Article
Neurosciences
Sebastian C. Schneider, Stephan Kaczmarz, Jens Goettler, Jan Kufer, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Summary: This study investigates and compares different hemodynamic-vascular processes and their impact on BOLD-FC in healthy controls and patients with ICAS. The results suggest that systemic perfusion delays have a stronger influence on BOLD-FC than impairments in local neurovascular coupling.
Article
Multidisciplinary Sciences
Gergely Somogyi, David Hlatky, Tamas Spisak, Zsofia Spisak, Gabriella Nyitrai, Andras Czurko
Summary: This study investigated the effects of scopolamine on brain activity using functional MRI in rats under different drug administration and anesthesia conditions. The results suggest that scopolamine may affect brain activation through central pathways, and its peripheral vascular actions depend on the type of anesthesia or dose.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Chun-Qiang Lu, Chu-Hui Zeng, Ying Cui, Xiang-Pan Meng, Ying Luan, Xiao-Min Xu, Shenghong Ju
Summary: This study investigated the task-fMRI and rs-fMRI results on SD and Wistar rats under different anesthetic regimens, and found differences in brain activation and functional connectivity patterns between the two rat strains.
BRAIN CONNECTIVITY
(2022)
Article
Biochemistry & Molecular Biology
Nguyen Thanh Nhu, David Yen-Ting Chen, Jiunn-Horng Kang
Summary: This study compared the accuracy of network rs-FC and brain structural features in identifying FM using a machine learning approach. The results showed that the rs-FC ML model outperformed the structural ML model in distinguishing FM patients from pain-free controls, and the combined rs-FC and structural ML model performed the best. Several rs-FC features in the final ML model were found to correlate with FM's clinical data.
Article
Neurosciences
Sebastian C. Schneider, Mario E. Archila-Melendez, Jens Goettler, Stephan Kaczmarz, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Summary: By studying asymptomatic patients with arterial stenosis and healthy controls, this study demonstrates a negative association between homotopic BOLD-FC and capillary transit time heterogeneity (CTH) differences, suggesting that increasing CTH differences lead to BOLD-FC reductions. Simulations also show that increasing CTH corresponds to broadened and delayed CBF responses to ongoing neuronal activity.
Article
Biology
Gidon Levakov, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Hila Zelicha, Matthias Blueher, Uta Ceglarek, Michael Stumvoll, Ilan Shelef, Galia Avidan, Iris Shai
Summary: This study found that weight loss may have a beneficial effect on the trajectory of brain aging. Using magnetic resonance imaging to assess resting-state functional connectivity, researchers found that a 1% decrease in body weight resulted in an 8.9-month decrease in predicted brain age. Furthermore, improvements in liver biomarkers, decreased liver fat, and fat deposition were significantly associated with attenuation of brain age. Lower consumption of processed food, sweets, and beverages was also associated with attenuated brain age.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nmachi Anumba, Eric Maltbie, Wen-Ju Pan, Theodore J. J. LaGrow, Nan Xu, Shella Keilholz
Summary: By comparing the differences between the global signal and the adjacent non-brain tissue signal in resting-state functional magnetic resonance imaging (rs-fMRI), this study reveals the relative contributions of neural and non-neural sources to the global signal. The study used three different anesthetics and found differences in spectral composition and spatial selectivity between the two signals.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Ron Levy, Douglas J. Cook, Ravi S. Menon, Stefan Everling, Jason P. Gallivan
Summary: Studies have found that under general anesthesia, the apparent fragmentation of whole-brain network structure is actually a result of a global reduction in functional connectivity rather than an actual change in network structure. This observation constrains current interpretations of how anesthesia-induced functional connectivity changes map onto existing neurobiological theories of consciousness.
Article
Biochemical Research Methods
Hui Bi, Shumei Cao, Hanying Yan, Zhongyi Jiang, Jun Zhang, Ling Zou
Summary: Monitoring the depth of anesthesia is important for administering general anesthetics during surgery. However, traditional EEG monitors have limitations in monitoring conscious states. This study used high-density EEG signals to compare two methods for functional connectivity analysis before and after anesthesia-induced loss of consciousness. The results show that the method based on sparse representation performs better in distinguishing loss of consciousness from awake states.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Xiangyu Zheng, Jiawei Sun, Yating Lv, Mengxing Wang, Xiaoxia Du, Xize Jia, Jun Ma
Summary: By calculating various metrics in different frequency bands, this study reveals that children with nocturnal enuresis may have abnormal neural oscillations mainly in the slow-5 bands.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Z. Moradimanesh, R. Khosrowabadi, M. Eshaghi Gordji, G. R. Jafari
Summary: The complexity of a network is determined not only by its size but also by the interactions between elements. The complexity of brain networks also arises from interactions beyond pair connections, particularly in genetically complex brain impairments like ASD. By analyzing ASD and control networks using structural balance theory, it was found that balanced triads are overrepresented in the ASD networks, providing empirical evidence for the concept of structural balance on brain networks.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Developmental
Bosi Chen, Annika Linke, Lindsay Olson, Cynthia Ibarra, Mikaela Kinnear, Inna Fishman
Summary: This study examined resting-state fMRI data from 24 typically developing toddlers aged 1.5-3.5 years, revealing that changes in spatial variability and network homogeneity were associated with age and developmental skills. Older children displayed less spatial variability in the default mode network, while higher-order functional networks showed increased network homogeneity related to more advanced developmental skills.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yali Chen, Shitong Li, Fan Wu, Ling Zou, Jun Zhang
Summary: The study demonstrates that propofol produces state-dependent effects on cortico-cortical undirected and directed functional connectivity. Propofol-induced unconsciousness is characterized by a decrease in functional connectivity and changes in the direction of information flow in the brain regions. This supports the idea that propofol-induced loss of consciousness may be through disrupting network interactions and cortical coordination.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Physiology
Larissa McKetton, Kevin Sam, Julien Poublanc, Adrian P. Crawley, Olivia Sobczyk, Lakshmikumar Venkatraghavan, James Duffin, Joseph A. Fisher, David J. Mikulis
Summary: This study examines the effect of variability in PaCO2 on the pattern of rs-fMRI connectivity. The findings suggest that fluctuations in PETCO2 during normal breathing can lead to changes in cerebral functional connections and affect the synchronization of BOLD signals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chenyan Zhang, Christian Beste, Luisa Prochazkova, Kangcheng Wang, Sebastian P. H. Speer, Ale Smidts, Maarten A. S. Boksem, Bernhard Hommel
Summary: Numerous studies have shown that neural variability is beneficial for tasks requiring cognitive flexibility. This study investigated the association between resting-state BOLD signal variability and two metacontrol policies. The results demonstrate that higher brain variability is associated with reduced cognitive persistence and greater flexibility.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Theresia J. M. Roelofs, Milou Straathof, Annette van der Toorn, Willem M. Otte, Roger A. H. Adan, Rick M. Dijkhuizen
Summary: Eating disorders and obesity are major health issues in Western Society, requiring an understanding of the neural mechanisms underlying their development. The study found that food intake and sucrose tasting can influence functional network organization, potentially explaining specific patterns in feeding behavior.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Psychiatry
Yue Cui, Chao Li, Bing Liu, Jing Sui, Ming Song, Jun Chen, Yunchun Chen, Hua Guo, Peng Li, Lin Lu, Luxian Lv, Yuping Ning, Ping Wan, Huaning Wang, Huiling Wang, Huawang Wu, Hao Yan, Jun Yan, Yongfeng Yang, Hongxing Zhang, Dai Zhang, Tianzi Jiang
Summary: This study used deep-learning techniques to identify grey matter abnormalities associated with schizophrenia. By analyzing data from eight independent centers, researchers developed a deep-learning classifier that accurately distinguished schizophrenia patients from healthy controls.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Cell Biology
Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu
Summary: The lack of predictive and translatable animal models has been a major obstacle in Alzheimer's disease (AD) research. While transgenic mice overexpressing App gene do not reflect disease progression accurately, the App knock-in rat model with humanized A beta sequence shows promise in mimicking AD pathologies and progression, including A beta plaques, tau pathology, neuronal death, and cognitive deficits. This rat model may provide valuable insights for AD research and drug development.
Article
Endocrinology & Metabolism
Pavel Yanev, Geralda A. F. van Tilborg, Annette van der Toorn, Xiangmei Kong, Ann M. Stowe, Rick M. Dijkhuizen
Summary: In this study, a slow-releasing hydrogel loaded with pro-angiogenic factors was injected into the stroke lesion of rats to promote recovery. The hydrogel showed prolonged release of the factors and resulted in significant sensorimotor recovery and increased vascularization in the perilesional cortex. This method supports brain tissue regeneration and functional recovery in the chronic phase post-stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Jin Li, Dan Cao, Vasileios Dimakopoulos, Weiyang Shi, Shan Yu, Lingzhong Fan, Lennart Stieglitz, Lukas Imbach, Johannes Sarnthein, Tianzi Jiang
Summary: This study recorded intracranial EEG from the anterior and posterior hippocampi in humans to investigate the involvement and functional connections of these subregions in working memory (WM) processing. The results showed elevated low-frequency activity and increased theta/alpha band phase synchronization between anterior and posterior subregions during WM maintenance. Correct WM trials were associated with unidirectional influence from the posterior to the anterior hippocampus, while WM errors were associated with bidirectional interactions between the two subregions. These findings suggest that theta/alpha band synchrony within the hippocampus supports successful WM via a posterior to anterior influence.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Aladdin Taha, Joaquim Bobi, Ruben Dammers, Rick M. Dijkhuizen, Antje Y. Dreyer, Adriaan C. G. M. van Es, Fabienne Ferrara, Matthew J. Gounis, Bjoern Nitzsche, Simon Platt, Michael H. Stoffel, Victor Volovici, Gregory J. del Zoppo, Dirk J. Duncker, Diederik W. J. Dippel, Johannes Boltze, Heleen M. M. van Beusekom
Summary: Translation of acute ischemic stroke research to the clinical setting remains limited, with only one drug successfully completing the path from experimental study to clinical practice. Large gyrencephalic animal models, such as dogs, swine, sheep, and nonhuman primates, have been recommended to improve the selection of experimental treatments before testing in clinical studies. This review discusses the characteristics of these animal models and aims to facilitate the selection of appropriate models for studying acute ischemic stroke.
Article
Neurosciences
Haixia Long, Ming Fan, Qiaojun Li, Xuhua Yang, Yujiao Huang, Xinli Xu, Ji Ma, Jie Xiao, Tianzi Jiang
Summary: This study investigates the effects of sex on aggression subscales, gray matter volume, and functional connectivity of each insula subregion, as well as the correlation between aggression subscales and gray matter volume and functional connectivity. The study finds that sex significantly influences physical aggression, anger, and hostility, as well as the gray matter volume of all insula subregions and the functional connectivity of specific subregions. Mediation analysis reveals that the gray matter volume of bilateral dorsal agranular insula mediates the association between sex and physical aggression, and the functional connectivity between left dorsal dysgranular insula and left medial orbital superior frontal gyrus mediates the relationship between sex and anger. These findings highlight the neural mechanism underlying sex differences in aggression subscales and emphasize the important role of the insula in aggression differences between males and females.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Dan Cao, Zhenying Qian, Yingying Tang, Jijun Wang, Tianzi Jiang, Yingjie Li
Summary: This study demonstrates the causal role of the left VLPFC in positive reappraisal, and provides a neural indicator to assess the degree to which single-pulse TMS modulates emotional experience using positive reappraisal.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Yaping Wang, Lin Chai, Congying Chu, Deying Li, Chaohong Gao, Xia Wu, Zhengyi Yang, Yu Zhang, Junhai Xu, Jens Randel Nyengaard, Simon B. Eickhoff, Bing Liu, Kristoffer Hougaard Madsen, Tianzi Jiang, Lingzhong Fan
Summary: This study decodes the genetic profiles of the cerebellar functional organization by investigating the genetic substrates linking cerebellar functional heterogeneity and its connections. The results show that the co-expression pattern of network-specific genes is strongly correlated with intra-cerebellar functional connectivity, and some of these genes are also linked to cortico-cerebellar cognitive-limbic networks. Additionally, a negative gene set is associated with cerebellar connectivity-behavior association and brain diseases related to cerebellar functional abnormalities.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Kaixin Li, Lingzhong Fan, Yue Cui, Xuehu Wei, Yini He, Jiyue Yang, Yuheng Lu, Wen Li, Weiyang Shi, Long Cao, Luqi Cheng, Ang Li, Bo You, Tianzi Jiang
Summary: This study unveiled the anatomical and functional organization of the human mediodorsal thalamic nucleus (MD) and demonstrated the specific involvement of different subregions in cognitive functions, highlighting the various roles of the prefrontal-thalamic circuitry in human cognition.
Article
Clinical Neurology
Eduardo Candelario-Jalil, Rick M. Dijkhuizen, Tim Magnus
Summary: The role of neuroinflammation in ischemic stroke pathology and its interactions with central nervous system and peripheral immune responses are critically discussed. Neuroinflammation is associated with blood-brain barrier breakdown, neuronal injury, and worse neurological outcomes during acute phase of stroke.
Review
Endocrinology & Metabolism
Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M. Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze, Peiying Li
Summary: Cognitive impairment (CI) is a significant health concern in aging populations and is often associated with vascular cognitive impairment (VCI). Reduced cerebral blood flow (CBF) plays a critical role in the progression of VCI, and arterial spin labeling (ASL) is a non-invasive MRI technique that can accurately assess CBF. Recent advancements in ASL have improved its usability and led to an increased application in identifying high-risk VCI patients. ASL, when combined with other imaging modalities and biomarkers, shows great potential in early detection and prevention strategies for VCI.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Noa van der Knaap, Bart A. A. Franx, Charles B. L. M. Majoie, Aad van der Lugt, Rick M. Dijkhuizen
Summary: The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood flow through recanalization of the occluded vessel. However, successful recanalization does not always result in favorable clinical outcome. Post-recanalization perfusion deficits (PRPDs), constituted by cerebral hypo- or hyperperfusion, may contribute to lagging patient recovery rates, but its clinical significance remains unclear.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Jord J. T. Vink, Eline C. C. van Lieshout, Willem M. M. Otte, Ruben P. A. van Eijk, Mirjam Kouwenhoven, Sebastiaan F. W. Neggers, H. Bart van der Worp, Johanna M. A. Visser-Meily, Rick M. M. Dijkhuizen
Summary: Inhibitory repetitive transcranial magnetic stimulation treatment started within 3 weeks after stroke onset promotes upper limb motor recovery, reduces disability and dependence, and leads to earlier discharge from the rehabilitation center.
Article
Endocrinology & Metabolism
Bart A. A. Franx, Geralda A. F. Van Tilborg, Aladdin Taha, Joaquim Bobi, Annette Van der Toorn, Caroline L. Van Heijningen, Heleen M. M. Van Beusekom, Ona Wu, Rick M. Dijkhuizen, CONTRAST Consortium
Summary: In this study, we investigated the effects of recanalization on disease outcome after experimental cerebral ischemia-reperfusion. We found that recanalization resulted in acute-to-subacute lesion volume reductions, particularly in females. Post-ischemic hyperperfusion developed differently in males and females, and had varying effects on disease outcome, depending on the perfusion parameter used.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
