期刊
SUPPORTIVE CARE IN CANCER
卷 23, 期 9, 页码 2579-2587出版社
SPRINGER
DOI: 10.1007/s00520-015-2616-x
关键词
Fatigue; Breast cancer; Trajectory; Daily; Treatment; Chemotherapy
资金
- National Institutes of Health (NIH) [1-U01AR057948-01]
- NIH Common Fund Initiative [U54AR057951, U01AR052177, U54AR057943, U54AR057926, U01AR057948, U01AR052170, U01AR057954, U01AR052171, U01AR052181, U01AR057956, U01AR052158, U01AR057929, U01AR057936, U01AR052155, U01AR057971, U01AR057940, U01AR057967, U01AR052186]
The goal of this study was to characterize changes in daily fatigue in women undergoing chemotherapy for breast cancer. We examined whether there are subgroups of patients with distinct fatigue trajectories and explored potential psychosocial and biomedical predictors of these subgroups. Participants were 77 women with breast cancer receiving adjuvant chemotherapy with AC-T (2-week cycle) and TC or TCH (3-week cycle) regimens. They completed 28 daily ratings online using an adapted version of the Patient-Reported Outcomes Measurement Information System (PROMISA (R)) fatigue instrument. Both regimens followed an inverted-U-shaped fatigue pattern over approximately 2 weeks. Growth mixture modeling identified three patient subgroups with distinct trajectories. Fatigue scores in the low fatigue group (23 %) increased following the infusion and quickly abated. The transient fatigue (27 %) group had a very pronounced increase. Patients in the high fatigue (50 %) group reported consistently elevated fatigue with a relatively small increase. Demographic and medical variables were not associated with fatigue trajectory. Patients in the high fatigue group reported significantly poorer physical, emotional, and social functioning, poorer general health, and more depressed mood than patients in the low fatigue group. The transient fatigue group reported significantly better physical and social functioning than the high fatigue group, but emotional distress and depression similar to the high fatigue group. The identification of patient subgroups with distinct fatigue trajectories during chemotherapy is an essential step for developing preventative strategies and tailored interventions. Our results suggest that different trajectories are associated with patients' psychosocial and general health.
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