Article
Psychology, Clinical
Delainey L. Wescott, Peter L. Franzen, Brant P. Hasler, Megan A. Miller, Adriane M. Soehner, Stephen F. Smagula, Meredith L. Wallace, Martica H. Hall, Kathryn A. Roecklein
Summary: This study aims to clarify the nature and extent of hypersomnolence in seasonal affective disorder (SAD) using multiple measurements. The results suggest that hypersomnolence is not a poor characterization of SAD, and self-reported hypersomnia captures multiple sleep disruptions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Anibal Fonte, Bruno Coutinho
Summary: The study found a statistically significant association between seasonal affective disorder and psychiatric morbidity, emphasizing the importance of the Seasonal Pattern Assessment Questionnaire in screening for related disorders.
Article
Neurosciences
Carla Iorio, Francesca Pacitti, Alessandro Rossi, Paola Iorio, Assunta Pompili
Summary: Seasonal Affective Disorder (SAD) is a specific subtype of Major Depressive Disorder (MDD) characterized by a seasonal pattern. This study aimed to investigate the cognitive processing of emotional stimuli in women with SAD, and found impaired declarative memory and attentional bias for negative emotional stimuli in SAD patients.
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Kathryn A. Roecklein, Peter L. Franzen, Delainey L. Wescott, Brant P. Hasler, Megan A. Miller, Shannon D. Donofry, Caitlin M. DuPont, Sarah M. Gratzmiller, Scott P. Drexler, W. Michael Wood-Vasey, Paul D. Gamlin
Summary: A retinal subsensitivity to environmental light may trigger Seasonal Affective Disorder (SAD) under low wintertime light conditions. The study found that SAD patients had significantly decreased responses to light in winter compared to controls, highlighting the seasonal variation in melanopsin driven non-visual responses to light as a potential risk factor for SAD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Natalia Karina Bartosik, Rafal Frankowski, Mateusz Kobierecki, Kacper Deska, Aleksander Twarowski, Bartlomiej Bak, Marcin Kosmalski, Tadeusz Pietras
Summary: This study investigates the potential link between symptoms of depression and the dominating type of affective temperament in medical students. A survey was conducted on 134 medical students using two validated questionnaires. The data analysis reveals a significant link between symptoms of depression and affective temperaments, specifically in students with an anxious temperament. This study confirms the role of various affective temperaments as a risk factor for mood disorders, specifically depression.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Lea Bertrand, Marie-Pia d'ortho, Eve Reynaud, Michel Lejoyeux, Patrice Bourgin, Pierre A. Geoffroy
Summary: The study focused on Seasonal Affective Disorder (SAD) and found that REM sleep is significantly increased in both acute and remitted phases of the disorder. This suggests that REM sleep alterations could serve as trait markers for the diagnosis and treatment of SAD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Paola Salvatore, Ross J. Baldessarini, Harimandir K. Khalsa, Mauricio Tohen
Summary: The study analyzed psychopathological details of prodromes leading to first-lifetime psychotic episodes and found that these features could predict and distinguish final diagnoses of MDD, BD-I, and SzAffD. The findings highlight the value of early psychopathology in predicting final diagnoses of major affective and schizoaffective disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Young Tak Jo, Sung Woo Joo, Harin Kim, Soojin Ahn, Young Jae Choi, Woohyeok Choi, So Yeon Park, Jungsun Lee
Summary: This study investigated diagnostic conversion between bipolar affective disorder and unipolar affective disorder, and identified the usage of antidepressants and younger age as risk factors for diagnostic conversion.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Ettore Favaretto, Martin Gogele, Fulvio Bedani, Andrew A. Hicks, Andreas Erfurth, Giulio Perugi, Peter P. Pramstaller, Roberto Melotti
Summary: This study found that affective temperaments have a modulation effect on pain sensitivity, with hyperthymic temperament suggesting pain resilience and cyclothymic temperaments suggesting pain susceptibility. Trait anxiety was found to have a stronger effect on this association.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Shuqi Kong, Zhiang Niu, Dongbin Lyu, Lvchun Cui, Xiaohui Wu, Lu Yang, Hong Qiu, Wenjie Gu, Yiru Fang
Summary: This study investigates the seasonal symptoms and non-enzymatic oxidative stress in first hospitalized patients with bipolar and unipolar depression, aiming to differentiate between the two disorders and reduce misdiagnosis. The study finds that patients with bipolar depression have distinct seasonal characteristics compared to those with unipolar depression. Clinical symptoms and indicators of oxidative stress may serve as factors for distinguishing between seasonal unipolar depression and bipolar depression. Young individuals aged 15-35 are more likely to develop bipolar depression in winter.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Yuqi S. Wang, Abbey L. Friedman, Karen P. Jakubowski, Delainey L. Wescott, Praise Iyiewuare, Julia S. Feldman, Daniel S. Shaw, Kathryn A. Roecklein
Summary: This study investigated the role of childhood maltreatment in Seasonal Affective Disorder (SAD) and found that insomnia, ruminative brooding, and seasonal maladaptive beliefs may account for the association between childhood maltreatment and SAD symptom severity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Marie Kim Wium-Andersen, Ida Kim Wium-Andersen, Terese Sara Hoj Jorgensen, Martin Balslev Jorgensen, Merete Osler
Summary: Patients with affective disorder have higher absolute and relative risks of most somatic diseases, except for cancers. The strongest associations were found for dementia, hip fracture, COPD, and stroke on both the relative and absolute scale. Further research on shared mechanisms could lead to targeted interventions to reduce the risk.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Charlotte B. Hansen, Christina V. L. Larsen, Peter Bjerregaard, Mylene Riva
Summary: The study investigates the association between household crowding and composition with self-rated health and mental health among the Inuit in Greenland. It found that living in overcrowded dwellings and living alone were associated with poorer health outcomes. Public health authorities should focus on ensuring affordable and good quality housing in all communities in Greenland.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Peter Bjerregaard, Christina Viskum Lytken Larsen
Summary: This study explored the role of social position in dietary patterns and expenditures among the Inuit in Greenland. It found that individuals with lower social position were more likely to choose unhealthy dietary patterns and spent more on non-nutritious food, alcohol, and tobacco compared to those with higher social position.
PUBLIC HEALTH NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Ryan K. Waples, Aviaja L. Hauptmann, Inge Seiding, Emil Jorsboe, Marit E. Jorgensen, Niels Grarup, Mette K. Andersen, Christina V. L. Larsen, Peter Bjerregaard, Garrett Hellenthal, Torben Hansen, Anders Albrechtsen, Ida Moltke
Summary: The study found that about 25% of the genetic ancestry of the present-day Greenlandic population comes from Europe, predominantly Danish, with substantial admixture occurring within the last few generations.
Article
Endocrinology & Metabolism
Theresia M. Schnurr, Emil Jorsboe, Alexandra Chadt, Inger K. Dahl-Petersen, Jonas M. Kristensen, Jorgen F. P. Wojtaszewski, Christian Springer, Peter Bjerregaard, Soren Brage, Oluf Pedersen, Ida Moltke, Niels Grarup, Hadi Al-Hasani, Anders Albrechtsen, Marit E. Jorgensen, Torben Hansen
Summary: In Arctic populations, physical activity can lower glucose levels, especially in carriers of the TBC1D4 risk variant. One hour of vigorous physical activity per day can further reduce the 2-hour plasma glucose levels in carriers of the risk variant.
Article
Environmental Sciences
Violeta Hansen, Anders Mosbech, Frank Farso Riget, Jens Sogaard-Hansen, Peter Bjerregaard, Rune Dietz, Christian Sonne, Gert Asmund, Niels Boknaes, Maia Olsen, Kim Gustavson, David Boertmann, Sandra Drewes Fabricius, Daniel Spelling Clausen, Alexander Serban Hansen
Summary: This study investigates the 210Po concentrations in Greenlandic marine organisms and assesses the potential dose risk to human consumers. The results show significant variations in 210Po concentrations among different organisms, with particularly high levels found in ringed seal and polar bear tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Clara Amalie Gade Timmermann, Henning Sloth Pedersen, Pal Weihe, Peter Bjerregaard, Flemming Nielsen, Carsten Heilmann, Philippe Grandjean
Summary: This study found a negative association between increased exposure to environmental chemicals among Greenlandic children and post-vaccination antibody concentrations, with an increased risk of not being protected against diphtheria despite appropriate vaccination. These findings emphasize the potential risks of environmental chemical exposures in the Arctic population.
ENVIRONMENTAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Mette K. Andersen, Line Skotte, Emil Jorsboe, Ryan Polito, Frederik F. Staeger, Peter Aldiss, Kristian Hanghoj, Ryan K. Waples, Cindy G. Santander, Niels Grarup, Inger K. Dahl-Petersen, Lars J. Diaz, Maria Overvad, Ninna K. Senftleber, Bolette Soborg, Christina V. L. Larsen, Clara Lemoine, Oluf Pedersen, Bjarke Feenstra, Peter Bjerregaard, Mads Melbye, Marit E. Jorgensen, Nils J. Faergeman, Anders Koch, Thomas Moritz, Matthew P. Gillum, Ida Moltke, Torben Hansen, Anders Albrechtsen
Summary: Adults with sucrase-isomaltase deficiency have better metabolic health, with lower BMI, body weight, fat percentage, fasting triglyceride, and remnant cholesterol levels. This is likely mediated by higher levels of acetate and reduced sucrose uptake, but not lower caloric intake.
Correction
Psychiatry
Ivalu Katajavaara Seidler, Janne Schurmann Tolstrup, Peter Bjerregaard, Allison Crawford, Christina Viskum Lytken Larsen
Article
Nutrition & Dietetics
Jack Ivor Lewis, Mads Vendelbo Lind, Grith Moller, Torben Hansen, Hanne Pedersen, Marie Mathilde Bjerg Christensen, Jens Christian Laursen, Sara Nielsen, Charlotte B. Ottendahl, Christina V. Lytken Larsen, Ken D. Stark, Peter Bjerregaard, Marit E. Jorgensen, Lotte Lauritzen
Summary: Consumption of traditional foods is decreasing in Greenland, leading to an increased incidence of type 2 diabetes. A study was conducted to analyze the effects of traditional marine diets on glucose metabolism and cardio-metabolic health in Greenlandic Inuit. Compared to a Western diet, the Traditional diet resulted in lower blood glucose levels, weight loss, and improved lipid profile. However, carriers of the TBC1D4 variant showed a potential negative effect on glucose tolerance. More research is needed on this gene-diet interaction.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Health Care Sciences & Services
Anne Cathrine Baun Thuesen, Frederik Filip Staeger, Alba Kaci, Marie Holm Solheim, Ingvild Aukrust, Emil Jorsboe, Cindy G. Santander, Mette K. Andersen, Zilong Li, Arthur Gilly, Sara Elizabeth Stinson, Anette Prior Gjesing, Peter Bjerregaard, Michael Lynge Pedersen, Christina Viskum Lytken Larsen, Niels Grarup, Marit E. Jorgensen, Eleftheria Zeggini, Lise Bjorkhaug, Pal Rasmus Njolstad, Anders Albrechtsen, Ida Moltke, Torben Hansen
Summary: This study aimed to identify and characterize novel variants in genes associated with MODY in the Greenlandic population. Through screening data from Greenlandic population cohorts, researchers identified a novel variant in the known MODY gene HNF1A that is specific to the Greenlandic Inuit population. The variant was found to be associated with diabetes and glucose levels, and had a significant impact on diabetes prevalence in Greenland.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Public, Environmental & Occupational Health
Maria Overvad, Lars Jorge Diaz, Peter Bjerregaard, Michael Lynge Pedersen, Christina Viskum Lytken Larsen, Niels Grarup, Torben Hansen, Peter Rossing, Marit Eika Jorgensen
Summary: The aim of this study was to investigate the impact of diabetes and the diabetogenic TBC1D4 variant on kidney function in a population-based setting in Greenland. Data from a health survey and TBC1D4 genotypes of 5,336 Greenlanders were analyzed to assess the odds ratios (ORs) of albuminuria and chronic kidney disease (CKD) in individuals with and without diabetes, taking into account the effect of the TBC1D4 variant. The results showed that diabetes was associated with an elevated risk of albuminuria, while the TBC1D4 variant was protective against the development of albuminuria. However, neither diabetes nor the TBC1D4 variant were significantly associated with CKD. The findings suggest a potential renoprotective effect of the TBC1D4 variant on albuminuria, warranting further investigation.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Peter Bjerregaard, Charlotte Brandstrup Ottendahl, Tenna Jensen, Kamilla Nortoft, Marit Eika Jorgensen, Christina Viskum Lytken Larsen
Summary: The study aimed to investigate the relationship between muscular strength, muscle pain, reduced mobility in daily life and mental wellbeing among older Inuit men and women in Greenland. Data from a countrywide health survey in 2018 (N = 846) was analyzed. Results showed that muscular strength and muscle pain were associated with reduced mobility, while muscle pain and reduced mobility were associated with mental wellbeing. Chair stand score was related to life satisfaction. The findings highlight the importance of considering reduced muscle strength, muscle pain, and reduced mobility in the prevention and management of poor mental health among older adults.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2023)
Article
Genetics & Heredity
Emil Jorsboe, Mette K. Andersen, Line Skotte, Frederik F. Staeger, Nils J. Faergeman, Kristian Hanghoj, Cindy G. Santander, Ninna K. Senftleber, Lars J. Diaz, Maria Overvad, Ryan K. Waples, Frank Geller, Peter Bjerregaard, Mads Melbye, Christina V. L. Larsen, Bjarke Feenstra, Anders Koch, Marit E. Jorgensen, Niels Grarup, Ida Moltke, Anders Albrechtsen, Torben Hansen
Summary: The common Arctic-specific LDLR p.G137S variant is associated with increased risk of familial hypercholesterolemia (FH) and cardiovascular disease in Greenlanders, affecting up to 30% of the population.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)
Article
Public, Environmental & Occupational Health
Peter Bjerregaard, Christina Viskum Lytken Larsen, Ingelise Olesen, Charlotte Brandstrup Ottendahl, Vibeke Backer, Ninna Senftleber, Marie Mathilde Bjerg Christensen, Trine Jul Larsen, Stine Byberg, Torben Hansen, Marit Eika Jorgensen
Summary: Regular population health surveys have been conducted in Greenland since 1993 to support public health strategy and monitor cardiometabolic and lung diseases. The most recent survey included 2539 individuals aged 15+ from 20 communities across the country. Data collection methods included interviews, questionnaires, and various health measurements. The study aims to contribute to the monitoring of risk factors and overall health conditions, as well as the investigation of chronic diseases and behavioral risk factors.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Ivalu Katajavaara Seidler, Lau Caspar Thygesen, Peter Bjerregaard, Christina Viskum Lytken Larsen
Summary: A study on the drinking patterns among Greenland Inuit indicates that occasional excessive drinking remains a major challenge for public health in Greenland. More than half of the men and one-third of the women have a drinking pattern characterized by occasional binge drinking. The proportion of abstainers increases with age, while the prevalence of occasional binge drinking decreases among men. Younger male cohorts are less likely to engage in occasional binge drinking, while the youngest females have the highest likelihood. The study highlights age as a strong predictor and stresses the coexistence of high proportions of abstainers and occasional binge drinkers in Greenland.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2022)
