Article
Clinical Neurology
Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W. Scholz
Summary: The GBA gene is associated with risk for dementia with Lewy bodies (DLB) in patients without the APOE ε4 allele, while the APOE ε4 allele is associated with DLB co-pathology with Alzheimer's disease. APOE ε4 is not an independent driver of alpha-synuclein pathology in pure DLB, but GBA plays a significant role in the pure DLB subgroup.
Article
Clinical Neurology
Young-gun Lee, Seun Jeon, Sung Woo Kang, Byoung Seok Ye
Summary: This study found that mixed pathologies are common in Alzheimer's disease and dementia with Lewy bodies, and the effects of amyloid beta and dopaminergic depletion on brain perfusion and clinical symptoms have not been elucidated.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Han Soo Yoo, Seong Ho Jeong, Kyeong Taek Oh, Sangwon Lee, Young H. Sohn, Byoung Seok Ye, Mijin Yun, Phil Hyu Lee
Summary: Yoo et al. investigated the relationship between striatal dopamine depletion, brain metabolism, and cognition in patients with dementia with Lewy bodies. They found that striatal dopamine loss and brain hypometabolism are closely related, impacting cognition in a specific manner, and predicting cognitive decline. Brain hypometabolism was found to be more relevant to longitudinal cognitive outcomes than striatal dopaminergic degeneration in patients with Lewy body dementia.
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Xudong Li, Miaoxin Shen, Ziling Han, Jinsong Jiao, Xiaopeng Tong
Summary: The gesture imitation test is a valuable tool for detecting DLB and differentiating DLB from ADD, especially in Items 1 and 4.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Yueyi Yu, Xinyi Xia, Xiaosheng Meng, Dan Li, Qi Qin
Summary: This study investigated the feasibility of using plasma p-tau181 and A beta(42) as potential biomarkers to differentiate AD and DLB. The results showed that plasma p-tau181 was significantly lower in DLB than in AD and healthy controls, while plasma A beta(42) was significantly higher in DLB than in AD but lower than in healthy controls. Both plasma biomarkers showed good accuracy in distinguishing DLB from healthy controls, while A beta(42) had better accuracy than p-tau181 in discriminating DLB from AD. These findings confirm the high diagnostic value of plasma p-tau181 and A beta(42) for distinguishing patients with DLB from healthy controls.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Guili Zhang, Shuai Liu, Zhichao Chen, Zhihong Shi, Wenzheng Hu, Lingyun Ma, Xiaodan Wang, Xudong Li, Yong Ji
Summary: Elevated plasma total homocysteine (tHcy) levels were independently associated with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The association was stronger for DLB than for AD, and future longitudinal studies are needed to confirm the causative role of tHcy in DLB.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychiatry
Ming-Chyi Pai, Chiu-Jun Yang, Sheng-Yu Fan
Summary: This study investigated the differences in time perception performance between prodromal AD and prodromal DLB patients. The findings revealed that prodromal AD patients exhibited imprecision and overestimation of time, while prodromal DLB patients tended to underestimate time intervals. The study suggests that the clinical and pathological severity of these two prodromal dementia stages may differ.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Olivier Bousiges, Frederic Blanc
Summary: Dementia with Lewy Bodies (DLB) is a common cognitive neurodegenerative disease with clinical similarity to Alzheimer's disease (AD). This review examines the interest of different biomarkers in distinguishing DLB from AD, with a focus on cerebrospinal fluid (CSF), brain MRI, FP-CIT SPECT, MIBG SPECT, and PET. FP-CIT SPECT shows high interest in discriminating DLB and AD, while other biomarkers like MIBG SPECT, perfusion SPECT, FDG PET, and CSF biomarkers have lower validity. The potential of CSF synuclein RT-QuIC as a discrimination tool is highlighted, but its application in clinical routine needs further demonstration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Clinical
Alan J. Thomas, Calum A. Hamilton, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, Louise M. Allan, John O'Brien, John-Paul Taylor, Paul C. Donaghy
Summary: Impaired olfaction may serve as a potential biomarker for early Lewy body disease, particularly in cases of mild cognitive impairment with Lewy bodies (MCI-LB). Olfactory function was significantly worse in individuals with probable MCI-LB compared to those with MCI-AD and healthy controls. A lower cutoff score of ≤ 7 on the SS-16 is recommended for identifying early LB disease in memory services.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Matthieu Lilamand, Josue Clery, Agathe Vrillon, Francois Mouton-Liger, Emmanuel Cognat, Sinead Gaubert, Claire Hourregue, Matthieu Martinet, Julien Dumurgier, Jacques Hugon, Elodie Bouaziz-Amar, Claire Paquet
Summary: This study found that cerebrospinal fluid levels of alpha-synuclein differ significantly between DLB and AD, suggesting its potential as a biomarker for distinguishing between these two diseases. CSF alpha-synuclein is associated with other AD biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Sandro Iannaccone, Elise Houdayer, Alfio Spina, Gianluca Nocera, Federica Alemanno
Summary: This study investigated the use of electroencephalography quantified with statistical pattern recognition (qEEG-SPR) as a tool for diagnosing dementia and differentiating dementia with Lewy bodies (DLB). The results showed that qEEG-SPR had high sensitivity and specificity for identifying dementia and DLB. It is a non-invasive, low-cost, and environmentally friendly method that can be implemented in healthcare settings.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neuroimaging
Wen-Ying Ma, Qun Yao, Guan-Jie Hu, Hong-Lin Ge, Chen Xue, Ying-Ying Wang, Yi-Xin Yan, Chao-Yong Xiao, Jing-Ping Shi, Jiu Chen
Summary: The study revealed different patterns of functional reorganization in DLB and AD patients, with the conversion and redistribution of rich club nodes possibly playing a causal role in disease-specific outcomes. This could serve as a potential biomarker for more accurate prevention and treatment strategies.
NEUROIMAGE-CLINICAL
(2022)
Article
Cardiac & Cardiovascular Systems
Senthil Selvaraj, Ph. Gabriel Steg, Yedid Elbez, Emmanuel Sorbets, Laurent J. Feldman, Kim A. Eagle, E. Magnus Ohman, Jacques Blacher, Deepak L. Bhatt
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Editorial Material
Medicine, General & Internal
Jacques Blacher, Bernard Levy, Jean-Jacques Mourad, Michel E. Safar, George Bakris
Article
Peripheral Vascular Disease
Alexandra Yannoutsos, Mathieu Ahouah, Celine Dreyfuss Tubiana, Jirar Topouchian, Michel E. Safar, Jacques Blacher
HYPERTENSION RESEARCH
(2018)
Article
Peripheral Vascular Disease
Alexandre Vallee, Alexandra Yannoutsos, Mohamed Temmar, Celine Dreyfuss Tubiana, Irina Spinu, Yi Zhang, Athanase Protogerou, Guillaume Henry-Bonniot, Philippe Sosner, Michel E. Safar, Jacques Blacher
JOURNAL OF HYPERTENSION
(2018)
Article
Peripheral Vascular Disease
Shikai Yu, Yuyan Lu, Jing Xiong, Jiadela Teliewubai, Chen Chi, Hongwei Ji, Yiwu Zhou, Ximin Fan, Jun Zhang, Jacques Blacher, Jue Li, Yi Zhang, Yawei Xu
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
(2018)
Article
Cardiac & Cardiovascular Systems
Benjamin Maier, Guillaume Turc, Guillaume Taylor, Raphael Blanc, Michael Obadia, Stanislas Smajda, Jean-Philippe Desilles, Hocine Redjem, Gabriele Ciccio, William Boisseau, Candice Sabben, Malek Ben Machaa, Mylene Hamdani, Morgan Leguen, Etienne Gayat, Jacques Blacher, Bertrand Lapergue, Michel Piotin, Mikael Mazighi
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Peripheral Vascular Disease
Alexandre Vallee, Laura Petruescu, Sandrine Kretz, Michel E. Safar, Jacques Blacher
AMERICAN JOURNAL OF HYPERTENSION
(2019)
Meeting Abstract
Education, Special
G. Young-Southward, C. Philo, S. -A. Cooper, J. Blacher
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2016)
Meeting Abstract
Education, Special
B. Baker, J. Blacher
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2016)
Meeting Abstract
Education, Special
J. Blacher, B. Baker
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2016)
Meeting Abstract
Education, Special
Y. Bolourian, J. Blacher
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2016)
Meeting Abstract
Pharmacology & Pharmacy
J. Blacher, I. Levy, J. J. Mourad, E. Safar, G. Bakris
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2016)
Article
Education, Special
S. R. Cohen, S. M. Zeedyk, L. A. Tipton, N. V. Rodas, J. Blacher
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2016)
Article
Education, Special
Sasha M. Zeedyk, Leigh Ann Tipton, Jan Blacher
FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
(2016)
Article
Psychology, Developmental
Sasha M. Zeedyk, Shana R. Cohen, Abbey Eisenhower, Jan Blacher
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2016)