Article
Cardiac & Cardiovascular Systems
Li Chen, Hongzhou Duan, Xiaoyan Li, Zuozhen Yang, Meng Jiao, Kangtai Sun, Mei Jin
Summary: Chest pain is common in pediatric cardiology clinics, with most cases being benign and only a small percentage originating from cardiac issues. By utilizing targeted myocardial enzyme testing based on medical history and physical examination, resources can be effectively reduced while still capturing all cardiac diagnoses.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Fred S. Apple, Simon A. Mahler, Richard Body, Paul O. Collinson, Allan S. Jaffe
Summary: The guidelines for the evaluation and diagnosis of acute chest pain released by multiple associations in 2021 provide important recommendations, including the use of high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker, defining myocardial injury with 99th percentile upper reference limits, and utilizing clinical decision pathways. However, the guidelines do not extensively address the details of integrating hs-cTn into clinical practice, and clinicians need to be aware of analytical aspects related to hs-cTn assays and how to best use it with clinical decision pathways.
Article
Medicine, General & Internal
Sivabaskari Pasupathy, Sarena La, Rosanna Tavella, Christopher Zeitz, Matthew Worthley, Ajay Sinhal, Margaret Arstall, John F. Beltrame
Summary: This study compares the chest pain characteristics between MINOCA and MICAD patients and finds no significant differences in terms of pain location, quality, associated symptoms, or duration. This suggests that the chest pain experienced by MINOCA patients is similar to that of MICAD patients, indicating an ischemic nature.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Andreas Seraphim, Kristopher D. Knott, Joao B. Augusto, Katia Menacho, Sara Tyebally, Benjamin Dowsing, Sanjeev Bhattacharyya, Leon J. Menezes, Daniel A. Jones, Rakesh Uppal, James C. Moon, Charlotte Manisty
Summary: Performing and interpreting non-invasive ischaemia testing in patients post CABG is challenging due to multiple factors, including advanced multi-vessel native vessel disease, variability in coronary hemodynamics post-surgery, differences in graft lengths and vasomotor properties, and complex myocardial scar morphology. Systematic assessment of these challenges in relation to each imaging modality may optimize diagnostic test selection by incorporating clinical information and individual patient characteristics. Recent technological advances in cardiac imaging offer the opportunity to re-evaluate the value of ischaemia testing and provide new insights into the pathophysiological processes that determine outcomes in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Vojislav Giga, Nikola Boskovic, Ana Djordjevic-Dikic, Branko Beleslin, Ivana Nedeljkovic, Goran Stankovic, Milorad Tesic, Ivana Jovanovic, Ivana Paunovic, Srdjan Aleksandric
Summary: This study aimed to identify predictors of long-term adverse events after a negative exercise test in patients with chest pain and a lower intermediate pre-test probability of coronary artery disease (CAD), and to evaluate the prognostic value of exercise electrocardiography and exercise stress echocardiography in this patient group. Results showed that in 862 patients with chest pain and a pre-test probability of CAD ranging from 15 to 65%, 10.1% experienced adverse events, which were independently associated with male gender, age, diabetes, and slow heart rate recovery in the first minute after exercise. There was no significant difference in the occurrence of adverse events between patients tested by exercise stress echocardiography and those who underwent stress electrocardiography.
Article
Biotechnology & Applied Microbiology
Vesa Anttila, Antti Saraste, Juhani Knuuti, Marja Hedman, Pekka Jaakkola, Karl -Ludwig Laugwitz, Markus Krane, Anders Jeppsson, Saara Sillanmaeki, Jaya Rosenmeier, Pernilla Zingmark, Anna Rudvik, Pavlo Garkaviy, Christina Watson, Menelas N. Pangalos, Kenneth R. Chien, Regina Fritsche-Danielson, Anna Collen, Li-Ming Gan
Summary: The first clinical study of injecting naked mRNA encoding VEGF-A (AZD8601) into the human heart showed therapeutic cardiovascular effects without serious adverse events.
Article
Cardiac & Cardiovascular Systems
Ning Yang, Rongzhen Zhang, Chaoqun Zhao, Bochen Sun, Biyu Wang, Yuwei Song, Shuhan Qi, Jianan Liu, Yujia Sun, Hui Liu, Huanhuan An, Xingyue Zhang, Fei Xiang, Qinghui Yang, Wei Han
Summary: Elevated high-sensitivity troponin I (hs-TnI) is associated with decreased myocardial perfusion and a higher incidence of cardiovascular events in patients with chest pain but no obstructive coronary artery disease.
Article
Cardiac & Cardiovascular Systems
Anirudh Kumar, Divyang R. Patel, Serge C. Harb, Neil L. Greenberg, Ajay Bhargava, Venu Menon, Stephen G. Ellis, Samir R. Kapadia, Rory Hachamovitch, Wael A. Jaber, Paul C. Cremer
Summary: The study developed a risk classification algorithm based on appropriate use criteria for SPECT-MPI to stratify patients undergoing stress testing. High and intermediate risk patients were more frequently referred for angiography and revascularization compared to low-risk patients, and had higher mortality rates.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Roberta Assante, Ciro Gabriele Mainolfi, Emilia Zampella, Valeria Gaudieri, Carmela Nappi, Teresa Mannarino, Adriana D'Antonio, Parthiban Arumugam, Mario Petretta, Alberto Cuocolo, Wanda Acampa
Summary: The study found that diabetic patients with reduced MFR had higher annualized event rate and lower event-free survival compared to those with preserved MFR and nondiabetic patients. Age, BMI, and reduced MFR were identified as independent predictors of events in diabetic patients. Diabetic patients with reduced MFR had lower event-free survival compared to both diabetic patients with normal MFR and nondiabetic patients with reduced MFR.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Engineering, Biomedical
Stefan Rasche, Christian Kleiner, Jens Mueller, Antje Rost, Tamer Ghazy, Katrin Ploetze, Ronald Tetzlaff, Klaus Matschke, Olimpiu Bota
Summary: Coronary artery disease is a leading cause of death worldwide, and coronary artery bypass graft is the main treatment method. In this study, infrared thermography was used to observe 42 patients, and it was found that the surface temperature of the chest wall significantly dropped after harvesting the internal mammary artery, but returned to normal after 24 hours.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shun Dai, Zhengguang Xiao, Chuanzhi Chen, Weiwu Yao, Jun Qian, Jun Yang
Summary: This study presents a high-accuracy nomogram to predict recurrent chest pain in patients with myocardial bridging (MB). The model incorporates clinical risk factors and CT imaging features and shows remarkable accuracy.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Martha Gulati, Phillip D. Levy, Debabrata Mukherjee, Ezra Amsterdam, Kim K. Birtcher, Ron Blankstein, Jack Boyd, Renee P. Bullock-Palmer, Theresa Conejo, Deborah B. Diercks, Federico Gentile, John P. Greenwood, Erik P. Hess, Steven M. Hollenberg, Wael A. Jaber, Hani Jneid, Jose A. Joglar, David A. Morrow, Robert E. O'Connor, Michael A. Ross, Leslee J. Shaw, Patrick T. O'Gara, Joshua A. Beckman, Glenn N. Levine, Sana M. Al-Kharib, Anastasia L. Armbruster, Ralph G. Brindis, Joaquin E. Cigarroa, Lisa de las Fuentes, Anita Deswal, Dave L. Dixon, Lee A. Fleisher, Adrian F. Hernandez
Summary: This guideline provides recommendations and algorithms for clinicians to assess and diagnose chest pain in adult patients, based on contemporary evidence of risk stratification and diagnostic workup. Cost-value considerations in diagnostic testing have been incorporated, and shared decision-making with patients is recommended.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Arianne Clare Agdamag, Erik H. H. Van Iterson, W. H. Wilson Tang, J. Emanuel Finet
Summary: Heart failure is a complex syndrome with diverse presentations and severity. Current prognostic markers, such as left ventricular ejection fraction, have limitations in accurately predicting outcomes and guiding management decisions. Metabolic exercise testing, which evaluates multisystem responses and aerobic capacity during exercise, provides a more comprehensive and reliable assessment, especially in heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pontus Thorild, Georgios Mourtzinis
Summary: This retrospective observational study assessed the usefulness of exercise ECG in patients with low pre-test probability (PTP) of significant coronary artery disease and stable chest pain. The study found that exercise ECG had a high negative predictive value and a low positive predictive value in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca, Naomi M. Hamburg, Mark A. Creager
Summary: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis with modifiable risk factors including smoking, dyslipidemia, and diabetes. Medical therapies can reduce the risk of major adverse cardiovascular events and major adverse limb events, and improve function. Diagnosis and treatment should consider the individual risk profile of the patient.
CIRCULATION RESEARCH
(2021)
Editorial Material
Medicine, General & Internal
Simone Vanni, Peiman Nazerian, Giancarlo Bini
INTERNAL AND EMERGENCY MEDICINE
(2020)
Article
Medicine, General & Internal
Luca Masotti, Elisa Grifoni, Lavinia Migli, Alessandro Dei, Rosario Spina, Italo Calamai, Giulia Guazzini, Irene Micheletti, Eleonora Cosentino, Gabriele Pinto, Simone Vanni
Summary: This study analyzed prognostic factors in patients with ICH in real-life clinical practice, finding that ENW, hematoma enlargement, Hemphill ICH score >= 3, and midline shift >10 mm were associated with short-term mortality risk, while age was associated with 90-day mRS >= 4.
ACTA CLINICA BELGICA
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Cristina Vedovati, Ludovica Anna Cimini, Lucia Pierpaoli, Simone Vanni, Marilena Cotugno, Piotr Pruszczyk, Francesco Di Filippo, Valerio Stefanone, Leticia Guirado Torrecillas, Marta Kozlowska, Maria Grazia De Natale, Federica Mannucci, Giancarlo Agnelli, Cecilia Becattini
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2020)
Article
Hematology
Laura Franco, Cecilia Becattini, Jan Beyer-Westendorf, Simone Vanni, Cinzia Nitti, Roberta Re, Giorgia Manina, Fulvio Pomero, Roberto Cappelli, Alberto Conti, Giancarlo Agnelli
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Letter
Infectious Diseases
Elisa Grifoni, Alice Valoriani, Francesco Cei, Roberta Lamanna, Anna Maria Grazia Gelli, Benedetta Ciambotti, Vieri Vannucchi, Federico Moroni, Lorenzo Pelagatti, Roberto Tarquini, Giancarlo Landini, Simone Vanni, Luca Masotti
JOURNAL OF INFECTION
(2020)
Letter
Medicine, General & Internal
Elisa Grifoni, Vieri Vannucchi, Alice Valoriani, Francesco Cei, Roberta Lamanna, Anna Maria Grazia Gelli, Benedetta Ciambotti, Federico Moroni, Lorenzo Pelagatti, Roberto Tarquini, Giancarlo Landini, Simone Vanni, Luca Masotti
INTERNAL MEDICINE JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Diletta Cozzi, Chiara Moroni, Edoardo Cavigli, Alessandra Bindi, Cosimo Caviglioli, Peiman Nazerian, Simone Vanni, Vittorio Miele, Maurizio Bartolucci
Summary: CTPA findings can predict 30-day mortality of patients with APE in the Emergency Department, particularly the quantification of right ventricular strain, which is associated with troponin I levels and echocardiographic signs of right-heart dysfunction. The study suggests that a dilated coronary sinus may have additional prognostic value in predicting mortality.
Article
Cardiac & Cardiovascular Systems
Cecilia Becattini, Giorgio Maraziti, David R. Vinson, Austin C. C. Ng, Paul L. den Exter, Benoit Cote, Simone Vanni, Rami Doukky, Danai Khemasuwan, Anthony J. Weekes, Thiago Horta Soares, Savas Ozsu, Hernan Polo Friz, Serhat Erol, Giancarlo Agnelli, David Jimenez
Summary: Assessing right ventricle dysfunction (RVD) or elevated troponin levels can improve identification of low-risk patients with acute pulmonary embolism (PE), who may benefit from outpatient management or short hospital stay.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Simone Vanni, Paola Bartalucci, Ubaldo Gargano, Alessandro Coppa, Gianfranco Giannasi, Peiman Nazerian, Barbara Tonietti, Roberto Vannini, Michele Lanigra, Fabio Daviddi, Alessio Baldini, Stefano Grifoni, Simone Magazzini
Summary: The study investigated the impact of reduced presentations to Italian Emergency Departments during the COVID-19 pandemic on key performance indicators. The findings revealed a negative relationship between the presentations/physician ratio and the proportion of patients with door-to-physician times under 60 minutes, as well as a positive relationship between high-priority triage codes and the proportion of patients with length-of-stay under 4 hours. Benchmarking ED performance indicators should consider specific hospital and patient-level factors.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Geriatrics & Gerontology
Alessandro Morandi, Marco Inzitari, Cristina Udina, Neus Gual, Miriam Mota, Elena Tassistro, Anita Andreano, Antonio Cherubini, Simona Gentile, Enrico Mossello, Alessandra Marengoni, Anna Olive, Francesc Riba, Domingo Ruiz, Elisabet de Jaime, Giuseppe Bellelli
Summary: This study investigated the association between sensory deficits and delirium, finding a link between bi-sensory impairment and delirium, while visual or hearing impairment alone did not show a significant association with delirium. Routine screening and specific interventions are recommended for optimal management of sensory impairments in patients with delirium.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Immunology
Luca Masotti, Elisa Grifoni, Giulia Pelagalli, Elisa Cioni, Chiara Mattaliano, Elisa Cioffi, Francesca Maggi, Gabriele Pinto, Irene Micheletti, Benedetta Ciambotti, Amanda Mannucci, Roberta Bello, Francesco Cei, Silvia Dolenti, Roberto Tarquini, Iolanda Montenora, Rosario Spina, Simone Vanni, Elisa Maria Madonia, Anna Maria Grazia Gelli
Summary: IL-6/Lym ratio appears to be an optimal prognosticator in SARS-CoV2 related pneumonia, being associated with mortality and/or oro-tracheal intubation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Letter
Emergency Medicine
Simone Vanni, Peiman Nazerian, Rudi Pecci, Giuseppe Pepe, Andrea Pavellini, Claudia Casula, Ersilia de Curtis, Mattia Ronchetti, Paolo Vannucchi, Maurizio Bartolucci
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Otorhinolaryngology
Rudi Pecci, Marco Mandala, Antonella Marcari, Roberto Bertolai, Paolo Vannucchi, Rossana Santimone, Lisa Bentivegna, Fabio Di Giustino, Arianna Mengucci, Simone Vanni, Federica Pollastri, Beatrice Giannoni
Summary: This study found a relationship between hypovitaminosis D and benign paroxysmal positional vertigo (BPPV), with vitamin D supplementation reducing the number of BPPV relapses. However, there was no significant effect of vitamin D supplementation on the responsivity of BPPV to physical therapy.
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
(2022)
Article
Geriatrics & Gerontology
Chiara Sidoli, Antonella Zambon, Elena Tassistro, Emanuela Rossi, Enrico Mossello, Marco Inzitari, Antonio Cherubini, Alessandra Marengoni, Alessandro Morandi, Giuseppe Bellelli
Summary: This study investigated the prevalence, features, and motor subtypes of delirium in older patients admitted to rehabilitation facilities. The results showed that delirium was relatively common during rehabilitation, with mixed delirium being the most prevalent subtype. Delirium was associated with factors such as dementia, disability, medications, and physical restraints.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Loris Roncon, Claudio Picariello, Marco Vatrano, Lolanda Enea, Sergio Caravita, Lucrezia De Michele, Simone Vanni, Franco Casazza, Pietro Zonzin, Amedeo Bongarzoni, Carlo D'Agostino, Michele Azzarito, Stefano Urbinati, Michele Massimo Gulizia, Domenico Gabrielli
GIORNALE ITALIANO DI CARDIOLOGIA
(2020)