biomedical
Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Carlisle R. DeJulius, R. Brock Fletcher, Alex G. Sorets, Fiona K. Cherry, Justin H. Lo, Mariah G. Bezold, Nora Francini, Richard d'Arcy, Jordan E. Brasuell, Rebecca S. Cook, Craig L. Duvall
Summary: This study explores the use of ternary siRNA nanoparticles (si-NPs) for gene silencing in tumors. By optimizing the molecular weight and ratio of the core and surface polymer components, safe and effective si-NPs with strong inhibitory effects were developed. This work provides new insights into the structure-function relationships of ternary si-NPs and identifies strategies for safe and potent oncogene silencing.
Article
Virology
Claire H. Birkenheuer, Laura Dunn, Rachel Dufour, Joel D. Baines
Summary: The protein ICP22 has been observed to reduce RNA polymerase II (Pol II) serine 2 phosphorylation, which is necessary for transcriptional elongation, yet this phosphorylation is also essential for viral replication. This study helps explain this paradox by demonstrating the advantages of negative regulation of transcriptional elongation, including the reduction of antisense and intergenic transcription.
JOURNAL OF VIROLOGY
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Virology
Abigail L. Whitford, Corinne A. Clinton, E. B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Summary: The cellular protein DLK plays an essential role in the reactivation of herpes simplex virus, and the mechanisms of gene expression during reactivation are distinct from replication.
JOURNAL OF VIROLOGY
(2022)
Review
Infectious Diseases
Ying Zhang, Li-Si Zeng, Juan Wang, Wen-Qi Cai, Weiwen Cui, Tong-Jun Song, Xiao-Chun Peng, Zhaowu Ma, Ying Xiang, Shu-Zhong Cui, Hong-Wu Xin
Summary: Latent infection affects HSV reactivation, and deleting LAT reduces the latency and recurrence of the virus, providing new ideas for the future development of therapeutics and vaccines.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Virology
Qing Wang, Yun Liu, Chong Han, Min Yang, Fengqi Huang, Xuzhuo Duan, Shaowen Wang, Yepin Yu, Jiaxin Liu, Huirong Yang, Danqi Lu, Huihong Zhao, Yong Zhang, Qiwei Qin
Summary: The study successfully engineered a highly effective CasRx system for fish virus interference by targeting the red-spotted grouper nervous necrosis virus (RGNNV) with synthetic mRNA coding for CasRx, resulting in significant interference with virus infections both in vitro and in vivo.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Sean R. Cuddy, Anna R. Cliffe
Summary: Innate immune responses play a role in different stages of viral life cycles, particularly in the case of herpes simplex virus latent infection and reactivation in neurons. Immune responses can have long-term effects on the virus's ability to reactivate, acting at the time of reactivation and during initial neuronal infection.
JOURNAL OF VIROLOGY
(2023)
Article
Genetics & Heredity
Armand V. Peeters, Sigri Beckers, An Verrijken, Ilse Mertens, Peter Roevens, Pieter J. Peeters, Wim Van Hul, Luc F. Van Gaal
Article
Clinical Neurology
Harriet F. A. Zoon, C. P. M. Veth, Martijn Arns, W. H. I. M. Drinkenburg, Willem Talloen, Pieter J. Peeters, J. L. Kenemans
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2013)
Article
Genetics & Heredity
Armand V. Peeters, Sigri Beckers, An Verrijken, Peter Roevens, Pieter J. Peeters, Luc F. Van Gaal, Wim Van Hul
JOURNAL OF GENETICS
(2010)
Article
Gastroenterology & Hepatology
R. M. van den Wijngaard, T. K. Klooker, O. Welting, O. I. Stanisor, M. M. Wouters, D. van der Coelen, D. C. Bulmer, P. J. Peeters, J. Aerssens, R. de Hoogt, K. Lee, W. J. de Jonge, G. E. Boeckxstaens
NEUROGASTROENTEROLOGY AND MOTILITY
(2009)
Article
Neurosciences
Kristof Van Kolen, Karin Verstraeten, Ines Royaux, Ronald De Hoogt, Eric Gutknecht, Pieter J. Peeters
Article
Psychiatry
Cornelis P. M. Veth, Martijn Arns, Wilhelmus Drinkenburg, Willem Talloen, Pieter J. Peeters, Evian Gordon, Jan K. Buitelaar
PSYCHIATRY RESEARCH
(2014)
Article
Cell Biology
Jeffrey van Haren, Katharina Draegestein, Nanda Keijzer, Jan Pieter Abrahams, Frank Grosveld, Pieter Johan Peeters, Dieder Moechars, Niels Galjart
CELL MOTILITY AND THE CYTOSKELETON
(2009)
Article
Multidisciplinary Sciences
Jacobine Kuijlaars, Tutu Oyelami, Annick Diels, Jutta Rohrbacher, Sofie Versweyveld, Giulia Meneghello, Marianne Tuefferd, Peter Verstraelen, Jan R. Detrez, Marlies Verschuuren, Winnok H. De Vos, Theo Meert, Pieter J. Peeters, Miroslav Cik, Rony Nuydens, Bert Brone, An Verheyen
SCIENTIFIC REPORTS
(2016)
Article
Cell & Tissue Engineering
Viola Volpato, James Smith, Cynthia Sandor, Janina S. Ried, Anna Baud, Adam Handel, Sarah E. Newey, Frank Wessely, Moustafa Attar, Emma Whiteley, Satyan Chintawar, An Verheyen, Thomas Barta, Majlinda Lako, Lyle Armstrong, Caroline Muschet, Anna Artati, Carlo Cusulin, Klaus Christensen, Christoph Patsch, Eshita Sharma, Jerome Nicod, Philip Brownjohn, Victoria Stubbs, Wendy E. Heywood, Paul Gissen, Roberta De Filippis, Katharina Janssen, Peter Reinhardt, Jerzy Adamski, Ines Royaux, Pieter J. Peeters, Georg C. Terstappen, Martin Graf, Frederick J. Livesey, Colin J. Akerman, Kevin Mills, Rory Bowden, George Nicholson, Caleb Webber, M. Zameel Cader, Viktor Lakics
Article
Genetics & Heredity
Hai Fang, Georg Beckmann, Chas Bountra, Paul Bowness, Nicola Burgess-Brown, Liz Carpenter, Liye Chen, David Damerell, Ursula Egner, Ryo Fujii, Trevor Howe, Per-Johan Jakobsson, Andreas Katopodis, Julian C. Knight, Brian D. Marsden, Julie De Martino, Gstaiger Matthias, Gilean McVean, Anke Mueller-Fahrnow, Anders Malarstig, Chris A. O'Callaghan, Nils Ostermann, Jesus R. Paez-cortez, Pieter J. Peeters, Florian Prinz, Patricia Soulard, Michael Sundstrom, Chiori Yabuki, Jaromir Vlach, Hans De Wolf, Bogdan Knezevic, Katie L. Burnham, Julie Osgood, Anna Sanniti, Alicia Lledo Lara, Silva Kasela, Stephane De Cesco, Jorg K. Wegner, Lahiru Handunnetthi, Fiona E. McCann, Takuya Sekine, Paul E. Brennan, Yvonne Sundstrom, Lili Milani, Louise Berg, Hinrich W. Gohlmann, Benjamin P. Fairfax
Correction
Cell & Tissue Engineering
An Verheyen, Annick Diels, Joke Reumers, Kirsten Van Hoorde, Ilse Van den Wyngaert, Constantin van Outryve d'Ydewalle, An De Bondt, Jacobine Kuijlaars, Louis De Muynck, Ronald De Hoogt, Alexis Bretteville, Steffen Jaensch, Arjan Buist, Alfredo Cabrera-Socorro, Selina Wray, Andreas Ebneth, Peter Roevens, Ines Royaux, Pieter J. Peeters
Article
Multidisciplinary Sciences
Michael J. Cox, Steffen Jaensch, Jelle Vande Waeter, Laure Cougnaud, Daan Seynaeve, Soulaiman Benalla, Seong Joo Koo, Ilse VanDen Wyngaert, Jean-Marc Neefs, Dmitry Malkov, Mart Bittremieux, Margino Steemans, Pieter J. Peeters, Jorg Kurt Wegner, Hugo Ceulemans, Emmanuel Gustin, Yolanda T. Chong, Hinrich W. H. Goehlmann
SCIENTIFIC REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Ping-Wei Ho, Supinya Piampongsant, Brigida Gallone, Andrea Del Cortona, Pieter-Jan Peeters, Frank Reijbroek, Jules Verbaet, Beatriz Herrera, Jeroen Cortebeeck, Robbe Nolmans, Veerle Saels, Jan Steensels, Daniel F. Jarosz, Kevin J. Verstrepen
Summary: Through the combination of fully sequenced inbred segregants and high-throughput phenotyping methods, 678 QTLs across 18 different traits relevant to industrial fermentation processes were identified. This study revealed that rare and common variants, located in coding and non-coding regions, contribute to the phenotypic variation and indicate many QTLs are pleiotropic. The findings open new routes for studying complex genetics, genetic interactions, and engineering novel industrial yeasts.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Biochemical Research Methods
Eberhard Krausz, Ronald de Hoogt, Emmanuel Gustin, Frans Cornelissen, Thierry Grand-Perret, Lut Janssen, Nele Vloemans, Dirk Wuyts, Sandy Frans, Amy Axel, Pieter Johan Peeters, Brett Hall, Miroslav Cik
JOURNAL OF BIOMOLECULAR SCREENING
(2013)