Article
Surgery
Steffane McLennan, Kevin Verhoeff, Valentin Mocanu, Uzair Jogiat, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: Revisional bariatric surgery is an option for patients with weight regain or inadequate weight loss after primary elective procedures. However, the safety outcomes of revisional procedures are conflicting. This study aims to characterize the patient demographics, procedure types, and safety outcomes for those undergoing revisional compared to initial bariatric interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Yeongkeun Kwon, Jin-Won Kwon, Dohyang Kim, Jane Ha, Shin-Hoo Park, Jinseub Hwang, Yoonseok Heo, Sungsoo Park
Summary: Preoperative clinical parameters predict diabetes remission and relapse, while greater postoperative weight decrease may increase the likelihood of diabetes remission.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Endocrinology & Metabolism
Naomi Holman, Sarah H. Wild, Kamlesh Khunti, Peter Knighton, Jackie O'Keefe, Chirag Bakhai, Bob Young, Naveed Sattar, Jonathan Valabhji, Edward W. Gregg
Summary: The incidence of remission of type 2 diabetes is generally low in routine care settings, but it may be a reasonable goal for patients who lose a significant amount of weight shortly after diagnosis. Factors associated with higher odds of remission include shorter duration of diagnosis, non-prescription of glucose-lowering medication, lower HbA(1c) and BMI levels, White ethnicity, female sex, and lower socioeconomic deprivation.
Article
Obstetrics & Gynecology
K. Johansson, A-k Wikstrom, J. Soderling, I Naslund, J. Ottosson, M. Neovius, O. Stephansson
Summary: A nationwide matched cohort study in Sweden involving over 843,000 singleton pregnancies found that gastric bypass surgery before pregnancy is associated with a reduced risk of pre-eclampsia, with the largest absolute risk reduction observed in nulliparous women.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Endocrinology & Metabolism
D. Moriconi, M. L. Manca, M. Anselmino, E. Rebelos, R. Bellini, S. Taddei, E. Ferrannini, M. Nannipieri
Summary: This study assessed the impact of bariatric surgery on remission and relapse of type 2 diabetes mellitus (T2DM) and analyzed predictive factors. The results showed that bariatric surgery significantly improved BMI, fasting glucose, and haemoglobin A1c (HbA1c). The remission rates at 1 and 10 years post-surgery were 74% and 53% respectively. T2DM duration, baseline HbA1c, and ensuing insulin therapy were identified as the strongest predictors of remission. Short T2DM duration and good glycemic control before surgery were essential for long-lasting remission, while weight loss did not impact the long-term relapse of T2DM.
DIABETES & METABOLISM
(2022)
Article
Immunology
Leena Zino, Ferdinand Wit, Casper Rokx, Jan G. den Hollander, Mark van der Valk, Olivier Richel, David M. Burger, Angela Colbers
Summary: Data from a Dutch cohort of people with HIV on antiretrovirals show that bariatric surgery is an effective intervention for weight loss and lipid improvement in HIV patients on ART, with no clear worsening of virologic control up to 18 months post-surgery.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Surgery
Theresa Burkard, Dag Holmberg, Anders Thorell, Farhad Hafezi, Andrea M. Burden
Summary: This study assessed the association between weight loss following bariatric surgery and cataracts. The results showed that substantial weight loss following bariatric surgery is associated with a decreased risk of cataracts, especially if the surgery was performed before age 60.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Nutrition & Dietetics
Serena Marchitelli, Eleonora Ricci, Cristina Mazza, Paolo Roma, Renata Tambelli, Giovanni Casella, Lucio Gnessi, Andrea Lenzi
Summary: This study investigated the relationship between psychological factors, adherence to nutritional plan, and weight loss after bariatric surgery. The results showed that non-planning impulsivity was the main factor affecting adherence to the diet plan. Adherence to the nutritional plan and non-planning impulsivity were reliable short-term predictors of weight loss after bariatric surgery.
Article
Surgery
Pouya Iranmanesh, Shinil K. Shah, Mickael Chevallay, Christian Toso, Stefan P. Monig, Monika E. Hagen, Erik B. Wilson, Minoa K. Jung
Summary: This study retrospectively analyzed patient data from two databases at two high-volume bariatric centers to identify predictors of early postoperative complications after RRYGB. The results showed that male sex and ASA score > 2 were independent predictors of early postoperative complications after RRYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Alexander Dimitri Miras, Anna Kamocka, Belen Perez-Pevida, Sanjay Purkayastha, Krishna Moorthy, Ameet Patel, Harvinder Chahal, Gary Frost, Paul Bassett, Lidia Castagnetto-Gissey, Lucy Coppin, Nicola Jackson, Anne Margot Umpleby, Stephen Robert Bloom, Tricia Tan, Ahmed Rashid Ahmed, Francesco Rubino
Summary: The study demonstrates that lengthening the intestinal bypass during RYGB does not affect GLP-1 secretion, suggesting that the characteristic enhancement of GLP-1 response after RYGB may not depend on delivering nutrients to more distal intestinal segments.
Article
Endocrinology & Metabolism
Louise L. Stentebjerg, Lene R. Madsen, Rene K. Stoving, Lise Lotte T. Andersen, Christina A. Vinter, Claus B. Juhl, Dorte M. Jensen
Summary: This study aimed to investigate glucose metabolism during pregnancy in women who had undergone Roux-en-Y gastric bypass (RYGB). The study found that women with RYGB were more susceptible to hypoglycemia and hyperglycemia compared with control participants. Further research is needed to explore the association between hypoglycemia and fetal growth restriction in women with RYGB.
Article
Nutrition & Dietetics
Gabriela Ribeiro, Marta Camacho, Ana B. Fernandes, Goncalo Cotovio, Sandra Torres, Albino J. Oliveira-Maia
Summary: This study aimed to investigate whether gustatory and psychometric measures of reward-related feeding are predictors of bariatric-induced weight loss. Results suggest that baseline sweet intensity and hedonic hunger scores are predictors of weight loss after surgery, indicating that these factors may reflect physiological processes variably modulated by bariatric surgery and influencing clinical outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Surgery
Mohamed AbdAlla Salman, Ahmed Rabiee, Ahmed Salman, Ahmed Elewa, Mohamed Tourky, Ahmed Abdelrahman Mahmoud, Ahmed Moustafa, Hossam El-Din Shaaban, Ahmed Abdelaziz Ismail, Khaled Noureldin, Mohamed Issa, Mohamed Farah, Hesham Barbary, Mujahid Gasemelseed Fadlallah Elhaj, Haitham S. E. Omar
Summary: This study aimed to identify predictors of diabetes remission after two types of bariatric procedures. The results showed that nearly half of the patients achieved complete remission of T2DM two years after surgery. The duration of diabetes and preoperative BMI and C-peptide levels were independent factors predicting complete remissions.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Ibiyemi Ilesanmi, George Tharakan, Kleopatra Alexiadou, Preeshila Behary, Haya Alessimii, Candace Bovill-Taylor, Julia Kenkre, Sirazum Choudhury, Chedie Doyle, Sanjay Purkayastha, Alex Miras, Christos Tsironis, Harvinder Chahal, Stephen R. Bloom, Nick S. Oliver, Ahmed R. Ahmed, Bernard Khoo, Tricia M. -M. Tan
Summary: This study showed that after RYGB surgery, patients experienced a decrease in mean glucose levels, an increase in glycemic variability, and an increase in GLP-1 response, which put them at risk for postbariatric hypoglycemia.
Article
Cardiac & Cardiovascular Systems
Aristithes G. Doumouras, Jorge A. Wong, J. Michael Paterson, Yung Lee, Branavan Sivapathasundaram, Jean-Eric Tarride, Lehana Thabane, Dennis Hong, Salim Yusuf, Mehran Anvari
Summary: This study indicates that bariatric surgery is associated with reduced incidence of major adverse cardiovascular events in patients with cardiovascular disease and obesity, particularly in those with heart failure and ischemic heart disease. These findings suggest the potential benefits of bariatric surgery in improving cardiovascular outcomes and warrant further investigation through large-scale randomized trials.
Article
Cell Biology
David L. Morris, Kelsie E. Oatmen, Taleen A. Mergian, Kae Won Cho, Jennifer L. DelProposto, Kanakadurga Singer, Carmella Evans-Molina, Robert W. O'Rourke, Carey N. Lumeng
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Immunology
Kae Won Cho, Brian F. Zamarron, Lindsey A. Muir, Kanakadurga Singer, Cara E. Porsche, Jennifer B. DelProposto, Lynn Geletka, Kevin A. Meyer, Robert W. O'Rourke, Carey N. Lumeng
JOURNAL OF IMMUNOLOGY
(2016)
Article
Endocrinology & Metabolism
Lindsey A. Muir, Christopher K. Neeley, Kevin A. Meyer, Nicki A. Baker, Alice M. Brosius, Alexandra R. Washabaugh, Oliver A. Varban, Jonathan F. Finks, Brian F. Zamarron, Carmen G. Flesher, Joshua S. Chang, Jennifer B. DelProposto, Lynn Geletka, Gabriel Martinez-Santibanez, Niko Kaciroti, Carey N. Lumeng, Robert W. O'Rourke
Article
Endocrinology & Metabolism
H. Frikke-Schmidt, R. W. O'Rourke, C. N. Lumeng, D. A. Sandoval, R. J. Seeley
Article
Endocrinology & Metabolism
Henriette Frikke-Schmidt, Brian F. Zamarron, Robert W. O'Rourke, Darleen A. Sandoval, Carey N. Lumeng, Randy J. Seeley
MOLECULAR METABOLISM
(2017)
Article
Endocrinology & Metabolism
Lindsey A. Muir, Nicki A. Baker, Alexandra R. Washabaugh, Christopher K. Neeley, Carmen G. Flesher, Jennifer B. DelProposto, Lynn M. Geletka, Amir A. Ghaferi, Jonathan F. Finks, Kanakadurga Singer, Oliver A. Varban, Carey N. Lumeng, Robert W. O'Rourke
Article
Endocrinology & Metabolism
Robert W. O'Rourke, Geoffrey S. Johnson, Jonathan Q. Purnell, Anita P. Courcoulas, Gregory F. Dakin, Luis Garcia, Marcelo Hinojosa, James E. Mitchell, Alfons Pomp, Walter J. Pories, Konstantinos Spaniolas, David R. Flum, Abdus S. Wahed, Bruce M. Wolfe
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Article
Immunology
Lynn M. Frydrych, Guowu Bian, Fatemeh Fattahi, Susan B. Morris, Robert W. O'Rourke, Carey N. Lumeng, Steven L. Kunkel, Peter A. Ward, Matthew J. Delano
JOURNAL OF IMMUNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Xiang Ma, Meng Cao, Qinghong Shen, Jie Yuan, Ting Feng, Qian Cheng, Xueding Wang, Alexandra R. Washabaugh, Nicki A. Baker, Carey N. Lumeng, Robert W. O'Rourke
APPLIED SCIENCES-BASEL
(2018)
Article
Biotechnology & Applied Microbiology
Richard Youngblood, Carmen G. Flesher, Jennifer Delproposto, Nicki A. Baker, Christopher K. Neeley, Fanghua Li, Carey N. Lumeng, Lonnie D. Shea, Robert W. O'Rourke
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Review
Endocrinology & Metabolism
Robert W. O'Rourke, Carey N. Lumeng
Summary: The increased morbidity and mortality of COVID-19 in individuals with obesity has drawn attention to the impaired responses to infections in this population. Research indicates a critical need to understand the physiological mechanisms underlying the increased risk for complications from COVID-19 in people with obesity, in order to develop tailored therapies for this group.
Article
Endocrinology & Metabolism
Strieder-Barboza, Carmen G. Flesher, Lynn Geletka, Tad Eichler, Olukemi Akinleye, Alexander P. Ky, Anne N. Ehlers, Carey W. Lumeng, Robert O'Rourke
Summary: Obesity-associated type 2 diabetes can lead to dysfunction in adipose tissue, and lumican, a proteoglycan, is involved in obesity, insulin resistance, and adipocyte dysfunction. In this study, lumican levels were found to be increased in visceral adipose tissue and adipocytes of individuals with DM. Knockdown of lumican in adipocytes led to decreased lipolysis and improved adipogenesis and insulin sensitivity in VAT adipocytes of DM patients, while treatment with human recombinant lumican increased lipolysis and impaired insulin-sensitivity through ERK signaling. This suggests that lumican can impair adipocyte metabolism, partly through ERK signaling, and may be a potential target for developing targeted therapeutics for adipose tissue in DM.
Article
Endocrinology & Metabolism
Alexander Ky, Atticus J. Mccoy, Carmen G. Flesher, Nicole E. Friend, Jie Li, Kore Akinleye, Christopher Patsalis, Carey N. Lumeng, Andrew J. Putnam, Robert W. O'Rourke
Summary: The alterations of extracellular matrix contribute to dysfunction of adipose tissue in metabolic disease. In this study, we found that intermediate density matrix promotes more adipocyte generation, reduces fibrosis, and enhances lipid and aerobic metabolism.
Article
Endocrinology & Metabolism
Nicki A. Baker, Lindsey A. Muir, Alexandra R. Washabaugh, Christopher K. Neeley, Sophie Yu-Pu Chen, Carmen G. Flesher, John Vorwald, Jonathan F. Finks, Amir A. Ghaferi, Michael W. Mulholland, Oliver A. Varban, Carey N. Lumeng, Robert W. O'Rourke
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)