期刊
NMR IN BIOMEDICINE
卷 26, 期 8, 页码 1028-1041出版社
WILEY
DOI: 10.1002/nbm.2996
关键词
DCE-MRI; model selection; microvascular permeability; cerebral glioma; patlak plot
资金
- National Cancer Institute of the National Institutes of Health [R01CA135329-01]
A review of the selection of models in dynamic contrast-enhanced MRI (DCE-MRI) is conducted, with emphasis on the balance between the bias and variance required to produce stable and accurate estimates of vascular parameters. The vascular parameters considered as a first-order model are the forward volume transfer constant K-trans, the plasma volume fraction v(p) and the interstitial volume fraction v(e). To illustrate the critical issues in model selection, a data-driven selection of models in an animal model of cerebral glioma is followed. Systematic errors and extended models are considered. Studies with nested and non-nested pharmacokinetic models are reviewed; models considering water exchange are considered. Copyright (C) 2013 John Wiley & Sons, Ltd.
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