Article
Substance Abuse
Simon Jangard, Nitya Jayaram-Lindstrom, Nils Hentati Isacsson, Granville James Matheson, Pontus Plaven-Sigray, Johan Franck, Jacqueline Borg, Lars Farde, Simon Cervenka
Summary: This study found no significant association between striatal dopamine D2 receptor availability and later alcohol use or alcohol-related factors. However, there was a negative association between D2 receptor availability and later impulsivity, although the effect size was small.
Article
Pharmacology & Pharmacy
Francesco Petragnano, Irene Fasciani, Clotilde Mannoury la Cour, Benjamin di Cara, Gabriella Aloisi, Marco Carli, Shivakumar Kolachalam, Mario Rossi, Francesco Marampon, Marco Scarselli, Mark J. Millan, Roberto Maggio
Summary: This study investigates the affinity and activation of (+)-4-Propyl-9-hydroxynaphthoxazine on various monoamine receptors. It is found to have high affinity for hD(4.4), h5-HT1A, and h5-HT7 receptors, as well as hD(3) and hD(2L) receptors. It also strongly activates dopamine hD(3)-hD(2L) heterodimers. These findings are important for interpreting PET studies and may have implications for the treatment of Parkinson's disease and other disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Yasuharu Yamamoto, Keisuke Takahata, Manabu Kubota, Harumasa Takano, Hiroyoshi Takeuchi, Yasuyuki Kimura, Yasunori Sano, Shin Kurose, Hiroshi Ito, Masaru Mimura, Makoto Higuchi
Summary: The study revealed a significant positive correlation between DA synthesis capacity and DA transporter availability in the putamen, but no significant correlation between DA synthesis capacity and D2 receptor availability in the striatum, indicating a relationship between DA synthesis capacity and reuptake, while the total abundance of D2 receptors may not directly participate in the regulatory mechanism.
Article
Neurosciences
Eugenii A. Rabiner, Tolga Uz, Ayla Mansur, Terry Brown, Grace Chen, Jingtao Wu, Joy Atienza, Adam J. Schwarz, Wei Yin, Yvonne Lewis, Graham E. Searle, Jeremy M. T. J. Dennison, Jan Passchier, Roger N. Gunn, Johannes Tauscher
Summary: The study demonstrated that TAK-041 attenuated d-amphetamine-induced dopamine release, offering a potential mechanism for treating schizophrenia and related disorders. Using [C-11]PHNO PET scans, researchers found that TAK-041 enters the human brain and interacts with GPR139.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Javad Khodaii, Yoshiyuki Nomura, Natalie Hong Siu Chang, Dean F. Wong, Arne Moller, Albert Gjedde
Summary: The study explores the age-related changes of dopamine D-2/3 receptor availability in different brain regions. The results show that the binding potential of the receptors differs in striatal and extrastriatal regions, with an inverted U-shaped age-dependent pattern. The decline of receptor availability with age is most significant in posterior cortices and least significant in the caudate nucleus.
NEUROCHEMICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hojun Choi, Myung-Yoon Kim, Dae-Hwan Kim, Hanoul Yun, Byung-Koo Oh, Su-Bin Kim, In-Ho Song, Hyun-Soo Park, Sang-Eun Kim, Cheolhyoung Park, Chulhee Choi
Summary: This study assessed the biodistribution and pharmacokinetics of therapeutic exosomes labeled with Zr-89 in mice and rats. The results showed that the exosomes were mainly distributed in the liver and spleen, with substantial uptake by parenchymal cells. They were also moderately distributed in the kidney, lung, stomach, intestine, urinary bladder, brain, and heart. Exosomes were rapidly cleared from circulation, indicating their rapid uptake by cells and tissues.
Article
Neurosciences
Tuulia Malen, Tomi Karjalainen, Janne Isojaervi, Aki Vehtari, Paul-Christian Buerkner, Vesa Putkinen, Valtteri Kaasinen, Jarmo Hietala, Pirjo Nuutila, Juha Rinne, Lauri Nummenmaa
Summary: This study investigated the influence of age, sex, BMI, cerebral hemisphere, and regional volume on striatal D2R availability in the human brain using a large historical dataset. The results showed that D2R availability decreased with age and was higher in females than males. BMI was weakly associated with D2R availability. The observed effects were independent of regional volumes and were validated using different spatial normalization methods. These findings contribute to our understanding of the vulnerability of neurological and psychiatric conditions involving altered D2R expression.
Article
Multidisciplinary Sciences
Se Jong Oh, Chul Hyoung Lyoo, Young Hoon Ryu, Jae Yong Choi
Summary: This study compared conventional and software-aided methods for deriving the effective dose. The average error rates for the mean effective dose between the two methods were 3.8% and 1.9%, respectively. The urinary bladder and liver showed the greatest differences in absorbed dose.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Dean F. Wong, Arash Raoufinia, Patricia Bricmont, James R. Brasic, Robert D. McQuade, Robert A. Forbes, Tetsuro Kikuchi, Hiroto Kuwabara
Summary: The study aimed to assess the D-2/D-3 receptor occupancy induced by brexpiprazole at different doses, showing a dose-dependent increase in occupancy up to 77-88%. Multiple doses of brexpiprazole are expected to result in an efficacious brexpiprazole concentration consistent with clinically active doses.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Neurosciences
Kyoungjune Pak, Lauri Nummenmaa
Summary: This study investigated the association between dopamine receptor availability and overweight/obesity using Bayesian and frequentist meta-analysis. The results showed that there was no difference in dopamine receptor availability between lean and overweight/obese subjects, but this effect was dependent on the radiopharmaceutical and the degree of obesity.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Hironori Nishibe, Amane Tateno, Takeshi Sakayori, Masahiro Yamamoto, WooChan Kim, Hiroyoshi Kakuyama, Yoshiro Okubo
Summary: Transdermal antipsychotic patch formulations, specifically blonanserin patches at doses of 40 mg/d and 80 mg/d, exhibit lower diurnal variability in occupancy compared to blonanserin tablets at doses of 8 mg/d and 16 mg/d, indicating that patches may be a suitable alternative for patients with schizophrenia. The study suggests that blonanserin patches could potentially offer a new treatment option for these patients.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Michael R. Kilbourn
Summary: The application of positron emission tomography (PET) imaging to study brain biochemistry, especially dopamine neurotransmission, has significantly grown over the past 40 years. PET imaging of dopaminergic functions in the central nervous system is routinely used for research in neurology, psychiatry, drug abuse and addiction, as well as drug development. The key advancement in PET imaging is the development of unique radiotracers labeled with positron-emitting radionuclides like carbon-11 and fluorine-18, which have greatly contributed to the progress in this field.
Article
Behavioral Sciences
Yasmin Zakiniaeiz, Ralitza Gueorguieva, MacKenzie R. Peltier, Terril L. Verplaetse, Walter Roberts, Sherry A. McKee, Kelly P. Cosgrove
Summary: Sex differences exist in tobacco smoking, with women having greater difficulty quitting smoking than men. This study found that lower estradiol levels in women were associated with lower dopamine levels in the dlPFC, which may contribute to the difficulty in resisting smoking.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Katina C. Calakos, Aleksandra Rusowicz, Brian Pittman, Jean-Dominique Gallezot, Marc N. Potenza, Kelly P. Cosgrove, David Matuskey
Summary: Social factors are associated with psychiatric outcomes and brain function. This study found that living in a populous area with fewer educational resources may lead to higher availability of dopamine D2/3 receptors. This suggests that the social environment has an impact on an individual's brain function.
NEUROSCIENCE LETTERS
(2022)
Article
Psychiatry
Yoko Ikoma, Yasuyuki Kimura, Makiko Yamada, Takayuki Obata, Tetsuya Suhara, Hiroshi Ito
Summary: The study evaluated the reproducibility of BP estimation using the dual-bolus injection approach in PET scans without stimulation and found good reproducibility. In PET scans with cognitive task performance, no reduction in BP was observed in the striatum, indicating that the changes in dopamine levels induced by the cognitive tasks may not be detectable by PET.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Andrea Mechelli, Diana Prata, Charles Kefford, Shitij Kapur
DRUG DISCOVERY TODAY
(2015)
Article
Clinical Neurology
Panayiota G. Michalopoulou, Shon W. Lewis, Richard J. Drake, Abraham Reichenberg, Richard Emsley, Anastasia K. Kalpakidou, Jane Lees, Tracey Bobin, James K. Gilleen, Gahan Pandina, Eve Applegate, Til Wykes, Shitij Kapur
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2015)
Letter
Psychiatry
Panayiota G. Michalopoulou, Bruno B. Averbeck, Anastasia K. Kalpakidou, Simon Evans, Tracey Bobin, Shitij Kapur, Sukhwinder S. Shergill
SCHIZOPHRENIA RESEARCH
(2015)
Letter
Neurosciences
Arsime Demjaha, Alice Egerton, Robin M. Murray, Shitij Kapur, Oliver D. Howes, James M. Stone, Philip K. McGuire
BIOLOGICAL PSYCHIATRY
(2014)
Article
Neurosciences
Anthony C. Vernon, William R. Crum, Jason P. Lerch, Winfred Chege, Sridhar Natesan, Michel Modo, Jonathan D. Cooper, Steven C. R. Williams, Shitij Kapur
BIOLOGICAL PSYCHIATRY
(2014)
Article
Neurosciences
Michael A. P. Bloomfield, Celia J. A. Morgan, Alice Egerton, Shitij Kapur, H. Valerie Curran, Oliver D. Howes
BIOLOGICAL PSYCHIATRY
(2014)
Editorial Material
Clinical Neurology
W. Wolfgang Fleischhacker, Shitij Kapur
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christophe Plisson, David Weinzimmer, Steen Jakobsen, Sridhar Natesan, Cristian Salinas, Shu-Fei Lin, David Labaree, Ming-Qiang Zheng, Nabeel Nabulsi, Tiago Reis Marques, Shitij Kapur, Eiji Kawanishi, Takeaki Saijo, Roger N. Gunn, Richard E. Carson, Eugenii A. Rabiner
JOURNAL OF NUCLEAR MEDICINE
(2014)
Review
Clinical Neurology
Faye Sim, Isabel Sweetman, Shitij Kapur, Maxine X. Patel
JOURNAL OF PSYCHOPHARMACOLOGY
(2015)
Article
Multidisciplinary Sciences
Hreinn Stefansson, Andreas Meyer-Lindenberg, Stacy Steinberg, Brynja Magnusdottir, Katrin Morgen, Sunna Arnarsdottir, Gyda Bjornsdottir, G. BragiWalters, Gudrun A. Jonsdottir, Orla M. Doyle, Heike Tost, Oliver Grimm, Solveig Kristjansdottir, Heimir Snorrason, Solveig R. Davidsdottir, Larus J. Gudmundsson, Gudbjorn F. Jonsson, Berglind Stefansdottir, Isafold Helgadottir, Magnus Haraldsson, Birna Jonsdottir, Johan H. Thygesen, Adam J. Schwarz, Michael Didriksen, Tine B. Stensbol, Michael Brammer, Shitij Kapur, Jonas G. Halldorsson, Stefan Hreidarsson, Evald Saemundsen, Engilbert Sigurdsson, Kari Stefansson
Review
Behavioral Sciences
Diana Prata, Andrea Mechelli, Shitij Kapur
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2014)
Article
Genetics & Heredity
K. E. Tansey, J. J. H. Rucker, D. H. Kavanagh, M. Guipponi, N. Perroud, G. Bondolfi, E. Domenici, D. M. Evans, J. Hausers, N. Henigsberg, B. Jerman, W. Maier, O. Mors, M. O'Donovan, T. J. Peters, A. Placentino, M. Rietschel, D. Souery, K. J. Aitchison, I. Craig, A. Farmer, J. R. Wendland, A. Malafosse, G. Lewis, S. Kapur, P. McGuffin, R. Uher
PHARMACOGENOMICS JOURNAL
(2014)
Article
Psychiatry
Suzanne Ho-Wai So, Emmanuelle Roisin Peters, Joel Swendsen, Philippa Anne Garety, Shitij Kapur
PSYCHIATRY RESEARCH
(2014)
Article
Psychology, Clinical
J. Gilleen, S. S. Shergill, S. Kapur
PSYCHOLOGICAL MEDICINE
(2015)
Article
Psychiatry
S. Natesan, S. Ashworth, J. Nielsen, S-P Tang, C. Salinas, S. Kealey, J. B. Lauridsen, T. B. Stensbol, R. N. Gunn, E. A. Rabiner, S. Kapur
TRANSLATIONAL PSYCHIATRY
(2014)