Article
Chemistry, Analytical
Alan Wong
Summary: High-Resolution Magic-Angle Spinning (HRMAS) NMR spectroscopy is considered an essential technique in metabolomics for assessing the biochemical composition of tissue samples. HRMAS localized profiling shows promise for spatial resolution of metabolic profiles within the sampling tissues.
ANALYTICAL METHODS
(2023)
Article
Biochemical Research Methods
Andrea Bertarello, Pierrick Berruyer, Urban Skantze, Samiksha Sardana, Malvika Sardana, Charles S. Elmore, Markus Schade, Elisabetta Chiarparin, Staffan Schantz, Lyndon Emsley
Summary: Dynamic nuclear polarization (DNP) significantly enhances the sensitivity of MAS NMR, but cross polarization (CP) is usually not quantitative. Research shows that absolute quantification in MAS DNP NMR is possible under DNP conditions, with errors below 10%.
JOURNAL OF MAGNETIC RESONANCE
(2021)
Article
Chemistry, Physical
Debashis Majhi, Boris B. Kharkov, Sergey Dvinskikh
Summary: Dipolar NMR spectroscopy is a powerful analytical tool for studying structural and dynamic properties of solids at the molecular level. An approach to determine the signs of dipolar couplings in liquid crystals is presented, where sign information can be directly obtained from one-dimensional NMR spectra in samples spinning slightly off the magic angle. This method can be used to develop an experimental strategy for sign-sensitive measurements of heteronuclear dipolar couplings in anisotropic soft materials.
CHEMICAL PHYSICS LETTERS
(2021)
Review
Biophysics
Leo L. Cheng
Summary: This article provides a history of the discovery and recent developments of high-resolution magic angle spinning (HRMAS) NMR, a technique used for intact biological material analysis. HRMAS NMR metabolomics studies have been applied in various fields such as human disease states, plant and food analysis, and cell structure studies. The article also discusses the potential applications of HRMAS NMR in future biomedical investigations.
NMR IN BIOMEDICINE
(2023)
Article
Physics, Multidisciplinary
Sebastien Designolle, Roope Uola, Kimmo Luoma, Nicolas Brunner
Summary: The coherence of a set of quantum systems can be characterized in a basis-independent way using the concept of set coherence, with measures that have operational meaning in discrimination games and capture the advantage offered by a given set over incoherent ones. This notion of set coherence is also connected to resource-theoretic approaches developed for quantum systems.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Marta Bonaccorsi, Tanguy Le Marchand, Guido Pintacuda
Summary: Magic-Angle Spinning Nuclear Magnetic Resonance (MAS NMR) is a rapidly developing technique that complements solution NMR, X-ray crystallography, and electron microscopy for the biophysical characterization of microcrystalline, poorly crystalline or disordered protein samples. MAS NMR is ideal for investigating both structures and dynamics, and has been increasingly applied in structural biology research in recent years to describe conformational dynamics in various systems.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2021)
Review
Chemistry, Physical
Bianca Chandler, Lauren Todd, Steven O. Smith
Summary: G protein-coupled receptors (GPCRs) are a class of transmembrane proteins with a simple structure that can recognize diverse chemical signals. There are over 800 GPCRs encoded in the human genome, serving as receptors for vision, smell, taste, and other physiological processes. While protein crystallography and electron cryo-microscopy have provided high-resolution structures of GPCRs, the structural changes induced by ligand or drug binding to stabilize active or inactive conformations are often subtle. NMR spectroscopy can provide insights into the local structure, dynamics, and activation pathways of GPCRs, capturing intermediate states and low-population conformations. Solid-state magic angle spinning NMR has been used to study the structure and activation mechanisms of GPCRs, particularly in the diverse class A family. This review highlights the application of solid-state and solution-state NMR spectroscopy in understanding the activation of different GPCR classes and subfamilies by their ligands and the modulation of GPCR activation by small molecule drugs. (c) 2021 Elsevier B.V. All rights reserved.
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
(2022)
Article
Plant Sciences
Matteo Scarsini, Adrien Thurotte, Brigitte Veidl, Frederic Amiard, Frederick Niepceron, Myriam Badawi, Fabienne Lagarde, Benoit Schoefs, Justine Marchand
Summary: A study on the cellular quota quantification method of the diatom Phaeodactylum tricornutum showed significant differences in lipid metabolism regulation between different ecotypes of the diatom.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matteo Sanchez-Dahl Gonzalez, Isabella H. Muti, Leo L. Cheng
Summary: This review discusses the potential clinical benefits of incorporating high-resolution magic angle spinning magnetic resonance spectroscopy in the diagnosis, prognostication, and monitoring of prostate cancer.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Biochemical Research Methods
Daniel Banks, Brian Michael, Natalie Golota, Robert G. Griffin
Summary: This paper discusses the use of 3D printing and rapid prototyping methods to fabricate 3.2 mm stators and drive caps for NMR experiments. With the assistance of CAD software, these components can be produced at a fraction of the cost of commercial parts, while demonstrating comparable performance to commercially available systems.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Biochemical Research Methods
Evgeny Nimerovsky, Stefan Becker, Loren B. Andreas
Summary: In this study, we investigate the windowed sequence for cross polarization (wCP) and find that it has additional matching conditions compared to traditional cross polarization. By considering the flip angle of the pulse, we observe a striking similarity between wCP and CP transfer conditions. Using spin-1/2 formalism and average Hamiltonian theory, we derive an analytical approximation that matches these observed transfer conditions. Data recorded at spectrometers with different external magnetic fields show that these transfers and the selectivity of CP are related to flip angle (average nutation).
JOURNAL OF MAGNETIC RESONANCE
(2023)
Review
Chemistry, Physical
Kai Xue, Riddhiman Sarkar, Zdenek Tosner, Bernd Reif
Summary: Proton detection in solid state NMR is continuously advancing, and current achievements include the necessity of deuteration for optimal spectral quality, the superiority of 13CH3 isotopomers for methyl groups at high MAS frequencies, and the sensitivity enhancement with increased static magnetic field.
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Suochang Xu, Nicholas R. Jaegers, Wenda Hu, Ja Hun Kwak, Xinhe Bao, Junming Sun, Yong Wang, Jian Zhi Hu
Summary: In this study, detailed analysis of three aluminum oxide phases was conducted using high-field NMR, revealing structural information of different aluminum sites and providing a method to quantify complex mixtures of aluminum sites in transition alumina samples. The results showcase the potential of high-field NMR in characterizing materials and identifying distinct phases within a sample.
Article
Biochemistry & Molecular Biology
Hyeon-Man Baek
Summary: This study evaluated the performance of an in-house basis set compared to a vendor-provided basis set for the quantification of human brain metabolites. The results showed that the in-house basis set was more precise, especially for the quantification of aspartate.
Article
Engineering, Mechanical
Rajdeep Deb, Andreas Hunkeler, Dirk Wilhelm, Patrick Jenny, Beat H. Meier
Summary: Numerical stability analysis was performed on aerostatic bearings for small cylindrical rotors. The modified Reynolds equation was used to obtain optimized design parameters and the maximum stable inertial force. Experimental observations and numerical investigations confirmed the role of nozzle diameter, nozzle number, and gas molecular weight in enhancing rotor spinning frequency.
TRIBOLOGY INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Eric Van Reeth, Pauline M. Lefebvre, Helene Ratiney, Simon A. Lambert, Michael Tesch, Elisabeth Brusseau, Denis Grenier, Olivier Beuf, Steffen J. Glaser, Dominique Sugny, Kevin Tse-Ve-Koon
JOURNAL OF MAGNETIC RESONANCE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eric Van Reeth, Helene Ratiney, Kevin Tse Ve Koon, Michael Tesch, Denis Grenier, Olivier Beuf, Steffen J. Glaser, Dominique Sugny
MAGNETIC RESONANCE IN MEDICINE
(2019)
Article
Biophysics
Angeline Nemeth, Berenice Segrestin, Benjamin Leporq, Amandine Coum, Giulio Gambarota, Kevin Seyssel, Martine Laville, Olivier Beuf, Helene Ratiney
NMR IN BIOMEDICINE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Angeline Nemeth, Berenice Segrestin, Benjamin Leporq, Kevin Seyssel, Khuram Faraz, Valerie Sauvinet, Emmanuel Disse, Pierre-Jean Valette, Martine Laville, Helene Ratiney, Olivier Beuf
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Article
Biology
Clement Daviller, Thomas Grenier, Helene Ratiney, Michael Sdika, Pierre Croisille, Magalie Viallon
COMPUTERS IN BIOLOGY AND MEDICINE
(2019)
Correction
Biology
Clement Daviller, Thomas Grenier, Helene Ratiney, Michael Sdika, Pierre Croisille, Magalie Viallon
COMPUTERS IN BIOLOGY AND MEDICINE
(2019)
Article
Physiology
Clement Daviller, Timothe Boutelier, Shivraman Giri, Helene Ratiney, Marie-Pierre Jolly, Jean-Paul Vallee, Pierre Croisille, Magalie Viallon
Summary: Cardiac magnetic resonance myocardial perfusion imaging is a valuable tool for detecting coronary artery disease, but challenges in signal complexity and quantification have limited its clinical application. A new Bayesian approach offers a more robust alternative for evaluating perfusion indexes, showing promising results in comparison to traditional methods.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Malgorzata Marjanska, Dinesh K. Deelchand, Roland Kreis, Jeffry R. Alger, Patrick J. Bolan, Tamas Borbath, Fawzi Boumezbeur, Carolina C. Fernandes, Eduardo Coello, Bharath Halandur Nagraja, Michal Povazan, Helene Ratiney, Diana Sima, Jana Starcukova, Brian J. Soher, Martin Wilson, Jack J. A. Van Asten
Summary: Fitting of MRS data is crucial in quantification of metabolite concentrations, and different spectral fitting packages show substantial differences in accuracy and precision of fit results. Soft constraints used in LCModel significantly influence the fitting results and their dependence on SNR.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Biochemical Research Methods
Nour El Sabbagh, Carine Chassain, Helene Ratiney, Guilhem Pages, Jean-Marie Bonny
Summary: IDEAL-type magnetic resonance spectroscopic imaging (MRSI) sequences require optimized sampling in the time domain to reconstruct metabolite maps, with phase variation during the evolution time dependent only on chemical shifts. This paper discusses the apparition of spurious phase due to transmit or receive frequencies and proposes corrections based on different cases. It is crucial to know which case is implemented on the MRI scanner for accurate corrections.
JOURNAL OF MAGNETIC RESONANCE
(2021)
Article
Multidisciplinary Sciences
Pilar Sango-Solanas, Kevin Tse Ve Koon, Eric Van Reeth, Helene Ratiney, Fabien Millioz, Cyrielle Caussy, Olivier Beuf
Summary: This study proposed a novel method for simultaneous multifrequency MRE in the absence of motion encoding gradients (MEGs). By using RF pulses designed via the Optimal Control (OC) theory, slice selection and motion encoding can be achieved simultaneously, reducing the acquisition time. Phantom experiments showed excellent agreement in the reconstructed shear storage modulus between the new method and the traditional monofrequency MRE.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Berenice Segrestin, Pauline Delage, Angeline Nemeth, Kevin Seyssel, Emmanuel Disse, Julie-Anne Nazare, Stephanie Lambert-Porcheron, Laure Meiller, Valerie Sauvinet, Stephanie Chanon, Chantal Simon, Helene Ratiney, Olivier Beuf, Francois Pralong, Naba-al-Huda Yassin, Alexia Boizot, Melanie Gachet, Kathryn J. Burton-Pimentel, Hubert Vidal, Emmanuelle Meugnier, Nathalie Vionnet, Martine Laville
Summary: This study tested the efficacy of grape polyphenol extract during high calorie-high fructose overfeeding and found that the supplementation did not have any impact on metabolic and weight changes in both men and women.
FRONTIERS IN NUTRITION
(2022)
Article
Biophysics
Pilar Sango Solanas, Kevin Tse Ve Koon, Helene Ratiney, Fabien Millioz, Cyrielle Caussy, Olivier Beuf
Summary: Magnetic resonance elastography (MRE) is used to quantify tissue viscoelastic properties based on shear wave propagation characteristics. A novel dual-frequency MRE method has been proposed to simultaneously generate and encode two different frequency shear waves in a single experiment, reducing acquisition time and increasing signal-to-noise ratio.
NMR IN BIOMEDICINE
(2021)
Article
Nutrition & Dietetics
Magalie Viallon, Benjamin Leporq, Stephan Drinda, Francoise Wilhelmi de Toledo, Bogdan Galusca, Helene Ratiney, Pierre Croisille
FRONTIERS IN NUTRITION
(2019)
Proceedings Paper
Computer Science, Theory & Methods
Nima Hatami, Michael Sdika, Helene Ratiney
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2018, PT I
(2018)
Article
Engineering, Electrical & Electronic
Jabrane Karkouri, Helene Ratiney, Magalie Viallon, Remy Prost, Fabien Millioz
Summary: This paper introduces an acceleration method for multidimensional signal acquisition by undersampling the time dimension and interleaving samples, resulting in a reduction in acquisition time by a factor of three when applied to realistic simulated magnetic resonance spectroscopic imaging data (MRSI).
IEEE TRANSACTIONS ON SIGNAL PROCESSING
(2021)