Article
Gastroenterology & Hepatology
Guillaume Le Cosquer, Lena Capirchio, Pauline Riviere, Marie Armelle Denis, Florian Poullenot, Christophe Remue, Frank Zerbib, Daniel Leonard, Bertrand Celerier, Alex Kartheuser, David Laharie, Olivier Dewit
Summary: This study aimed to determine the trend of colectomy in ulcerative colitis (UC) by comparing colectomy indications and outcomes between 2000 and 2010 and 2011-2020. The results showed that the proportion of surgery for refractory UC significantly decreased compared to other surgical indications while surgical outcomes improved despite larger exposure to biologics.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Nick Dai, Omar Haidar, Alan Askari, Jonathan P. Segal
Summary: This study aimed to understand the changing prevalence of colectomy in Ulcerative Colitis (UC) over time. The results showed that the overall colectomy rate has decreased over the past three decades. Biologics may have played a role in reducing the risk of colectomy, but the relative risk reduction is likely to be modest.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Daniela Pugliese, Giuseppe Privitera, Federica Crispino, Nicolo Mezzina, Fabiana Castiglione, Gionata Fiorino, Lucrezia Laterza, Anna Viola, Lorenzo Bertani, Flavio Caprioli, Maria Cappello, Brigida Barberio, Chiara Ricci, Paola Balestrieri, Marco Daperno, Dario Pluchino, Fernando Rizzello, Maria Lia Scribano, Renato Sablich, Luca Pastorelli, Francesco Manguso, Angela Variola, Antonio Di Sario, Laurino Grossi, Alessandro Armuzzi
Summary: The study included 198 elderly (108 UC, 90 CD) and 396 matched nonelderly patients (205 UC, 191 CD). Nonelderly UC patients had a significantly higher persistence on vedolizumab compared to elderly patients. No significant difference in effectiveness was observed between elderly and nonelderly CD patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Kengo Kanayama, Jun Kato, Wataru Shiratori, Ariki Nagashima, Yuki Ohta, Takashi Taida, Keiko Saito, Chihiro Goto, Satsuki Takahashi, Ryosuke Horio, Akane Kurosugi, Tsubasa Ishikawa, Tatsuya Kaneko, Naoki Akizue, Kenichiro Okimoto, Tomoaki Matsumura, Naoya Kato
Summary: This study found that selecting subsequent treatment based on the response to initial anti-tumor necrosis factor (TNF)alpha antibody (ATA) is feasible in refractory ulcerative colitis (UC) patients. Non-ATA may be suitable as subsequent biologics for UC patients regardless of the efficacy of the first ATA.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Alice Burgevin, Benedicte Caron, Alexa Sasson, Amandine Luc, Patrick Netter, Cedric Baumann, Ashwin N. Ananthakrishnan, Laurent Peyrin-Biroulet
Summary: The safety of vedolizumab and ustekinumab therapies in older patients with inflammatory bowel disease was compared. The study found that there was no difference in terms of safety between vedolizumab and ustekinumab in patients with Crohn's disease. The occurrence of adverse events per year of follow-up was also similar between vedolizumab and anti-TNF therapy for ulcerative colitis and Crohn's disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ohad Atia, Sasha Harel, Natan Ledderman, Shira Greenfeld, Revital Kariv, Iris Dotan, Ran Balicer, Barbara Silverman, Eran Matz, Zohar Levi, Matti Waterman, Iris Fried, Jacob M. Rowe, Dan Turner
Summary: Pediatric onset inflammatory bowel disease (PIBD) patients have a higher risk of developing cancer compared to non-inflammatory bowel disease (IBD) children, but the absolute risk is very low, and no significant differences in risk were found among different treatment methods in our data.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Immunology
Yiyoung Kwon, Yoon Zi Kim, Yon Ho Choe, Mi Jin Kim
Summary: This study found that patients with high monocyte counts at the time of discontinuation were more likely to experience relapse after stopping biologics. The monocyte percentage can be used to predict the risk of relapse within 6 months after discontinuation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Lorenzo Bertani, Brigida Barberio, Domenico Trico, Federico Zanzi, Daria Maniero, Linda Ceccarelli, Ilaria Marsilio, Francesca Coppini, Greta Lorenzon, Maria Gloria Mumolo, Fabiana Zingone, Francesco Costa, Edoardo Vincenzo Savarino
Summary: The study found that hospitalization for intravenous biologics treatment did not increase the risk of COVID-19 infection in patients with inflammatory bowel diseases during the COVID-19 outbreak. Additionally, there was a similar level of anxiety between patients receiving intravenous and subcutaneous drug treatments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Neasa Mc Gettigan, Aman Shah Afridi, Grace Harkin, Caroline Lardner, Stephen Patchett, Danny Cheriyan, Gavin Harewood, Karen Boland, Aoibhlinn O'Toole
Summary: The study aimed to identify optimal management strategies for anti-drug antibodies (ADAs) in patients receiving infliximab (IFX) to prevent therapy discontinuation. Results showed that increasing IFX dosage and adjusting combination therapy can lower rates of discontinuation of IFX, with significant cut-off values for ADA trough levels and important clinical outcomes identified through ROC curve analysis.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Gastroenterology & Hepatology
Ole Haagen Nielsen, John Mark Gubatan, Carsten Bogh Juhl, Sarah Elizabeth Streett, Cynthia Maxwell
Summary: Adverse pregnancy outcomes among pregnant IBD women using biologics are comparable with that of the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Panu Wetwittayakhlang, Lorant Gonczi, Laszlo Lakatos, Zsuzsanna Kurti, Petra Golovics, Tunde Pandur, Gyula David, Zsuzsanna Erdelyi, Istvan Szita, Peter L. Lakatos
Summary: This study aimed to assess the colectomy rates of ulcerative colitis (UC) patients in Veszprem Province, Hungary over 40 years. The results showed no significant differences in colectomy rates among different therapeutic eras, despite increasing use of immunomodulators and biologic therapies.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Koji Yokoyama, Yoko Yamamoto, Ryusuke Nambu, Shin-Ichiro Hagiwara, Daiki Abukawa, Tatsuki Mizuochi, Takahiro Kudo, Tomomitsu Sado, Naomi Iwata, Takashi Ishige, Itaru Iwama, Hideki Kumagai, Katsuhiro Arai, Toshiaki Shimizu
Summary: This study evaluated the safety and efficacy of Vedolizumab (VDZ) in pediatric ulcerative colitis (UC) patients in Japan. The results showed that VDZ was a safe and effective treatment option for children with UC. Hematocrit, albumin, and erythrocyte sedimentation rate (ESR) at VDZ initiation may predict VDZ effectiveness. This study is of great importance for treatment decisions in pediatric patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Eleni Orfanoudaki, Kalliopi Foteinogiannopoulou, Eirini Theodoraki, Ioannis E. Koutroubakis
Summary: Despite advancements in inflammatory bowel disease (IBD) management, anti-TNF agents continue to be the primary treatment for Crohn's disease and ulcerative colitis. However, optimizing treatment strategies is essential due to the progressive nature of the disease and potential loss of response. This overview examines the role of therapeutic drug monitoring (TDM), combining anti-TNF with immunomodulators, and the treat-to-target approach in enhancing the efficacy and outcomes of anti-TNF treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Yiyoung Kwon, Eun Sil Kim, Yon Ho Choe, Mi Jin Kim
Summary: After the introduction of infliximab, the relapse rate has decreased and the steroid-free period has increased in pediatric ulcerative colitis patients. The clinical course showed a different pattern from the IBSEN study.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Andrea Cassinotti, Nicolo Mezzina, Annalisa De Silvestri, Dhanai Di Paolo, Marco Vincenzo Lenti, Cristina Bezzio, Davide Stradella, Martina Mauri, Valentina Zadro, Chiara Ricci, Valentina Casini, Elisa Radice, Alessandro Massari, Giovanni Maconi, Simone Saibeni, Flavio Caprioli, Roberto Tari, Maria Fichera, Claudio Camillo Cortelezzi, Marco Parravicini, Carmine Tinelli, Pier Alberto Testoni, Fabio Pace, Sergio Segato, Pietro Invernizzi, Pietro Occhipinti, Gianpiero Manes, Antonio Di Sabatino, Luca Pastorelli, Maurizio Vecchi, Sandro Ardizzone
Summary: This study compared the efficacy of adalimumab, infliximab biosimilar, golimumab, and vedolizumab in the treatment of ulcerative colitis. The results showed that all four biologics had similar rates of clinical remission at one year, while vedolizumab was more effective in patients who had failed previous anti-TNF alpha treatment.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Keisuke Hata, Hiroyuki Anzai, Hiroki Ikeuchi, Kitaro Futami, Kouhei Fukushima, Akira Sugita, Motoi Uchino, Daijiro Higashi, Michio Itabashi, Kazuhiro Watanabe, Kazutaka Koganei, Toshimitsu Araki, Hideaki Kimura, Tsunekazu Mizushima, Takeshi Ueda, Soichiro Ishihara, Yasuo Suzuki
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Hiroto Kinoshita, Hitomi Nishioka, Aya Ikeda, Kyoko Ikoma, Yoichi Sameshima, Hidehisa Ohi, Mizuki Tatsuno, Junka Kouyama, Chiaki Kawamoto, Tomohiro Mitsui, Yuko Tamura, Yu Hashimoto, Masashi Nishio, Tsuyoshi Ogashiwa, Yusuke Saigusa, Shin Maeda, Hideaki Kimura, Reiko Kunisaki, Kazuhiko Koike
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Takahide Shinagawa, Keisuke Hata, Hiroki Ikeuchi, Kouhei Fukushima, Kitaro Futami, Akira Sugita, Motoi Uchino, Kazuhiro Watanabe, Daijiro Higashi, Hideaki Kimura, Toshimitsu Araki, Tsunekazu Mizushima, Michio Itabashi, Takeshi Ueda, Kazutaka Koganei, Koji Oba, Soichiro Ishihara, Yasuo Suzuki
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Akira Sugita, Kazutaka Koganei, Kenji Tatsumi, Ryo Futatsuki, Hirosuke Kuroki, Kyoko Yamada, Hideaki Kimura, Tsuneo Fukushima
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2019)
Article
Surgery
Motoi Uchino, Hiroki Ikeuchi, Keisuke Hata, Satoshi Okada, Soichiro Ishihara, Koji Morimoto, Rikisaburo Sahara, Kazuhiro Watanabe, Kouhei Fukushima, Kenichi Takahashi, Hideaki Kimura, Keiji Hirata, Tsunekazu Mizushima, Toshimitsu Araki, Masato Kusunoki, Riichiro Nezu, Sayumi Nakao, Michio Itabashi, Akira Hirata, Heita Ozawa, Takashi Ishida, Koji Okabayashi, Takayuki Yamamoto, Toshihiro Noake, Junya Arakaki, Yusuke Watadani, Hiroki Ohge, Ryo Futatsuki, Kazutaka Koganei, Akira Sugita, Daijiro Higashi, Kitaro Futami
Article
Gastroenterology & Hepatology
Katsuki Yaguchi, Tomohiko Sasaki, Tsuyoshi Ogashiwa, Masafumi Nishio, Yu Hashimoto, Aya Ikeda, Misato Izumi, Akiho Hanzawa, Naomi Shibata, Hiromi Yonezawa, Kentaro Sakamaki, Yoko Tateishi, Kazushi Numata, Shin Maeda, Hideaki Kimura, Reiko Kunisaki
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Medicine, General & Internal
Feiqian Wang, Kazushi Numata, Hiromi Yonezawa, Kana Sato, Yoshito Ishii, Katsuki Yaguchi, Nao Kume, Yu Hashimoto, Masafumi Nishio, Yoshinori Nakamori, Aya Ikeda, Akira Madarame, Atsuhiro Hirayama, Tsuyoshi Ogashiwa, Tomohiko Sasaki, Misato Jin, Akiho Hanzawa, Naomi Shibata, Shinichi Hashimorto, Yusuke Saigusa, Yoshiaki Inayama, Shin Maeda, Hideaki Kimura, Reiko Kunisaki
Article
Surgery
Kenichiro Toritani, Hideaki Kimura, Hironori Fukuoka, Jun Watanabe, Atsushi Ishibe, Reiko Kunisaki, Itaru Endo
Summary: The study identified CRP, albumin levels, and preoperative blood transfusion as predictors of incisional surgical site infections in severe or intractable ulcerative colitis patients. Patients with these predictors had a higher incidence of infections and complications, as well as a longer postoperative hospital stay.
Article
Surgery
Hiroki Ohya, Hideaki Kimura, Jun Watanabe, Kazuya Nakagawa, Yusuke Suwa, Mayumi Ozawa, Atsushi Ishibe, Reiko Kunisaki, Chikara Kunisaki, Itaru Endo
Summary: The purpose of this study was to compare the prevalence and risk factors of perioperative deep vein thrombosis (DVT) in surgical ulcerative colitis (UC) patients and colorectal cancer (CRC) patients, showing no significant differences in DVT prevalence between the two groups. Risk factors for preoperative DVT in UC surgical patients include older age, overweight status, poor ASA status, and high preoperative dose of steroids.
Article
Gastroenterology & Hepatology
Hiroshi Kuwabara, Hideaki Kimura, Reiko Kunisaki, Kenji Tatsumi, Kazutaka Koganei, Akira Sugita, Kenji Katsumata, Akihiko Tsuchida, Itaru Endo
Summary: After comparing the postoperative complications, bowel function, and prognosis of stapled IPAA and hand-sewn IPAA for ulcerative colitis, it was found that while there was no significant difference in postoperative complications between the two groups, stapled IPAA resulted in better postoperative bowel function.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Hideaki Kimura, Kenichiro Toritani, Reiko Kunisaki, Kenji Tatsumi, Kazutaka Koganei, Akira Sugita, Itaru Endo
Summary: This study retrospectively analyzed the medical records of 163 patients with ulcerative colitis who underwent DS-IPAA. The results showed that high BMI was significantly associated with the retention of a large amount of anorectal mucosa. The possible risk of mucosa retention should be considered in high BMI patients.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Kenichiro Toritani, Hideaki Kimura, Koki Goto, Reiko Kunisaki, Jun Watanabe, Atsushi Ishibe, Itaru Endo
Summary: This study aimed to evaluate the frequency and grade of stapled ileal pouch-anal anastomosis (IPAA) anastomotic leakage (AL) and its long-term impact on pouch functions. The study found that curable AL does not affect late complications (except anastomotic stricture), pouch survival, bowel function, or pouch inflammation over the long term. Perioperative management to prevent the severity of AL is as important as preventing its occurrence.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Michio Itabashi, Hiroki Ikeuchi, Hideaki Kimura, Kohei Fukushima, Hisao Fujii, Riichiro Nezu, Kitaro Futami, Akira Sugita, Yasuo Suzuki, Tadakazu Hisamatsu
Summary: This study in Asia focused on VTE in ulcerative colitis surgery, revealing a high prevalence that emphasizes the importance of VTE management in the perioperative period. Prolonged preoperative hospital stay and perioperative blood transfusion were significant risk factors for VTE.
CROHNS & COLITIS 360
(2021)
Article
Gastroenterology & Hepatology
Hiroki Ikeuchi, Motoi Uchino, Akira Sugita, Kitaro Futami, Kouhei Fukushima, Keisuke Hata, Kazutaka Koganei, Masato Kusunoki, Keiichi Uchida, Riichiro Nezu, Hideaki Kimura, Kenichi Takahashi, Michio Itabashi, Hitoshi Kameyama, Daijiro Higashi, Fumikazu Koyama, Takeshi Ueda, Tsunekazu Mizushima, Yasuo Suzuki
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2018)
Article
Gastroenterology & Hepatology
Michio Itabashi, Hiroki Ikeuchi, Hideaki Kimura, Kohei Fukushima, Hisao Fujii, Riichiro Nezu, Kitaro Futami, Akira Sugita, Yasuo Suzuki, Tadakazu Hisamatsu
Summary: This study is the first scheduled VTE study in ulcerative colitis surgery in Asia, indicating a significant occurrence of VTE during surgery and the necessity of VTE-conscious perioperative management in Asia. Surgery for inflammatory bowel disease is a risk factor for VTE, with long hospital stays and blood transfusions being significant factors related to VTE risk.
CROHNS & COLITIS 360
(2021)