Article
Substance Abuse
Rebecca McKetin, Philip J. Clare, David Castle, Alyna Turner, Peter J. Kelly, Dan I. Lubman, Shalini Arunogiri, Victoria Manning, Michael Berk
Summary: This study aimed to determine whether the risk of psychotic symptoms during methamphetamine use was dependent on, increased by, or independent of having a family history of psychosis. The findings showed that both methamphetamine use and family history of psychosis were independently associated with psychotic symptoms in the past week, and the joint risk was even larger when they occurred together. There was no significant interaction between family history of psychosis and methamphetamine use in predicting psychotic symptoms, but family history of psychosis was an independent risk factor for the absolute risk of psychotic symptoms in this population.
Article
Psychiatry
Ryan Turner, Krisya Louie, Ameerah Parvez, Mustapha Modaffar, Rowan Rezaie, Talya Greene, James Bisby, Peter Fonagy, Michael A. P. Bloomfield
Summary: Developmental trauma is associated with psychotic experiences, and deficits in Theory of Mind (ToM) are a candidate mechanism underlying the association between developmental trauma and psychosis.
PSYCHIATRY RESEARCH
(2022)
Article
Medicine, General & Internal
Markku Lahteenvuo, Ari Ahola-Olli, Kimmo Suokas, Minna Holm, Zuzanna Misiewicz, Tuomas Jukuri, Teemu Maennynsalo, Asko Wegelius, Willehard Haaki, Risto Kajanne, Aija Kyttala, Annamari Tuulio-Henriksson, Kaisla Lahdensuo, Katja Hakkinen, Jarmo Hietala, Tiina Paunio, Jussi Niemi-Pynttari, Tuula Kieseppa, Juha Veijola, Jouko Lonnqvist, Erkki Isometsa, Olli Kampman, Jari Tiihonen, Steven Hyman, Benjamin Neale, Mark Daly, Jaana Suvisaari, Aarno Palotie
Summary: The purpose of this study is to establish a large Finnish collection of psychosis cases, including diverse populations from Asia, Latin America, and Africa, in addition to known population isolates like Finland. A total of 10,474 individuals aged 18 years or older were recruited and genotyped. The future plans of this study include investigating the effects of common variants, rare variants, and copy number variations on the severity of psychotic illness, as well as tracking the longitudinal course of illness based on nationwide register data.
Article
Psychiatry
Ilkka Ojansuu, Antti Latvala, Hannu Kautiainen, Jonas Forsman, Jari Tiihonen, Markku Lahteenvuo
Summary: This study examined the criminal recidivism rates of discharged forensic psychiatric patients in Finland. The results showed that 16.6% of the patients committed another crime after discharge, indicating a relatively low recidivism rate. Longer treatment duration was associated with a decreased risk of recidivism.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Patrick Koeck, Elisabeth Lang, Valerie-Noelle Trulley, Frieder Dechent, Katja Mercer-Chalmers-Bender, Priska Frei, Christian Huber, Stefan Borgwardt
Summary: Psychotic disorders are often accompanied by substance use disorders, with the use of THC-rich cannabis linked to a higher risk of psychosis. While previous studies suggest CBD as a potential antipsychotic agent, this trial investigated the effects of smoked CBD-cigarettes as adjunctive therapy for psychotic symptoms, indicating a possible antipsychotic medication-sparing effect. However, the small sample size limited further statistical analysis and suggests the need for larger studies with more rigorous study design.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Alina Laskowski, Tania M. Lincoln
Summary: This planned network meta-analysis aims to compare the efficacy of different types of family interventions for psychotic disorders by looking at various content and format factors. Main outcomes will focus on patients' clinical state and relatives' attitudes towards psychosis, with additional measures including symptom severity, functioning, burden, and compliance/drop-out. This study will use a random effects model within a frequentist framework to rank interventions based on relative efficacy and address issues of transitivity, heterogeneity, and inconsistency.
Article
Psychology, Clinical
Julia M. Longenecker, R. Michael Bagby, Kwame McKenzie, Bruce G. Pollock, Tony P. George, Peter Voore, Lena C. Quilty
Summary: The research indicates that internalizing symptoms are the strongest predictor of functional outcomes for outpatients with psychotic disorders, especially in individuals with high levels of substance use. The study also found similar results when using the clinician-rated World Health Organization Disability Assessment Schedule 2.0.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Anthony M. Battaglia, Mini Mamak, Joel O. Goldberg
Summary: This study aims to understand the stigma towards individuals with mental illness who commit violent offences, and find ways to mitigate the negative impact of social media news stories about schizophrenia and violent offending. The results show that providing contextual clinical explanatory information can help overcome negative attitudes towards mentally ill individuals who commit violent offences. However, both conditions showed an increase in social-distancing behaviours, perceptions of dangerousness, and negative beliefs about mental illness. Incorporating clinical knowledge-based information may be helpful in mitigating some aspects of stigma.
JOURNAL OF COMMUNITY PSYCHOLOGY
(2022)
Article
Clinical Neurology
G. Fond, M. Faugere, R. Richieri, M. Cermolacce, T. Korchia, J. A. Micoulaud-Franchi, P. L. Sunhary de Verville, L. Boyer, C. Lancon
Summary: This study found that depressive symptoms and chronic peripheral inflammation are associated with impaired functional remission in patients with schizophrenia, independent of psychotic remission. These findings emphasize the potential of improving depressive symptoms and chronic peripheral inflammation to help patients achieve functional remission.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
August Jernbom Falk, Cherrie Galletly, David Just, Catherine Toben, Bernhard T. Baune, Scott R. Clark, Dennis Liu, Peter Nilsson, Anna Manberg, K. Oliver Schubert
Summary: Autoimmune processes may be involved in the pathophysiology of psychotic disorders, with associations found between autoimmune IgG repertoires and clinical features of mental illness. Females and individuals with family histories of obesity or psychiatric disorders other than schizophrenia had higher overall autoantibody counts, while those with subjective thought disorder experiences or treated with clozapine had lower counts. Specific autoantibodies were linked to certain psychopathology symptoms, suggesting potential for clinical markers in patient stratification and treatment choices.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Ilaria Rossetto, Massimo Clerici, Filippo Franconi, Alan R. Felthous, Fulvio Carabellese, Giancarlo Di Vella, Maria Gloria Gandellini, Lia Parente, Felice Carabellese
Summary: This study compared readmitted and non-readmitted female psychiatric patients released from Italian inpatient forensic services to identify variables linked with readmission. Factors like substance use disorders, primary diagnosis on Axis II, younger age, unconditional discharge, shorter inpatient stay, and crime type were associated with readmission. Recommendations include focusing on treatment approaches for young female patients with personality disorders and SUD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Sinead Lambe, Kate Cooper, Seena Fazel, Daniel Freeman
Summary: This study conducted in-depth interviews with 20 patients with psychosis to explore the psychological processes underlying violence in this population. The analysis identified a seven-factor model of violence, which can guide the development of targeted treatments to reduce violence by individuals with psychosis.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Pawel Gosek, Justyna Kotowska, Elzbieta Rowinska-Garbien, Dariusz Bartczak, Janusz Heitzman
Summary: Patients with schizophrenia spectrum disorders represent the largest group of forensic inpatients worldwide. Factors such as mental disorders among family members, alcohol or substance dependence, severity of criminal behavior, and treatment resistance affect the length of stay in forensic hospitals.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, Legal
Eloise Provoost, Sophie Raymond, Ivan Gasman
Summary: This study compared two groups of delusional homicidal patients from near present day and nearly a century ago, exploring their sociodemographic and clinical characteristics. The more recent patients were typically single males suffering from schizophrenia, with varied delusional themes, while the historical patients were older, more often married and employed, and mostly had persecutory delusions. Additional studies can help reinforce the findings and explore prevention possibilities.
JOURNAL OF FORENSIC SCIENCES
(2022)
Article
Psychiatry
Kerem Boge, David J. Hallford, Matthias Pillny
Summary: The relationship between mindfulness, psychological flexibility (PF), and psychopathology in schizophrenia spectrum disorders (SSD) is not clear. A study with 43 participants with SSD and 43 controls found that SSD patients had lower mindfulness and PF. Mindfulness was associated with higher PS, anticipatory pleasure, behavioral activation, and lower depressive and negative symptoms. PS was associated with lower depressive and negative symptoms and higher anticipatory pleasure and behavioral activation. The findings suggest that targeting mindfulness and PF may help alleviate the amotivational psychopathology seen in SSD.
PSYCHIATRY RESEARCH
(2023)