期刊
NUCLEAR MEDICINE COMMUNICATIONS
卷 32, 期 11, 页码 1011-1017出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MNM.0b013e32834b45a3
关键词
[C-11]Pittsburgh compound-B; [C-11]raclopride; positron emission tomography
资金
- Departamento de Industria, Comercio y Turismo of the Basque Government
Introduction The use of C-11-labeled radiotracers in routine positron emission tomography studies is dependent on the production capability of radiochemistry laboratories. Therefore, considerable efforts are being focused on the development of fast, efficient, and robust methods for the preparation of such radiotracers. Methods The fully automated syntheses of [C-11]raclopride and [C-11]Pittsburgh compound-B (PIB) starting from cyclotron-produced [C-11]CH4 are reported. [C-11]methyl iodide and [C-11]methyl triflate were produced in the TRACERlab FXC Pro synthesis box. Methylation reactions and the final formulation were performed using the AutoLoop (captive solvent method) and the ReFORM-plus systems, respectively. Results [C-11]raclopride (n = 30) and [C-11]PIB (n = 24) were synthesized by O-[C-11]-methylation and N-[C-11]-methylation of (S)-O-desmethylraclopride and 6-OH-BTA-0 using [C-11]methyl iodide and [C-11]methyl triflate, respectively. Good radiochemical yields (51.3 +/- 11.2 and 32.9 +/- 6.6%, referred to as [C-11]methyl iodide, decay corrected) and specific activities (109 +/- 20 and 143 +/- 26GBq/lmol) were obtained for [C-11]raclopride and [C-11]PIB, respectively, in a fully automated process. Radiochemical purity was higher than 99% in all cases. Conclusion The fast, robust and fully automated processes reported here allow [C-11]raclopride and [C-11]PIB synthesis with good radiochemical yields and high specific activities. Consecutive productions can be performed with minimal intervention on the synthesis modules and minimal exposure to radiation. Nucl Med Commun 32: 1011-1017 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据